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Otol Neurotol ; 45(6): e490-e493, 2024 Jul 01.
Article in English | MEDLINE | ID: mdl-38773842

ABSTRACT

OBJECTIVE: To present and evaluate the treatment of ciprofloxacin-resistant Pseudomonas mastoid cavity otorrhea with a ceftazidime thermosensitive poloxamer gel. STUDY DESIGN: A retrospective clinical capsule report. PATIENTS: Three patients diagnosed with ciprofloxacin-resistant Pseudomonas otorrhea in the setting of a previous canal-wall-down mastoidectomy between March 2019 and June 2023 visiting our tertiary care institution were retrospectively reviewed. INTERVENTION: Application of a 2% ceftazidime thermosensitive poloxamer gel to mastoid cavity. MAIN OUTCOME MEASURES: No evidence of disease during microscopic inspection of the ear within a month of initial treatment or bacterial eradication on subsequent culture. RESULTS: Two patients had complete resolution of symptoms and achieved a safe and dry ear after topical application of the hydrogel. The second patient had pseudomonal eradication on culture, but persistent otorrhea due to other multidrug-resistant bacteria and an anatomically unfavorable mastoid cavity, which ultimately resolved after revision surgery. CONCLUSIONS: This small case series suggests that topical treatment of mastoid cavity otorrhea with a 2% ceftazidime poloxomer gel is a potential therapeutic avenue in patients with ciprofloxacin-resistant Pseudomonas .


Subject(s)
Anti-Bacterial Agents , Ceftazidime , Ciprofloxacin , Gels , Poloxamer , Pseudomonas Infections , Humans , Ciprofloxacin/therapeutic use , Ciprofloxacin/administration & dosage , Anti-Bacterial Agents/therapeutic use , Anti-Bacterial Agents/administration & dosage , Pseudomonas Infections/drug therapy , Pseudomonas Infections/microbiology , Ceftazidime/therapeutic use , Ceftazidime/administration & dosage , Female , Male , Middle Aged , Retrospective Studies , Mastoid/surgery , Drug Resistance, Bacterial , Otitis Media with Effusion/drug therapy , Otitis Media with Effusion/microbiology , Otitis Media with Effusion/surgery , Aged , Adult , Administration, Topical
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