ABSTRACT
INTRODUCTION: The efficiency of The International Classification of Headache Disorders (ICHD-3) in reflecting patients' disability has recently been questioned. This prompts consideration that clinical features beyond pain may more accurately indicate the extent of underlying brain impairment than the mere frequency of headache days. Important cognitive dysfunctions and psychological impairment have been reported in burdensome cases of migraine, and the presence of these alterations has been associated with biological changes in the nervous system. This study aimed to compare migraine-related disability within a specific patient group, classified using ICHD-3 criteria or classified based on findings from a neuropsychological evaluation using machine learning. Additionally, a complementary voxel-based morphometry (VBM) comparison was conducted to explore potential neuroanatomical differences between the resulting groups. PATIENTS AND METHODS: The study included episodic and chronic migraine patients seeking consultation at a specialized headache department. A neuropsychological evaluation protocol, encompassing validated standardized tests for cognition, anxiety, depression, perceived stress, and headache-related impact (HIT-6) and disability (MIDAS), was administered. Results from this evaluation were input into an automated K-means clustering algorithm, with a predefined K=2 for comparative purposes. A supplementary Voxel-based Morphometry (VBM) evaluation was conducted to investigate neuroanatomical contrasts between the two distinct grouping configurations. RESULTS: The study involved 111 participants, with 49 having chronic migraine and 62 having episodic migraine. Seventy-four patients were assigned to cluster one, and 37 patients were assigned to cluster two. Cluster two exhibited significantly higher levels of depression, anxiety, and perceived stress, and performed worse in alternating and focalized attention tests. Differences in HIT-6 and MIDAS scores between episodic and chronic migraine patients did not reach statistical significance (HIT-6: 64.39 (±7,31) vs 62.92 (±11,61); p= 0. 42 / MIDAS: 73.63 (±68,61) vs 84.33 (±63,62); p=0.40). In contrast, patients in cluster two exhibited significantly higher HIT-6 (62.32 (±10,11) vs 66.57 (±7,21); p=0.03) and MIDAS (68.69 (±62,58) vs 97.68 (±70,31); p=0.03) scores than patients in cluster one. Furthermore, significant differences in grey matter volume between the two clusters were noted, particularly involving the precuneus, while differences between chronic and episodic migraine patients did not withstand correction for multiple comparisons. CONCLUSIONS: The classification of migraine patients based on neuropsychological characteristics demonstrates a more effective separation of groups in terms of disability compared to categorizing them based on the chronic or episodic diagnosis of ICHD-3. These findings could reveal biological changes that might explain differences in treatment responses among apparently similar patients.
Subject(s)
Disabled Persons , Headache Disorders , Migraine Disorders , Humans , Migraine Disorders/complications , Migraine Disorders/diagnostic imaging , Headache , Headache Disorders/diagnosis , Data CollectionABSTRACT
BACKGROUND: Roughly three percent of episodic migraine patients evolve into the most burdensome chronic form of this condition every year. While some of the determinants behind this transformation are well established, others are still ill defined. Hypothyroidism is a prevalent endocrinological disorder that can both produce a secondary headache or aggravate a pre-existing primary headache disorder such as migraine. OBJECTIVE: We aimed to re-assess the association between hypothyroidism and chronic migraine controlling for factors such as hormone replacement treatment status and bodyweight. METHODS: We retrospectively analyzed the medical records of episodic and chronic migraine patients who consecutively consulted our headache clinic in order to determine the prevalence of adequately treated hypothyroidism in each group. Only patients receiving a stable dose regimen were included. The body mass index and other possibly confounding covariates were also collected. RESULTS: Data from 111 migraine patients was included for analysis. Most (88.6%) of chronic migraine sufferers were overusing acute medication. Treated hypothyroidism was significantly more prevalent in chronic migraine patients (29.55%) compared to episodic migraine patients (8.96%). This association was independent of the patients' body mass index or other variables. CONCLUSION: Alterations of neuronal metabolism, deficient calcitonin release, or focal inflammation causing local hormonal deactivation might explain why hypothyroidism, in spite of levothyroxine replacement therapy, is associated with migraine chronification. Further studies evaluating these factors are warranted.
Subject(s)
Hypothyroidism , Migraine Disorders , Headache , Humans , Hypothyroidism/drug therapy , Hypothyroidism/epidemiology , Migraine Disorders/drug therapy , Migraine Disorders/epidemiology , Referral and Consultation , Retrospective StudiesABSTRACT
INTRODUCTION: The purpose of this research is to establish if there is a seasonal pattern in hospitalizations due to affective episodes of bipolar disorder in Hospital Colonia Santa María, Córdoba, Argentina, between 2000-2003. MATERIALS AND METHODS: The affective episodes considered were those which required patient hospitalization with bipolar disorder diagnosis (ICD-10). Medical histories were analyzed subsequently, according to the DSM-IV criteria. The episodes considered were those with hospitalization during all the pathobiographical history of the patient. OUTCOME: 84 affective episodes were considered. 43 were maniac (51%), 20 were depressive (24%), 15 were mixed (18%) and 6 were hypomaniac (7%). A statistically significant association was found (p0.001) between affective episodes of bipolar disorder and the season of the year, with a seasonal pattern of mania-hypomania in summer and depression in winter. Mixed episodes were distributed more consistently in the year with a peak in summer. CONCLUSION: In this research a relationship is established between bipolar disorder and seasonal nature in hospitalizations.
Subject(s)
Bipolar Disorder/epidemiology , Hospitalization/statistics & numerical data , Seasons , Adult , Argentina , Female , Humans , MaleABSTRACT
Introducción: el objetivo del trabajo es establecer si existe un patrón de estacionalidad en las internaciones hospitalarias por trastorno bipolar en el Hospital Colonia Santa María, Córdoba, Argentina, entre los años 2000 y 2003. Materiales y métodos: se tomaron los episodios afectivos internados con diagnóstico de trastorno bipolar (CIE-IO) durante el período y se analizaron las historias clínicas según los criterios del DSM-IV. Se incluyeron las internaciones de toda la historia patobiográfica del individuo. Resultados: se incluyeron 84 episodios afectivos: 43 maníacos (51%), 20 depresivos (24%), 15 mixtos (18%) y 6 hipomaníacos (7%). Se encontró una asociación estadísticamente significativa (p<0,001) entre episodios afectivos del trastorno bipolar y estación del año, con un patrón estacional de manía-hipomanía en verano y depresión en invierno. Los episodios mixtos presentan pico en verano pero se distribuyen más uniformemente en el año. Conclusiones: existe estacionalidad en las internaciones por trastorno bipolar.
Introduction: The purpose of this research is to establish if there is a seasonal pattern in hospitalizations due to affective episodes of bipolar disorder in Hospital Colonia Santa Maria, Córdoba, Argentina, between 2000-2003. Materials and methods: The affective episodes considered were those which required patient hospitalization with bipolar disorder diagnosis (ICD-I0). Medical histories were analyzed subsequently, according to the DSM-IV criteria. The episodes considered were those with hospitalization during all the pathobiographical history of the patient. Outcome: 84 affective episodes were considered. 43 were maniac (51 %), 20 were depressive (24%), 15 were mixed (18%) and 6 were hypomaniac (7%). A statistically significant association was found (p<0,00l) between affective episodes of bipolar disorder and the season of the year, with a seasonal pattern of mania-hypomania in summer and depression in winter. Mixed episodes were distributed more consistently in the year with a peak in summer. Conclusion: In this research a relationship is established between bipolar disorder and seasonal nature in hospitalizations.
Subject(s)
Humans , Male , Female , Seasonal Affective Disorder/diagnosis , Seasonal Affective Disorder/ethnology , Bipolar Disorder , Argentina , Periodicity , Admitting Department, Hospital/statistics & numerical dataABSTRACT
Introducción: el objetivo del trabajo es establecer si existe un patrón de estacionalidad en las internaciones hospitalarias por trastorno bipolar en el Hospital Colonia Santa María, Córdoba, Argentina, entre los años 2000 y 2003. Materiales y métodos: se tomaron los episodios afectivos internados con diagnóstico de trastorno bipolar (CIE-IO) durante el período y se analizaron las historias clínicas según los criterios del DSM-IV. Se incluyeron las internaciones de toda la historia patobiográfica del individuo. Resultados: se incluyeron 84 episodios afectivos: 43 maníacos (51%), 20 depresivos (24%), 15 mixtos (18%) y 6 hipomaníacos (7%). Se encontró una asociación estadísticamente significativa (p<0,001) entre episodios afectivos del trastorno bipolar y estación del año, con un patrón estacional de manía-hipomanía en verano y depresión en invierno. Los episodios mixtos presentan pico en verano pero se distribuyen más uniformemente en el año. Conclusiones: existe estacionalidad en las internaciones por trastorno bipolar.(AU)
Introduction: The purpose of this research is to establish if there is a seasonal pattern in hospitalizations due to affective episodes of bipolar disorder in Hospital Colonia Santa Maria, Córdoba, Argentina, between 2000-2003. Materials and methods: The affective episodes considered were those which required patient hospitalization with bipolar disorder diagnosis (ICD-I0). Medical histories were analyzed subsequently, according to the DSM-IV criteria. The episodes considered were those with hospitalization during all the pathobiographical history of the patient. Outcome: 84 affective episodes were considered. 43 were maniac (51 %), 20 were depressive (24%), 15 were mixed (18%) and 6 were hypomaniac (7%). A statistically significant association was found (p<0,00l) between affective episodes of bipolar disorder and the season of the year, with a seasonal pattern of mania-hypomania in summer and depression in winter. Mixed episodes were distributed more consistently in the year with a peak in summer. Conclusion: In this research a relationship is established between bipolar disorder and seasonal nature in hospitalizations.(AU)
