Influence of the diagnostic protocol and age on the prostate cancer incidence rate in Castilla y León according to the national registry 2010.

OBJECTIVE: Cross-sectional descriptive observational study of incidence and association, to determine whether the higher incidence of prostate cancer in Castilla y León (with respect to the national rate) could be due to modifiable factors. LOCATION: University Hospital Río Hortega. PARTICIPANTS: New prostate cancer diagnoses. MAIN MEASUREMENTS: Incidence rate (IR). Age, family history, symptoms, comorbidity, rectal examination, ultrasound volume (cc), PSA (ng/mL), cylinders, volume cylinder ratio, Gleason, TNM and D'Amico groups. RESULTS: Castilla y León showed the highest prostate cancer IR in Spain (141.1 per 100,000 inhabitants per year), with a peak of early incidence (65-74 years) and significant differences in < 64 and 65-74 years. Age at diagnosis was the lowest (Castilla y León, 66.9 ±7.1 vs. Spain, 69.1 ±â€¯8.2 years; P < .001). No differences: family history, symptoms, comorbidity and PSA. The number of cylinders was 10.7 ±â€¯1.8. In multivariate analysis (AUC = 0.801; P < .001), they were more frequent in Castilla y León: grade i rectal examination, non-palpable rectal examination, Gleason < 6, stage T2c and the volume cylinder ratio < 6 (only in < 64 years: OR 5.2; 95% CI 1.2-22-22.3; P = .027). In Spanish regions, volume cylinder ratio showed inverse correlation with IR in < 74 years, while age showed positive correlation in all age groups. CONCLUSIONS: The higher prostate cancer IR in Castilla y León in 2010 was not associated to an older population. However, the biopsy technique influenced IR, as more cylinders were obtained in younger subjects, without conditioning overdiagnosis.

Influencia del protocolo diagnóstico y la edad en la tasa de incidencia de cáncer de próstata en Castilla y León según el registro nacional de 2010 / Influence of the diagnostic protocol and age on the prostate cancer incidence rate in Castilla y León according to the national registry 2010

Objetivo: Estudio observacional descriptivo transversal de incidencia y asociación, para conocer si la mayor incidencia de cáncer de próstata en Castilla y León (respecto a la tasa nacional) pudiera deberse a factores modificables.EmplazamientoHospital Universitario Río Hortega.ParticipantesNuevos diagnósticos de cáncer de próstata.Mediciones principalesTasa de incidencia (TI). Edad, antecedentes familiares, síntomas, comorbilidad, tacto rectal, volumen ecográfico (cc), PSA (ng/ml), cilindros, relación volumen cilindros, Gleason, TNM y grupos D’Amico.ResultadosLa TI en Castilla y León fue la más alta (141,1 por 100.000 habitantes-año), con un pico de incidencia precoz (65-74 años) y diferencias significativas en<64 y 65-74 años. La edad al diagnóstico fue la más baja (66,9±7,1 vs. 69,1±8,2 años; p<0,001). No hubo diferencias en: antecedentes familiares, síntomas, comorbilidad y PSA. El número de cilindros fue 10,7±1,8. En el análisis multivariante (AUC=0,801; p<0,001) fueron más frecuentes: tacto rectal grado i, tacto rectal no palpable, Gleason<6, estadio T2c y la relación volumen cilindros <6 (solo en<64 años: OR 5,2; IC 95% 1,2-22,3; p=0,027). En las CC. AA., la relación volumen cilindros mostró una correlación inversa con la TI en<74 años, mientras que la edad presentó correlación positiva en todos los tramos.ConclusionesLa mayor TI de cáncer de próstata en Castilla y León 2010 no guardó relación con una población más envejecida. Sin embargo, la técnica de biopsia influyó en la TI, al obtenerse más cilindros en los sujetos más jóvenes, sin condicionar sobrediagnóstico. (AU)

Objective: Cross-sectional descriptive observational study of incidence and association, to determine whether the higher incidence of prostate cancer in Castilla y León (with respect to the national rate) could be due to modifiable factors.LocationUniversity Hospital Río Hortega.ParticipantsNew prostate cancer diagnoses.Main measurementsIncidence rate (IR). Age, family history, symptoms, comorbidity, rectal examination, ultrasound volume (cc), PSA (ng/mL), cylinders, volume cylinder ratio, Gleason, TNM and D’Amico groups.ResultsCastilla y León showed the highest prostate cancer IR in Spain (141.1 per 100,000 inhabitants per year), with a peak of early incidence (65-74 years) and significant differences in<64 and 65-74 years. Age at diagnosis was the lowest (Castilla y León, 66.9±7.1 vs. Spain, 69.1±8.2 years; P<.001). No differences: family history, symptoms, comorbidity and PSA. The number of cylinders was 10.7±1.8. In multivariate analysis (AUC=0.801; P<.001), they were more frequent in Castilla y León: grade i rectal examination, non-palpable rectal examination, Gleason<6, stage T2c and the volume cylinder ratio<6 (only in<64 years: OR 5.2; 95% CI 1.2-22.3; P=.027). In Spanish regions, volume cylinder ratio showed inverse correlation with IR in<74 years, while age showed positive correlation in all age groups.ConclusionsThe higher prostate cancer IR in Castilla y León in 2010 was not associated to an older population. However, the biopsy technique influenced IR, as more cylinders were obtained in younger subjects, without conditioning overdiagnosis. (AU)

Características nutricionales y estilo de vida en universitarios / Nutritional characteristics and lifestyle in university students

La obesidad y el estilo de vida característico de nuestra sociedad llevan a los jóvenes a situaciones de potencial riesgo cardiovascular. El objetivo de este estudio fue valorarla situación antropométrica y estilo de vida de una muestra de universitarios. Se realizó una valoración antropométrica completa, incluyendo un análisis por impedancia bioeléctrica (AIB), a 111 estudiantes de último curso de Nutrición Humana y Dietética, así como una encuesta sobre su estilo de vida (actividad física, tabaquismo y consumo de alcohol). Se encontró un dimorfismo sexual en la distribución del peso según la clasificación propuesta por la SEEDO: un 6,4% de mujeres presentaron un peso inferior al saludable (ningún hombre se encontraba en este grupo), mientras que un 27,8% hombres y un 6,5% mujeres estaban en rango de sobrepeso. Un 15,3% de casos presentó un perímetro de cintura excesivo. La masa grasa, hallada por AIB, fue superior en las mujeres. Por otro lado, un 67% de universitarios declararon realizar ejercicio físico habitualmente, un 16,7% se declararon fumadores, y un 55,6% declararon consumo de alcohol de alta graduación. En conclusión, nos encontramos ante una población de sujetos jóvenes y sanos donde, sin embargo, aparece un significativo porcentaje de mujeres en peso inferior al saludable, personas con sobrepeso, fumadores bebedores de alcohol de alta graduación de manera habitual. Estos datos deben poner en aviso de que el grupo de población universitaria está en riesgo de sufrir patologías cardiovasculares en un futuro si no se actúa, y no deben estar olvidados en los planes de promoción de la salud (AU)

Obesity and the lifestyle characteristic of our society lead young people to conditions of potential cardiovascular risk. The aim of this study was to assess the anthropometrical situation and the lifestyle in a sample of university students. A full anthropometrical evaluation was undertaken, including bioelectric impedance analysis(BIA), in 111 students in the last year of Human Nutrition and Dietetics, as well as a lifestyle questionnaire (physical activity, alcohol and cigarette consumption). A sexual dimorphism was found in weight distribution according to the classification proposed by SEEDO: 6.4% of women presented a weight lower than the health recommendations (there no men in this group) where as 27.8% of men and 6.5% of women were in the overweight range. 15.3% of the cases had excessive waist circumference. Fat mass by BIA was higher among women. On the other hand,67% of university students stated to perform regular physical activity, 16.7% stated being cigarette smokers, and 55.6% stated to consume high-grade alcohol. To conclude, we studied a sample population of young and healthy subjects with, however, a significant percentage of women with body weight lower than the healthy standards, over weighed people, and smokers usually taking high-grade alcohol. These data should elicit an alert of the potential cardiovascular risk in the university population if action is not taken. This population should be included in the health promotion plans (AU)

[Nutritional characteristics and lifestyle in university students]. / Características nutricionales y estilo de vida en universitarios.

Obesity and the lifestyle characteristic of our society lead young people to conditions of potential cardiovascular risk. The aim of this study was to assess the anthropometrical situation and the lifestyle in a sample of university students. A full anthropometrical evaluation was undertaken, including bioelectric impedance analysis (BIA), in 111 students in the last year of Human Nutrition and Dietetics, as well as a lifestyle questionnaire (physical activity, alcohol and cigarette consumption). A sexual dimorphism was found in weight distribution according to the classification proposed by SEEDO: 6.4% of women presented a weight lower than the health recommendations (there no men in this group) whereas 27.8% of men and 6.5% of women were in the overweight range. 15.3% of the cases had excessive waist circumference. Fat mass by BIA was higher among women. On the other hand, 67% of university students stated to perform regular physical activity, 16.7% stated being cigarette smokers, and 55.6% stated to consume high-grade alcohol. To conclude, we studied a sample population of young and healthy subjects with, however, a significant percentage of women with body weight lower than the healthy standards, overweighed people, and smokers usually taking high-grade alcohol. These data should elicit an alert of the potential cardiovascular risk in the university population if action is not taken. This population should be included in the health promotion plans.

[Evaluation of two methods for correcting the impact factor using the investigation done at the "Del Río Hortega" University Hospital (1999-2004) as the data source]. / Evaluación de dos métodos de corrección del Factor de Impacto utilizando la investigación del H.U. "Del rio Hortega" (1999-2007) como fuentes de datos.

BACKGROUND AND OBJECTIVE: To adjust the Impact Factor (IF) provided by the Institute for Scientific Information (ISI) is necessary for improving bibliometric analysis among the various areas of knowledge. Our objective was to evaluate two parameters (the maximum and the median value of each subject area) for IF adjustment using the original (not corrected) IF as the reference method in a tertiary hospital biomedical investigation model. MATERIAL AND METHOD: We retrieved articles from Hospital Universitario "Del Río Hortega" from Valladolid (Spain) for the period 1999-2004 as data source. We have describe the characteristics of the followed IF distributions: IF Corrected by the Maximum value (IFCORMAX), IF Corrected by the Median value (IFCORMED) and IF without adjustments (IF). Besides, we have analyzed both the inter-annual and the inter-subject differences obtained by the three methods. RESULTS: The three analyzed IF series shown not normal distributions that are positively skewed. The IF adjusted by the median showed the highest coefficient of variation (CV = 357.3%). The IF adjusted by the Maximum value increased the "weight" of journals with the highest not corrected IF for each subject category. Inter-annual differences were similarly estimated by the three methods. The IF adjusted by the median increased the inter-subject difference from 7.3% to 12.4%. CONCLUSIONS: Our results suggests that IF adjusted by the maximum value of each discipline is the best method to correct the ISI-IF values, because journals with the high IF are always rewarded, while IF adjusted by the median infra-estimated most of them.

Evaluación de dos métodos de corrección del Factor de Impacto utilizando la investigación del H. U. "Del Río Hortega" (1999-2004) como fuente de datos / Evaluation of two methods for correcting the impact factor using the investigation done at the "Del Río Hortega" University Hospital (1999-2004) as the dara source

Fundamento y objetivo: La ponderación del Factor de Impacto (FI) publicado por el Institute for Scientific Information es una estrategia fundamental para mejorar el análisis bibliométrico entre áreas temáticas. Nuestro objetivo ha sido evaluar dos parámetros de corrección (el valor Máximo y la Mediana) utilizando el FI sin corregir como referencia en un modelo de investigación biomédica desarrollada en un Hospital terciario. Material y método: Se han utilizado las publicaciones del Hospital Universitario "Del Río Hortega" de Valladolid del periodo 1999-2004 como fuente de datos (artículos en MEDLINE). Se analizaron las características de las distribuciones de los FI corregidos por el Máximo (FICORMAX), por la Mediana (FICORMED) y sin corregir (FI), así como las diferencias interanuales e interservicios obtenidas por los tres métodos. Resultados: Las tres series de valores muestran distribuciones no normales con marcada asimetría positiva. La distribución con mayor dispersión corresponde a la corrección por la Mediana (CV% = 357,3%). La corrección por el Máximo aumenta el número de revistas con FI más altos en sus categorías. Las diferencias interanuales son estimadas de forma semejante por los tres métodos. Las diferencias entre áreas temáticas aumentan del 7,3 al 12,4% utilizando la corrección por la mediana. Conclusiones: La corrección del FI por el valor máximo de cada área temática es el método de ponderación más justo, puesto que premia a las revistas con mayor FI de cada categoría, independientemente de su valor absoluto. Además, al disponerse en una escala de 0 a 1, los resultados obtenidos con FICORMAX proporcionan una información más precisa sobre la posición del valor dentro de la serie temática (AU)

Background and objective: To adjust the Impact Factor (IF) provided by the Institute for Scientific Information (ISI) is necessary for improving bibliometric analysis among the various areas of knowledge. Our objective was to evaluate two parameters (the maximum and the median value of each subject area) for IF adjustment using the original (not corrected) IF as the reference method in a tertiary hospital biomedical investigation model. Material and method: We retrieved articles from Hospital Universitario "Del Río Hortega" from Valladolid (Spain) for the period 1999-2004 as data source. We have describe the characteristics of the followed IF distributions: IF Corrected by the Maximum value (IFCORMAX), IF Corrected by the Median value (IFCORMED) and IF without adjustments (IF). Besides, we have analyzed both the inter-annual and the inter-subject differences obtained by the three methods. Results: The three analyzed IF series shown not normal distributions that are positively skewed. The IF adjusted by the median showed the highes coefficient of variation (CV = 357.3%). The IF adjusted by the Maximum value increased the "weight" of journals with the highest not corrected IF for each subject category. Inter-annual differences were similarly estimated by the three methods. The IF adjusted by the median increased the inter-subject difference from 7.3% to 12.4%. Conclusions: Our results suggests that IF adjusted by the maximum value of each discipline is the best method to correct the ISI-IF values, because journals with the high IF are always rewarded, while IF adjusted by the median infra-estimated most of them (AU)