ABSTRACT
In nuclear medicine, the search for the perfect hepatobiliary agent started in 1955 with the rose bengal dye labeled with 131I. With the advent of technetium-99m, many ligands were labeled and Tc-99m-PG and 99mTc-HIDA were among the best suited for this purpose. Both were synthesized at the radiopharmacy laboratory during 1977-1980 and have been used at INNSZ for clinical studies. For the last three years, a new ligand with a bromine atom and an extra methyl radical has been reported as being one of the best third generation HIDAs. We received the gift of several kits of trimethyl-Br-IDA from Sorin Biomedica, Italy, (A) and of Mebrofenin from ININ, Mexico, (B) to be labeled and tested in order to select one of them for clinical work. For a comparative study on the radiopharmacodynamic characteristics of the two labeled ligands, six healthy women volunteered to undergo two tests with a 72 hour hour rest period to assure complete washout. After the I.V. dose of 111 MBq (3 mCi) the dynamic study was started and a total of 127 16-second images were acquired with a Siemens Digitrac 750 scintillation camera coupled to a Scintiview computer. Static images were taken at the end of the dynamic study and after breakfast. Blood and urine samples were collected for 24 hours and the amount of radioactivity was measured with a well type scintillation detector. The radiopharmacokinetic results are listed in tables 1-4.(ABSTRACT TRUNCATED AT 250 WORDS)
Subject(s)
Biliary Tract/diagnostic imaging , Liver/diagnostic imaging , Adolescent , Adult , Female , Humans , Radionuclide Imaging , Technetium/pharmacokineticsSubject(s)
Atropine/pharmacokinetics , Technetium/pharmacokinetics , Adult , Animals , Chromatography, Paper , Humans , Male , Mexico , Mice , Mice, Inbred BALB C , Tissue DistributionSubject(s)
Biomarkers, Tumor/analysis , Organometallic Compounds/pharmacokinetics , Organotechnetium Compounds , Technetium/pharmacokinetics , Tetracyclines/pharmacokinetics , Adult , Female , Humans , Lung Neoplasms/diagnostic imaging , Male , Organometallic Compounds/analysis , Radionuclide Imaging , Technetium/analysis , Tetracyclines/analysisABSTRACT
In the present study total body water was determined in a group of cardiac patients, using titriated water. The study was performed in a service of internal medicine of an important hospital in Mexico City. Of the 30 patients originally evaluated, only 23 could be considered cardiacs; of these 47.83% had an excess of water, 39.13% had a normal amount and 13.04% were dehidrated. The patients belonged to both sexes and their ages were anywhere between 14 and 82 years. Very often, other aliments or conditions were present which had a bearing on the total body water. The test is innocuous and the bother to the patient is minimal constituting a valuable auxiliary to the clinician.
