[Is socioeconomic residential segregation associated with sleep problems? Insights from ELSA-Brasil]. / A segregação residencial socioeconômica está associada aos problemas do sono? Insights do ELSA-Brasil.

Several factors influence sleep, which is essential for health. While the role of neighborhood socioeconomic context on sleep health has been studied in recent years, results are inconsistent. The study aimed to investigate the association between socioeconomic residential segregation and sleep problems, using data from the second evaluation (2012-2014) of 9,918 public servants participating in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Socioeconomic residential segregation was assessed using the Getis-Ord Local Gi* statistic. Sleep duration and deprivation, complaints of insomnia, and daytime sleepiness were obtained through interviews. Binomial and multinomial logistic regression models were used to estimate the odds ratio (OR). Regarding sleep, 49% had short duration and 3% long duration, 23% reported complaints of insomnia, 45% sleep deprivation, 42% daytime sleepiness, and 48% reported ≥ 2 sleep problems. In the model adjusted for demographic and socioeconomic variables, there was an association between high socioeconomic residential segregation and short sleep duration (OR = 1.22; 95%CI: 1.07; 1.40), sleep deprivation (OR = 1.20; 95%CI: 1.05; 1.37), daytime sleepiness (OR = 1.17; 95%CI: 1.03; 1.34) and ≥ 2 associated sleep problems (OR = 1.24; 95%CI: 1.08; 1.41). Individuals living in neighborhoods with high socioeconomic residential segregation are more likely to have short sleep duration, sleep deprivation, daytime sleepiness, and ≥ 2 associated sleep problems. This information reinforces that public policy measures to reduce socioeconomic inequalities can improve the population's sleep health.

O sono é influenciado por diversos fatores e é essencial para a saúde. O papel do contexto socioeconômico da vizinhança na saúde do sono foi estudado nos últimos anos, mas os resultados são inconsistentes. O objetivo deste estudo foi investigar a associação entre a segregação residencial socioeconômica e os problemas do sono. Utilizou-se dados da 2ª avaliação (2012-2014) de 9.918 servidores públicos participantes do Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil). A segregação residencial socioeconômica foi avaliada por meio da estatística Getis-Ord Local Gi*, e a duração e privação do sono, as queixas de insônia e a sonolência diurna foram obtidas por meio de entrevistas. Para as estimativas da odds ratio (OR), foram utilizados modelos de regressão logística binomial e multinomial. Em relação ao sono, 49% tinham curta duração e 3% longa duração, 23% relataram queixas de insônia, 45% relataram privação do sono, 42% relataram sonolência diurna e 48% relataram ≥ 2 problemas do sono. No modelo ajustado por variáveis demográficas e socioeconômicas, houve associação entre alta segregação residencial socioeconômica e duração curta do sono (OR = 1,22; IC95%: 1,07; 1,40), privação do sono (OR = 1,20; IC95%: 1,05; 1,37), sonolência diurna (OR = 1,17; IC95%: 1,03; 1,34) e ≥ 2 problemas associados do sono (OR = 1,24; IC95%: 1,08; 1,41). Indivíduos que vivem em vizinhanças com alta segregação residencial socioeconômica apresentam maior chance de terem curta duração, privação do sono, sonolência diurna e ≥ 2 problemas associados ao sono. Essas informações reforçam que políticas públicas para reduzir as desigualdades socioeconômicas podem contribuir para melhorar a saúde do sono da população.

El sueño se influye por varios factores y es esencial para la salud. Se estudió el papel del contexto socioeconómico del barrio en la salud del sueño en los últimos años, pero los resultados son inconsistentes. El objetivo del estudio fue investigar la asociación entre la segregación residencial socioeconómica y los problemas de sueño. Se utilizó datos de la 2ª evaluación (2012-2014) de 9918 servidores públicos participantes del Estudio Longitudinal de Salud del Adulto (ELSA-Brasil). Se evaluó la segregación residencial socioeconómica a través de la estadística Getis-Ord Local Gi*. La duración y privación del sueño, las quejas de insomnio y somnolencia diurna se obtuvieron a través de entrevista. Se utilizaron modelos de regresión logística binomial y multinominal para estimar el odds ratio (OR). Con respecto al sueño, el 49% tenía una duración corta y el 3% tenía una duración larga, el 23% relató quejas de insomnio, el 45% relató privación de sueño, el 42% relató somnolencia diurna y el 48% relató ≥ 2 problemas de sueño. En el modelo ajustado por variables demográficas y socioeconómicas, hubo una asociación entre la alta segregación residencial socioeconómica y la duración corta de sueño (OR = 1,22; IC95%: 1,07; 1,40), la privación de sueño (OR = 1,20; IC95%: 1,05; 1,37), la somnolencia diurna (OR = 1,17; IC95%: 1,03; 1,34) y ≥ 2 problemas asociados con el sueño (OR = 1,24; IC95%: 1,08; 1,41). Personas que viven en barrios con una alta segregación residencial socioeconómica presentan una mayor probabilidad de tener duración corta del sueño, privación de sueño, somnolencia diurna y ≥ 2 problemas asociados con el sueño. Estas informaciones resaltan que medidas de políticas públicas para reducir las desigualdades socioeconómicas pueden contribuir a mejorar la salud del sueño en la población.

Giving meaning to internalized violence throughout life by older adults living in rural areas.

OBJECTIVES: to understand the meanings of violence internalized throughout life by older adults living in rural areas. METHODS: a qualitative study, anchored in the Symbolic Interactionism theoretical framework and the Grounded Theory methodological framework in the constructivist aspect. Data collection occurred through individual interviews. Data were coded using the Atlas.ti software. RESULTS: it was possible to identify that the context of rural areas strengthens patriarchy culture as well as contributing to violence silence and naturalization. It was also found that violence is a product of social inequality and gender inequality. FINAL CONSIDERATIONS: older adults living in rural areas internalized the violence suffered in a unique way, and this scenario's specific aspects can increase intra-family abuse, as there is a patriarchal culture that promotes social and gender inequality.

Analysis of Key Factors for Evaluating Mucosal Adhesion Using Swine Buccal Tissue.

The assessment of the mucoadhesive properties peak mucoadhesive force (Fmax) and work of mucoadhesion (Wmuc) with texture analyzers is a common in vitro method for analyzing formulation capabilities. Challenges arise in selecting and standardizing experimental conditions due to various variables influencing mucoadhesion. This complexity hampers direct product performance comparisons. In our study, we explored factors (contact force and time, probe speed and mucin in artificial saliva) impacting a model formulation's mucoadhesive capacity. Using Omcilon-A®Orabase on porcine buccal mucosa, we systematically varied experimental conditions, employing a statistical approach (Central Composite Design - CCD). Three variables (contact force, contact time, probe speed) and their interactions were assessed for their impact on Fmax and Wmuc. Results showed that contact time and force positively affected Fmax, while only contact time influenced Wmuc. In the mucin artificial saliva test, a force of 0.5 N, time of 600 s, and speed of 1 mm/s yielded optimal Fmax (0.587 N) and Wmuc (0.468 N.s). These conditions serve as a reference for comparing mucoadhesive properties of formulations for topical oral use.

Obesity and the risk of multiple or severe frequent knee pain episodes: a 4-year follow-up of the ELSA-Brasil MSK cohort.

BACKGROUND/OBJECTIVE: Knee pain is an important health problem due to its high prevalence, negative impact on daily activities and quality of life, and societal burden. While the link between excess weight and knee pain has been well-documented in the literature, many studies are limited to patients with osteoarthritis or use cross-sectional data. This longitudinal study investigated whether overweight and obesity were associated with the frequency and severity of frequent knee pain (FKP) episodes over 4 years in civil servants enrolled in the ELSA-Brasil MSK cohort. METHODS: Knee pain was assessed during baseline face-to-face interviews (2012-2014) and four yearly telephone follow-ups (2015-2019). Disabling FKP episodes or those of moderate to very severe intensity were classified as severe. Multinomial logistic regression models adjusted for confounders were used to test for associations in two participant groups: those with knee pain at baseline (prognosis cohort) and those without knee pain (incidence cohort). RESULTS: A total of 2644 participants were included: 54.2% female, mean age 55.8 (SD 8.8) years. In the incidence cohort (n = 1896), obesity increased the risk of one (OR: 1.63; 95% CI 1.13-2.37) and multiple FKP episodes (OR: 2.61; 95% CI 1.71-3.97), as well as the risk of non-severe (OR: 1.72; 95% CI 1.04-2.84) and severe FKP episodes (OR: 2.10; 95% CI 1.50-2.95). In the prognosis cohort (n = 748), obesity increased the risk of multiple (OR: 2.54; 95% CI 1.60-4.05) and severe FKP episodes (OR: 2.31; 95% CI 1.49-3.59). Overweight presented the same trends but fell short of significance. CONCLUSIONS: These results provide further support that overweight and obesity are important contributors to the incidence and worsening of FKP, and that weight management must be prioritized in multidisciplinary knee pain prevention and treatment programs to reduce the burden of musculoskeletal disorders.

Shared reading: Interaction between parents and children in a natural setting / Leitura compartilhada: interação entre pais e filhos em situação natural

Abstract Objective The present study aimed to describe and analyze how parents naturally carry out shared reading with their children, without specific instructions. Additionally, the effect of a brief intervention to teach parents to use shared reading strategies was evaluated. Method Four families with children between the ages of four and five without a diagnosis of any disorder participated. We analyzed home footage captured by parents of shared reading moments, and to analyze the intervention, we measured the number of language stimulus strategies used by the parents as well as measures of the children's language. Results The description of the natural situation generated four categories of analysis: organization of the physical space, contact with the book, the way the story is told and the emotional relationship between parents and children. After the brief intervention, improvements were found in all measured variables when compared to pre-intervention data. Conclusion The importance of guiding families to use more language stimulation strategies in the context of shared reading is discussed, in order to enrich the child's speaking opportunities.

RESUMO Objetivo O presente estudo teve como objetivo descrever e analisar como os pais realizam a leitura compartilhada com seus filhos, naturalmente, sem instruções específicas. Adicionalmente, foi avaliado o efeito de uma intervenção breve para ensinar pais a usarem estratégias de leitura compartilhada. Método Participaram quatro famílias com crianças entre quatro e cinco anos sem diagnóstico de qualquer transtorno. Foram analisadas filmagens que os pais realizaram em suas casas de um momento de leitura compartilhada e para análise da intervenção foi mensurado o número de utilização das estratégias de estímulo da linguagem pelos pais e medidas de linguagem das crianças. Resultados A descrição da situação natural gerou quatro categorias de análise: organização do espaço físico, contato com o livro, forma como a história é contada e relação afetiva entre pais e filhos. Após a intervenção breve foram encontradas melhorias em todas as variáveis medidas quando comparadas aos dados pré-intervenção. Conclusão Discute-se a importância de orientar as famílias a utilizarem mais estratégias de estímulo de linguagem no contexto de leitura compartilhada, para enriquecer as oportunidades de fala da criança.

Giving meaning to internalized violence throughout life by older adults living in rural areas / Dar sentido a la violencia internalizada a lo largo de la vida para adultos mayores que viven en zonas rurales / Significando a violência internalizada ao longo da vida por idosos que vivem na área rural

ABSTRACT Objectives: to understand the meanings of violence internalized throughout life by older adults living in rural areas. Methods: a qualitative study, anchored in the Symbolic Interactionism theoretical framework and the Grounded Theory methodological framework in the constructivist aspect. Data collection occurred through individual interviews. Data were coded using the Atlas.ti software. Results: it was possible to identify that the context of rural areas strengthens patriarchy culture as well as contributing to violence silence and naturalization. It was also found that violence is a product of social inequality and gender inequality. Final Considerations: older adults living in rural areas internalized the violence suffered in a unique way, and this scenario's specific aspects can increase intra-family abuse, as there is a patriarchal culture that promotes social and gender inequality.

RESUMEN Objetivos: comprender los significados de la violencia internalizada a lo largo de la vida por personas mayores que viven en zonas rurales. Métodos: estudio cualitativo, anclado en el marco teórico del Interaccionismo Simbólico y el marco metodológico de la Teoría Fundamentada en el aspecto constructivista. La recolección de datos se produjo a través de entrevistas individuales. Los datos fueron codificados utilizando el software Atlas. ti. Resultados: se pudo identificar que el contexto del área rural fortalece la cultura del patriarcado, además de contribuir al silencio y naturalización de la violencia. También se encontró que la violencia es producto de la desigualdad social y de la desigualdad de género. Consideraciones Finales: los adultos mayores residentes de zonas rurales interiorizaron de manera singular la violencia sufrida, y las particularidades de este escenario pueden incrementar la violencia intrafamiliar, pues existe una cultura patriarcal que promueve la desigualdad social y de género.

RESUMO Objetivos: compreender os significados da violência internalizados ao longo da vida por idosos que vivem na área rural. Métodos: estudo qualitativo, ancorado no referencial teórico do Interacionismo Simbólico e no referencial metodológico da Teoria Fundamentada nos Dados na vertente construtivista. A coleta de dados ocorreu por meio de entrevistas individuais. Os dados foram codificados com auxílio do software Atlas.ti. Resultados: foi possível identificar que o contexto da área rural fortalece a cultura do patriarcalismo, bem como contribui para que a violência seja silenciada e naturalizada. Constatou-se também que a violência é um produto da desigualdade social e da desigualdade de gênero. Considerações Finais: os idosos moradores da área rural internalizaram a violência sofrida de forma singular, e os aspectos próprios desse cenário podem potencializar a violência intrafamiliar, pois há uma cultura patriarcalista que promove a desigualdade social e de gênero.

Procedimento online de incentivo à leitura em crianças com dificuldades escolares e seus responsáveis, durante a pandemia de COVID-19 / Online procedure to encourage reading in children with school difficulties and their guardians, during the COVID-19 pandemic

RESUMO A escola é o principal ambiente para a promoção formal da alfabetização e do letramento, os quais são portas para o mundo da leitura. Porém, com a ocorrência da pandemia do COVID-19, as atividades pedagógicas tiveram que ser suspensas ou adaptadas ao modelo remoto, acarretando prejuízos a todos os alunos, e principalmente àqueles que já apresentavam dificuldades escolares, especialmente as relacionadas à leitura. Sabe-se que a proficiência e o hábito de leitura são condições importantes para o desenvolvimento acadêmico geral. Estudos têm demonstrado que a aplicação de estratégias no contexto familiar e a utilização de plataformas digitais, com a finalidade de compartilhamento de leituras, são práticas favorecedoras do hábito leitor. Dessa forma, o presente estudo objetivou relatar as experiências da aplicação online de um procedimento de incentivo à leitura, em crianças com dificuldades escolares e seus respectivos responsáveis (seis díades), com a utilização de uma plataforma digital específica para compartilhamentos de leituras. Dentre os resultados obtidos estão: a mudança de comportamentos das crianças envolvidas para maior propensão a hábitos leitores, a mudança de atitudes diárias das mães no ambiente familiar para o incentivo à leitura, e a presença de comportamentos incentivadores por parte das mães, frente ao compartilhamento de leituras de seus filhos. As experiências relatadas mostraram-se promissoras e para maior consolidação dos achados, sugerem-se novos estudos com número amostral que permita análises estatísticas, estudos longitudinais e também com uma possível aplicação presencial ou híbrida do procedimento.

ABSTRACT School is the main environment for the formal promotion of literacy and it is the first step to the world of reading. However, with the occurrence of the COVID-19 pandemic, pedagogical activities had to be suspended or adapted to the remote model, causing harm to all students, and notably to those who already had school difficulties, especially those related to reading. Proficiency and the habit of reading are important conditions for academic development. Studies have shown that the application of strategies in the family context and the use of digital platforms, with the purpose of sharing readings, are practices that promote the reading habit. Therefore, the present study aimed to report the experiences of applying an online procedure to encourage reading in children with school difficulties and their respective guardians (six dyads), using a specific digital platform for sharing readings. The results obtained include a behavioral change in the children towards solid reading habits, a change in mothers' daily attitudes in the family environment towards encouraging reading, and mothers' encouraging behaviors when sharing their children's reading. The experiences reported were promising and, to further consolidate the findings, new studies are suggested with a sample size that allows statistical analyses, longitudinal studies and also with a possible face-to-face or hybrid application of the procedure.

Online procedure to encourage reading in children with school difficulties and their guardians, during the COVID-19 pandemic. / Procedimento online de incentivo à leitura em crianças com dificuldades escolares e seus responsáveis, durante a pandemia de COVID-19.

School is the main environment for the formal promotion of literacy and it is the first step to the world of reading. However, with the occurrence of the COVID-19 pandemic, pedagogical activities had to be suspended or adapted to the remote model, causing harm to all students, and notably to those who already had school difficulties, especially those related to reading. Proficiency and the habit of reading are important conditions for academic development. Studies have shown that the application of strategies in the family context and the use of digital platforms, with the purpose of sharing readings, are practices that promote the reading habit. Therefore, the present study aimed to report the experiences of applying an online procedure to encourage reading in children with school difficulties and their respective guardians (six dyads), using a specific digital platform for sharing readings. The results obtained include a behavioral change in the children towards solid reading habits, a change in mothers' daily attitudes in the family environment towards encouraging reading, and mothers' encouraging behaviors when sharing their children's reading. The experiences reported were promising and, to further consolidate the findings, new studies are suggested with a sample size that allows statistical analyses, longitudinal studies and also with a possible face-to-face or hybrid application of the procedure.

A escola é o principal ambiente para a promoção formal da alfabetização e do letramento, os quais são portas para o mundo da leitura. Porém, com a ocorrência da pandemia do COVID-19, as atividades pedagógicas tiveram que ser suspensas ou adaptadas ao modelo remoto, acarretando prejuízos a todos os alunos, e principalmente àqueles que já apresentavam dificuldades escolares, especialmente as relacionadas à leitura. Sabe-se que a proficiência e o hábito de leitura são condições importantes para o desenvolvimento acadêmico geral. Estudos têm demonstrado que a aplicação de estratégias no contexto familiar e a utilização de plataformas digitais, com a finalidade de compartilhamento de leituras, são práticas favorecedoras do hábito leitor. Dessa forma, o presente estudo objetivou relatar as experiências da aplicação online de um procedimento de incentivo à leitura, em crianças com dificuldades escolares e seus respectivos responsáveis (seis díades), com a utilização de uma plataforma digital específica para compartilhamentos de leituras. Dentre os resultados obtidos estão: a mudança de comportamentos das crianças envolvidas para maior propensão a hábitos leitores, a mudança de atitudes diárias das mães no ambiente familiar para o incentivo à leitura, e a presença de comportamentos incentivadores por parte das mães, frente ao compartilhamento de leituras de seus filhos. As experiências relatadas mostraram-se promissoras e para maior consolidação dos achados, sugerem-se novos estudos com número amostral que permita análises estatísticas, estudos longitudinais e também com uma possível aplicação presencial ou híbrida do procedimento.

Impact of intestinal colonization by Gram-negative bacteria on the incidence of bloodstream infections and lethality in critically ill neonates.

BACKGROUND: Early detection of antimicrobial-resistant microorganisms is crucial to prevent subsequent invasive infections and contain their spread in the Neonatal Intensive Care Unit (NICU). This study aims to investigate the association between intestinal colonization (IC) by Gram-negative bacteria and the risk of bloodstream infection (BSI) in critically ill neonates. METHODS: Data from the electronic medical records of 678 newborns admitted to a NICU Brazilian between 2018 and 2022 were retrospectively analyzed. Participants were monitored by the National Health Security Network. RESULTS: Among neonates, 6.9 % had IC (56.9 % attributed to Acinetobacter baumannii); of these, 19.1 % developed BSI (66.7 % by Staphylococcus spp.). Within the A. baumannii colonization, 34.5 % occurred during an outbreak in September 2021. Colonized individuals had a longer mean length of stay (49.3 ± 26.4 days) and higher mortality rate (12.8 %) compared to non-colonized individuals (22.2 ± 16.9 days; 6.7 %, respectively). Previous use of antimicrobials and invasive devices significantly increased the risk of colonization. Colonization by drug-resistant microorganisms, along with the occurrence of BSI, was associated with increased mortality and reduced survival time. CONCLUSIONS: IC contributed to the incidence of BSI, leading to more extended hospital stays and higher mortality rates. Its early detection proved to be essential to identify an outbreak and control the spread of resistant microorganisms within the NICU.

Domínios e facetas da qualidade de vida de pessoas idosas segundo a prática sexual / Domains and facets of the quality of life of olders adults according to sexual practice

A pesquisa objetivou comparar os domínios e facetas da qualidade de vida de idosos segundo a prática de relação sexual nos últimos seis meses. Estudo quantitativo, transversal e observacional realizado com 219 idosos de um município do Estado de Minas Gerais. Aplicaram-se os instrumentos WHOQoL-Bref e WHOQoL-Old para a coleta de dados referentes à qualidade de vida, e o teste Mann-Whitney (p < 0,05) para análise. Os domínios físico (p = 0,002), psicológico (p < 0,001) e relações sociais (p < 0,001), e as facetas atividades passadas, presentes e futuras (p = 0,013), participação social (p = 0,007) e intimidade (p = 0,018) estiveram associados à prática de relação sexual nos últimos seis meses, com maiores escores entre aqueles que referiram ser ativos sexualmente.

The objective of this study was to compare the domains and facets of quality of life of older adults, according to the practice of sexual intercourse in the last six months. Quantitative, cross-sectional and observational study, carried out with 219 elderly from a municipality in the State of Minas Gerais. The WHOQoL-Bref and WHOQoL-Old instruments were used to collect data regarding quality of life and the Mann-Whitney test (p < 0.05) for analysis. In the physical (p = 0.002), psychological (p < 0.001) and social relations (p < 0.001) domains, and in the facets past, present and future activities (p = 0.013), social participation (p = 0.007) and intimacy (p = 0.018) were associated with the practice of sexual intercourse in the last six months, with higher scores among those who reported being sexually active.

Breastfeeding lifespan control of growth, maintenance, and metabolism of small intestinal epithelium.

Gastrointestinal epithelial cells respond to milk-born molecules throughout breastfeeding, influencing growth, and development. The rapid renewal of the small intestine depends on the proliferation in the crypt that drives cell fates. We used early weaning model to investigate immediate and late effects of breastfeeding on proliferation, differentiation of jejunal epithelial cells. Wistar rats were either allowed to suckle (S) until 21 postnatal days or submitted to early weaning (EW) at 15 days. By comparing ages (18, 60, and 120 days), we found that EW decreased Ki67 indices and villi height at 18 and 60 days (p < 0.05), and at 120 days they were similar between diets. Proliferative reduction and augmented expression of Cdkn1b (p27 gene) were parallel. In the stem cell niche, EW increased the number and activity (Defa24) of Paneth cells at 18 and 60 days (p < 0.05), and Lgr5 and Ascl2 genes showed inverted responses between ages. Among target cells, EW decreased goblet cell number at 18 and 60 days (p < 0.05) and increased it at 120 days (p < 0.05), whereas enteroendocrine marker genes were differentially altered. EW reduced enterocytes density at 18 days (p < 0.05), and at 120 days this population was decreased (vs. 60 days). Among cell fate crypt-controlling genes, Notch and Atoh1 were the main targets of EW. Metabolically, intraperitoneal glucose tolerance was immediately reduced (18 days), being reverted until 120 days (p < 0.05). Currently, we showed that breastfeeding has a lifespan influence on intestinal mucosa and on its stem cell compartment. We suggest that, although jejunum absorptive function is granted after early weaning, the long lasting changes in gene expression might prime the mucosa with a different sensitivity to gut disorders that still have to be further explored.

A Novel Kinetic Modeling of Enzymatic Hydrolysis of Sugarcane Bagasse Pretreated by Hydrothermal and Organosolv Processes.

Lignocellulosic biomasses have a complex and compact structure, requiring physical and/or chemical pretreatments to produce glucose before hydrolysis. Mathematical modeling of enzymatic hydrolysis highlights the interactions between cellulases and cellulose, evaluating the factors contributing to reactor scale-up and conversion rates. Furthermore, this study evaluated the influence of two pretreatments (hydrothermal and organosolv) on the kinetics of enzymatic hydrolysis of sugarcane bagasse. The kinetic parameters of the model were estimated using the Pikaia genetic algorithm with data from the experimental profiles of cellulose, cellobiose, glucose, and xylose. The model considered the phenomenon of non-productive adsorption of cellulase on lignin and inhibition of cellulase by xylose. Moreover, it included the behavior of cellulase adsorption on the substrate throughout hydrolysis and kinetic equations for obtaining xylose from xylanase-catalyzed hydrolysis of xylan. The model for both pretreatments was experimentally validated with bagasse concentration at 10% w/v. The Plackett-Burman design identified 17 kinetic parameters as significant in the behavior of process variables. In this way, the modeling and parameter estimation methodology obtained a good fit from the experimental data and a more comprehensive model.

The rs1800469 T/T and rs1800470 C/C genotypes of the TGFB1 gene confer protection against diabetic retinopathy in a Southern Brazilian population.

The transforming growth factor beta 1 (TGFB1) is a pro-inflammatory cytokine that plays a key role in the mechanisms of angiogenesis and breakdown of the blood-retina barrier, which are implicated in the pathogenesis of diabetic retinopathy (DR). Polymorphisms in the TGFB1 gene have been associated with DR; however, results are still contradictory. Therefore, the aim of this study was to investigate the potential association between two TGFB1 polymorphisms and DR. This study included 992 patients with diabetes mellitus (DM): 546 patients with DR (cases) and 446 patients without DR and with ≥10 years of DM (controls). The TGFB1 rs1800469 and rs1800470 polymorphisms were genotyped by real-time PCR. Frequency of rs1800469 T/T genotype was higher in controls compared to DR cases (18.3% vs. 12.7%, P= 0.022). This genotype remained associated with protection for DR, adjusting for covariables (OR= 0.604; 95% CI 0.395 - 0.923; P= 0.020, recessive model). The rs1800470 C/C genotype was observed in 25.4% of the controls and 18.0% of the cases (P= 0.015); thus, being associated with protection against DR under the recessive model (OR= 0.589; 95% CI 0.405 - 0.857; P= 0.006), adjusting for covariables. In conclusion, the TGFB1 rs1800469 and rs1800470 polymorphisms are associated with protection against DR in DM patients from Southern Brazil.

Distribuição espacial de violência com idosos antes e durante a pandemia de covid-19 / Spatial distribution of violence against older adults before and during the covid-19 pandemic / Distribución espacial de la violencia hacia las personas mayores antes y durante la pandemia covid-19

RESUMO: Objetivo: analisar a distribuição espacial da violência contra a pessoa idosa na região Sul do Brasil antes e no primeiro ano de vigência da pandemia de COVID-19. Método: estudo ecológico que analisou as notificações de violência contra o idoso, entre 2019 e 2020, no Sul do Brasil. Foram calculadas as taxas bayesianas empíricas locais, o Índice de Autocorrelação Local de Moran e a análise de Getis Ord Gi. Resultados: houve redução da taxa suavizada de violência contra o idoso. As cidades alto-alto e hot-spot em 2019, se tornaram mais violentas em 2020; e as cidades com baixa prevalência, se tornaram menos violentas em 2020. As maiores taxas de letalidade por COVID-19 também foram naquelas cidades com maiores taxas de violência. Conclusão: os dados reforçam a complexidade da violência e seu agravamento pela pandemia. E contribuem com as tomadas de decisões na enfermagem, desatacando-se a necessidade de suscitar novas pesquisas sobre esta temática.

ABSTRACT Objective: to analyze the spatial distribution of violence against older adults in the Brazilian South region before and in the first year of the COVID-19 pandemic. Method: an ecological study that analyzed reports of violence against older adults between 2019 and 2020, in Southern Brazil. Local empirical Bayesian rates, Moran's Local Autocorrelation Index and Getis Ord Gi analysis were calculated. Results: there was a reduction in the smoothed rate of violence against older adults. The high-high and hot-spot cities in 2019 became more violent in 2020; and cities with low prevalence became less violent in 2020. The highest COVID-19 fatality rates were also in those cities with the highest violence rates. Conclusion: the data reinforces the complexity of violence and its worsening due to the pandemic. In addition, they contribute to decision-making in Nursing, highlighting the need to encourage new research studies on this theme.

RESUMEN Objetivo: analizar la distribución espacial de la violencia contra las personas mayores en la región sur de Brasil antes y durante el primer año de la pandemia de COVID-19. Método: estudio ecológico que analizó denuncias de violencia contra las personas mayores, entre 2019 y 2020, en la región sur de Brasil. Se calcularon las tasas bayesianas empíricas locales, el índice de autocorrelación local de Moran y el análisis Getis Ord Gi. Resultados: hubo reducción en la tasa suavizada de violencia contra las personas mayores. Las ciudades alto-alto y hotspot de 2019 se volvieron más violentas en 2020; y las ciudades con baja prevalencia se volvieron menos violentas en 2020. Las tasas de mortalidad por COVID-19 más altas también se registraron en las ciudades con mayores tasas de violencia. Conclusión: los datos confirman la complejidad de la violencia y el agravamiento debido a la pandemia; además contribuyen a la toma de decisiones en enfermería y destacan la necesidad de fomentar nuevas investigaciones sobre este tema.

Ascending Flaccid Paralysis Secondary to Hypokalemia in A Cancer Patient using Abiraterone - A Case Report.

BACKGROUND: Prostate cancer (PC) is the most common type of neoplasm in men and the fourth leading cause of mortality in Brazil. The prostate cancer refractory metastatic castration can be treated with abiraterone acetate (AA). CASE PRESENTATION: Its use has been associated with increased survival. However, there are also side effects associated with the use of this drug, such as severe electrolyte disturbances. CONCLUSION: The objective is to report the clinical case of a patient with castration-resistant metastatic prostate cancer who developed ascending flaccid paralysis secondary to severe hypokalemia, probably due to hyperaldosteronism secondary to the use of Abiraterone Acetate, despite the use of Prednisone.

Organosolv pretreatment for biorefineries: Current status, perspectives, and challenges.

Biorefineries integrate processes for the sustainable conversion of biomass into chemicals, materials, and bioenergy so that resources are optimized and effluents are minimized. Despite the vast potential of lignocellulosic biorefineries, their success depends heavily on effective, economically viable, and sustainable biomass fractionation. Although efficient, organosolv pretreatment still faces challenges that must be overcome for its widespread utilization, mainly related to solvent type and recycling, robustness regarding biomass type and integration of hemicellulose recovery and use. This review shows the recent advances and state-of-the-art of organosolv pretreatment, discussing the advances, such as the use of biobased solvents, whilst also shedding light on the perspectives of using the streams - cellulose, hemicellulose, and lignin - to produce biofuels and products of high added value. In addition, it presents an overview of the existing industrial implementations of organosolv processes and, lastly, shows the main scientific and industrial challenges and opportunities for this process.

Perfil epidemiológico de pacientes vítimas de trauma torácico em um hospital de urgência e trauma / Epidemiological profile of patients victims of thoracic trauma in an emergency and trauma hospital

O trauma é responsável por significativos impactos na sociedade. De acordo com dados da Organização Mundial de Saúde (OMS), mais de nove pessoas morrem por minuto, vítimas de trauma. Entre os principais tipos de trauma, o torácico representa na atualidade cerca de 25% dos mortos em politraumatizados, constituindo um problema complexo, tendo em vista os elevados índices de mortalidade e sequelas incapacitantes permanentes. Objetivo: Descrever o perfil epidemiológico dos pacientes atendidos em um hospital de urgências da região centro-oeste, vítimas de trauma torácico. Método: Estudo quantitativo, de caráter transversal e retrospectivo, realizado a partir de coleta de dados efetuada em prontuário eletrônico no período de março a maio de 2022. Resultados: Identificou-se 73 pacientes vítimas de trauma torácico, com maior acometimento de pessoas do sexo masculino, com idade entre 26 e 35 anos. Como causa mais frequente, se destacaram os acidentes motociclísticos, resultando principalmente em lesões do tipo hemopneumotórax. Conclusão: o perfil epidemiológico dos pacientes vítimas de trauma torácico foi representado com maior frequência pelo sexo masculino, com idade entre 26 a 35 anos, causados predominantemente por acidentes motociclísticos, resultando na maioria das vezes em lesões do tipo hemopneumotórax

Trauma is responsible for significant impacts on society. According to data from the World Health Organization (WHO), more than nine people die per minute victims of trauma. Among the main types of trauma, thoracic trauma currently represents about 25% of polytrauma deaths, constituting a complex problem, in view of the high rates of mortality and sequelae permanent disabling. Objective: To describe the epidemiological profile of patients treated at an emergency hospital in the Midwest region, victims of thoracic trauma. Method: Quantitative, cross-sectional and retrospective study carried out from data collection of electronic medical records in the period from March to May of 2022. Results: We identified 73 patients who were victims of chest trauma with higher affecting males aged between 26 and 35 years. As the most frequent cause motorcycle accidents stood out, resulting mainly in lesions of the hemopneumothorax type. Conclusion: the profile epidemiology of patients victims of thoracic trauma was represented with greater frequency by males, aged between 26 and 35 years, caused predominantly by motorcycle accidents, often resulting in hemopneumothorax lesions

Indicadores de infecção relacionados à assistência à saúde em um hospital de urgência e trauma / Indicators of infection related to health care in an emergency and trauma hospital

As infecções hospitalares caracterizam-se como um fator importante para a saúde pública, por tratar-se de infecções recorrentes, principalmente em unidades de terapia intensiva (UTI), que tem causando alta taxa de morbidade e mortalidade, consequentemente aumento no tempo de internação e nos custos associados à internação. O objetivo deste estudo é analisar os indicadores de infecção hospitalar na unidade de terapia intensiva e descrever a incidência das Infecções Relacionadas à Assistência à Saúde (IRAS) na UTI. Trata-se de um estudo transversal, descritivo, com abordagem quantitativa, realizado na UTI de um hospital de grande porte do estado de Goiás. Durante o período analisado, foram notificados 44 casos de IRAS pela SCIH e 1779 pacientes passaram pela unidade. A partir da análise das notificações nas Fichas Referência do SCIH no período de abril a junho de 2022, foi possível observar o registro de IRAS nos referentes meses do semestre na UTI II, com um número maior de ocorrências no mês de maio com 23 casos, e um menor número de casos em abril, com 10 casos notificados. Em relação aso indicadores a PAV destacou-se como o indicador mais prevalente e de grande relevância entre as IRAS notificadas a SCIH. Conclui-se que é extremamente necessário conhecer a importância e a efetividade que os indicadores possuem e como eles podem contribuir para desenvolver medidas eficazes de prevenção e controle de infecção, melhorando tanto a qualidade dos cuidados prestados quanto os custos e credibilidade do estabelecimento de saúde

Hospital infections are characterized as an important factor for public health, because they are recurrent infections, especially in intensive care units (ICU), which has caused a high morbidity and mortality rate, consequently an increase in hospitalization time and costs associated with hospitalization. OBJECTIVE: the objective of this study is to analyze the indicators of nosocomial infection in the intensive care unit and to describe the incidence of HAI in the ICU. This is a cross-sectional, descriptive study with a quantitative approach, conducted in the ICU of a large hospital in the state of Goiás. During the analyzed period, 44 cases of AIS were reported by SCIH and 1779 patients passed through the unit. From the analysis of the notifications in the SCIH Reference Forms from April to June 2022, it was possible to observe the record of IRAS in the referring months of the semester in ICU II, with a higher number of occurrences in The Month of May with 23 cases, and a smaller number of cases in April, with 10 cases reported. In relation to the indicators, VAP stood out as the most prevalent and relevant indicator among the HAI reported to SCIH. It is concluded that it is extremely necessary to know the importance and effectiveness that the indicators have and how they can contribute to develop effective measures for prevention and infection control, improving both the quality of care provided and the costs and credibility of the health establishment.

Adaptação transcultural para o português brasileiro da Escala de Ruminação Relacionada ao Trabalho (B-WRRS) / Transcultural adaptation to Brazilian Portuguese of the Work-related rumination scale (B-WRRS)

Resumo Introdução A ruminação relacionada ao trabalho se refere aos pensamentos relativos aos diversos aspectos do trabalho que ocorrem nos períodos de folga. Objetivo Descrever o processo de adaptação transcultural da escala de ruminação relacionada ao trabalho para o contexto brasileiro (B-WRRS) e analisar suas propriedades psicométricas. Método Foi realizada a tradução, retrotradução e avaliação psicométrica inicial de uma escala composta por 15 itens e três dimensões, onde a B-WRRS foi testada em 173 trabalhadores de cargos administrativos de uma instituição pública. Para a avaliação da validade dimensional, iniciou-se com a análise fatorial confirmatória, tendo como base o modelo original proposto pelos autores da escala. Foi realizada também a análise fatorial exploratória, utilizando o Mplus. Resultados A adaptação da escala cumpriu as etapas de avaliação da equivalência conceitual, de itens, semântica e operacional, apresentando grande aceitabilidade e compreensão por parte dos respondentes. A avaliação da estrutura fatorial da B-WRRS corroborou a tridimensionalidade da escala. Conclusão Por ser simples e rápido, o preenchimento da B-WRRS se destaca como promissor para o uso no ambiente de trabalho. O processo de adaptação transcultural do instrumento não apresentou divergências conceituais nem semânticas. Entretanto, as diferenças observadas na composição das dimensões indicam a necessidade de novas avaliações psicométricas para estabelecer a equivalência funcional da B-WRRS.

Abstract Background The work-related rumination scale refers to thoughts related to various aspects of work that occur during periods of rest. Objective To describe the transcultural adaptation process of the work-related rumination scale to the Brazilian context (B-WRRS), and to analyze psychometric properties. Method Translation, back-translation, and initial psychometric evaluation of the scale, which comprised 15 items and 3 dimensions, were performed. B-WRRS was tested on a sample of 173 administrative staff at a public institution. To evaluate the dimensional validity, the confirmatory factor analysis was tested based on the original model proposed by the authors of the scale. Exploratory factor analysis was also performed using Mplus. Results The transcultural adaptation of the scale fulfilled the steps of assessment of conceptual, item, semantic, and operational equivalence, showing acceptability and understanding by the respondents. The evaluation of the factorial structure of B-WRRS corroborated the three-dimensionality of the scale. Conclusion The simple and quick filling of the scale highlights that the use of B-WRRS in the work environment is promising. The process of cross-cultural adaptation of the instrument did not present conceptual or semantic divergences. However, the differences observed in the composition of the dimensions indicate the need for new psychometric assessments to establish the functional equivalence of B-WRRS.