Subject-specific rib finite element models with material data derived from coupon tests under bending loading.

Rib fractures are common thoracic injuries in motor vehicle crashes. Several human finite element (FE) human models have been created to numerically assess thoracic injury risks. However, the accurate prediction of rib biomechanical response has shown to be challenging due to human variation and modeling approaches. The main objective of this study was to better understand the role of modeling approaches on the biomechanical response of human ribs in anterior-posterior bending. Since the development of subject specific rib models is a time-consuming process, the second objective of this study was to develop an accurate morphing approach to quickly generate high quality subject specific rib meshes. The exterior geometries and cortical-trabecular boundaries of five human 6th-level ribs were extracted from CT-images. One rib mesh was developed in a parametric fashion and the other four ribs were developed with an in-house morphing algorithm. The morphing algorithm automatically defined landmarks on both the periosteal and endosteal boundaries of the cortical layer, which were used to morph the template nodes to target geometries. Three different cortical bone material models were defined based on the stress-strain data obtained from subject-specific tensile coupon tests for each rib. Full rib anterior-posterior bending tests were simulated based on data recorded in testing. The results showed similar trends to test data with some sensitivity relative to the material modeling approach. Additionally, the FE models were substantially more resistant to failure, highlighting the need for better techniques to model rib fracture. Overall, the results of this work can be used to improve the biofidelity of human rib finite element models.

Development and validation of a finite element model of a small female pedestrian.

Pedestrians are the most vulnerable road user and represent about 23% of the road traffic deaths in the world. A finite element (FE) model corresponding to a 5th percentile female pedestrian (F05-PS) was developed by morphing the Global Human Body Models Consortium (GHBMC) 50th percentile male pedestrian (M50-PS) model to the reconstructed geometry of a recruited small female subject. The material properties of the pedestrian model were assigned based on GHBMC M50-PS model. In model validation, the knee lateral stiffness and force time histories of F05-PS upper body showed similar trends, but softer responses than the corresponding data recorded in post mortem human surrogate (PMHS) tests and linearly scaled to average male anthropometry. Finally, the pedestrian model was verified in a Car-to-Pedestrian Collison (CPC) simulation. The marker trajectories recorded in simulation were close to the data recorded on small PMHS in testing and the model predicted typical knee ligament ruptures. Therefore, we believe the F05-PS model, the first FE model developed based on a female reconstructed geometry, could be used to improve vehicle front-end design for pedestrian protection and/or to investigate various pedestrian accidents.

Evaluation of finite element human body models for use in a standardized protocol for pedestrian safety assessment.

Objective: Finite element human body models (HBMs) must be certified for use within the EuroNCAP pedestrian safety assessment protocol. We demonstrate that the Global Human Body Model Consortium (GHBMC) simplified pedestrian series of HBMs meet all criteria set forth in Technical Bulletin (TB) 024 (v 1.1 Jan. 2019) for model certification. We further explore variation in head contact time (HIT) and location by HBM size and impact speed across 48 full body impact simulations.Methods: The EuroNCAP Pedestrian Protocol (v. 8.5, Oct. 2018) assesses the overall safety of adult and child pedestrians by outlining a variety of physical tests and finite element simulations using HBMs. These tests are designed to assess the efficacy of vehicle safety technology such as active bonnets. The 50th percentile male simplified pedestrian model (M50-PS, H:175 cm, W:74.5 kg), six-year-old (6YO-PS, H:117 cm, W:23.4 kg), 5th percentile female (F05-PS, H:150 cm, W:50.7 kg), and 95th percentile male (M95-PS, H:190 cm, W:102 kg) were simulated through the suite of cases totaling 48 simulations (12 each). The process gathers three kinematic trajectories and contact force data from designated anatomical locations. The impacting vehicles include a family car (FCR), multi-purpose vehicle (MPV), roadster (RDS), and sports utility vehicle (SUV), all provided by TU Graz, Vehicle Safety Institute as part of the Coherent Project, each simulated at 30 kph, 40 kph, and 50 kph. Each simulation underwent a 23-point pre-simulation check and post-simulation model response comparison. The posture of all HBMs met criteria consisting of 15 measures. All simulations were conducted in LS-Dyna R. 7.1.2.Results and Conclusions: All simulations normal terminated. For each of the simulations, sagittal plane coordinate histories of the center of the head, 12th thoracic vertebrae, and center of acetabulum were compared with standard corridors and did not exceed the tolerance of 50 mm deviation. Head contact time was also compared with the reference values and did not exceed the tolerance interval of +3.5% and -7%. Comparison of contact forces was required for monitoring purposes only. The head contact time of the models for each simulation was recorded and compared by model size, impact speed, and vehicle geometry. Head contact times varied by roughly 3-fold, were lowest for the child model, and showed the greatest sensitivity for the tallest stature model (M95-PS). As stated in the certification process, other body sizes within a model family qualify for certification if the 50th percentile male model passes, provided that model sizes meet the required posture.

A finite element model of an anthropomorphic test device lower limb to assess risk of injuries during vertical accelerative loading.

Improvised explosive devices (IEDs) were used extensively to target occupants of military vehicles during the conflicts in Iraq and Afghanistan (2003-2011). War fighters exposed to an IED attack were highly susceptible to lower limb injuries. To appropriately assess vehicle safety and make informed improvements to vehicle design, a novel Anthropomorphic Test Device (ATD), called the Warrior Injury Assessment Manikin (WIAMan), was designed for vertical loading. The main objective of this study was to develop and validate a Finite Element (FE) model of the WIAMan lower limb (WIAMan-LL). Appropriate materials and contacts were applied to realistically model the physical dummy. Validation of the model was conducted based on experiments performed on two different test rigs designed to simulate the vertical loading experienced during an under-vehicle explosion. Additionally, a preliminary evaluation of the WIAMan and Hybrid-III test devices was performed by comparing force responses to post-mortem human surrogate (PMHS) corridors. The knee axial force recorded by the WIAMan-LL when struck on the plantar surface of the foot (2 m/s) fell mostly within the PMHS corridor, but the corresponding data predicted by the Hybrid-III was almost 60% higher. Overall, good agreements were observed between the WIAMan-LL FE predictions and experiments at various pre-impact speeds ranging from 2 m/s up to 5.8 m/s. Results of the FE model were backed by mean objective rating scores of 0.67-0.76 which support its accuracy relative to the physical lower limb dummy. The observations and objective rating scores show the model is validated within the experimental loading conditions. These results indicate the model can be used in numerical studies related to possible dummy design improvements once additional PMHS data is available. The numerical lower limb is currently incorporated into a whole body model that will be used to evaluate the vehicle design for underbody blast protection.

A Review of Pediatric Lower Extremity Data for Pedestrian Numerical Modeling: Injury Epidemiology, Anatomy, Anthropometry, Structural, and Mechanical Properties.

Pedestrian injuries are the fourth leading cause of unintentional injury-related death among children aged 1 to 19. The lower extremity represents the most frequently injured body region in car-to-pedestrian accidents. The goal of this study was to perform a systematic review of the data related to pedestrian lower extremity injuries, anatomy, anthropometry, structural, and mechanical properties, which can be used in the development of new pediatric computational models. The study began with a review of epidemiologic data related to pediatric pedestrian accidents. Anatomy of the child lower extremity and age-related anthropometry data were presented as well. Then, both the mechanical and structural properties of the lower extremity main components (e.g., bones, cartilages, knee ligaments, muscles, tendons, and growth plates) available in literature were summarized. The study concluded with a brief description of current child pedestrian models, which included a discussion about their limitations. We believe that data included in this review study can help in improving the biofidelity of current child models and support the development and validation of new child models used by safety researchers for protection of pediatric population.

Finite element modeling of the human kidney for probabilistic occupant models: Statistical shape analysis and mesh morphing.

Statistical shape analysis was conducted on 15 pairs (left and right) of human kidneys. It was shown that the left and right kidney were significantly different in size and shape. In addition, several common modes of kidney variation were identified using statistical shape analysis. Semi-automatic mesh morphing techniques have been developed to efficiently create subject specific meshes from a template mesh with a similar geometry. Subject specific meshes as well as probabilistic kidney meshes were created from a template mesh. Mesh quality remained about the same as the template mesh while only taking a fraction of the time to create the mesh from scratch or morph with manually identified landmarks. This technique can help enhance the quality of information gathered from experimental testing with subject specific meshes as well as help to more efficiently predict injury by creating models with the mean shape as well as models at the extremes for each principal component.

Validation of a booted finite element model of the WIAMan ATD lower limb in component and whole-body vertical loading impacts with an assessment of the boot influence model on response.

OBJECTIVE: A novel anthropomorphic test device (ATD) representative of the 50th percentile male soldier is being developed to predict injuries to a vehicle occupant during an underbody blast (UBB). The main objective of this study was to develop and validate a finite element (FE) model of the ATD lower limb outfitted with a military combat boot and to insert the validated lower limb into a model of the full ATD and simulate vertical loading experiments. METHODS: A Belleville desert combat boot model was assigned contacts and material properties based on previous experiments. The boot model was fit to a previously developed model of the barefoot ATD. Validation was performed through 6 matched pair component tests conducted on the Vertically Accelerated Loads Transfer System (VALTS). The load transfer capabilities of the FE model were assessed along with the force-mitigating properties of the boot. The booted lower limb subassembly was then incorporated into a whole-body model of the ATD. Two whole-body VALTS experiments were simulated to evaluate lower limb performance in the whole body. RESULTS: The lower limb model accurately predicted axial loads measured at heel, tibia, and knee load cells during matched pair component tests. Forces in booted simulations were compared to unbooted simulations and an amount of mitigation similar to that of experiments was observed. In a whole-body loading environment, the model kinematics match those recorded in experiments. The shape and magnitude of experimental force-time curves were accurately predicted by the model. Correlation between the experiments and simulations was backed up by high objective rating scores for all experiments. CONCLUSION: The booted lower limb model is accurate in its ability to articulate and transfer loads similar to the physical dummy in simulated underbody loading experiments. The performance of the model leads to the recommendation to use it appropriately as an alternative to costly ATD experiments.

A Finite Element Model of a Midsize Male for Simulating Pedestrian Accidents.

Pedestrians represent one of the most vulnerable road users and comprise nearly 22% the road crash-related fatalities in the world. Therefore, protection of pedestrians in car-to-pedestrian collisions (CPC) has recently generated increased attention with regulations involving three subsystem tests. The development of a finite element (FE) pedestrian model could provide a complementary component that characterizes the whole-body response of vehicle-pedestrian interactions and assesses the pedestrian injuries. The main goal of this study was to develop and to validate a simplified full body FE model corresponding to a 50th male pedestrian in standing posture (M50-PS). The FE model mesh and defined material properties are based on a 50th percentile male occupant model. The lower limb-pelvis and lumbar spine regions of the human model were validated against the postmortem human surrogate (PMHS) test data recorded in four-point lateral knee bending tests, pelvic\abdomen\shoulder\thoracic impact tests, and lumbar spine bending tests. Then, a pedestrian-to-vehicle impact simulation was performed using the whole pedestrian model, and the results were compared to corresponding PMHS tests. Overall, the simulation results showed that lower leg response is mostly within the boundaries of PMHS corridors. In addition, the model shows the capability to predict the most common lower extremity injuries observed in pedestrian accidents. Generally, the validated pedestrian model may be used by safety researchers in the design of front ends of new vehicles in order to increase pedestrian protection.

Mechanical characterization and finite element implementation of the soft materials used in a novel anthropometric test device for simulating underbody blast loading.

Soft materials (e.g. polymers) are widely used in biomechanical devices to represent the nonlinear viscoelastic properties inherent in biological soft tissues. Knowledge of their mechanical properties is used to inform design choices and develop accurate finite element (FE) models of human surrogates. The goal of this study was to characterize the behavior of eight polymeric materials used in the design of a novel anthropomorphic test device (ATD) and implement these materials in an FE model of the ATD. Tensile and compressive tests at strain rates ranging from 0.01s-1 to 1000s-1 were conducted on specimens from each material. Stress-strain relationships at discrete strain rates were used to define strain rate-dependent hyper-elastic material models in a commercial finite element solver. Then, the material models were implemented into an FE model of the ATD. The performance of the material models in the FE model was evaluated by simulating experiments that were conducted on the ATD lower limb. The material characterization tests revealed viscoelastic strain rate-dependent properties in the flesh and compliant elements of the ATD. Higher modulus polymers exhibited rate-dependent, strain-hardening properties. A strong agreement was seen between the material model simulations and corresponding experiments. In component simulations, the materials performed well and the model reasonably predicted the forces observed in experiments.

A finite element model of a six-year-old child for simulating pedestrian accidents.

Child pedestrian protection deserves more attention in vehicle safety design since they are the most vulnerable road users who face the highest mortality rate. Pediatric Finite Element (FE) models could be used to simulate and understand the pedestrian injury mechanisms during crashes in order to mitigate them. Thus, the objective of the study was to develop a computationally efficient (simplified) six-year-old (6YO-PS) pedestrian FE model and validate it based on the latest published pediatric data. The 6YO-PS FE model was developed by morphing the existing GHBMC adult pedestrian model. Retrospective scan data were used to locally adjust the geometry as needed for accuracy. Component test simulations focused only the lower extremities and pelvis, which are the first body regions impacted during pedestrian accidents. Three-point bending test simulations were performed on the femur and tibia with adult material properties and then updated using child material properties. Pelvis impact and knee bending tests were also simulated. Finally, a series of pediatric Car-to-Pedestrian Collision (CPC) were simulated with pre-impact velocities ranging from 20km/h up to 60km/h. The bone models assigned pediatric material properties showed lower stiffness and a good match in terms of fracture force to the test data (less than 6% error). The pelvis impact force predicted by the child model showed a similar trend with test data. The whole pedestrian model was stable during CPC simulations and predicted common pedestrian injuries. Overall, the 6YO-PS FE model developed in this study showed good biofidelity at component level (lower extremity and pelvis) and stability in CPC simulations. While more validations would improve it, the current model could be used to investigate the lower limb injury mechanisms and in the prediction of the impact parameters as specified in regulatory testing protocols.

Statistical shape analysis of the human spleen geometry for probabilistic occupant models.

Statistical shape models are an effective way to create computational models of human organs that can incorporate inter-subject geometrical variation. The main objective of this study was to create statistical mean and boundary models of the human spleen in an occupant posture. Principal component analysis was applied to fifteen human spleens in order to find the statistical modes of variation, mean shape, and boundary models. A landmark sliding approach was utilized to refine the landmarks to obtain a better shape correspondence and create a better representation of the underlying shape contour. The first mode of variation was found to be the overall volume, and it accounted for 69% of the total variation. The mean model and boundary models could be used to develop probabilistic finite element (FE) models which may identify the risk of spleen injury during vehicle collisions and consequently help to improve automobile safety systems.

INTRAOCULAR BIODISTRIBUTION OF INTRAVITREAL INJECTED FLUORESCENT DEXAMETHASONE-CHITOSAN NANOPARTICLES IN RABBIT EYES.

AIM: To evaluate intraocular biodistribution of fluorescent nanoparticles composed of dexamethasone bound to chitosan after intravitreal administration in rabbit eyes. MATERIAL AND METHODS: The chitosan and gelatin based nanoparticles were synthetized using a reverse emulsion-double crosslinking technique (ionic and covalent) and then dexamethasone was bound. Two units of 1% suspension of these nanoparticles in saline solution were injected intravitreally into rabbit eyes. The histologic sections obtained at 72 hours were analyzed by confocal microscopy. RESULTS: The chitosan-fluorescein conjugate bound to dexamethasone was present in all ocular tissues at 72 hours. The nanoparticles were present in the retina and lens in a larger amount than in the other ocular tissues. CONCLUSIONS: The reverse emulsion-double crosslinking technique was efficient in synthesizing a biocompatible polymeric nanosystem. The in vivo study of intraocular biodistribution of fluorescein-marked nanoparticles capable of binding dexamethasone revealed their affinity for the retina and lens after intravitreal administration.

Development and evaluation of a finite element model of the THOR for occupant protection of spaceflight crewmembers.

New vehicles are currently being developed to transport humans to space. During the landing phases, crewmembers may be exposed to spinal and frontal loading. To reduce the risk of injuries during these common impact scenarios, the National Aeronautics and Space Administration (NASA) is developing new safety standards for spaceflight. The Test Device for Human Occupant Restraint (THOR) advanced multi-directional anthropomorphic test device (ATD), with the National Highway Traffic Safety Administration modification kit, has been chosen to evaluate occupant spacecraft safety because of its improved biofidelity. NASA tested the THOR ATD at Wright-Patterson Air Force Base (WPAFB) in various impact configurations, including frontal and spinal loading. A computational finite element model (FEM) of the THOR to match these latest modifications was developed in LS-DYNA software. The main goal of this study was to calibrate and validate the THOR FEM for use in future spacecraft safety studies. An optimization-based method was developed to calibrate the material models of the lumbar joints and pelvic flesh. Compression test data were used to calibrate the quasi-static material properties of the pelvic flesh, while whole body THOR ATD kinematic and kinetic responses under spinal and frontal loading conditions were used for dynamic calibration. The performance of the calibrated THOR FEM was evaluated by simulating separate THOR ATD tests with different crash pulses along both spinal and frontal directions. The model response was compared with test data by calculating its correlation score using the CORrelation and Analysis rating system. The biofidelity of the THOR FEM was then evaluated against tests recorded on human volunteers under 3 different frontal and spinal impact pulses. The calibrated THOR FEM responded with high similarity to the THOR ATD in all validation tests. The THOR FEM showed good biofidelity relative to human-volunteer data under spinal loading, but limited biofidelity under frontal loading. This may suggest a need for further improvements in both the THOR ATD and FEM. Overall, results presented in this study provide confidence in the THOR FEM for use in predicting THOR ATD responses for conditions, such as those observed in spacecraft landing, and for use in evaluating THOR ATD biofidelity.

Quality of life for amblyopic children and their parents.

AIM: To highlight the changes in the quality of life in patients with anisometric, refractive, strabic and mixed amblyopia and to assess the psychosocial implication for their family. MATERIAL AND METHODS: Prospective observational transversal study of 44 ambulatory pa- tients (88 eyes) treated in the Ophthalmology Clinic of Iasi "Sf. Spiridon" Hospital and Iasi Stereopsis Ophthalmology Clinic. Clinical parameters: visual acuity, objective refraction (autorefractometry), optical correction type, stage of binocular vision, ocular motility, strabic deviation. The patients or their attendants accepted to fill out a questionnaire comprising 46 items pertaining to 9 domains to assess patient (or parents) adherence to treatment and issues related to quality of life. RESULTS: Mean age of study patients was 8.19 ± 2.92 years (range 4-16 years) and age at first diagnosis was: 3.90 ± 2.15 years. Moderate and severe amblyopia in the right eye was present in 47.72% of cases and in the left eye in 43.18%. Right eye uncorrected visual acuity was 0.45 ± 0.31 and corrected 0.63 ± 0.31 (p < 0.0001). Left eye uncorrected visual acuity was 0.49 ± 0.33 and corrected was 0.69 ± 0.32 (p < 0.0001). No statistically significant difference between the right and left eye were found. A 46-item questionnaire focused on child health, visual acuity, binocular vision, time to occlusion or penalization, child emotions/activity, family and society integration was used. CONCLUSIONS: The first presentation to the ophthalmologist was at age 3.9091 ± 2.1597 years (range 3 months-7 years). Health promotion and education is important to determine parents to seek help from an ophthalmologist not later than age 3. The main symptoms that led the parents to seek eye care were: strabic deviation--45.45%, difficulty seeing the blackboard--11.36%, and difficulty in seeing closer--20.45%. Quality life questionnaires detect life or school problems of children with amblyopia and educate parents. In 15.91% of parents they did not knew that before treatment the child had poor school results. This study represents the first step in Romanian ophthalmologists concern for socio-professional integration of children with amblyopia, because as we know some jobs require healthy eyes and for those who do not receive appropriate treatment their dream will be denied.

Modeling the biomechanical and injury response of human liver parenchyma under tensile loading.

The rapid advancement in computational power has made human finite element (FE) models one of the most efficient tools for assessing the risk of abdominal injuries in a crash event. In this study, specimen-specific FE models were employed to quantify material and failure properties of human liver parenchyma using a FE optimization approach. Uniaxial tensile tests were performed on 34 parenchyma coupon specimens prepared from two fresh human livers. Each specimen was tested to failure at one of four loading rates (0.01s(-1), 0.1s(-1), 1s(-1), and 10s(-1)) to investigate the effects of rate dependency on the biomechanical and failure response of liver parenchyma. Each test was simulated by prescribing the end displacements of specimen-specific FE models based on the corresponding test data. The parameters of a first-order Ogden material model were identified for each specimen by a FE optimization approach while simulating the pre-tear loading region. The mean material model parameters were then determined for each loading rate from the characteristic averages of the stress-strain curves, and a stochastic optimization approach was utilized to determine the standard deviations of the material model parameters. A hyperelastic material model using a tabulated formulation for rate effects showed good predictions in terms of tensile material properties of human liver parenchyma. Furthermore, the tissue tearing was numerically simulated using a cohesive zone modeling (CZM) approach. A layer of cohesive elements was added at the failure location, and the CZM parameters were identified by fitting the post-tear force-time history recorded in each test. The results show that the proposed approach is able to capture both the biomechanical and failure response, and accurately model the overall force-deflection response of liver parenchyma over a large range of tensile loadings rates.

A statistical geometrical description of the human liver for probabilistic occupant models.

Realistic numerical assessments of liver injury risk for the entire occupant population require incorporating inter-subject variations into numerical models. Statistical shape models of the abdominal organs have been shown to be useful tools for the investigation of the organ variations and could be applied to the development of statistical computational models. The main objective of this study was to establish a standard procedure to quantify the shape variations of a human liver in a seated posture, and construct three-dimensional (3D) statistical shape boundary models. Statistical shape analysis was applied to construct shape models of 15 adult human livers. Principal component analysis (PCA) was then utilized to obtain the modes of variation, the mean model, and a set of statistical boundary shape models, which were constructed using the q-hyper-ellipsoid approach. The first five modes of a human liver accounted for the major anatomical variations. The modes were highly correlated to the height, thickness, width, and curvature of the liver, and the concavity of the right lobe. The mean model and the principal components were utilized to construct four boundary models of human liver. The statistical boundary model approach presented in this study could be used to develop probabilistic finite element (FE) models. In the future, the probabilistic liver models could be used in FE simulations to better understand the variability in biomechanical responses and abdominal injuries under impact loading.

A numerical investigation on the variation in hip injury tolerance with occupant posture during frontal collisions.

OBJECTIVE: More than half of occupant lower extremity (LEX) injuries during automotive frontal crashes are in the knee-thigh-hip (KTH) complex. The objective of this study is to develop a detailed and biofidelic finite element (FE) occupant LEX model that may improve current understanding of mechanisms and thresholds of KTH injuries. METHODS: Firstly, the pelvis, thigh-knee-hip, and foot models developed in our previous studies were connected into an occupant lower limb model. Further validations, including posterior cruciate ligament (PCL) stretching, thigh lateral loading, KT, and KTH impact loading were then performed to verify the injury predictability of the model under complex frontal and lateral loading corresponding to automotive impacts. Finally, a sensitivity study was performed with the whole lower limb model to investigate the effect of the hip joint angle to acetabulum injury tolerance in frontal impacts. RESULTS: The whole lower limb model proved to be stable under severe impacts along the knee, foot, and lateral components. In addition, the biomechanical and injury responses predicted by the model correlated well with the corresponding test data. An increase in hip joint extension angle from -30 to +20° relative to neutral posture showed an increase of 19 to 58 percent hip injury tolerance. CONCLUSIONS: The stability and biofidelity response of the pelvis-lower limb (PLEX) model indicates its potential application in future frontal and lateral impact FE simulations.

Development, calibration, and validation of a head-neck complex of THOR mod kit finite element model.

INTRODUCTION/OBJECTIVE: In an effort to continually improve upon the design of the test device for human occupant restraint (THOR) dummy, a series of modifications have recently been applied. The first objective of this study was to update the THOR head-neck finite element (FE) model to the specifications of the latest dummy modifications. The second objective was to develop and apply a new optimization-based methodology to calibrate the FE head-neck model based on experimental test data. The calibrated head-neck model was validated against both frontal and lateral impact test data. Finally, the sensitivities of the model, in terms of head and neck injury criteria, to pretest positioning conditions were evaluated in a frontal crash test simulation. METHODS: The updated parts of the head-neck THOR FE model were remeshed from CAD geometries of the modified parts. In addition, further model modifications were made to improve the effectiveness of the model (e.g., model stability). A novel calibration methodology, which incorporates the CORA (CORelation and Analysis) rating system with an optimization algorithm implemented in Isight software, was developed to improve both kinematic and kinetic responses of the model in various THOR dummy certification and biomechanical response tests. A parametric study was performed to evaluate head and neck injury criteria values in the calibrated head-neck model during a 40 km/h frontal crash test with respect to variation in the THOR model upper body and belt pretest position. RESULTS: Material parameter optimization was shown to greatly improve the updated model response by increasing the average rating score from 0.794 ± 0.073 to 0.964 ± 0.019. The calibrated neck showed the biggest improvement in the pendulum flexion simulation from 0.681 in the original model up to 0.96 in the calibrated model. The fully calibrated model proved to be effective at predicting dummy response in frontal and lateral loading conditions during the validation phase (0.942 average score). Upper body position was shown to have a greater effect on head-neck response than belt position. The pretest positioning variation resulted in a 10 percent maximum change in HIC36 values and 14 percent maximum change in NIJ values. CONCLUSION: The optimization-based calibration methodology was effective as it markedly improved model performance. The calibrated head-neck model demonstrated application in a crash safety analysis, showing slight head-neck injury sensitivity to pretest positioning in a frontal crash impact scenario.

From thorite to coffinite: a spectroscopic study of Th(1-x)U(x)SiO4 solid solutions.

Coffinite (USiO4), along with Th(1-x)U(x)SiO4 uranothorite solid solutions, are frequently present in reduced economically exploitable uranium ores. They could also control the concentration of uranium in the environment in the case of accidental release from underground radwaste repository. This paper reports for the first time a thorough FTIR and Raman study relative to the Th(1-x)U(x)SiO4 system, including synthetic analogues of thorite and coffinite end-members. Both sets of spectra confirmed the formulation of the samples and allowed to rule out the presence of structural water molecules and/or hydroxyl groups in the coffinite. Also, no characteristic signal of UO2(2+) uranyl ion was recorded, ensuring that uranium was fully incorporated under its tetravalent oxidation state. The variation of the positions corresponding to SiO4 internal vibration modes was then followed versus the chemical composition of the samples. If the FTIR spectra did not revealed any significant shift in the bands position, several Raman modes followed a linear trend as a function of the uranium incorporation rate. On this basis, Raman spectroscopy could be considered as a promising tool for the semi-quantitative determination of chemical composition of uranothorite samples, particularly for those coming from mineral ores. Finally, the data collected for the coffinite end-member, as the first to be obtained on pure synthetic samples, allowed a review of the results previously reported in the literature for this compound.

Effect of storage on tensile material properties of bovine liver.

Cadaveric tissue models play an important role in the assessment and optimization of novel restraint systems for reducing abdominal injuries. However, the effect of tissue preservation by means of freezing on the material properties of abdominal tissues remains unknown. The goal of this study was to investigate the influence of frozen storage time on the material responses of the liver parenchyma in tensile loading. Specimens from ten bovine livers were equally divided into three groups: fresh, 30-day frozen storage, and 60-day frozen storage. All preserved specimens were stored at -12°C. Dog-bone specimens from each preservation group were randomly assigned to one of three strain rates (0.01s(-1), 0.1s(-1), and 1.0s(-1)) and tested to failure in tensile loading. The local material response recorded at the tear location and the global material response of the whole specimen of the liver parenchyma specimens were investigated based on the experimental data and optimized analytical material models. The local and global failure strains decreased significantly between fresh specimens and specimens preserved for 30 days (p<0.05), and between fresh specimens and specimens preserved for 60 days (p<0.05) for all three loading rates. Changes on the material model parameters were also observed between fresh and preserved specimens. Preservation by means of frozen storage was found to affect both the material and failure response of bovine liver parenchyma in tensile loading. The stiffness of the tissue increased with increased preservation time and increased strain rate. In summary, significant changes (p<0.05) between the failure strain of previously frozen liver parenchyma samples and fresh samples were demonstrated at both global and local levels in this study. In addition, nonlinear and viscoelastic characteristics of the liver parenchyma were observed in tension for both fresh and preserved samples.