ABSTRACT
Duodenal type follicular lymphoma is a rare malignancy accounting for less than 4% of primary non-Hodgkin lymphomas of the gastrointestinal tract and it is a new entity that was recently described in the new update WHO 2016. Data regarding long-term outcome are currently lacking, and for that reason, a consensus on the management of this disease has not been established and treatment. We report a case of a 57-year-old female patient diagnosed with duodenal- type follicular lymphoma grade 3a who was treated with R-CHOP. The aim of this study is to add more data for a greater characterization of the entity and thus select the best management for each case.
Subject(s)
Duodenal Neoplasms , Lymphoma, Follicular , Duodenal Neoplasms/classification , Duodenal Neoplasms/drug therapy , Duodenal Neoplasms/pathology , Female , Humans , Lymphoma, Follicular/classification , Lymphoma, Follicular/drug therapy , Lymphoma, Follicular/pathology , Middle AgedSubject(s)
Plasmablastic Lymphoma/diagnosis , Skin Neoplasms/diagnosis , Adult , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy , Female , Humans , Immunohistochemistry , Immunophenotyping , Plasmablastic Lymphoma/immunology , Plasmablastic Lymphoma/therapy , Skin Neoplasms/immunology , Skin Neoplasms/therapy , Treatment OutcomeSubject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Epstein-Barr Virus Infections/drug therapy , Lymphoma, Large B-Cell, Diffuse/drug therapy , Aged , Antibodies, Monoclonal, Murine-Derived/administration & dosage , Cyclophosphamide/administration & dosage , Doxorubicin/administration & dosage , Epstein-Barr Virus Infections/pathology , Epstein-Barr Virus Infections/virology , Herpesvirus 4, Human/isolation & purification , Humans , Lymphoma, Large B-Cell, Diffuse/pathology , Lymphoma, Large B-Cell, Diffuse/virology , Male , Prednisolone/administration & dosage , Prognosis , Rituximab , South America , Vincristine/administration & dosageABSTRACT
INTRODUCTION: Adult T-cell leukemia/lymphoma (ATLL) is a clinically aggressive and heterogeneous entity; hence it is likely that different variants of ATLL have different prognostic factors. METHODS: 95 patients with ATLL seen at our institution between 1987 and 2008 were included. Clinical data were compared, according to ATLL variant, using the Mann-Whitney and the Chi-square tests for continuous and categorical variables, respectively. Kaplan-Meier estimates compared using the log-rank test and Cox proportional-hazard test were used for the univariate and multivariate analysis, respectively. RESULTS: Median age was 61 years with male-to-female ratio of 1.07:1. Patients with acute ATLL were more likely to present with bone marrow, liver and spleen involvement, higher ß2-microglobulin and lower albumin levels. Poor performance status, high IPI score, presence of B symptoms, high LDH and low albumin levels were associated with a worse survival in lymphomatous ATLL. High LDH, high ß2-microglobulin and high PIT score were associated with worse survival in acute ATLL. In the multivariate analysis, low albumin level and presence of B symptoms were independent factors for worse survival in lymphomatous ATLL, and high ß2-microglobulin level was independent factor for worse survival in acute ATLL. CONCLUSIONS: Aggressive ATLL variants have a distinct, almost mutually exclusive profile of prognostic factors.
Subject(s)
Albumins/metabolism , Biomarkers, Tumor/metabolism , L-Lactate Dehydrogenase/metabolism , Leukemia-Lymphoma, Adult T-Cell/mortality , beta 2-Microglobulin/metabolism , Acute Disease , Adult , Aged , Aged, 80 and over , Calcium/metabolism , Female , Flow Cytometry , Humans , Leukemia-Lymphoma, Adult T-Cell/diagnosis , Leukemia-Lymphoma, Adult T-Cell/metabolism , Male , Middle Aged , Prognosis , Survival Rate , Young AdultABSTRACT
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive disease associated with human T-cell lymphotropic virus type-I (HTLV-I) with heterogeneous clinical presentation and outcomes. We report four cases with gastric involvement. We describe clinical and endoscopic findings of cases and review literature.
Subject(s)
Leukemia-Lymphoma, Adult T-Cell , Stomach Neoplasms , Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cyclophosphamide/administration & dosage , Doxorubicin/administration & dosage , Etoposide/administration & dosage , Fatal Outcome , Female , Human T-lymphotropic virus 1/isolation & purification , Humans , Leukemia-Lymphoma, Adult T-Cell/complications , Leukemia-Lymphoma, Adult T-Cell/diagnosis , Leukemia-Lymphoma, Adult T-Cell/drug therapy , Leukemia-Lymphoma, Adult T-Cell/epidemiology , Leukemia-Lymphoma, Adult T-Cell/virology , Male , Middle Aged , Prednisolone/administration & dosage , Prednisone/administration & dosage , Prevalence , Stomach Neoplasms/complications , Stomach Neoplasms/diagnosis , Stomach Neoplasms/drug therapy , Stomach Neoplasms/epidemiology , Stomach Neoplasms/virology , Stomach Ulcer/etiology , Vincristine/administration & dosageABSTRACT
Leucemia/Linfoma T del Adulto (ATLL) es una enfermedad agresiva asociada con el virus linfotrópico de células T tipo I (HTLV-1) con presentación y curso clínico heterogéneo. El reporte describe cuatro casos con compromiso gástrico, considerando características clínicas y hallazgos endoscópicos, con la respectiva revisión de la literatura.
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive disease associated with human T-cell lymphotropic virus type-I (HTLV-I) with heterogeneous clinical presentation and outcomes. We report four cases with gastric involvement. We describe clinical and endoscopic findings of cases and review literature.