ABSTRACT
Headache after subarachnoid hemorrhage and corresponding craniotomy with aneurysm clipping can be severe and difficult to treat. Currently accepted analgesic therapies are often ineffective at treating the pain without incurring unacceptable side effects. We present an innovative approach wherein intravenous lidocaine infusions were used to successfully treat 2 patients with hyperalgesia refractory to traditional analgesic therapies. Opioid consumption fell to zero for both patients during lidocaine infusions without lidocaine toxicity. Moreover, after discontinuation of lidocaine infusions, both patients reported good pain control using only standard oral medications.
Subject(s)
Lidocaine , Subarachnoid Hemorrhage , Analgesics, Opioid/therapeutic use , Headache/drug therapy , Headache/etiology , Humans , Pain/drug therapy , Subarachnoid Hemorrhage/complicationsABSTRACT
Goff comments that faulting is important for creation of abyssal hills and is the dominant process at slow-spreading ridges. We respond that faulting is indeed important but cannot alone explain the bathymetric signal predicted by our models and observed at the Australian-Antarctic Ridge. We show that for intermediate- to fast-spreading ridges, abyssal hill spacing is consistent with the periodicity of the obliquity cycle.
ABSTRACT
Glacial cycles redistribute water between oceans and continents, causing pressure changes in the upper mantle, with consequences for the melting of Earth's interior. Using Plio-Pleistocene sea-level variations as a forcing function, theoretical models of mid-ocean ridge dynamics that include melt transport predict temporal variations in crustal thickness of hundreds of meters. New bathymetry from the Australian-Antarctic ridge shows statistically significant spectral energy near the Milankovitch periods of 23, 41, and 100 thousand years, which is consistent with model predictions. These results suggest that abyssal hills, one of the most common bathymetric features on Earth, record the magmatic response to changes in sea level. The models and data support a link between glacial cycles at the surface and mantle melting at depth, recorded in the bathymetric fabric of the sea floor.
ABSTRACT
The 'snowball Earth' hypothesis interprets geological evidence as indicating multi-million-year episodes of global glaciation near the beginning and end of the Proterozoic eon. On the basis of a coupled carbon cycle-climate model, Peltier et al. propose that temperature-dependent remineralization of organic carbon in a Neoproterozoic ocean with 100-1,000x more dissolved organic carbon than today could create a negative climate feedback, thereby preventing a snowball Earth. Their results are sensitive to initial conditions and model parameters; moreover, important geological observations and components of the carbon cycle are not considered-notably the absence of sources or sinks of carbon. Their model results fall short of explaining the geological evidence in the absence of global glaciation.
ABSTRACT
The 'snowball Earth' hypothesis posits the occurrence of a sequence of glaciations in the Earth's history sufficiently deep that photosynthetic activity was essentially arrested. Because the time interval during which these events are believed to have occurred immediately preceded the Cambrian explosion of life, the issue as to whether such snowball states actually developed has important implications for our understanding of evolutionary biology. Here we couple an explicit model of the Neoproterozoic carbon cycle to a model of the physical climate system. We show that the drawdown of atmospheric oxygen into the ocean, as surface temperatures decline, operates so as to increase the rate of remineralization of a massive pool of dissolved organic carbon. This leads directly to an increase of atmospheric carbon dioxide, enhanced greenhouse warming of the surface of the Earth, and the prevention of a snowball state.