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1.
Rev Bras Ortop (Sao Paulo) ; 59(2): e278-e283, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38606142

ABSTRACT

Objective To evaluate the stability of osteotomies created in the subtrochanteric and trochanteric regions in a pediatric femur model fixed by flexible intramedullary rods. Method Tomographic sections were obtained from a pediatric femur model with two elastic titanium rods and converted to a three-dimensional model. This model created a mesh with tetrahedral elements according to the finite element method. Three virtual models were obtained, and osteotomies were performed in different regions: mediodiaphyseal, subtrochanteric, and trochanteric. A vertical load of 85N was applied to the top of the femoral head, obtaining the displacements, the maximum and minimum main stress, and the equivalent Von Mises stress on the implant. Results With the applied load, displacements were observed at the osteotomy site of 0.04 mm in the diaphyseal group, 0.5 mm in the subtrochanteric group, and 0.06 mm in the trochanteric group. The maximum stress in the diaphyseal, subtrochanteric, and trochanteric groups was 10.4 Pa, 7.52 Pa, and 26.4 Pa, respectively. That is around 40% higher in the trochanteric group in regards to the diaphyseal (control). The minimum stress of the bone was located in the inner cortical of the femur. The equivalent Von Mises stress on the implants occurred at osteotomy, with a maximum value of 27.6 Pa in the trochanteric group. Conclusion In both trochanteric and subtrochanteric osteotomies, fixation stability was often lower than in the diaphyseal model, suggesting that flexible intramedullary nails are not suitable implants for proximal femoral fixations.

2.
Acta Ortop Bras ; 31(spe2): e260008, 2023.
Article in English | MEDLINE | ID: mdl-37323156

ABSTRACT

Objective: Evaluate the stability provided by two flexible intramedullary nails (FINs) in a simulation of fractures at the proximal levels in pediatric femur models. Methods: Two FINs were inserted in 18 synthetic models of pediatric femurs. Fractures were simulated at one of three levels, and the models were divided into the following groups (n=6): diaphysis (control), subtrochanteric and trochanteric. Flex-compression tests were performed with force up to 85 N. Relative stiffness and the average deformation was obtained. Torsion tests were performed by rotating the proximal fragment until 20°, to obtain the average torque. Results: At flex-compression, the set's average relative stiffness and average deformations were: 54.360x103 N/m and 1.645 mm in the control group, respectively. In the subtrochanteric group, the relative stiffness was 31.415x103 N/m (-42.2%) and the deformation was 2.424 mm (+47.3%) (p<0.05). For the trochanteric group, the relative stiffness was 30.912x103 N/m (+43.1%) and the deformation was 2.508 mm (+52.4%) (p<0.05). In torsion, the average torque was 1.410 Nm in the control group; 1.116 Nm in the subtrochanteric group (-20.8%), and 2.194 Nm in the trochanteric group (+55.6%) (p<0.05). Conclusion: FINs do not seem to be biomechanically competent for the treatment of proximal femoral fractures. Level of Evidence I; Therapeutic Studies - Investigating the results of treatment.


Objetivo: avaliar a estabilidade proporcionada por duas hastes intramedulares flexíveis na simulação de fraturas nos níveis proximais em modelos pediátricos de fêmur. Métodos: Duas hastes foram inseridas em 18 modelos sintéticos de fêmures pediátricos. As fraturas foram simuladas em um dos três níveis, e os modelos foram divididos nos seguintes grupos (n=6): diáfise(controle), subtrocantérico e trocantérico. Testes de flexão-compressão foram realizados com força de até 85N. A rigidez relativa e a deformação média foram obtidas. Os testes de torção foram realizados girando o fragmento proximal até 20°, para obter o torque médio. Resultados: Na flexo-compressão, a rigidez relativa média e as deformações médias do conjunto foram: 54,360x103 N/m e 1,645 mm no grupo controle, respectivamente. No grupo subtrocantérico a rigidez relativa foi de 31,415x103 N/m (-42,2%) e a deformação foi de 2,424 mm (+47,3%) (p<0,05). Para o grupo trocantérico a rigidez relativa foi de 30,912x103 N/m (+43,1%) e a deformação foi de 2,508 mm (+52,4%) (p<0,05). Na torção, o torque médio foi de 1.410 Nm no grupo controle; 1,116 Nm no grupo subtrocantérico (-20,8%) e 2,194 Nm no grupo trocantérico (+55,6%) (p<0,05). Conclusão: As hastes intramedulares flexíveis não parecem ser biomecanicamente competentes para o tratamento das fraturas proximais do fêmur. Nível de Evidência I; Estudos terapêuticos - Investigação dos resultados do tratamento.

3.
Acta ortop. bras ; 31(spe2): e260008, 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1439148

ABSTRACT

ABSTRACT Objective Evaluate the stability provided by two flexible intramedullary nails (FINs) in a simulation of fractures at the proximal levels in pediatric femur models. Methods Two FINs were inserted in 18 synthetic models of pediatric femurs. Fractures were simulated at one of three levels, and the models were divided into the following groups (n=6): diaphysis (control), subtrochanteric and trochanteric. Flex-compression tests were performed with force up to 85 N. Relative stiffness and the average deformation was obtained. Torsion tests were performed by rotating the proximal fragment until 20°, to obtain the average torque. Results At flex-compression, the set's average relative stiffness and average deformations were: 54.360x103 N/m and 1.645 mm in the control group, respectively. In the subtrochanteric group, the relative stiffness was 31.415x103 N/m (-42.2%) and the deformation was 2.424 mm (+47.3%) (p<0.05). For the trochanteric group, the relative stiffness was 30.912x103 N/m (+43.1%) and the deformation was 2.508 mm (+52.4%) (p<0.05). In torsion, the average torque was 1.410 Nm in the control group; 1.116 Nm in the subtrochanteric group (-20.8%), and 2.194 Nm in the trochanteric group (+55.6%) (p<0.05). Conclusion FINs do not seem to be biomechanically competent for the treatment of proximal femoral fractures. Level of Evidence I; Therapeutic Studies - Investigating the results of treatment.


RESUMO Objetivo avaliar a estabilidade proporcionada por duas hastes intramedulares flexíveis na simulação de fraturas nos níveis proximais em modelos pediátricos de fêmur. Métodos Duas hastes foram inseridas em 18 modelos sintéticos de fêmures pediátricos. As fraturas foram simuladas em um dos três níveis, e os modelos foram divididos nos seguintes grupos (n=6): diáfise(controle), subtrocantérico e trocantérico. Testes de flexão-compressão foram realizados com força de até 85N. A rigidez relativa e a deformação média foram obtidas. Os testes de torção foram realizados girando o fragmento proximal até 20°, para obter o torque médio. Resultados Na flexo-compressão, a rigidez relativa média e as deformações médias do conjunto foram: 54,360x103 N/m e 1,645 mm no grupo controle, respectivamente. No grupo subtrocantérico a rigidez relativa foi de 31,415x103 N/m (-42,2%) e a deformação foi de 2,424 mm (+47,3%) (p<0,05). Para o grupo trocantérico a rigidez relativa foi de 30,912x103 N/m (+43,1%) e a deformação foi de 2,508 mm (+52,4%) (p<0,05). Na torção, o torque médio foi de 1.410 Nm no grupo controle; 1,116 Nm no grupo subtrocantérico (-20,8%) e 2,194 Nm no grupo trocantérico (+55,6%) (p<0,05). Conclusão As hastes intramedulares flexíveis não parecem ser biomecanicamente competentes para o tratamento das fraturas proximais do fêmur. Nível de Evidência I; Estudos terapêuticos - Investigação dos resultados do tratamento.

4.
Rev Col Bras Cir ; 46(6): e20192284, 2020.
Article in Portuguese, English | MEDLINE | ID: mdl-32022108

ABSTRACT

OBJECTIVE: to evaluate newborns with suspected hip instability, referred by pediatricians to a tertiary orthopedic service. METHODS: newborns from a public university maternity hospital, with suspected instability or risk factors for hip dysplasia, were referred to the Department of Orthopedics and Anesthesiology, Ribeirão Preto/SP, where we evaluated them clinically and through ultrasound examinations of the hips. Once we found dysplasia, we initiated treatment, and in cases in which there was only hip immaturity and normal clinical examination, we performed clinical and ultrasound observation and review at two or three months of age. RESULTS: we examined 448 newborns, with female predominance and average age at first evaluation of 27 days. The main cause of referral was pelvic presentation at delivery. In 8% there was a positive Ortolani sign and in 12.5%,. At orthopedic examination, 405 (90.5%) patients were normal, 8.5% had hip click and 1.1% had positive Ortolani test. At ultrasound, 368 (89.5%) had immaturity, 26 (6.3%) had moderate dysplasia and in 17 (4.1%) patients the hips were frankly dysplastic. All cases with positive Ortolani sign showed dysplasia at ultrasound. CONCLUSION: there was an excess diagnosis of hip instability in the pediatrician evaluation, which, however, allowed the patient a second assessment, in a more specialized environment and with more technological resources.


OBJETIVO: avaliar recém-nascidos com suspeita de instabilidade do quadril, encaminhados por pediatras a um serviço ortopédico terciário. MÉTODOS: recém-nascidos de uma maternidade pública universitária, com suspeita de instabilidade ou fatores de risco para displasia do quadril, eram encaminhados ao Departamento de Ortopedia e Anestesiologia, Ribeirão Preto/SP, onde eram avaliados clinicamente e através de exames ultrassonográficos dos quadris. Constatada a displasia, iniciava-se o tratamento, e em casos em que havia apenas imaturidade do quadril e exame clínico normal, procedia-se à observação e re-exame clinico e ultrassonográfico com dois ou três meses de vida. RESULTADOS: foram examinados 448 recém-nascidos, com predominância feminina e média de idade na primeira avaliação de 27 dias. A principal causa do encaminhamento foi apresentação pélvica. Em 8% havia sinal de Ortolani positivo e em 12,5% estalido no quadril. No exame ortopédico, 405 (90,5%) pacientes eram normais, 8,5% apresentavam estalido no quadril e 1,1% apresentavam teste de Ortolani positivo. À ultrassonografia, 368 (89,5%) apresentavam imaturidade, 26 (6,3%) tinham displasia moderada e em 17 (4,1%) pacientes os quadris eram francamente displásicos. Todos os casos com sinal de Ortolani positivo apresentavam quadro ultrassonográfico de displasia. CONCLUSÃO: houve excesso de diagnóstico de instabilidade do quadril na avaliação do pediatra, o que, no entanto, permitiu ao paciente uma segunda avaliação, em ambiente mais especializado e com mais recursos tecnológicos.


Subject(s)
Hip Dislocation, Congenital/diagnosis , Joint Dislocations/diagnosis , Joint Instability/diagnosis , Cross-Sectional Studies , Female , Hip Dislocation, Congenital/therapy , Humans , Infant , Infant, Newborn , Joint Dislocations/therapy , Joint Instability/therapy , Male , Orthopedic Fixation Devices , Orthopedic Procedures/instrumentation , Physical Examination , Retrospective Studies , Risk Factors , Severity of Illness Index , Ultrasonography
5.
Rev. Col. Bras. Cir ; 46(6): e20192284, 2019. graf
Article in Portuguese | LILACS | ID: biblio-1057188

ABSTRACT

RESUMO Objetivo: avaliar recém-nascidos com suspeita de instabilidade do quadril, encaminhados por pediatras a um serviço ortopédico terciário. Métodos: recém-nascidos de uma maternidade pública universitária, com suspeita de instabilidade ou fatores de risco para displasia do quadril, eram encaminhados ao Departamento de Ortopedia e Anestesiologia, Ribeirão Preto/SP, onde eram avaliados clinicamente e através de exames ultrassonográficos dos quadris. Constatada a displasia, iniciava-se o tratamento, e em casos em que havia apenas imaturidade do quadril e exame clínico normal, procedia-se à observação e re-exame clinico e ultrassonográfico com dois ou três meses de vida. Resultados: foram examinados 448 recém-nascidos, com predominância feminina e média de idade na primeira avaliação de 27 dias. A principal causa do encaminhamento foi apresentação pélvica. Em 8% havia sinal de Ortolani positivo e em 12,5% estalido no quadril. No exame ortopédico, 405 (90,5%) pacientes eram normais, 8,5% apresentavam estalido no quadril e 1,1% apresentavam teste de Ortolani positivo. À ultrassonografia, 368 (89,5%) apresentavam imaturidade, 26 (6,3%) tinham displasia moderada e em 17 (4,1%) pacientes os quadris eram francamente displásicos. Todos os casos com sinal de Ortolani positivo apresentavam quadro ultrassonográfico de displasia. Conclusão: houve excesso de diagnóstico de instabilidade do quadril na avaliação do pediatra, o que, no entanto, permitiu ao paciente uma segunda avaliação, em ambiente mais especializado e com mais recursos tecnológicos.


ABSTRACT Objective: to evaluate newborns with suspected hip instability, referred by pediatricians to a tertiary orthopedic service. Methods: newborns from a public university maternity hospital, with suspected instability or risk factors for hip dysplasia, were referred to the Department of Orthopedics and Anesthesiology, Ribeirão Preto/SP, where we evaluated them clinically and through ultrasound examinations of the hips. Once we found dysplasia, we initiated treatment, and in cases in which there was only hip immaturity and normal clinical examination, we performed clinical and ultrasound observation and review at two or three months of age. Results: we examined 448 newborns, with female predominance and average age at first evaluation of 27 days. The main cause of referral was pelvic presentation at delivery. In 8% there was a positive Ortolani sign and in 12.5%,. At orthopedic examination, 405 (90.5%) patients were normal, 8.5% had hip click and 1.1% had positive Ortolani test. At ultrasound, 368 (89.5%) had immaturity, 26 (6.3%) had moderate dysplasia and in 17 (4.1%) patients the hips were frankly dysplastic. All cases with positive Ortolani sign showed dysplasia at ultrasound. Conclusion: there was an excess diagnosis of hip instability in the pediatrician evaluation, which, however, allowed the patient a second assessment, in a more specialized environment and with more technological resources.


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Joint Dislocations/diagnosis , Hip Dislocation, Congenital/diagnosis , Joint Instability/diagnosis , Orthopedic Fixation Devices , Physical Examination , Severity of Illness Index , Cross-Sectional Studies , Retrospective Studies , Risk Factors , Ultrasonography , Orthopedic Procedures/instrumentation , Joint Dislocations/therapy , Hip Dislocation, Congenital/therapy , Joint Instability/therapy
6.
Acta sci., Health sci ; 39(2): 203-209, July-Dec. 2017. tab
Article in English | LILACS | ID: biblio-859818

ABSTRACT

The study aimed to evaluate the association of the components of body composition (body mass index ­ BMI, waist circumference, basal metabolism, body fat percentage, fat weight, fat free percentage and lean weight) with gender, age, income and schooling in patients with hepatic steatosis. Descriptive and survey study, with quantitative analytical approach. Data were collected through ultrasound and bioimpedance tests. The significance was p < 0.05 and software used was SPSS 22.0. A sample of 114 patients with hepatic steatosis, 70.1% were women. The mean age was 46.2, only 11.4% had normal BMI. The mean BMI was 30.4, waist circumference 100.2 cm, fat percentage 37.97%, basal metabolism 1451.9 kcal, fat weight 31.0 kg. Statistical differences in several variables in relation to gender and age were found. However, no statistically significant differences were found regarding schooling and income. Changes in body composition were obvious in patients with hepatic steatosis.


O estudo teve como objetivo avaliar a associação dos componentes da composição corporal (índice de massa corporal ­ IMC, circunferência abdominal, metabolismo basal, percentual de gordura, peso gordo, percentual livre de gorduras e peso magro) com gênero, idade, renda e escolaridade em pacientes com esteatose hepática. Estudo descritivo tipo survey, com abordagem analítica quantitativa. Os dados foram coletados através de exames de ultrassonografia e bioimpedância. A significância foi p < 0,05 e o software usado SPSS 22.0. Uma amostra de 114 pacientes com esteatose hepática, 70,1% de mulheres. A média de idade foi 46,2 apenas 11,4% tinham IMC normal. As médias de IMC foram: 30,4, circunferência abdominal: 100,2 cm, percentual de gordura: 37,97%, metabolismo basal: 1451,9 Kcal, peso gordo 31,0 kg. Foram encontradas diferenças estatísticas em diversas variáveis em relação ao gênero e idade. Entretanto, não foram encontradas diferenças estatisticamente significantes a respeito da escolaridade e da renda. Mudanças da composição corporal foram óbvias em pacientes com esteatose hepática.


Subject(s)
Anthropometry , Ultrasonography , Social Indicators , Fatty Liver , Obesity
7.
Radiol Bras ; 49(1): 1-5, 2016.
Article in English | MEDLINE | ID: mdl-26929453

ABSTRACT

OBJECTIVE: To estimate the prevalence and evaluate sonographic findings compatible with changes consistent with hepatic steatosis in patients referred for abdominal ultrasonography at four reference centers in Aracaju, SE, Brazil. MATERIALS AND METHODS: Prospective, descriptive survey, with analytical and quantitative approach, comprising abdominal ultrasonography scans performed with a convex, dynamic 3.75 MHz transducer. Liver dimensions and parenchymal echotexture were evaluated, classifying hepatic steatosis into grades (1, 2 or 3). The SPSS(®) 22.0 software was used for statistical analysis, adopting p < 0.05 as significance level. RESULTS: A total of 800 individuals (561 women and 239 men) were evaluated. The prevalence of steatosis was 29.1%, and the male patients were most affected, presenting with more advanced grades of disease (p = 0.021), as follows: 119 grade 1 (51.0%); 94 grade 2 (40.4%); and 20 grade 3 (8.6%). The median age patients' was 46 years. CONCLUSION: In the present study sample, the prevalence of hepatic steatosis was high, particularly in the male patients. Ultrasonography is suggested as a first choice for the diagnosis of this condition, considering its wide availability, low cost and absence of side effects or risks to the patient.


OBJETIVO: Estimar a prevalência e avaliar as alterações ecográficas compatíveis com esteatose hepática em pacientes encaminhados para exame de ultrassonografia abdominal em quatro centros de referência de Aracaju, SE, Brasil. MATERIAIS E MÉTODOS: Estudo prospectivo, descritivo tipo survey, com abordagem analítica e quantitativa, realizado mediante exame de ultrassonografia abdominal com transdutor convexo, dinâmico e com 3,75 MHz. Foram avaliadas as dimensões do fígado e a ecotextura do parênquima, classificando a esteatose hepática em graus (1, 2 ou 3). Considerou-se nível de significância p < 0,05 e foi utilizado o programa estatístico SPSS® 22.0. RESULTADOS: Foram avaliados 800 indivíduos, sendo 561 mulheres e 239 homens. A prevalência de esteatose foi 29,1%, sendo maior em homens. O gênero masculino apresentou graus mais avançados de esteatose hepática (p = 0,021). Dos diagnosticados, 119 tinham grau 1 (51,0%), 94 apresentavam grau 2 (40,4%) e 20 tinham grau 3 (8,6%). A mediana de idade foi 46 anos. CONCLUSÃO: A prevalência da esteatose hepática foi alta na amostra analisada, sendo maior no gênero masculino. Sugere-se a ultrassonografia como primeira opção para o diagnóstico desta afecção, por ser um método acessível, de baixo custo e sem efeitos colaterais ou riscos para o paciente.

8.
Radiol. bras ; 49(1): 1-5, Jan.-Feb. 2016. tab, graf
Article in Portuguese | LILACS | ID: lil-775191

ABSTRACT

Abstract Objective: To estimate the prevalence and evaluate sonographic findings compatible with changes consistent with hepatic steatosis in patients referred for abdominal ultrasonography at four reference centers in Aracaju, SE, Brazil. Materials and Methods: Prospective, descriptive survey, with analytical and quantitative approach, comprising abdominal ultrasonography scans performed with a convex, dynamic 3.75 MHz transducer. Liver dimensions and parenchymal echotexture were evaluated, classifying hepatic steatosis into grades (1, 2 or 3). The SPSS® 22.0 software was used for statistical analysis, adopting p < 0.05 as significance level. Results: A total of 800 individuals (561 women and 239 men) were evaluated. The prevalence of steatosis was 29.1%, and the male patients were most affected, presenting with more advanced grades of disease (p = 0.021), as follows: 119 grade 1 (51.0%); 94 grade 2 (40.4%); and 20 grade 3 (8.6%). The median age patients' was 46 years. Conclusion: In the present study sample, the prevalence of hepatic steatosis was high, particularly in the male patients. Ultrasonography is suggested as a first choice for the diagnosis of this condition, considering its wide availability, low cost and absence of side effects or risks to the patient.


Resumo Objetivo: Estimar a prevalência e avaliar as alterações ecográficas compatíveis com esteatose hepática em pacientes encaminhados para exame de ultrassonografia abdominal em quatro centros de referência de Aracaju, SE, Brasil. Materiais e Métodos: Estudo prospectivo, descritivo tipo survey, com abordagem analítica e quantitativa, realizado mediante exame de ultrassonografia abdominal com transdutor convexo, dinâmico e com 3,75 MHz. Foram avaliadas as dimensões do fígado e a ecotextura do parênquima, classificando a esteatose hepática em graus (1, 2 ou 3). Considerou-se nível de significância p < 0,05 e foi utilizado o programa estatístico SPSS® 22.0. Resultados: Foram avaliados 800 indivíduos, sendo 561 mulheres e 239 homens. A prevalência de esteatose foi 29,1%, sendo maior em homens. O gênero masculino apresentou graus mais avançados de esteatose hepática (p = 0,021). Dos diagnosticados, 119 tinham grau 1 (51,0%), 94 apresentavam grau 2 (40,4%) e 20 tinham grau 3 (8,6%). A mediana de idade foi 46 anos. Conclusão: A prevalência da esteatose hepática foi alta na amostra analisada, sendo maior no gênero masculino. Sugere-se a ultrassonografia como primeira opção para o diagnóstico desta afecção, por ser um método acessível, de baixo custo e sem efeitos colaterais ou riscos para o paciente.

9.
Rev. Soc. Bras. Clín. Méd ; 14(2): 79-83, 2016.
Article in Portuguese | LILACS | ID: biblio-1247

ABSTRACT

OBJETIVO: Avaliar a prevalência de esteatose hepática não alcoólica em pacientes que realizaram exame de ultrassonografia abdominal de rotina e sua associação com componentes da síndrome metabólica e da resistência à insulina. MÉTODOS: Estudo prospectivo, descritivo, do tipo survey, com abordagem analítica quantitativa. As variáveis numéricas foram expressas como mediana e quartis, e foi utilizado o teste de Kruskal-Wallis, para comparar as variáveis com graus de esteatose. Foi realizada Análise de Covariância com reamostragem por bootstrapping, após correção para sexo, idade e índice de massa corporal. A significância adotada foi de p<0,05, e o programa estatístico utilizado foi o Statistical Package for Social Science (SPSS), versão 22.0. RESULTADOS: Foram avaliados 800 indivíduos; destes, 233 (29,1%) foram diagnosticados com esteatose hepática não alcoólica. Nos pacientes com infiltração gordurosa hepática, foram observados valores elevados de circunferência da cintura (95%), de triglicerídeos (46,4%), de glicemia (35,9%) e de Índice do Modelo de Avaliação da Homeostase (HOMA-IR; 33,3%). Os níveis de lipoproteína de alta densidade estavam baixos em 61,1%. Circunferência da cintura, glicemia, triglicerídeos, insulina basal e HOMA-IR apresentaram associação estatisticamente significativa com os graus de esteatose hepática (p<0,05). Entretanto, após análise multivariada, foi obtida significância para triglicerídeos, insulina e HOMA-IR (p<0,05). CONCLUSÃO: Desordens associadas à síndrome metabólica estão fortemente relacionadas à presença de esteatose hepática não alcoólica.


OBJECTIVE: To evaluate the prevalence of nonalcoholic fatty liver disease in patients who underwent routine abdominal ultrasound examination, and its association with componentes of metabolic syndrome and insulin resistance. METHODS: A prospective, descriptive survey study, using a quantitative analytical approach. Numerical variables were expressed as median and quartiles, and we used Kruskal-Wallis test to compare the variables with degrees of steatosis. Covariance analysis was performed with bootstrapping resampling, after correction for gender, age, and body mass index. The adopted significance was p<0.05, and the software Statistical Package for Social Science (SPSS), version 22.0, was used. RESULTS: A total of 800 individuals was evaluated; of these, 233 (29.1%) were diagnosed with nonalcoholic fatty liver disease. In patients with fatty liver infiltration, high values for waist circumference (95%), triglycerides (46.4%), glucose (35.9%) and Homeostasis Model Assessment (HOMA-IR, 33.3%) were observed. The high-density lipoprotein levels were low at 61.1%. Waist circumference, glucose, triglycerides, basal insulin and HOMA-IR were significantly associated with the degree of hepatic steatosis (p<0.05). However, after a multivariate analysis, significance was achieved for triglycerides, insulin and HOMA-IR (p<0.05). CONCLUSION: metabolic syndromeassociated disorders are strongly related to the presence of nonalcoholic fatty liver disease.


Subject(s)
Humans , Adolescent , Adult , Middle Aged , Metabolic Syndrome/epidemiology , Non-alcoholic Fatty Liver Disease/complications , Fatty Liver , Prospective Studies
10.
Gastroenterology Res ; 8(5): 260-264, 2015 Oct.
Article in English | MEDLINE | ID: mdl-27785306

ABSTRACT

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is among the most common chronic diseases of the modern world with a wide variety of factors including genetic, environmental and metabolic. The aim of this study was to verify the association between the degrees of hepatic steatosis at the abdominal ultrasound and the values of aminotransferases (aspartate aminotransferase (AST) and alanine transferase (ALT)), gamma glutamyl transpeptidase (GGT) and homeostasis model assessment-insulin resistance (HOMA-IR) index. METHODS: A prospective, descriptive survey study, using a quantitative analytical examination, was conducted from July 2013 to July 2014. In the statistical analysis, values were expressed as median, first and third quartiles. We used the nonparametric Kruskal-Wallis test to compare the medians between the degrees of steatosis, adopted a statistical significance of 5% (P ≤ 0.05) and used the statistical program SPSS 22.0. RESULTS: We diagnosed 233/800 (29.1%) patients with hepatic steatosis on routine ultrasound, and 65.7% were female. Regarding degrees, 119 had grade 1 (51.0%), 94 grade 2 (40.4%) and 20 grade 3 (8.6%). The median age of the patients with grade 1, 2 or 3 did not vary significantly (P > 0.05). The median body mass index (BMI), although clinically important because of its elevation, did not differ significantly (P > 0.05). ALT levels increased as the degree of hepatic steatosis has advanced as well as the levels of AST, GGT and HOMA-IR. AST values showed a greater association with the severity of fatty liver (P = 0.0001) than the ALT (P = 0.001). CONCLUSIONS: ALT, AST, GGT and HOMA-IR are associated to the degrees of hepatic steatosis on ultrasound and can help in the selection of patients for the liver histological evaluation.

11.
Rev Bras Ginecol Obstet ; 36(6): 276-80, 2014 Jun.
Article in Portuguese | MEDLINE | ID: mdl-25099468

ABSTRACT

Schistosomiasis mansoni is found in different endemic areas of Brazil. It is a serious public health problem in Brazil and worldwide. Ectopic forms of the disease may affect the female reproductive system, representing a rare type of Schistosoma mansoni infection. A 26-year-old patient complained of vaginal discharge, dyspareunia and pain on palpation of the hypogastrium. Gynecological examination revealed an endocervical polyp. A biopsy was performed. Under microscopy, several granulomas surrounding degenerate and viable eggs of Schistosoma mansoni were seen. Treated with praziquantel, she was asymptomatic after four weeks of treatment. Vaginal discharge and dyspareunia may be secondary causes of cervicitis caused by Schistosoma mansoni. The search for eggs in routine vaginal smear or histological examination should be part of the gynecologic evaluation of patients from endemic areas, with the purpose of tracking ectopic schistosomiasis of the female genital tract.


Subject(s)
Schistosomiasis mansoni , Uterine Cervical Diseases/parasitology , Adult , Brazil , Female , Humans , Schistosomiasis mansoni/diagnosis , Schistosomiasis mansoni/drug therapy , Uterine Cervical Diseases/diagnosis , Uterine Cervical Diseases/surgery
12.
Rev. bras. ginecol. obstet ; 36(6): 276-280, 06/2014. graf
Article in Portuguese | LILACS | ID: lil-716362

ABSTRACT

A esquistossomose mansoni, endemia encontrada em diferentes áreas do território brasileiro, constitui um grave problema de saúde pública no Brasil e no mundo. Formas ectópicas da doença podem acometer o sistema reprodutor feminino, constituindo um tipo raro de infecção pelo S. mansoni. Paciente com 26 anos queixava-se de corrimento vaginal, dispareunia e dor à palpação do hipogástrio. No exame ginecológico foi observado pólipo endocervical, que foi biopsiado. O exame histológico evidenciou vários granulomas envolvendo ovos degenerados e viáveis de Schistosoma mansoni. Tratada com praziquantel, retornou assintomática após quatro semanas do tratamento. Corrimento vaginal e dispareunia podem ser causas secundárias de cervicite por Schistosoma mansoni. Pesquisa de ovos em esfregaço vaginal de rotina ou exame histológico devem fazer parte da avaliação ginecológica de pacientes de área endêmica, com o objetivo de rastrear forma ectópica da esquistossomose do trato genital feminino.


Schistosomiasis mansoni is found in different endemic areas of Brazil. It is a serious public health problem in Brazil and worldwide. Ectopic forms of the disease may affect the female reproductive system, representing a rare type of Schistosoma mansoni infection. A 26-year-old patient complained of vaginal discharge, dyspareunia and pain on palpation of the hypogastrium. Gynecological examination revealed an endocervical polyp. A biopsy was performed. Under microscopy, several granulomas surrounding degenerate and viable eggs of Schistosoma mansoni were seen. Treated with praziquantel, she was asymptomatic after four weeks of treatment. Vaginal discharge and dyspareunia may be secondary causes of cervicitis caused by Schistosoma mansoni. The search for eggs in routine vaginal smear or histological examination should be part of the gynecologic evaluation of patients from endemic areas, with the purpose of tracking ectopic schistosomiasis of the female genital tract.


Subject(s)
Adult , Female , Humans , Schistosomiasis mansoni , Uterine Cervical Diseases/parasitology , Brazil , Schistosomiasis mansoni/diagnosis , Schistosomiasis mansoni/drug therapy , Uterine Cervical Diseases/diagnosis , Uterine Cervical Diseases/surgery
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