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PLoS One ; 17(8): e0273099, 2022.
Article in English | MEDLINE | ID: mdl-35972989

ABSTRACT

The damage to the gastrointestinal mucosa induced by ischemia/reperfusion (I/R) is closely related to high mortality in critically ill patients, which is attributable, in part, to the lack of an early method of diagnosis to show the degree of ischemia-induced injury in this type of patients. Electrical Impedance Spectroscopy (EIS) has been shown to be a tool to early diagnose gastric mucosal damage induced by ischemia. A therapeutic alternative to reduce this type of injury is melatonin (MT), which has gastroprotective effects in I/R models. In this work, the effect of treatment with MT on the electrical properties of gastric tissue, biomarkers of inflammatory (iNOS and COX-2), proliferation, and apoptotic process under I/R conditions in male Wistar rats was evaluated through EIS, histological and immunohistochemical analysis. Treatment with MT prevents gastric mucosa damage, causing a decrease in gastric impedance parameters related to the inflammatory process and cellular damage. This suggests that EIS could be used as a tool to diagnose and monitor the evolution of gastric mucosal injury, as well as in the recovery process in critically ill patients.


Subject(s)
Melatonin , Reperfusion Injury , Stomach Diseases , Animals , Biomarkers , Critical Illness , Electric Impedance , Gastric Mucosa/pathology , Ischemia/pathology , Male , Melatonin/pharmacology , Melatonin/therapeutic use , Rats , Rats, Wistar , Reperfusion , Reperfusion Injury/pathology , Stomach Diseases/pathology
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