ABSTRACT
Ancient DNA shows continuity between living and ancient Maya communities.
Subject(s)
Ceremonial Behavior , Civilization , DNA, Ancient , Twins , Female , Humans , Male , History, Ancient , Twins/history , Child , Civilization/historyABSTRACT
Complex tools from 300,000-year-old deposit at Schöningen in Germany point to a "wood age".
Subject(s)
Neanderthals , Wood , Animals , Archaeology , Germany , Neanderthals/psychologyABSTRACT
Among Europeans, risk of multiple sclerosis rises with genes from Bronze Age Yamnaya herders.
Subject(s)
DNA, Ancient , Multiple Sclerosis , Humans , Europe/epidemiology , Genome, Human , Multiple Sclerosis/epidemiology , Multiple Sclerosis/genetics , Multiple Sclerosis/historyABSTRACT
8000 years ago-long before farming arrived-people in Siberia built defensive structures.
Subject(s)
Hunting , Humans , Farms/history , Siberia , Hunting/historyABSTRACT
Despite more than 80 years of use in a number of conditions, including in critically ill patients, comments have recently arisen regarding the safety and efficacy of human serum albumin (HSA) as a therapeutic product and stabilizer/excipient in botulinum neurotoxins. This review summarizes the literature on the safety of HSA. Beyond decades of safe use, the largest clinical dataset of HSA safety is a large meta-analysis of HSA supplier data, which found only an extremely remote risk of serious adverse events across millions of doses of therapeutic concentrations of HSA. There is a paucity of literature identifying HSA-specific adverse events when used as a stabilizer/excipient; however, studies of HSA-containing botulinum neurotoxins (BoNTs) suggest that adverse events are not related to HSA. Polysorbates, which are synthetically produced and not physiologically inert, are contained in pending or new-to-market BoNT formulations. In contrast to HSA, evidence exists to suggest that polysorbates (particularly PS20/PS80) can cause serious adverse events (e.g., hypersensitivity, anaphylaxis, and immunogenicity).
Subject(s)
Botulinum Toxins, Type A , Botulinum Toxins , Humans , Botulinum Toxins/adverse effects , Serum Albumin, Human/adverse effects , Excipients , Polysorbates , Botulinum Toxins, Type A/adverse effectsABSTRACT
Giant family trees based on ancient DNA from thousands of people are revealing prehistoric politics and social structure.
ABSTRACT
DNA from enslaved Black workers at a 19th century iron forge links them to living descendants. But the research swirls with ethical questions.
ABSTRACT
Genes reveal striking diversity within similar ice age cultures.
Subject(s)
Cultural Diversity , DNA, Ancient , Europe , HumansABSTRACT
After the Spanish conquest, horses transformed Native American tribes much earlier than historians thought.
Subject(s)
American Indian or Alaska Native , Horses , Human-Animal Interaction , Animals , North America , Spain , Archaeology , HumansABSTRACT
Ancient DNA reflects foreign influx to Swahili coast, but its culture is largely local.
ABSTRACT
Analysis reveals the chemicals applied to corpses in a 2700-year-old mummification workshop.
Subject(s)
Mummies , Humans , Cadaver , Egypt , History, Ancient , Mummies/historyABSTRACT
Meat from the butchered beasts would have fed hundreds.
Subject(s)
Feeding Behavior , Group Processes , Hunting , Meat , Neanderthals , Animals , Eating , Meat/history , Neanderthals/psychology , Hunting/history , ElephantsABSTRACT
DNA from a medieval German cemetery opens a window on the history of today's largest Jewish population.
Subject(s)
Jews , Jews/genetics , Population/genetics , Germany , Cemeteries/history , DNA, Ancient , HumansABSTRACT
By sequencing ancient hominins' DNA, Pääbo explored "what makes us uniquely human".
Subject(s)
DNA, Ancient , Hominidae , Animals , Hominidae/genetics , Humans , Nobel PrizeABSTRACT
Genetic study of burials suggests whole families migrated to the island in the first millennium C.E.
Subject(s)
Emigration and Immigration , White People , Burial , DNA, Ancient , Emigration and Immigration/history , England , History, Ancient , Humans , Sequence Analysis, DNA , White People/geneticsABSTRACT
Studies seek clues to origins of farming, early languages.
Subject(s)
Civilization , DNA, Ancient , Farms , Language , Civilization/history , Farms/history , History, Ancient , Humans , Language/history , Middle EastABSTRACT
Russian disinformation campaign targets routine research on bat parasites.
ABSTRACT
Researchers hide ancient weapons and bat skulls, upload data as bombs fall.