ABSTRACT
BACKGROUND: Eccrine porocarcinoma is an uncommon neoplasm of the intraepidermal sweat gland duct. METHODS: A case of porocarcinoma of the right heel in a male age 51 years is described with a review of pertinent literature. The surgically excised neoplasm was evaluated by routine histology and transmission electron microscopy. RESULTS: The porocarcinoma showed extensive nuclear pleomorphisms with frequent, multinucleated tumor giant cells, focal epidermotrophic spread within the epidermis, a peripheral, eccrine syringofibroadenoma-like growth pattern, and an origin in a contiguous eccrine poroma. Ultrastructurally, the squamous tumor cells contained rare intracytoplasmic lumens. CONCLUSIONS: The extensive nuclear pleomorphism with frequent tumor giant cells was an unusual feature of the porocarcinoma. Its epidermotrophic spread within the epidermis and its origin in a contiguous eccrine poroma supported the diagnosis of porocarcinoma. The eccrine syringofibroadenoma-like growth pattern in the periphery of the tumor was a unique and previously undescribed feature of the porocarcinoma. The presence of intracytoplasmic lumens in squamous tumor cells mimicked embryonic development of the intraepidermal sweat gland duct.
Subject(s)
Acrospiroma/pathology , Carcinoma, Squamous Cell/pathology , Heel/pathology , Skin Neoplasms/pathology , Sweat Gland Neoplasms/pathology , Acrospiroma/surgery , Biopsy , Carcinoma, Squamous Cell/surgery , Cell Division/physiology , Heel/surgery , Humans , Male , Middle Aged , Skin Neoplasms/surgery , Sweat Gland Neoplasms/surgerySubject(s)
Blood Proteins/metabolism , Gout/blood , Menstrual Cycle , Progesterone/blood , Testosterone/blood , Uric Acid/blood , Adolescent , Adult , Allopurinol/therapeutic use , Child , Child, Preschool , Female , Gout/drug therapy , Humans , Male , Menopause , Prolactin/blood , Protein Binding , Reference Values , Sex FactorsSubject(s)
Blood Proteins/metabolism , Estradiol/pharmacology , Progesterone/pharmacology , Testosterone/pharmacology , Uric Acid/blood , Colorimetry , Contraceptives, Oral , Cyclofenil/therapeutic use , Female , Humans , In Vitro Techniques , Norethindrone/analogs & derivatives , Norethindrone/therapeutic use , Norethindrone Acetate , Protein Binding , Time Factors , UltrafiltrationABSTRACT
Modifications on the binding of uric acid to human plasma proteins have been studied in regularly menstruating females aged 25-30 years with a normal cycle, in comparison with a group of healthy age-matched males and with a group of post-menopausal females. The binding of uric acid to plasma proteins was estimated using micropartition system Amicon. The results obtained demonstrate a significant increase of uric acid binding during ovulatory and mid-luteal phase of menstrual cycle. No modifications are shown in post-menopausal females and in healthy males. No modifications have been shown with the same experiments performed in vitro.
