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Data sharing has facilitated the digitisation of society. We can access our bank accounts or make an appointment with our doctor anytime and anywhere. To achieve this, we have to share certain information, whether personal, professional, etc. This may seem like a minor cost for an individual user, but actually the data economy as the backbone of a digital transformation that is reshaping all aspects of human life. However, one of the major concerns arises regarding what happens to such individual data; once shared, control over it is often lost. For that reason, users and companies are reluctant to share their data. The European Union, through its European Strategy for Data, is establishing a policy and legal framework for establishing a single market for data in Europe by improving the trust and fairness of the data economy. Data spaces are a commitment to sharing data in a reliable and secure way, but this endeavour should, of course, not be at the expense of privacy rights. In recent years, Privacy-Enhancing Technologies (PETs) have emerged to achieve data sharing and privacy preservation that can address the requirements of data spaces around sensitive citizen and business data. In this work, we review existing PETs and assess their relevance, technological maturity, and applicability in the context of common European data spaces. Finally, we illustrate the benefits of secure data sharing via Federated Learning in a healthcare use case, where the preservation of privacy is a primer requirement and is therefore to be guaranteed.
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OBJECTIVE: To compare the accuracy of Kane, Barrett Universal II, Haigis, and SRK-T formulas in eyes with average keratometry greater than 46 diopters (D). METHODS: A retrospective analysis was conducted on 101 eyes of 101 patients with average keratometry greater than 46 D. The absolute prediction error (EA) was obtained for each patient one month after surgery. The mean absolute prediction error (MEA), median absolute prediction error (MedEA) and the percentage of patients with absolute refractive error less than 0.25 D, 0.50 D, and 1.00 D were calculated for each formula analyzed. RESULTS: The Kane formula achieved the lowest MEA (0.53⯱â¯0.43) and the lowest MedEA (0.41), followed by Barrett Universal II (MEA: 0.56⯱â¯0.42, MedEA: 0.49), SRK-T (MEA: 0.59⯱â¯0.44, MedEA: 0.54), and Haigis (MEA: 0.77⯱â¯0.47, MedEA: 0.69), showing a significant difference in the results. It was also observed that the Kane formula was the most accurate, with the highest percentage of patients, with EA less than 0.25 D, 0.50 D, and 1.00 D (30.7%, 54.4%, and 86.1%, respectively), while the Haigis formula was the least accurate (12.9%, 33.7%, and 69.3%, respectively). CONCLUSION: In eyes with corneas having average keratometry greater than 46 D, the Kane formula proves to be a useful tool in intraocular lens (IOL) power calculation and demonstrates higher precision compared to the Barrett Universal II, SRK-T, and Haigis formulas.
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INTRODUCTION: revision joint replacement surgery presents a surgical challenge. The use of rotating hinge prostheses is an option in patients with femorotibial bone defects, ligament insufficiency, or significant deformities. The aim of this study was to evaluate the clinical, functional, and radiological outcomes of a series of patients who underwent surgery using the GMK Hinge (Medacta®) rotational hinge model. MATERIAL AND METHODS: a descriptive, retrospective, and analytical study was conducted on a series of 36 patients, with a mean age of 72.5 years (47-85), operated on by the same surgical team between January 2015 and January 2022. The etiology of revision was chronic infection in 38.9% of cases, instability in 33.3%, aseptic loosening in 19.4%, and stiffness in 8.4%. The Knee Society Score (KSS) and the Forgotten Joint Score (FJS) were used to assess functional outcomes. The degree of femorotibial bone defect was evaluated using the Anderson Orthopaedic Research Institute (AORI) classification. Postoperative complications are also recorded. RESULTS: a total of 36 patients, 17 males and 19 females, were included, with a mean follow-up of 30 months (12-66). Twelve patients had type 1 defects, ten had 2A defects, ten had 2B defects, and two had type 3 defects on the femoral side, with the use of wedges required for asymmetrical defects (21 patients). The predominant tibial defect was type 1 without the need for wedges. The majority achieved a satisfactory outcome on the KSS scale (72.2 ± 9.4), with significant differences compared to the previous KSS (54.3 ± 8.9). A score of 31 (12-67) was also obtained on the FJS scale. Postoperative complications were present in 16.7% of patients. CONCLUSIONS: complex prosthetic revision surgery using a rotating hinge prosthesis represents a suitable therapeutic option, yielding appropriate clinical and functional outcomes, albeit not without complications.
INTRODUCCIÓN: la cirugía de revisión protésica constituye un reto quirúrgico. La utilización de prótesis tipo bisagra rotatoria es una opción en pacientes con defectos óseos femorotibiales, insuficiencia ligamentosa o importantes deformidades. El objetivo del presente estudio es evaluar los resultados clínicos, funcionales y radiológicos de una serie de pacientes intervenidos mediante un modelo de bisagra rotacional GMK Hinge (Medacta®). MATERIAL Y MÉTODOS: estudio descriptivo retrospectivo y analítico que incluyó una serie de 36 pacientes, con edad media de 72.5 años (47-85) intervenidos entre Enero de 2015 y Enero de 2022 por el mismo equipo quirúrgico. La etiología de revisión fue infección crónica en 38.9%, inestabilidad en 33.3%, aflojamiento aséptico en 19.4% y rigidez en 8.4%. Para la evaluación de resultados funcionales se utiliza la escala Knee Society Score (KSS), así como la escala Forgotten Joint Score (FJS). El grado de defecto óseo femorotibial se evaluó mediante la clasificación de Anderson Orthopaedic Research Institute (AORI). También se registraron las complicaciones postquirúrgicas. RESULTADOS: se analizó un total de 36 pacientes, 17 varones y 19 mujeres, con seguimiento medio de 30 meses (12-66). Se encontraron doce pacientes con defectos tipo 1, diez con defectos 2A, diez con defectos 2B y dos con defecto tipo 3 en la vertiente femoral, siendo necesario la utilización de cuñas en defectos asimétricos (21 pacientes). El defecto tibial mayoritario fue el tipo 1 sin necesidad de cuñas. La mayoría obtuvo un resultado satisfactorio en la escala KSS (72.2 ± 9.4), con diferencias significativas respecto al KSS previo (54.3 ± 8.9). Se obtuvo también una puntuación de 31 (12-67) en la escala FJS. Presentaron complicaciones postoperatorias 16.7% de los pacientes. CONCLUSIONES: la cirugía de revisión protésica compleja mediante prótesis tipo bisagra rotacional constituye una correcta opción terapéutica, presentando resultados clínicos y funcionales adecuados, no exentos de complicaciones.
Subject(s)
Arthroplasty, Replacement, Knee , Knee Prosthesis , Prosthesis Design , Reoperation , Humans , Male , Female , Aged , Retrospective Studies , Arthroplasty, Replacement, Knee/methods , Reoperation/statistics & numerical data , Middle Aged , Aged, 80 and over , Prosthesis Failure , Postoperative Complications/epidemiology , Follow-Up Studies , Treatment OutcomeABSTRACT
OBJECTIVE: Vitiligo is a common systemic, idiopathic autoimmune disease. The aim of this study was to analyze the frequency of variants of the superoxide dismutase 1 (SOD1) gene (50 bp Ins/Del, rs4817415, rs2070424, rs1041740, rs17880135) and circulating plasma protein levels through in-silico analysis. PATIENTS AND METHODS: Blood samples were collected from adult patients of both sexes with a clinical diagnosis of vitiligo. ELISA tests for SOD and analysis of gene variants by qPCR were compared to a disease-free reference group. RESULTS: The population analyzed was young people between 29 and 37 years old, with a higher percentage of women. The population was found in the Hardy-Weinberg equilibrium (HWE). The 50 bp Ins/Del, rs4817415, and rs2070424 variants showed no significant difference between groups (p > 0.05). Although, in the dominant model, the CT and CTTT genotypes of the rs1041740 and rs17880135 variants showed an association with susceptibility to vitiligo compared to the control. Plasma SOD levels showed significant differences between the groups, and when stratified according to the genotypes of each variant, there was a significant difference, except with the rs17880135 variant. The haplotypes InsCGTC and InsAGCC are shown to be risk factors for susceptibility to vitiligo. The in-silico analysis demonstrated that the rs4817415, rs2070424, rs1041740, and rs17880135 variants of the SOD1 gene participate in the modification of selected regulatory elements for differentiating the protein, transcription factors, and long non-coding RNA. CONCLUSIONS: Information regarding the pathogenesis of vitiligo helps recognize risk factors and identify the relationship of diagnostic markers of cell damage inherent to the disease. This will help improve aspects of prevention and the choice of treatment alternatives appropriate to each case.
Subject(s)
Vitiligo , Male , Adult , Humans , Female , Adolescent , Superoxide Dismutase-1/genetics , Vitiligo/genetics , Genotype , Risk Factors , Blood Proteins/genetics , Case-Control Studies , Genetic Predisposition to Disease , Polymorphism, Single NucleotideABSTRACT
Scientific knowledge is produced in multiple languages but is predominantly published in English. This practice creates a language barrier to generate and transfer scientific knowledge between communities with diverse linguistic backgrounds, hindering the ability of scholars and communities to address global challenges and achieve diversity and equity in science, technology, engineering and mathematics (STEM). To overcome those barriers, publishers and journals should provide a fair system that supports non-native English speakers and disseminates knowledge across the globe. We surveyed policies of 736 journals in biological sciences to assess their linguistic inclusivity, identify predictors of inclusivity, and propose actions to overcome language barriers in academic publishing. Our assessment revealed a grim landscape where most journals were making minimal efforts to overcome language barriers. The impact factor of journals was negatively associated with adopting a number of inclusive policies whereas ownership by a scientific society tended to have a positive association. Contrary to our expectations, the proportion of both open access articles and editors based in non-English speaking countries did not have a major positive association with the adoption of linguistically inclusive policies. We proposed a set of actions to overcome language barriers in academic publishing, including the renegotiation of power dynamics between publishers and editorial boards.
Subject(s)
Biological Science Disciplines , Publishing , Language , LinguisticsABSTRACT
Aggression is a social behavior that is critical for survival and reproduction. In adults, circulating gonadal hormones, such as androgens, act on neural circuits to modulate aggressive interactions, especially in reproductive contexts. In many species, individuals also demonstrate aggression before reaching gonadal maturation. Adult male song sparrows, Melospiza melodia, breed seasonally but maintain territories year-round. Juvenile (hatch-year) males aggressively compete for territory ownership during their first winter when circulating testosterone is low. Here, we characterized the relationship between the steroid milieu and aggressive behavior in free-living juvenile male song sparrows in winter. We investigated the effect of a 10 min simulated territorial intrusion (STI) on behavior and steroid levels in blood, 10 microdissected brain regions, and four peripheral tissues (liver, pectoral muscle, adrenal glands, and testes). Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), we quantified 12 steroids: pregnenolone, progesterone, corticosterone, 11-dehydrocorticosterone, dehydroepiandrosterone, androstenedione, testosterone, 5α-dihydrotestosterone, 17ß-estradiol, 17α-estradiol, estrone, and estriol. We found that juvenile males are robustly aggressive, like adult males. An STI increases progesterone and corticosterone levels in blood and brain and increases 11-dehydrocorticosterone levels in blood only. Pregnenolone, androgens, and estrogens are generally non-detectable and are not affected by an STI. In peripheral tissues, steroid concentrations are very high in the adrenals. These data suggest that adrenal steroids, such as progesterone and corticosterone, might promote juvenile aggression and that juvenile and adult songbirds might rely on distinct neuroendocrine mechanisms to support similar aggressive behaviors.
Subject(s)
Songbirds , Humans , Animals , Male , Songbirds/physiology , Corticosterone , Progesterone/pharmacology , Chromatography, Liquid , Tandem Mass Spectrometry , Testosterone , Androgens , Aggression/physiology , Estradiol/pharmacology , Pregnenolone/pharmacologyABSTRACT
AIM: The aim of this study was to add robustness and provide further evidence on the bioequivalence, safety and immunogenicity between MB02 and reference bevacizumab. No similar study has been performed before with a biosimilar monoclonal antibody. METHODS: Population analysis by pooling data from three independent pharmacokinetic (PK) studies was performed. The studies had a single-dose, double-blind, three-arm, parallel-group design and two studies, MB02-A-02-17 and MB02-A-05-18, compared MB02 to EU- and US-bevacizumab in Caucasian subjects, while study MB02-A-04-18 compared MB02 and EU-bevacizumab in Japanese participants. Primary endpoints included maximum observed serum concentration (Cmax ), area under the serum concentration-time curve (AUC) from time zero and extrapolated to infinity (AUC0-∞ ) and AUC from time zero to the time of last quantifiable concentration (AUC0-t ). Secondary endpoints included other PK parameters, safety and immunogenicity. A sensitivity analysis using actual protein concentration as a correction factor was applied to primary PK parameters. RESULTS: Point estimates and 90% confidence intervals for the geometric mean ratios of primary PK parameters for MB02, EU- and US-bevacizumab were all contained within the predefined bioequivalence margins (80%-125%) for all pairwise comparisons. The same results for all pairwise comparisons were observed when protein-corrected primary PK parameters were analyzed. Safety and immunogenicity were similar between MB02 and the EU- and US-reference bevacizumab in healthy subjects. CONCLUSIONS: This pooled analysis of three comparable PK studies further supports the bioequivalence of biosimilar MB02 to EU- and US-reference bevacizumab. No clinically meaningful differences in safety or immunogenicity were observed.
Subject(s)
Biosimilar Pharmaceuticals , Humans , Antibodies, Monoclonal , Area Under Curve , Bevacizumab/adverse effects , Bevacizumab/pharmacokinetics , Biosimilar Pharmaceuticals/adverse effects , Biosimilar Pharmaceuticals/pharmacokinetics , Therapeutic EquivalencyABSTRACT
A raspberry-like SiO2@TiO2 new material supported on functionalized graphene oxide was prepared to reduce titania's band gap value. The material was characterized through different analytical methods such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and high-resolution transmission electron microscopy (HR-TEM). The band gap value was studied via UV-Vis absorption spectra and determined through the Kubelka-Munk equation. A theoretical study was also carried out to analyze the interaction between the species.
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BACKGROUND: To contain intra-hospital transmission of third-generation cephalosporin-resistant Enterobacterales (3GCR-E), contact isolation precautions are recommended. AIM: To quantify transmissions of 3GCR Escherichia coli and 3GCR Klebsiella pneumoniae within a hospital. METHODS: An automated outbreak detection system (AODS) was used to identify clusters (N≥2) of 3GCR Enterobacterales for the years 2016, 2018 and 2020. Clusters were defined by phenotypic agreement of microbiological results and spatial and temporal relationship. Core genome multi-locus sequence typing (cgMLST) was used to confirm whether the cluster isolates were transmitted between patients. FINDINGS: A total of 4343 3GCR E. coli and 1377 K. pneumoniae isolates were analysed. Among the 3GCR E. coli isolates, the AODS identified 304 isolates as cluster isolates, the median cluster size was two (range: 2-5). The cgMLST analysis revealed that a total of 23 (7.5%) 3GCR E. coli cluster isolates were transmission-associated, of which 20 isolates (87%) were detected in intensive care patients. Among the 3GCR K. pneumoniae isolates, the AODS identified 73 isolates as cluster isolates, the median cluster size was two (range: 2-4). CgMLST revealed that 35 (48%) 3GCR K. pneumoniae cluster isolates were transmission associated, of which 27 isolates (77%) were detected in intensive care patients. CONCLUSION: For 3GCR K. pneumoniae, cgMLST confirmed the AODS results more frequently than for 3GCR E. coli. Therefore, contact isolation precautions for 3GCR K. pneumoniae may be appropriate on intensive care units, but only in certain circumstances, such as outbreaks, for Enterobacterales with lower transmissibility, such as E. coli.
Subject(s)
Escherichia coli , Klebsiella Infections , Humans , Escherichia coli/genetics , Multilocus Sequence Typing , Klebsiella pneumoniae/genetics , Infection Control/methods , Cephalosporins/pharmacology , beta-Lactamases/genetics , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/therapeutic use , Microbial Sensitivity Tests , Klebsiella Infections/microbiologyABSTRACT
PREMISE: Variation in fruit and seed traits could originate from selection pressures exerted by frugivores or other ecological factors (adaptive hypotheses) and developmental constraints (by-product hypotheses) or chance. METHODS: We evaluated fruit and leaf traits for nearly 850 plant species from a rainforest in Tinigua Park, Colombia. Through a series of linear regressions controlling for the phylogenetic signal of the traits (minimum N = 542), we tested (1) whether the allometry between seed width and length depends on seed dispersal system (Mazer and Wheelwright's adaptive hypothesis of allometry for species dispersed in the guts of animals = endozoochory) and (2) whether fruit length is associated with leaf length (i.e., Herrera's by-product hypothesis derived from the assumption that both organs develop from homologous structures). RESULTS: We found a strong negative allometric association between seed width and length for seeds of endozoochorous species, as expected; but also, for anemochorous species. We found a positive relationship between fruit and leaf length, but this relationship was not evident for zoochorous species. Fruit size was highly correlated with seed size. CONCLUSIONS: The allometry between seed length and width varied among dispersal systems, supporting that fruit and seed morphology has been modified by interactions with frugivores and by the possibility to rotate for some wind dispersed species. We found some support for the hypothesis on developmental constraints because fruit and leaf size were positively correlated, but the predictive power of the relationship was low (10-15%).
PREMISA: La variación en los rasgos de frutos y semillas de las plantas podría tener su origen en las presiones de selección ejercidas por los frugívoros u otros factores ecológicos (hipótesis adaptativas), así como en limitaciones del desarrollo (hipótesis de subproductos) o en el azar. MÉTODOS: Nosotros evaluamos rasgos de frutos y hojas en cerca de 850 especies de plantas de un bosque húmedo tropical en el Parque Nacional Natural Tinigua, Colombia. Usando una serie de regresiones lineales que controlan por la señal filogenética de dichos rasgos (mínimo N = 542), nosotros probamos (1) si la alometría entre el ancho y largo de la semilla depende del sistema de dispersión de la semilla (i.e., hipótesis adaptativa de Mazer y Wheelwright; en la que se espera una alometría negativa para especies dispersadas por endozoocoria) y (2) si el largo del fruto está asociado con el largo de la hoja (i.e., la hipótesis del subproducto de Herrera derivada de la suposición de que ambos órganos se desarrollan a partir de estructuras homólogas). RESULTADOS: Nosotros encontramos una fuerte asociación alométrica negativa entre el ancho y el largo de las semillas para las semillas de las especies endozoócoras, como era de esperar; pero también, para las especies anemócoras. Nosotros también hallamos una relación positiva entre el largo del fruto y de la hoja, pero esta relación no fue evidente para las especies endozoócoras. Detectamos que el tamaño del fruto esta altamente correlacionado con el tamaño de la semilla. CONCLUSIONES: La alometría entre el largo y el ancho de la semilla varió entre sistemas de dispersión, lo que sugiere que la morfología de frutos y semillas ha sido moldeada por interacciones con frugívoros en el caso de las semillas endozoócoras y por la posibilidad de rotar para algunas especies dispersadas por el viento. Aunque el poder predictivo de la relación entre el tamaño del fruto y de la hoja fue bajo (10-15%), nosotros encontramos un apoyo moderado a la hipótesis sobre las limitaciones del desarrollo, ya que el tamaño del fruto y de la hoja estaban correlacionados positivamente.
Subject(s)
Fruit , Seed Dispersal , Animals , Fruit/anatomy & histology , Rainforest , Phylogeny , Seeds/anatomy & histology , Plant LeavesABSTRACT
Explaining broad molecular, phenotypic and species biodiversity patterns necessitates a unifying framework spanning multiple evolutionary scales. Here we argue that although substantial effort has been made to reconcile microevolution and macroevolution, much work remains to identify the links between biological processes at play. We highlight four major questions of evolutionary biology whose solutions require conceptual bridges between micro and macroevolution. We review potential avenues for future research to establish how mechanisms at one scale (drift, mutation, migration, selection) translate to processes at the other scale (speciation, extinction, biogeographic dispersal) and vice versa. We propose ways in which current comparative methods to infer molecular evolution, phenotypic evolution and species diversification could be improved to specifically address these questions. We conclude that researchers are in a better position than ever before to build a synthesis to understand how microevolutionary dynamics unfold over millions of years.
Subject(s)
Biological Evolution , Evolution, Molecular , BiodiversityABSTRACT
Background: The COVID-19 pandemic has significantly impacted daily life. Beyond severe health and economic consequences, psychological consequences have surfaced that require in-depth research to understand the pandemic's effects on mental health. Aims: This study aimed to evaluate the association between anxiety levels and anhedonia with food consumption patterns and changes in body weight over the two years since the COVID-19 outbreak in Israel. Methods: This cross-sectional study utilized non-randomized sampling through an online survey that included 741 study participants aged 18 to 94. participants were asked to complete the Beck's Anxiety Questionnaire, the Snaith-Hamilton Pleasure Scale for Anhedonia Measurement, the Mediterranean Nutrition Questionnaire, and self-reports of body weight and serving size changes. Results: Those who reported severe anxiety and anhedonia reported the highest intake of fats, sugars, and carbohydrates and the highest weight gain (e.g., Butter and cream food: severe anxiety (M = 1.342, SEM = 0.217); low anxiety (M = 0.682, SEM = 0.042), Sweet pastries: severe anxiety (M = 4.078, SEM = 0.451); low anxiety (M = 3.175, SEM = 0.436)). Anhedonic participants consumed more sweetened beverages (M = 0.987, SEM = 0.013) than hedonic participants (M = 0.472, SEM = 0.231). Among participants that gained weight, severe anxiety participants consumed significantly more salty pastries (M = 2.263, SEM = 0.550) than those with low anxiety (M = 1.096, SEM = 0.107; p = .003). A significant interaction was found between weight, anxiety, and consuming salty pastries. High anxiety subjects and weight gain declared the highest intake of this food (p = .018); Significant interactions were found between those with severe anxiety and anhedonia, who reported the highest consumption of butter and cream (p = .005) and salty pastries (p = .021). Significant associations were found between weight and anhedonia and weight and anxiety levels (p = .000, p = .006 - respectively). Conclusions: The outbreak of COVID-19 and its long-term presence strengthen the negative psychological aspects and increase the consumption of foods high in fat and sugar. Further attention to nutritional health is needed since crises may occur, and we must be prepared to prevent adverse consequences.
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In June 2019 in Seville, at the first course in fetal MRI, endorsed by the Spanish Society of Medical Radiology (SERAM) and the Spanish Society of Pediatric Radiology (SERPE), the Spanish fetal MRI group was founded. To establish this group, a questionnaire was designed for radiologists dedicated to prenatal imaging in Spain and disseminated to the SERAM's members. The questions were related to the type of hospital, to MRI studies (magnetic field, gestational age, use of sedation, number of studies per year, proportion of fetal neuroimaging studies), and to teaching and research about fetal MRI. A total of 41 responses were received from radiologists in 25 provinces (88% working in public hospitals). Very few radiologists in Spain perform prenatal ultrasonography (7%) or prenatal CT. MRI is done in the second trimester (34%) or in the third trimester (44%). In 95% of centers, fetal brain MRI studies predominate. In 41% of the centers, studies can be done on 3 T MRI scanners. Maternal sedation is used in 17% of centers. The number of fetal MRI studies per year varies widely, being much higher in Barcelona and Madrid than in the rest of Spain.
Subject(s)
Fetus , Magnetic Resonance Imaging , Pregnancy , Female , Child , Humans , Spain , Magnetic Resonance Imaging/methods , Fetus/diagnostic imaging , Ultrasonography, Prenatal , Surveys and QuestionnairesABSTRACT
En junio de 2019 se organizó en Sevilla el primer curso de resonancia magnética (RM) fetal, con el aval de las sociedades españolas de Radiología Médica (SERAM) y Radiología Pediátrica (SERPE), y se fundó el grupo español de RM fetal. Para establecer este grupo, se diseñó un cuestionario para radiólogos que se dediquen a la imagen prenatal en España que anunció la Sociedad Española de Radiología a sus socios. Las preguntas estaban relacionadas con el tipo de hospital, con los estudios de RM (campo magnético, edad gestacional, uso de sedación, número de estudios por año, proporción de estudios de neuroimagen fetal) y con la docencia e investigación de la RM fetal. Recogimos 41 respuestas de 25 provincias (88% hospitales públicos). Muy pocos radiólogos realizan ecografía (7%) o tomografía computarizada prenatal en España. La RM se realiza en el segundo trimestre (34%) o tercer trimestre (44%). En el 95% de los centros predominan los estudios del cerebro fetal. El 41% de los centros tienen la posibilidad de realizar sus estudios en RM 3 Tesla. La sedación materna se usa en el 17% de los centros. El número de estudios de RM fetal por año es muy variable, siendo mucho mayor en Barcelona y Madrid que en el resto de España.(AU)
In June 2019 in Seville, at the first course in fetal MRI, endorsed by the Spanish Society of Medical Radiology (SERAM) and the Spanish Society of Pediatric Radiology (SERPE), the Spanish fetal MRI group was founded. To establish this group, a questionnaire was designed for radiologists dedicated to prenatal imaging in Spain and disseminated to the SERAM's members. The questions were related to the type of hospital, to MRI studies (magnetic field, gestational age, use of sedation, number of studies per year, proportion of fetal neuroimaging studies), and to teaching and research about fetal MRI. A total of 41 responses were received from radiologists in 25 provinces (88% working in public hospitals). Very few radiologists in Spain perform prenatal ultrasonography (7%) or prenatal CT. MRI is done in the second trimester (34%) or in the third trimester (44%). In 95% of centers, fetal brain MRI studies predominate. In 41% of the centers, studies can be done on 3 T MRI scanners. Maternal sedation is used in 17% of centers. The number of fetal MRI studies per year varies widely, being much higher in Barcelona and Madrid than in the rest of Spain.(AU)
Subject(s)
Humans , Magnetic Resonance Spectroscopy , Fetus/diagnostic imaging , Prenatal Diagnosis , Ultrasonography, Prenatal , Spain , Surveys and QuestionnairesABSTRACT
Se presenta el caso de una mujer de 79 años con glaucoma severo y falta de adherencia al tratamiento, que es sometida a cirugía de catarata e implante XEN® en su ojo izquierdo. Dos semanas después de la intervención se objetiva una erosión conjuntival con exposición del extremo distal del implante, por lo que se realiza una reparación quirúrgica mediante la combinación de una sutura aposicional del tubo, adaptando su trayectoria a la curvatura escleral, y el recubrimiento con injerto de membrana amniótica. Tras 6 meses de seguimiento, presenta una presión intraocular controlada, sin necesidad de tratamiento adicional, y sin mostrar progresión de su enfermedad (AU)
We report a case of a 79-year-old woman with severe glaucoma and absence of therapeutic adherence, who underwent cataract surgery and XEN® implant in her left eye. Two weeks after the intervention, conjunctival erosion was observed with exposure of the distal end of the implant, so a surgical repair was performed by combining an appositional suture of the tube, adapting its trajectory to the scleral curvature, and an amniotic membrane graft. After 6 months of follow-up, the intraocular pressure was controlled, without additional treatment needed, and no disease progression (AU)
Subject(s)
Humans , Female , Aged , Glaucoma/surgery , Lenses, Intraocular , Severity of Illness Index , Tomography, Optical CoherenceABSTRACT
This work presents a study of synthesis and characterization of catalysts-based cerium and nickel supported on the pumice stone (Ce/Pumice and Ni/Pumice) to be used in the gasification process of an invasive species present in the Canary Islands, such as Pennisetum setaceum to obtain syngas. Specifically, the effect of the metal impregnated on the pumice, and the effect of catalyst on the gasification process was studied. For this purpose, the composition of the gas was determined and the results obtained were compared with those obtained in non-catalytic thermochemical processes. Gasification tests were performed using a simultaneous thermal analyzer coupled with a mass spectrometer, providing a detailed analysis of the gases released during the process. The results showed that during the catalytic gasification process of the Pennisetum setaceum, the gases produced appear at lower temperatures in the catalytic process that in the non-catalytic process. Specifically, H2 appears at 640.42 °C and 641.84 °C when Ce/pumice and Ni/pumice were used as catalyst, respectively, compared to 697.41 °C for the non-catalytic process. Moreover, the reactivity at 50 % of char conversion for the catalytic process (0.34 and 0.38 min-1 for Ce/pumice and Ni/pumice, respectively) was higher than for the non-catalytic process (0.28 min-1), indicating that the incorporation of Ce and Ni on the pumitic material increases the gasification rate of the char compared to the pumitic support. Catalytic biomass gasification is an innovative technology that can provide new opportunities for research and development of renewable energy technologies, as well as for the creation of green jobs.
Subject(s)
Gases , Silicates , Biomass , Gases/chemistry , CatalysisABSTRACT
Evolutionary dynamics operating across deep time leave footprints in the shapes of phylogenetic trees. For the last several decades, researchers have used increasingly large and robust phylogenies to study the evolutionary history of individual clades and to investigate the causes of the glaring disparities in diversity among groups. Whereas typically not the focal point of individual clade-level studies, many researchers have remarked on recurrent patterns that have been observed across many different groups and at many different time scales. Whereas previous studies have documented various such regularities in topology and branch length distributions, they have typically focused on a single pattern and used a disparate collection (oftentimes, of quite variable reliability) of trees to assess it. Here we take advantage of modern megaphylogenies and unify previous disparate observations about the shapes embedded in the Tree of Life to create a catalog of the "major features of macroevolution." By characterizing such a large swath of subtrees in a consistent way, we hope to provide a set of phenomena that process-based macroevolutionary models of diversification ought to seek to explain.