ABSTRACT
Introduction: The multiple forced expiratory maneuvers that must be performed during methacholine test require a high degree of collaboration and can lead to fatigue. However, impulse oscillometry (IOS) is a noninvasive test, quick and easy to perform, that does not require effort-dependent maneuvers.Objectives: The primary endpoint was to evaluate the relationship between IOS and spirometry during the methacholine test. The secondary endpoint was to study the predictive value of baseline IOS in the development of bronchial hyperreactivity.Methods: Observational, prospective, cross-sectional study, with recruitment of consecutive patients from the pulmonology department with clinical suspicion of bronchial asthma with negative bronchodilator test and normal FeNO.Results: Twenty-five patients were included, with a mean age of 49 ± 18 years. Thirteen patients (52%) had a positive methacholine test. The correlation between IOS indices and FEV1 was significant (p < 0.05) in all cases. The indices with the highest predictive power were R5-20 and AX. The optimal cutoff points were an increase of greater than 32.96% in R5, greater than 120.83% for X5, an increase of 30.30 [kPa l-1s-1] in R5-20, and an increase of 1.01 [kPa l-1] for AX. Baseline oscillometry demonstrated a strong predictive value in the development of bronchial hyperreactivity, with a sensitivity of 61.5% and a specificity of 91.7%, using the cut-off point of 160.0% for R5.Conclusions: IOS may be a valuable alternative to forced spirometry in detecting bronchial hyperreactivity during the methacholine test, showing a good correlation between both tests.
Subject(s)
Asthma/prevention & control , Asthma/physiopathology , Biological Therapy , COVID-19/epidemiology , Adolescent , Adult , Aged , Asthma/epidemiology , Asthma/therapy , COVID-19/physiopathology , COVID-19/therapy , Female , Hospitalization , Humans , Lung/physiopathology , Male , Middle Aged , Prevalence , Retrospective Studies , SARS-CoV-2Subject(s)
Humans , Male , Female , Adolescent , Young Adult , Adult , Middle Aged , Aged , Aged, 80 and over , Asthma/therapy , Biological Therapy , Coronavirus Infections/complications , Pneumonia, Viral/complications , Pandemics , Severity of Illness Index , Retrospective Studies , Asthma/physiopathology , PrevalenceSubject(s)
Antibodies, Monoclonal, Humanized/therapeutic use , Eosinophils/pathology , Granulomatosis with Polyangiitis/diagnosis , Granulomatosis with Polyangiitis/drug therapy , Adult , Antibodies, Monoclonal, Humanized/pharmacology , Biomarkers , Biopsy , Female , Granulomatosis with Polyangiitis/etiology , Granulomatosis with Polyangiitis/metabolism , Humans , Immunoglobulin E/immunology , Male , Tomography, X-Ray Computed , Treatment OutcomeSubject(s)
Asthma/diagnosis , Autoimmune Diseases/diagnosis , Th1 Cells/immunology , Th2 Cells/immunology , Adult , Aged , Aged, 80 and over , Asthma/complications , Autoimmune Diseases/complications , Autoimmunity , Female , Humans , Male , Middle Aged , SpainABSTRACT
Introducción: La fibrobroncoscopia (FB) es una técnica de gran utilidad en el diagnóstico del nódulo pulmonar solitario (NPS) y de las masas pulmonares. La rentabilidad de la biopsia transbronquial (BTB) es variable y depende de distintos factores como la experiencia del operador. El objetivo del estudio fue determinar la rentabilidad de la BTB en el diagnóstico de la lesión pulmonar focal (LPF) maligna coincidiendo con la incorporación de dos nuevos médicos en nuestra Unidad sin experiencia previa en esta técnica, comparando los resultados con los datos previos de nuestro centro.Material y métodos: Se consideró LPF toda lesión pulmonar intraparenquimatosa bien circunscrita, rodeada de tejido pulmonar normal. Se incluyeron los pacientes remitidos desde febrero de 2008 a agosto de 2009 por una LPF (sin lesión endobronquial visible) y diagnóstico definitivo de malignidad. Se estudiaron 85 pacientes.Resultados: La rentabilidad diagnóstica de la BTB fue 0,55. La rentabilidad de la BTB fue mayor en lesiones > 2 cm (≤ 2 cm frente a > 2 cm; 0,38 frente a 0,62; p = 0,02) pero no hubo diferencias según la localización (central frente a periférica; 0,67 frente a 0,54; p = 0,16). La rentabilidad previa era de 0,76; sin diferencias según el tamaño (≤ 2 cm frente a > 2 cm; 0,72 frente a 0,78; p = 0,48), ni la localización (central frente a periférica; 0,83 frente a 0,74; p = 0,39).Conclusión: La experiencia del broncoscopista influye en la rentabilidad diagnóstica de la BTB en LPF malignas (AU)
Introduction: The fiberoptic bronchoscopy (FB) is a useful technique in the diagnosis of focal pulmonary nodules and masses. The profitability of the FB and transbronchial biopsy (TB) is variable and depends on different factors such as the operator's experience. The aim of this study was to determine if the diagnostic profitability of these techniques, in the diagnosis of malignant focal pulmonary lesions (FPL), changed with the incorporation of a new medical staff compared with previous data of our center. Material and methods: A FPL was defined as an intra ¿ parenchymatous pulmonary lesion that is well circumscribed and completely surrounded by healthy lung.We analyzed all the FBs between 02/2008 and 08/2009 in patients with a FPL with a definitive diagnosis of malignancy. 85 patients were included. Results: The diagnostic profitability of the TB was 0.55; it was higher when the FPL was > 2 cm (≤ 2 cm vs > 2 cm; 0.38 vs 0.62; p = 0.02) but no difference was found by site (central vs. peripheral; 0.67 vs 0.54; p = 0.16). The previous profitability of TB was 0.76 without differences by size (≤ 2cm vs > 2 cm; 0.72 vs 0,78; p = 0,48) or site (central vs peripheral; 0.83 vs 0.74; p = 0,39).Conclusion: We conclude that the operator's experience influences in the diagnostic profitability of the TB, in the malignant FPL (AU)
