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1.
Rev. Bras. Cancerol. (Online) ; 69(3)jul-set. 2023.
Article in English, Spanish, Portuguese | LILACS, Sec. Est. Saúde SP | ID: biblio-1512807

ABSTRACT

A Revista Brasileira de Cancerologia (RBC) preza pela integridade na pesquisa, estimulando a publicação de artigos desenvolvidos de forma respeitosa, honesta, rigorosa, transparente e aberta, além de envolver cuidado e respeito com os envolvidos. A revista viabiliza as correções em manuscritos sempre que estes afetarem substancialmente o significado ou a interpretação dos dados, mas que não comprometam os resultados ou conclusões gerais do artigo. Além disso, disponibiliza as retratações de um manuscrito indicadas por diversas razões, incluindo publicação duplicada, plágio, práticas de investigação não éticas. Sendo um periódico financiado pelo governo federal, a RBC não reproduz nem divulga anúncios publicitários em seus artigos ou em seu website, concentrando sua atuação na divulgação do conhecimento científico, com vistas ao aprimoramento dos serviços oferecidos pelo Sistema Único de Saúde (SUS) e por outros sistemas nacionais de saúde. Dentro de rígidos princípios éticos, a RBC segue crescendo tanto na publicação como no alcance nacional e internacional de seus artigos, expandindo pela ciência aberta a geração de novas práticas destinadas à prevenção e ao controle do câncer no cenário brasileiro e no contexto global.


Subject(s)
Editorial
2.
Mem Inst Oswaldo Cruz ; 101(2): 207-11, 2006 Mar.
Article in English | MEDLINE | ID: mdl-16830714

ABSTRACT

Propolis has shown activity against pathogenic microorganisms that cause diseases in humans and animals. The ethanol (Et-Blg) and acetone (Ket-Blg) extracts from a Bulgarian propolis, with known chemical compositions, presented similar activity against tissue culture-derived amastigotes. The treatment of Trypanosoma cruzi-infected skeletal muscle cells with Et-Blg led to a decrease of infection and of the intracellular proliferation of amastigotes, while damage to the host cell was observed only at concentration 12.5 times higher than those affecting the parasite. Ultrastructural analysis of the effect of both extracts in epimastigotes revealed that the main targets were the mitochondrion and reservosomes. Et-Blg also affected the mitochondrion-kinetoplast complex in trypomastigotes, offering a potential target for chemotherapeutic agents.


Subject(s)
Anti-Infective Agents/pharmacology , Muscle, Skeletal/cytology , Propolis/pharmacology , Trypanosoma cruzi/drug effects , Animals , Cells, Cultured , Host-Parasite Interactions/drug effects , Mice , Microscopy, Electron, Transmission , Muscle, Skeletal/parasitology , Trypanosoma cruzi/ultrastructure
3.
Mem. Inst. Oswaldo Cruz ; 101(2): 207-211, Mar. 2006. ilus, graf
Article in English | LILACS | ID: lil-430898

ABSTRACT

Propolis has shown activity against pathogenic microorganisms that cause diseases in humans and animals. The ethanol (Et-Blg) and acetone (Ket-Blg) extracts from a Bulgarian propolis, with known chemical compositions, presented similar activity against tissue culture-derived amastigotes. The treatment of Trypanosoma cruzi-infected skeletal muscle cells with Et-Blg led to a decrease of infection and of the intracellular proliferation of amastigotes, while damage to the host cell was observed only at concentration 12.5 times higher than those affecting the parasite. Ultrastructural analysis of the effect of both extracts in epimastigotes revealed that the main targets were the mitochondrion and reservosomes. Et-Blg also affected the mitochondrion-kinetoplast complex in trypomastigotes, offering a potential target for chemotherapeutic agents.


Subject(s)
Animals , Mice , Anti-Infective Agents , Muscle, Skeletal/cytology , Propolis/pharmacology , Trypanosoma cruzi/drug effects , Cells, Cultured , Microscopy, Electron, Transmission , Muscle, Skeletal/parasitology , Host-Parasite Interactions/drug effects , Trypanosoma cruzi/ultrastructure
4.
J Pharmacol Sci ; 93(3): 307-13, 2003 Nov.
Article in English | MEDLINE | ID: mdl-14646248

ABSTRACT

Propolis is a bee product, which has long been used in folk medicine for the management of different diseases. In this study we evaluated the analgesic and anti-inflammatory effects of a standard ethanolic extract of Bulgarian propolis (Et-Blg) in mice and its in vitro effect on airway smooth muscle. Et-Blg inhibited acetic acid-induced abdominal contortions with an ID(50) = 7.4 +/- 0.7 mg. kg(-1). In the formalin test, the extract caused a significant reduction in pain in mice treated with 100 mg. kg(-1) Et-Blg during the neurogenic phase and for the inflammatory phase with all doses of the extract, with an ID(50) = 2.5 +/- 0.4 mg. kg(-1). Et-Blg inhibited also the capsaicin-induced ear edema in mice; however, this extract was ineffective when assessed in the tail-flick and hot-plate thermal assays. The analgesic effect of Et-Blg was associated with the inhibition of inflammatory responses and not to a simple irritation of nervous terminals. In vitro, this extract inhibited the contraction of trachea smooth muscle induced by histamine (IC(50) = 50 +/- 5 microg. mL(-1)), capsaicin (IC(50) = 26.8 +/- 3 microg. mL(-1)), 80 mM KCl (IC(50) = 27.8 +/- 3 microg. mL(-1)), and carbachol (IC(50) = 54 +/- 2 microg. mL(-1)).


Subject(s)
Analgesics, Non-Narcotic/pharmacology , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Muscle Contraction/drug effects , Muscle, Smooth/drug effects , Propolis/pharmacology , Analgesics, Non-Narcotic/isolation & purification , Analgesics, Non-Narcotic/therapeutic use , Animals , Anti-Inflammatory Agents, Non-Steroidal/isolation & purification , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Bulgaria , Dose-Response Relationship, Drug , Guinea Pigs , Male , Mice , Muscle Contraction/physiology , Muscle, Smooth/physiology , Pain Measurement/drug effects , Pain Measurement/methods , Propolis/isolation & purification , Propolis/therapeutic use , Trachea/drug effects , Trachea/physiology
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