ABSTRACT
Nutritional care after bariatric surgery is an issue of major importance, especially insofar as risk of deficiency has been extensively described in the literature. Subsequent to the deliberations carried out by a multidisciplinary working group, we are proposing a series of recommendations elaborated using the Delphi-HAS (official French health authority) method, which facilitates the drawing up of best practice and consensus recommendations based on the data of the literature and on expert opinion. The recommendations in this paper pertain to dietary management and physical activity, multivitamin and trace element supplementation and the prevention and treatment of specific deficiencies in vitamins B1, B9, B12, D and calcium, iron, zinc, vitamins A, E and K, dumping syndrome and reactive hypoglycemia.
Subject(s)
Bariatric Surgery , Obesity, Morbid , Bariatric Surgery/adverse effects , Consensus , Humans , Nutritional Support , Vitamins/therapeutic useABSTRACT
BACKGROUND: Annular lichenoid dermatitis of youth (ALDY) is a rare form of dermatitis mainly affecting children and young people. All cases reported show a consistent clinical and histological picture. This is the first case described in the French literature. PATIENTS AND METHODS: A 5-year-old girl presented an annular isolated patch of the lower abdomen with an erythematosquamous border and central hypopigmentation for one year. Topical corticosteroids and pimecrolimus proved effective but relapse occurred after treatment withdrawal. DISCUSSION: Over sixty cases of ALDY are described in the English-language medical literature. The main differential diagnosis is childhood mycosis fungoides, particularly the hypopigmented variant. Biopsy is necessary for diagnosis since it can reveal typical histological features. Histopathology in all cases shows lichenoid reaction with CD4+ and CD8+ polyclonal lymphocytes. It is limited to the tips of rete ridges and associated with apoptosis of keratinocytes resulting in quadrangular-shaped rete ridges. Our case does not demonstrate either epidermotropism or atypical lymphocytes. CONCLUSION: Annular lichenoid dermatitis of youth (ALDY) is a poorly known distinctive entity within the lichenoid dermatitis family. Clinical-histological correlation is essential to diagnosis. The etiology is still unknown and the course is mostly chronic.
Subject(s)
Dermatitis/diagnosis , Lichenoid Eruptions/diagnosis , Child, Preschool , Dermatitis/pathology , Diagnosis, Differential , Female , Humans , Lichenoid Eruptions/pathology , Mycosis Fungoides/diagnosisABSTRACT
BACKGROUND: Synthetic antithyroid drugs are often used in the treatment of hyperthyroidism, regardless of aetiology. They may cause various side effects, including the development of anti-neutrophil cytoplasmic antibodies (ANCA), ANCA-associated vasculitis, and neutrophilic dermatoses. Propylthiouracil (PTU) is the antithyroid drug most frequently implicated in ANCA-associated diseases specifically involving anti-myeloperoxidase ANCA (MPO-ANCA). To our knowledge, there are no clinical reports describing the association of pyoderma gangrenosum (PG) and anti-proteinase3-ANCA (PR3-ANCA) induced by PTU, with ANCA levels decreasing after antithyroid drug withdrawal. PATIENTS AND METHODS: A 68-year-old woman was treated with propylthiouracil (PTU) for toxic multinodular goitre. She presented necrotic ulceration of the lower abdomen. The patient's history, physical examination, and bacteriological and histological samples led to a diagnosis of pyoderma gangrenosum. This pyoderma involved ANCA with antigenic specificity for proteinase 3. Withdrawal of PTU and a short course of corticosteroids and cyclosporine resulted in rapid and complete resolution of the pyoderma gangrenosum as well as a decrease in ANCA. No relapse was observed one year after cessation of treatment. DISCUSSION: We report a case of PG associated with PR3-ANCA induced by PTU, without any demonstrable vasculitis.
Subject(s)
Antithyroid Agents/adverse effects , Cyclosporine/therapeutic use , Dermatologic Agents/therapeutic use , Glucocorticoids/therapeutic use , Propylthiouracil/adverse effects , Pyoderma Gangrenosum/chemically induced , Abdomen , Aged , Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis , Antibodies, Antineutrophil Cytoplasmic , Biomarkers/blood , Drug Therapy, Combination , Female , Humans , Hyperthyroidism/drug therapy , Treatment OutcomeABSTRACT
OBJECTIVE: To compare the weight loss, change in quality of life (QOL) and safety of closed-loop gastric electrical stimulation (CLGES) versus adjustable gastric band (LAGB) in the treatment of obesity. METHODS: This multicenter, randomized, non-inferiority trial randomly assigned the patients in a 2:1 ratio to laparoscopic CLGES versus LAGB and followed them for 1 year. We enrolled 210 patients, of whom 50 were withdrawn preoperatively. Among 160 remaining patients (mean age=39±11 years; 75% women; mean body mass index=43±6 kg m-2) 106 received CLGES and 54 received LAGB. The first primary end point was non-inferiority of CLGES versus LAGB, ascertained by the proportion of patients who, at 1 year, fulfilled: (a) a ⩾20% excess weight loss (EWL); (b) no major device- or procedure-related adverse event (AE); and (c) no major, adverse change in QOL. Furthermore, ⩾50% of patients had to reach ⩾25% EWL. The incidence and seriousness of all AE were analyzed and compared using Mann-Whitney's U-test. RESULTS: At 1 year, the proportions of patients who reached all components of the primary study end point were 66.7 and 73.0% for the LAGB and CLGES group, respectively, with a difference of -6.3% and an upper 95% CI of 7.2%, less than the predetermined 10% margin for confirming the non-inferiority of CLGES. The second primary end point was also met, as 61.3% of patients in the CLGES group reached ⩾25% EWL (lower 95% CI=52.0%; P<0.01). QOL improved significantly and similarly in both groups. AE were significantly fewer and less severe in the CLGES than in the LAGB group (P<0.001). CONCLUSIONS AND RELEVANCE: This randomized study confirmed the non-inferiority of CLGES compared with LAGB based on the predetermined composite end point. CLGES was associated with significantly fewer major AE.
Subject(s)
Electric Stimulation Therapy , Gastroplasty , Laparoscopy , Obesity, Morbid/therapy , Weight Loss , Adolescent , Adult , Device Removal , Electrodes, Implanted , Feeding Behavior , Female , Follow-Up Studies , Gastroplasty/adverse effects , Gastroplasty/instrumentation , Gastroplasty/methods , Humans , Laparoscopy/adverse effects , Laparoscopy/methods , Male , Middle Aged , Treatment Outcome , Young AdultABSTRACT
Pulmonary nodules are a common reason for consultation and their investigation must always exclude a possible neoplastic cause. This means that, in addition to a thorough history, investigations may be necessary which are sometimes invasive and therefore potentially a cause of iatrogenic harm. The toxic aetiologies for pulmonary nodules are rare. We report a case of a patient with pulmonary nodules occurring predominantly in the right lung, about 1cm in diameter, non-cavitating without calcification, and sometimes surrounded by a peripheral halo. The nodules were a chance finding during preoperative evaluation. After a comprehensive review, a reaction to an inhaled irritant was the preferred hypothesis, specifically overuse of a compound insecticide containing, in addition to the propellant gas and solvent type hydrocarbon - a mixture of piperonyl butoxide, of esbiothrine and permethrin. Removal of this led to the complete disappearance of nodules. Pathological examination identified bronchiolitis obliterans with organising pneumonia accompanied by non-necrotizing granulomas and lipid vacuoles.
Subject(s)
Insecticides/toxicity , Multiple Pulmonary Nodules/chemically induced , Multiple Pulmonary Nodules/diagnosis , Phobic Disorders/complications , Aged , Animals , Female , Humans , Multiple Pulmonary Nodules/complications , Multiple Pulmonary Nodules/pathology , SpidersABSTRACT
We report the case of a 55-year-old woman who presented at the emergency department with hypogastric pain, fever, clinical signs of sepsis and a critical inflammation syndrome in her blood test values. CT-scan of the abdomen demonstrated an infected aneurysm of the right iliac artery. The patient underwent surgery with a favorable outcome. Histological examination of resected artery was performed and compared to the CT features. The authors review the literature and stress the importance of early diagnosis and treatement.
Subject(s)
Aneurysm, Infected/diagnostic imaging , Iliac Aneurysm/diagnostic imaging , Aneurysm, Infected/pathology , Aneurysm, Infected/surgery , Female , Humans , Iliac Aneurysm/pathology , Iliac Aneurysm/surgery , Middle Aged , Tomography, X-Ray ComputedABSTRACT
BACKGROUND: Reintervention for failed bariatric procedures is a subject of much debate. Our experience in remediating failed vertical banded gastroplasty (VBG) suggests that the placement of an adjustable lapband may be a useful technique. PATIENTS AND METHODS: Over a 13-year period, 98 patients with failed VBG underwent remedial placement of an adjustable lapband. Unsatisfactory results of VBG were due to disruption of the staple line in 58% of cases and to outlet enlargement in 37% of patients. Mean BMI was 38 (range: 28-48); BMI was less than 35 in 37% of cases. RESULTS: Seven postoperative complications (7%) were noted and required the removal of the lapband in five cases. The average loss of excess weight was 52% at 8 years. Twenty-two percent of patients were lost to follow-up. CONCLUSION: Placement of an adjustable lapband has proved to be a useful remedial approach in the majority of cases and demonstrates that further restriction of a previous restrictive procedure is useful in patients who initially responded well to VBG.
Subject(s)
Gastroplasty/instrumentation , Female , Humans , Male , Postoperative Complications/surgery , Reoperation , Retreatment , Treatment FailureSubject(s)
Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Lymphoma, B-Cell/pathology , Lymphoma, Large B-Cell, Diffuse/pathology , Neoplasms, Second Primary/pathology , Pleural Effusion, Malignant/etiology , Aged , Humans , Immunohistochemistry , Leukemia, Lymphocytic, Chronic, B-Cell/metabolism , Lymphoma, B-Cell/complications , Lymphoma, B-Cell/metabolism , Lymphoma, Large B-Cell, Diffuse/complications , Lymphoma, Large B-Cell, Diffuse/metabolism , Male , Neoplasms, Second Primary/complications , Neoplasms, Second Primary/metabolism , Pleural Effusion, Malignant/cytology , Sarcoma, Kaposi/pathologySubject(s)
Leukemia, Myeloid/surgery , Peripheral Blood Stem Cell Transplantation , Primary Myelofibrosis/surgery , Acute Disease , Anemia, Refractory/drug therapy , Anemia, Refractory/etiology , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Combined Modality Therapy , Cytarabine/administration & dosage , Erythropoietin/therapeutic use , Etoposide/administration & dosage , Follow-Up Studies , Granulocyte Colony-Stimulating Factor/therapeutic use , Humans , Leukemia, Myeloid/drug therapy , Leukemia, Myeloid/pathology , Male , Methotrexate/administration & dosage , Middle Aged , Mitoxantrone/administration & dosage , Postoperative Complications/drug therapy , Postoperative Complications/etiology , Primary Myelofibrosis/drug therapy , Primary Myelofibrosis/pathology , Recombinant Proteins , Transplantation Conditioning/adverse effects , Transplantation, Autologous , Whole-Body Irradiation/adverse effectsABSTRACT
In France, indications for bariatric surgery are clearly defined in the recommendations issued by ANAES and medical societies. The number of surgical procedures performed in France, is currently estimated to be 10 to 12.000 per year, with a regular increase of the gastric banding technique, which represents now more than 75% of the procedures. This review presents the main surgical procedures, and particularly, insists on their post-operative complications and their prevention, diagnosis and management.
Subject(s)
Gastroplasty , Obesity/therapy , Stomach/physiology , Electric Stimulation Therapy , France/epidemiology , Gastric Balloon/statistics & numerical data , Gastric Bypass/statistics & numerical data , Gastroplasty/adverse effects , Gastroplasty/statistics & numerical data , Humans , Malabsorption Syndromes/etiology , Malabsorption Syndromes/therapy , Obesity/epidemiology , Postoperative Complications/epidemiology , Postoperative Complications/therapy , Stomach/physiopathologyABSTRACT
Histoplasmosis is an endemic mycosis. Histoplasma capsulatum, and duboisiï are the pathogenic agents in humans. The disease is reported as endemic in more than 30 countries. Three clinical forms are distinguished; acute, chronic and disseminated. Oral lesions may take on different clinical aspects which are often associated with disseminated histoplasmosis. Disseminated histoplasmosis is frequently diagnosed in immunocompromised hosts. High risk of mortality dictates rapid diagnosis and treatment.
Subject(s)
Histoplasmosis/pathology , Mouth Diseases/microbiology , AIDS-Related Opportunistic Infections/microbiology , Acute Disease , Antifungal Agents/therapeutic use , Chronic Disease , Endemic Diseases , Histoplasmosis/diagnosis , Histoplasmosis/drug therapy , Humans , Immunocompromised Host , Mouth Diseases/diagnosis , Mouth Diseases/drug therapyABSTRACT
Ameloblastic fibro-odontoma is a rare and benign tumor. It usually affects young patients. This report describes the case of a ten year old child presenting an asymptomatic and slow-growing tumor located in the posterior region of the mandible. The course was normal and no recurrence was found after simple enucleation of the tumor.
Subject(s)
Mandibular Neoplasms/pathology , Odontoma/pathology , Child , Connective Tissue/pathology , Dental Enamel/pathology , Dental Pulp/pathology , Dentin/pathology , Epithelium/pathology , Female , Follow-Up Studies , HumansSubject(s)
Fallopian Tube Neoplasms/diagnosis , Lipoma/diagnosis , Adult , Aged , Broad Ligament , Diagnosis, Differential , Fallopian Tube Neoplasms/complications , Fallopian Tube Neoplasms/pathology , Fallopian Tube Neoplasms/surgery , Female , Humans , Lipoma/complications , Lipoma/pathology , Lipoma/surgery , SalpingostomyABSTRACT
Verrucous carcinoma is a rare subtype of well-differentiated squamous cell carcinoma that may occur anywhere on the skin. It is slow growing, enlarging relentlessly and invading locally. Some cases were reported to occur on chronic scar tissue but demonstrated the same clinical course than in other locations. Herein, we report on a very unusual case of cutaneous verrucous carcinoma arisen from a long-standing (40 years old) burn scar and which involved the pleura five years after the initial surgical resection. To our best knowledge, this is the first case of pleural involvement by a verrucous carcinoma originating from the skin.
Subject(s)
Carcinoma, Verrucous/pathology , Skin Neoplasms/pathology , Aged , Carcinoma, Verrucous/surgery , Fatal Outcome , Female , Humans , Skin Neoplasms/surgeryABSTRACT
Primary T-cell lymphoma of the stomach is a rare disease, most gastric lymphomas being of B-cell type. Here we describe a unique case of primary neutrophil-rich CD30-positive anaplastic large cell lymphoma (ALCL) of the stomach that was treated and cured by combined chemotherapy. According to our literature review, only 7 cases of primary gastric ALCL have been previously reported, none of them being of the neutrophil-rich subtype. Although very peculiar in its histological presentation, which may simulate an inflammatory or carcinomatous process, the natural history as well as the clinical features of this unusual gastric lymphoma does not differ from the other reported cases of gastric ALCL.