ABSTRACT
Antibodies to thyroid peroxidase (AB-TPO), antibodies to thyroglobulin (AB-TG), and the content of α2-macroglobulin (α2-MG) have been studied in serum samples of patients with autoimmune thyroiditis (AIT). All the patients were divided into 3 groups depending on age: 25-35, 36-50, 51-65 years. We found a significant change in the thyroid panel parameters in AIT, but without significant changes in the average concentration of α2-MG in the age groups of patients. This may be due to the accumulation and retention of complexes of defective forms of α2-MG in the circulation associated with their decreased ability to bind to receptors.
Subject(s)
Autoantibodies , Thyroiditis, Autoimmune , alpha-Macroglobulins , Adult , Aged , Female , Humans , Male , Middle Aged , alpha-Macroglobulins/metabolism , Autoantibodies/blood , Autoantibodies/immunology , Iodide Peroxidase/immunology , Iodide Peroxidase/blood , Iron-Binding Proteins/immunology , Iron-Binding Proteins/blood , Thyroglobulin/blood , Thyroglobulin/immunology , Thyroiditis, Autoimmune/blood , Thyroiditis, Autoimmune/immunologyABSTRACT
Results of populational-genetic research of genetic diseases in children up to 14-year-old of the population of Lenkoran district are presented. It was shown that the phenotypic frequencies of hereditary diseases and congenital malformations is 0.274% according to the data of Medical-Labor Expert Commission and 5.12% according to the data of research survey. The high level of multifactoral and autosome-reccessive types of inheritance indicates the high level of consanguine marriages in the population of the studied areas.
Subject(s)
Congenital Abnormalities/genetics , Genetic Diseases, Inborn/genetics , Genetic Testing , Adolescent , Azerbaijan/epidemiology , Child , Congenital Abnormalities/diagnosis , Congenital Abnormalities/epidemiology , Consanguinity , Diagnosis, Differential , Genetic Diseases, Inborn/diagnosis , Genetic Diseases, Inborn/epidemiology , Genetics, Population , Humans , Inheritance Patterns/genetics , Pedigree , PrevalenceABSTRACT
The occurrence of congenital hip dislocation in Lenkoran and Massaly areas of Azerbaijan Republic was studied. The population-genetic assessment in Lenkoran and Massaly regions was conducted. The phenotypic frequency of hip congenital dislocation according to Medical- Labor Expert Commission data are 0,065% and 0,035% respectively. According to present survey congenital hip dislocation data are: 0, 7% and 0, 4% respectively. The results of the study demonstrate strong demand of accurate data on the occurrence of congenital and genetic diseases in Azerbaijan Republic. The highest prevalence of multiple-factor type of heredity indicates the necessity to control teratogen factors of the environment.
