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2.
Rev Neurol (Paris) ; 171(8-9): 613-5, 2015 Sep.
Article in English | MEDLINE | ID: mdl-25857461

ABSTRACT

The introduction of direct oral anticoagulants (DOA) in the early stage of cerebral infarction after thrombolysis may reduce the recurrence rate but raises safety concern. We sought to study the feasibility and safety of the introduction of rivaroxaban or dabigatran in this context. Thirty-four consecutive patients admitted for ischemic stroke related to non-valvular atrial fibrillation in whom DOA were given within the first two weeks following intravenous rt-PA were studied. A clinical and radiological monitoring protocol was established to ensure the safety of the prescription. None of the patients experienced symptomatic hemorrhagic transformation or a symptomatic recurrent ischemic event after early rivaroxaban or dabigatran introduction.


Subject(s)
Antithrombins/therapeutic use , Brain Ischemia/drug therapy , Dabigatran/therapeutic use , Factor Xa Inhibitors/therapeutic use , Fibrinolytic Agents/therapeutic use , Intracranial Hemorrhages/chemically induced , Rivaroxaban/therapeutic use , Thrombolytic Therapy , Tissue Plasminogen Activator/therapeutic use , Aged , Aged, 80 and over , Antithrombins/administration & dosage , Antithrombins/adverse effects , Atrial Fibrillation/blood , Atrial Fibrillation/complications , Dabigatran/administration & dosage , Dabigatran/adverse effects , Drug Administration Schedule , Factor Xa Inhibitors/administration & dosage , Factor Xa Inhibitors/adverse effects , Female , Fibrinolytic Agents/administration & dosage , Humans , Intracranial Hemorrhages/diagnostic imaging , Length of Stay , Male , Pilot Projects , Radiography , Recombinant Proteins/administration & dosage , Recombinant Proteins/therapeutic use , Recurrence , Retrospective Studies , Rivaroxaban/administration & dosage , Rivaroxaban/adverse effects , Severity of Illness Index , Thrombophilia/drug therapy , Thrombophilia/etiology , Tissue Plasminogen Activator/administration & dosage
3.
Neurophysiol Clin ; 29(6): 463-72, 1999 Dec.
Article in French | MEDLINE | ID: mdl-10674221

ABSTRACT

This report describes the observations of two patients with a several years' history of multiple sclerosis who presented sudden neurologic impairment. The symptomatology was suggestive of a non-convulsive partial status epilepsy. The clinical presentation was a paroxysmal dysphasic phenomenon in the first case without any consciousness impairment, associated with slight right hemiparesis. Electroencephalographic investigations revealed asymmetrical patterns, left-sided slow waves and periodic lateralized epileptiform discharges (PLEDs). Antiepileptic treatments were partially effective and intravenous steroids were needed for complete recovery. For the second patient, clinical presentation was acute psychiatric symptoms with disorientation, alternating manic symptomatology and mutism. Electroencephalography showed left fronto-central rhythmic continuous slow wave and spike wave activity. Intravenous antiepileptic treatment quickly improved the symptomatology. These observations draw attention to the fact that an epileptic cause should not be ruled out when a patient with multiple sclerosis presents sudden neurologic or psychiatric impairment. An early diagnosis allows immediate antiepileptic treatment. Intravenous steroids can be added to stop seizures.


Subject(s)
Epilepsies, Partial/etiology , Multiple Sclerosis/complications , Status Epilepticus/etiology , Adult , Anti-Inflammatory Agents/administration & dosage , Electroencephalography , Epilepsies, Partial/diagnosis , Female , Humans , Injections, Intravenous , Magnetic Resonance Imaging , Middle Aged , Multiple Sclerosis/drug therapy , Status Epilepticus/diagnosis , Steroids
4.
Pathol Biol (Paris) ; 41(4): 329-36, 1993 Apr.
Article in French | MEDLINE | ID: mdl-8233631

ABSTRACT

ATB Plus Expert (Biomérieux SA) is an expert system which has been developed to perform an interpretative reading of ATB susceptibility tests. The system was tested on the results obtained for 217 strains of enterobacteriaceae. These strains were selected in order to cover a maximum of bacterial species and resistance mechanisms. The isolates were tested on rapid ATB E, rapid ATB G-, rapid ATB Ur, ATB G- and ATB Ur strips. In parallel, a disc diffusion susceptibility test was performed with 5 discs of aminoglycosides (kanamycin, gentamicin, tobramycin, netilmicin, amikacin) and the interpretation was carried out according to the criteria usually followed. Of the 217 strains tested, 122 showed a resistance phenotype. Only the rapid ATB E strips included kanamycin and allowed the detection of APH(3') phenotypes. Amikacin was not included in the ATB Ur strip, consequently it was impossible to discriminate AAC(3)-II and AAC(6') + AAC(3)-I phenotypes. 12 strains did not grow within 5 hours using the rapid ATB methodology. Not taking into account the problems previously encountered, different phenotypes between the 6 susceptibility tests were found for 16 strains. In 5 cases the expert system detected an anomaly instead of the correct phenotype, and in 3 cases of unknown phenotypes, the answers were variable. In the other cases, the main difficulty was the detection of the isolated resistance to gentamicin (AAC(3)-I phenotype). The expert system automatically corrects the susceptibility test result according to the phenotype observed.


Subject(s)
Enterobacteriaceae/drug effects , Gentamicins/pharmacology , Kanamycin/pharmacology , Netilmicin/pharmacology , Tobramycin/pharmacology , Amikacin/pharmacology , Drug Resistance, Microbial , In Vitro Techniques , Kanamycin Resistance , Microbiological Techniques , Phenotype
5.
Presse Med ; 19(18): 864-8, 1990 May 05.
Article in French | MEDLINE | ID: mdl-2140182

ABSTRACT

Thirty-two consecutive cases of hypoglossal nerve palsy (excluding syringomyelia and amyotrophic lateral sclerosis) collected between 1971 and 1987 were reviewed. The XIIth nerve palsy was clinically isolated in 8 cases, associated with other cranial nerve palsies in 16 cases and with long tracts involvement in 8 cases. Seventeen cases were related to tumours. Malignant tumours were predominant, especially middle and posterior fossa bone metastases. Carcinomatous meningitis and brainstem glioma were also found, as well as lymphoproliferative disorders and benign tumours such as chemodectoma and neurinoma. A vascular origin was established in 6 cases, related to vertebrobasilar infarct, truncular ischaemia and internal carotid dissection. The paralysis was consecutive to head or neck trauma in 4 cases and to various inflammatory processes in 4 other cases. The last case was caused by Chiari's malformation. To our knowledge, this is the first aetiological review of XIIth nerve palsy in the literature.


Subject(s)
Hypoglossal Nerve , Neoplasms/complications , Paralysis/etiology , Adolescent , Adult , Aged , Central Nervous System Diseases/complications , Cerebral Ventricle Neoplasms/complications , Cerebral Ventricle Neoplasms/metabolism , Cranial Nerve Diseases/etiology , Cranial Nerve Neoplasms/complications , Cranial Nerve Neoplasms/secondary , Craniocerebral Trauma/complications , Female , Humans , Male , Middle Aged , Neoplasms/pathology , Retrospective Studies , Vascular Diseases/complications
7.
Rev Neurol (Paris) ; 146(2): 107-15, 1990.
Article in French | MEDLINE | ID: mdl-2181586

ABSTRACT

Two patients with autosomal dominant pure cortical cerebellar atrophy, belonging to the same family, exhibited imitation synkineses of hands and feet when the contralateral extremity was moved. The phenomenon was observed particularly when alternate movements of one hand were performed, but it also existed when flexion-extension movements of one foot took place. The induced synkinetic movements were mainly observed on the right side in one patient and exclusively observed on the right side in the other one. At electromyography, the imitation synkinesis took place about 200 milliseconds after the first inducing movement, but tended to be simultaneous with the following ones. Imitation synkinesis appeared to be shared by other cerebellar conditions: 8 cases of sporadic pure cerebellar atrophy and 2 cases of post-surgical injury of the anterior lobe vermis. In the 2 genetic cases, there was no pyramidal sign nor sensitive disturbance, the somesthesic evoked potentials being normal. Thus, the imitation synkinesis was considered as having a cerebellar origin. The cerebellar imitation synkinesis might be provoked by the lack of a physiologic cerebellar inhibition located in the paleo- and/or neo-cerebellum. The predominance of imitation synkineses on the right side suggests that cerebellar inhibition is stronger for the dominant side, in order to liberate it from archaic synkineses.


Subject(s)
Cerebellar Diseases/genetics , Cerebellum/pathology , Movement Disorders/etiology , Aged , Atrophy , Cerebellar Diseases/physiopathology , Cerebellum/physiopathology , Electromyography , Female , Humans , Magnetic Resonance Imaging , Male , Movement Disorders/physiopathology , Tomography, X-Ray Computed
8.
Genomics ; 4(1): 110-1, 1989 Jan.
Article in English | MEDLINE | ID: mdl-2563350

ABSTRACT

A linkage analysis with chromosome 9 markers was performed in 33 families with Friedreich ataxia (FA). Linkage with D9S15, previously established by S. Chamberlain et al. (1988, Nature London 334:248-249) was confirmed in our sample (z(theta) = 6.82 at theta = 0.02) while INFB (interferon-beta gene) shows looser linkage. An additional marker, D9S5, was also shown to be closely linked to FA (z(theta) = 5.77 at theta = 0.00).


Subject(s)
Chromosomes, Human, Pair 9 , Friedreich Ataxia/genetics , Deoxyribonucleases, Type II Site-Specific , Genetic Linkage , Genetic Markers , Humans , Interferon Type I/genetics , Polymorphism, Restriction Fragment Length
9.
Rev Neurol (Paris) ; 145(11): 799-801, 1989.
Article in French | MEDLINE | ID: mdl-2595170

ABSTRACT

A case of giant, thrombosed, non haemorrhagic aneurysm of the distal portion of the left vertebral artery is reported. The patient came to medical attention with an acute cervical pain after a minimal cervical traumatism and a diagnosis of torticollis from rheumatologic cause was made. In fact, a few weeks before, he had suffered three episodes of right homonymous hemianopsia. Subsequently, hiccup, vomiting, orthostatic dizziness with postural hypotension appeared, suggesting a medullary lesion. CT scan showed a round, heterogeneous high-density lesion near the fourth ventricle. Angiography was normal. MRI showed an oval mass in the fourth ventricle, between the medulla and the cerebellum. Surgery found an aneurysm of the end of the left vertebral artery.


Subject(s)
Intracranial Aneurysm/diagnosis , Intracranial Embolism and Thrombosis/etiology , Vertebral Artery , Adult , Cerebral Ventricles/pathology , Humans , Intracranial Aneurysm/diagnostic imaging , Intracranial Aneurysm/surgery , Intracranial Embolism and Thrombosis/diagnostic imaging , Magnetic Resonance Imaging , Male , Radiography , Tomography Scanners, X-Ray Computed
10.
Rev Neurol (Paris) ; 141(6-7): 490-2, 1985.
Article in French | MEDLINE | ID: mdl-4089410

ABSTRACT

In two case of cystic craniopharyngioma the initial presentation was misleading and suggested acute retrobulbar optic neuritis: 1) isolated and unilateral drop of visual acuity of recent onset; 2) total remission in a few weeks, then a relapsing and steroid-sensitive course; 3) increase of C.S.F. gammaglobulins content in one case, normal CT scan in the second one. The diagnosis was corrected 36 and 18 months respectively after the onset of the clinical disorders.


Subject(s)
Brain Neoplasms/diagnosis , Craniopharyngioma/diagnosis , Optic Neuritis/diagnosis , Vision Disorders/etiology , Adult , Aged , Brain Neoplasms/complications , Craniopharyngioma/complications , Diagnostic Errors , Female , Humans , Tomography, X-Ray Computed , Visual Acuity
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