Anatomical Variation in the Mandibular Foramen in Non-Atrophic and Atrophic Mandibles.

OBJECTIVES: Previous studies of variation in mandibular foramen characteristics with age have involved comparison in different populations, but few data, between non-atrophic and atrophic mandibles are available. The aim of this original article was to compare the position, shape and area of the mandibular foramen between non-atrophic and atrophic mandibles. MATERIAL AND METHODS: Morphometric methods were used to study the mandibular foramen variation. Fifty adult dry mandibles from the laboratory of anatomy were selected. Mandibles were considered non-atrophic if the distance between the base and alveolar ridge was homogeneous and greater than 25 mm in the anterior region and 20 mm in the posterior region. Conversely, mandibles were considered atrophic if that distances were lower than those described to a minimum of 11 mm in all areas. All measurements were performed with a digital caliper. For statistical analysis, the admitted level of significance was 5%. RESULTS: When non-atrophic mandibles were compared to atrophic ones, the mandibular foramen shifted significantly to an anterior position (mean difference [MD]: 4.81 mm; P < 0.0001) and to an inferior position (MD: 3.04 mm; P < 0.0001) and changed from an elliptical shape to round one, with a significant decrease in its area (MD: 3.66 mm2; P < 0.05). CONCLUSIONS: The results indicate that there are significant differences in the position, shape and area of the mandibular foramen between non-atrophic and atrophic mandibles. These data should be considered in anaesthetic techniques and surgical procedures to prevent vascular and nervous lesions.

Effects of aerobic training, resistance training, or combined resistance-aerobic training on the left ventricular myocardium in a rat model.

This study follows the left ventricular (LV) hypertrophy in rats undergoing aerobic training alone (A), resistance training alone (R), or combined resistance and aerobic training (RA) (usually referred as concurrent training) program. A sedentary control group (C) was included. LV remodeling was evaluated using electron and light microscopy. The LV weight to body weight (LVW: BW) increased 11.4% in A group, 35% in the R group, and 18% in the RA group compared to the C group. The LV thickness increased 6% in the A group, 17% in the R group, and 10% in the RA group. The LV internal diameter increased 19% in the A group, 3% in the R group, and 8% in the RA group compared with the C group. The cross-sectional area of cardiomyocyte increased by 1% with the A group, 27% with R group, and 12% with RA training. The capillary density increased by 5.4% with A training, 11.0% with R training, and 7.7% with RA training compared with the C group. The volume fraction of interstitial collagen increased by 0.4% with training A, increased by 2.8% with R training, and 0.9% with RA training. In conclusion, except for the LV internal diameter, which increased more in the A group, the cardiac parameters increased more in the R group than in the other groups and in RA group than in A group. Collagen density increased from 5.4 ± 0.8% in the C group to 5.8 ± 0.6% in the A group (n. s.) (P > 0.05), to 8.2 ± 0.7% in the R group (P < 0.05), and to 6.3 ± 0.4% in the RA group (P < 0.05). These results demonstrate a significant increase for collagen content in the LV with R and RA exercise, but the increase was higher with R training alone than with RA training.

The effects of joint immobilization on articular cartilage of the knee in previously exercised rats.

Studies have determined the effects of joint immobilization on the articular cartilage of sedentary animals, but we are not aware of any studies reporting the effects of joint immobilization in previously trained animals. The objective of the present study was to determine whether exercise could prevent degeneration of the articular cartilage that accompanies joint immobilization. We used light microscopy to study the thickness, cell density, nuclear size, and collagen density of articular cartilage of the femoral condyle of Wistar rats subjected to aerobic physical activity on an adapted treadmill five times per week. Four groups of Wistar rats were used: a control group (C), an immobilized group (I), an exercised group (E), and an exercised and then immobilized group (EI). The right knee joints from rats in groups I and EI were immobilized at 90 °C of flexion using a plastic cast for 8 weeks. Cartilage thickness decreased significantly in group I (mean, 120.14 ± 15.6 µm, P < 0.05), but not in group EI (mean, 174 ± 2.25), and increased significantly in group E (mean, 289.49 ± 9.15) compared with group C (mean, 239.20 ± 6.25). The same results were obtained for cell density, nuclear size, and collagen density (in all cases, P < 0.05). We concluded that exercise can prevent degenerative changes in femoral articular cartilage caused by immobilization of the knee joint.