[The prevention of nitrate tolerance in angina patients treated with transdermal nitroglycerin: a comparison of 2 therapeutic regimens (therapeutic outlook versus dosage reduction)]. / Prevenzione della tolerance ai nitrati in pazienti anginosi trattati con nitroglicerina per via transdermica: confronto di due schemi terapeutici (finestra terapeutica verso riduzione di dosaggio).

We studied the long-term antianginal and anti-ischemic effects of two dosage regimens designed to prevent tolerance to transdermal nitroglycerin (TNTG): (1) 10 mg TNTG applied for 16 h with a 'nitrate-free' interval of 8 h; (2) 10 mg TNTG applied for 16 h followed by a 'nitrate-low' interval of 5 mg applied for 8 h. 129 patients completing a 3-month study period were evaluated by repeated exercise tests. Both regimens significantly increased maximum exercise duration at 3 months, from 699.1 +/- 23.4 to 833 +/- 21.9 s and from 686.1 +/- 20 to 789.6 +/- 22.6 s, respectively, reduced the number of patients with 1 mm S-T segment depression and increased the time duration to 1 mm S-T segment depression. Marked reductions in anginal attacks was observed in both groups: from 6.5 to 0.15 attacks per week and from 6.0 to 0.15 attacks per week, respectively. No statistically significant differences were found between the groups, and both regimens were well tolerated. In conclusion, our results demonstrate sustained antianginal efficacy, without tolerance, of either 'nitrate-free' of 'nitrate-low' interval therapy with transdermal nitroglycerin.

[Angio-immunoblastic lymphadenopathy. Apropos of a clinical case]. / Linfoadenopatia angio-immunoblastica. A proposito di un caso clinico.

Reference is made to a personal case in an account of the clinical and pathological criteria that provide the diagnostic hinges of angio-immunoblastic lymphadenopathy. Stress is laid on the systemic and progressive nature of the disease, and support is given to the view that is an affection of the immuno-competent system. The fact that the course is unpredictable is seen as a reason for adopting an extremely cautions therapeutic approach based on corticosteroid hormones. Resort to the cytotoxic chemotherapeutical drugs customarily employed in other lymphoproliferative forms should be reserved for a few selected cases.

[Studies on the risk factors of arteriosclerosis in a health district region of Lombardy]. / Indagine sui fattori di rischio dell'aterosclerosi in una zona sanitaria della Lombardia

Atherosclerosis risk factor, 8,5% two, 2,7% three and 0,6% four.rs have been investigated in 194 males and 135 female, 25 years old. Elevated lipids were found in 7,3% of the sample; "labile" and stable hypertension in 2,7%; diabetes mellitus in 2,7% and overweight in 19%. 19% of the subjects smoked more than 20 cigarettes daily. Prevalence of hyperlipemia and electrocardiographic changes was higher among people in the lower socioeconomic classes. Taking into consideration hyperlipidemia, hypertension, cigarette smoking, overweight and diabetes mellitus as risk factors, 25% exhibited one risk factor, 8.5% two, 2.7% three and 0.6% four.