A new insight into the hepatoprotective effect of sildenafil: The role of H2S.

High-calorie diet, alcohol, and multiple drug use increase reactive oxygen species (ROS) and cause liver damage. ROS are crucial in the initiation/progression of liver diseases. Antioxidants have beneficial effects but produce clinically complex results. The hydrogen sulfide (H2S) pathway is considered a promising therapeutic target since it plays role in the pathogenesis/treatment of liver diseases. Sildenafil exerts antioxidant and hepatoprotective effects by increasing specific antioxidants such as superoxide dismutase, glutathione peroxidase, and regulating the Keap1/Nrf2 pathway which are common mechanisms underlying the effects of H2S. We aimed to determine if H2S has a role in the hepatoprotective and antioxidant effects of sildenafil. The effect of sildenafil on endogenous H2S production was elucidated with an H2S microsensor in the presence/absence of pyrogallol-induced oxidative stress and H2S synthesis inhibitor aminoxyacetic acid (AOAA) in the liver. The relation between the antioxidant effect of sildenafil and H2S was determined by luminol and lucigenin chemiluminescence. Sildenafil increased L-cysteine-induced H2S synthesis in the healthy liver and prevented the pyrogallol-induced reduction in H2S production. Sildenafil decreased the ROS production induced by pyrogallol and its protective effect was inhibited by AOAA. These results reveal that H2S is a new pharmacological mechanism of action of sildenafil on the liver. Therefore, sildenafil can be a potential therapeutic agent in treating many liver diseases in which H2S bioavailability is impaired. Additionally, the hepatoprotective effect of sildenafil by increasing endogenous H2S synthesis advances our knowledge in terms of developing H2S-targeting molecules.

Factors Affecting the Intervention of Health-Care Professionals in Radiological Events: A Systematic Review.

This research aims to explore the factors affecting the intervention of health-care professionals regarding a radiological event and to determine what actions they cause. In line with the keywords determined, a search was conducted on Cochrane, Scopus, Web of Science, and PubMed until March 2022. Eighteen peer-reviewed articles that met the inclusion criteria were reviewed. This systematic review was conducted using the PICOS and PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses)guidelines. Of the 18 studies included in the study, 8 were cross-sectional studies, 7 were descriptive studies, 2 were interventional studies, and 1 was a systematic review. As a result of the qualitative analysis, 7 factors affecting the intervention of health-care professionals in a radiological event were identified as follows: rarity of the event; inadequacy of health-care professionals against the radiological event; sensory responses; dilemma and ethical concern; communication, workload; and other factors. The most important factor affecting the intervention of health-care professionals in a radiological event is inadequate education about a radiological event, which influences the formation of other factors. These and other factors cause actions such as delayed treatment, death, and disruption of health services. Further studies are needed on the factors affecting the intervention of health-care professionals.

Web search behaviors and infodemic attitudes regarding COVID-19 in Turkey: A framework study for improving response and informing policy on the COVID-19 infodemic.

Objective: This study aimed to develop a framework regarding COVID-19 infodemic response and policy informing through focusing on infodemic concepts circulating on the online search engine in Turkey in relation to the COVID-19 outbreak and comparing the contents of these concepts with Maslow's hierarchy of needs and disaster stages. Materials and methods: The universe of this descriptive epidemiological research consists of internet search activities on COVID-19 circulating online on Google Trends between March 10, 2020, when the first case was seen in Turkey, and June 01, 2020, when the lockdown restrictions were lifted. Findings: There was no internet trend regarding a misinformed attitude within the given date range. While an infodemic attitude toward superficial attitude and racist attitude in the internet environment was detected for 1 week, an infodemic attitude toward definitive attitude was detected for 2 weeks. The non-infodemic concepts were more common than the other infodemic attitudes. The infodemic concepts were able to reach Maslow's physiological, safety, and social need levels. With the infodemic concepts obtained, a COVID-19 development process framework was developed. The framework consists of three domains (COVID-19, applications and outcomes), including disaster phases and health/social impacts, built on seven public health epochs. Results: A systematized COVID-19 development process framework was modeled in order to conceptualize COVID-19 internet searches and to reveal the development processes and outcomes.