Subject(s)
Coronavirus Infections/diagnosis , Pneumonia, Viral/diagnosis , Sweet Syndrome/diagnosis , Sweet Syndrome/drug therapy , Amides/administration & dosage , Antibodies, Monoclonal, Humanized/administration & dosage , Biopsy, Needle , COVID-19 , COVID-19 Testing , Clinical Laboratory Techniques/methods , Coronavirus Infections/pathology , Diagnosis, Differential , Erythema/diagnosis , Erythema/etiology , Facial Dermatoses/diagnosis , Facial Dermatoses/etiology , Female , Fever/diagnosis , Fever/etiology , Humans , Immunohistochemistry , Middle Aged , Pandemics , Pneumonia, Viral/pathology , Pyrazines/administration & dosage , Real-Time Polymerase Chain Reaction/methods , Sweet Syndrome/pathology , Tomography, X-Ray Computed/methodsSubject(s)
Fusariosis , Fusarium , Purpura , Antifungal Agents/therapeutic use , Humans , Immunocompromised Host , Purpura/drug therapy , SkinSubject(s)
Aminoquinolines/administration & dosage , Pagetoid Reticulosis/drug therapy , Skin Neoplasms/drug therapy , Administration, Topical , Antineoplastic Agents/administration & dosage , Biopsy , Female , Follow-Up Studies , Humans , Imiquimod , Middle Aged , Pagetoid Reticulosis/pathology , Skin/pathology , Skin Neoplasms/pathologySubject(s)
Hyperpigmentation/complications , Penile Diseases/complications , Pigmentation Disorders/complications , Skin Diseases, Genetic/complications , Skin Diseases, Papulosquamous/complications , Biopsy , Diagnosis, Differential , Humans , Hyperpigmentation/diagnosis , Male , Middle Aged , Penile Diseases/diagnosis , Pigmentation Disorders/diagnosis , Skin/pathology , Skin Diseases, Genetic/diagnosis , Skin Diseases, Papulosquamous/diagnosisABSTRACT
Pancreatic panniculitis (PP) is a rare disease presenting during the course of pancreatic diseases such as acute and chronic pancreatitis, pancreatic carcinoma. There are also a few reports of PP associated with other carcinomas. We present a 69-year-old male patient of gastric carcinoma with PP. The literature is reviewed, clinical and histological features of the case are discussed. This is the first case of PP in a gastric carcinoma patient reported in literature. As a conclusion, PP can be the first manifestation of a pancreatic metastasis of any carcinoma.
Subject(s)
Adenocarcinoma/complications , Pancreatic Diseases/etiology , Panniculitis/etiology , Stomach Neoplasms/complications , Adenocarcinoma/pathology , Aged , Humans , Lipase/metabolism , Male , Pancreatic Diseases/pathology , Panniculitis/pathology , Stomach Neoplasms/pathologyABSTRACT
A 54-year-old woman presented with angiomatous lesions located on the upper extremities and right cruris. Histopathological findings were typical of Kaposi's sarcoma (KS). She had had mild to moderate psoriasis since she was 25 years old. She had been using cilazapril (an angiotensin-converting enzyme inhibitor) for the last 9 months. She had had similar lesions in the past while taking the same medication. Because our patient's KS lesions had developed during treatment with cilazapril, the drug was stopped. One month later, spontaneous regression of KS nodules was noted and after 4 months no KS lesions were seen.
Subject(s)
Angiotensin-Converting Enzyme Inhibitors/adverse effects , Cilazapril/adverse effects , Psoriasis/drug therapy , Sarcoma, Kaposi/chemically induced , Sarcoma, Kaposi/pathology , Skin Neoplasms/chemistry , Skin Neoplasms/pathology , Angiotensin-Converting Enzyme Inhibitors/administration & dosage , Cilazapril/administration & dosage , Female , Humans , Middle Aged , Psoriasis/complications , Sarcoma, Kaposi/complications , Skin Neoplasms/complications , Upper ExtremityABSTRACT
Elephantiasis Nostras Verrucosa is a rare disorder of an extremity or a body region, which is associated with chronic lymphedema. There are 7 reported cases of abdominal elephantiasis in the medical literature. Here we report a morbidly obese female patient with elephantiasis nostras verrucosa on the abdominal wall.
Subject(s)
Abdomen , Elephantiasis/diagnosis , Elephantiasis/etiology , Obesity, Morbid/complications , Skin Diseases/diagnosis , Adult , Chronic Disease , Elephantiasis/drug therapy , Female , Humans , Obesity, Morbid/drug therapy , Skin Diseases/pathology , Sleep Apnea, Obstructive/complicationsSubject(s)
Facial Dermatoses/microbiology , Lupus Vulgaris/microbiology , Mycobacterium bovis , Adult , Antitubercular Agents/therapeutic use , Drug Therapy, Combination , Facial Dermatoses/pathology , Female , Humans , Lupus Vulgaris/pathology , Mycobacterium bovis/isolation & purification , Neck , Treatment OutcomeABSTRACT
A 48-year-old woman presented with red papules on the thigh. Histopathological examination indicated pyogenic granuloma, and the patient was treated with total excision in 2003 and electrocauterization in 2005. Three months later, upon recurrence of the lesions, a diagnosis of composite haemangioendothelioma (CHE) was made. The patient was treated by total excision and lymph-node dissection, which revealed inguinal lymph-node metastasis. Despite the surgery, a further local recurrence occurred, subsequently treated by wide excision en bloc, with adjuvant radiotherapy and chemotherapy. Although CHE is defined as a vascular tumour with low-grade malignancy, the local recurrences and lymph-node metastases resulted in treatment difficulties in this case. Unlike earlier cases, the tumour in our patient presented as localized numerous small papulonodules, and lymph-node metastasis was detected within a relatively short time. Dermatologists and pathologists should be aware of this rare condition and include it in the differential diagnosis of vascular lesions.
Subject(s)
Hemangioendothelioma/secondary , Skin Neoplasms/pathology , Female , Hemangioendothelioma/surgery , Humans , Lymph Node Excision , Lymphatic Metastasis , Middle Aged , Skin Neoplasms/surgery , Thigh/pathology , Treatment OutcomeABSTRACT
Endogenous ochronosis or alkaptonuria is a rare, autosomal recessive disease of tyrosine metabolism that is caused by a deficiency of the enzyme homogentisic acid oxidase. The disease results in the accumulation and deposition of homogentisic acid in the cartilage, eyelids, forehead, cheeks, axillae, genital region, buccal mucosa, larynx, tympanic membranes, and tendons. The disease generally presents in adults with arthritis and skin abnormalities; occasionally, involvement of other organs may be seen. A 49-year-old man was referred to our clinic with verrucous lesions on his hands. On physical examination, caviar-like ochronotic papules were found around his eyes and the helix cartilage of his ears, and on the dorsa of both hands. There were brown macules on the sclera (Osler's sign). The patient had arthritis and nephrolithiasis, and a sample of his urine darkened upon standing. Histopathological examination showed deposition of ochronotic pigment. High-dose ascorbic acid was given, and the patient showed improvement on follow-up examination 6 months later.
Subject(s)
Ascorbic Acid/therapeutic use , Ear, External/pathology , Ochronosis/pathology , Female , Humans , Middle Aged , Ochronosis/drug therapy , Treatment OutcomeABSTRACT
Mycosis fungoides is very rare in children. Hypopigmented lesions of this disease are usually observed in dark-skinned individuals and often show a T supressor CD8(+) phenotype. Two Caucasian children with predominantly hypopigmented lesions of mycosis fungoides are presented here. Atopy was a concomitant feature in both.
Subject(s)
Hypersensitivity, Immediate/complications , Hypopigmentation/etiology , Mycosis Fungoides/etiology , Skin Neoplasms/etiology , Child, Preschool , Female , Humans , Hypopigmentation/pathology , Hypopigmentation/therapy , Mycosis Fungoides/pathology , Mycosis Fungoides/therapy , Skin Neoplasms/pathology , Skin Neoplasms/therapyABSTRACT
This paper focuses on skin manifestations that can be observed in autoimmune diseases such as rheumatoid arthritis (RA), Sjögren syndrome (SS), dermatomyositis (DM) and Behçet syndrome (BS). In RA the most widely recognized skin lesion is the rheumatoid nodule. Other cutaneous manifestations can be observed either non-specific or related to the disease itself and/or to the commonly used drugs. Cutaneous manifestations are considered one of the most typical extraglandular features of primary SS, generally they are distinguished in vasculitic and non vasculitic lesions. Among non-vasculitc lesions, skin dryness (xerosis) has been shown to be very common in pSS while vasculitis lesions include typically flat and palpable purpura and urticarial vasculits. In DM the skin manifestations are also frequent and include a heliotrope rash (blue-purple discoloration) on the upper eyelids with edema, a flat red rash on the face and upper trunk, and erythema of the knuckles with a raised violaceous scaly eruption (Gottron rash). The most frequent mucocutaneous finding in BS is aphthous stomatitis which can not usually be differentiated from idiopatic reccurrent aphthous stomatitis on clinical grounds. The most typical skin manifestations are nodular lesions, which are commonly seen in BS and may be due to panniculitis [erythema nodosum (EN)-like lesions] or superficial thrombophlebitis.
Subject(s)
Autoimmune Diseases/complications , Skin Diseases/etiology , Arthritis, Rheumatoid/complications , Behcet Syndrome/complications , Dermatomyositis/complications , Humans , Outcome Assessment, Health Care , Rheumatoid Nodule/etiology , Sjogren's Syndrome/complicationsSubject(s)
Mycosis Fungoides/radiotherapy , Skin Neoplasms/radiotherapy , Ultraviolet Therapy/methods , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Female , Humans , Male , Middle Aged , Treatment OutcomeSubject(s)
Lymphomatoid Granulomatosis/diagnosis , Skin Neoplasms/diagnosis , Adult , Diagnosis, Differential , Female , Humans , Lymphomatoid Granulomatosis/drug therapy , Lymphomatoid Granulomatosis/pathology , PUVA Therapy , Skin Neoplasms/drug therapy , Skin Neoplasms/pathology , Upper ExtremityABSTRACT
BACKGROUND: There are few reports about Stevens-Johnson syndrome, a bullous form of erythema multiforme, that can develop in patients treated with cranial irradiation and antiepileptic drugs, especially with phenytoin. We present a patient who developed toxic epidermal necrolysis, a rare and severe form of Stevens-Johnson syndrome, during cranial radiotherapy and phenytoin treatment. CASE REPORT: A 65-year-old male patient with stage IIIB non-small cell lung carcinoma developed a brain metastasis. The patient was treated with phenytoin and dexamethasone. Palliative total cranial irradiation was performed. On the 23rd day of phenytoin administration, erythema and edema in the radiotherapy area and lips, as well as widespread maculopapular eruptions and rashes in the upper thoracic area were observed. The dermal lesions progressed to bullae and subsequently toxic epidermal necrolysis covering 70% of the whole body surface developed. The patient died within 15 days of appearance of the lesions due to secondary infections, despite supportive and symptomatic treatment. CONCLUSION: Although toxic epidermal necrolysis is a rare toxicity it must always be considered during cranial irradiation and antiepileptic prophylaxis.