Altered transcallosal inhibition evidenced by transcranial magnetic stimulation highlights neurophysiological consequences of premature birth in early adulthood.

BACKGROUND AND OBJECTIVE: A very preterm birth can induce deleterious neurophysiological consequences beyond childhood; alterations of the corpus callosum (CC) are reported in adolescents born very preterm along with cognitive impairments. The question remains whether neurophysiological alterations are still detectable in adulthood such as an alteration in CC inhibitory function. The aim of the present study was thus to examine transcallosal inhibition in young adults born very preterm compared to counterparts born at term. STUDY PARTICIPANTS & METHODS: Transcallosal inhibition was probed by measuring the ipsilateral silent period (iSP) using transcranial magnetic stimulation (TMS) in 13 young adults born at 33w of gestation or less (20 ±â€¯3. 2y) and 12 young adults born at term (22 ±â€¯1. 75y). Single high-intensity TMS were delivered to the primary motor cortex (M1) ipsilateral to the preactivated first dorsal interosseous (FDI) muscle. Occurrence, latency, and duration of iSP were measured in the FDI EMG activity, for both hemispheres alternatively (10-12 trials each) along with their resting motor threshold (RMT). RESULTS: In individuals born very preterm as compared to individuals born at term, ISP occurred less frequently (p < .0001), its latency was longer (p = .004), especially in the non-dominant hemisphere, its duration shorter (p < .0001), and RMT was higher in the non-dominant M1 than in the dominant. CONCLUSIONS: Impairment of transcallosal inhibition along with asymmetry of M1 excitability in young adults born very preterm as compared to those born at term underline that neurophysiological consequences of a preterm birth can still be detected in early adulthood.