ABSTRACT
Dengue, a common tropical viral disease, often has complications of thrombocytopenia causing bleeding and warranting blood transfusion. This is costly in low-income settings. We conducted an observational study using a relatively new parameter called immature platelet fraction which indicates regeneration of platelets by the bone marrow. Our study on 124 dengue patients showed a strong correlation between platelet count and immature platelet fraction and we observed that 96.1% and 97.4% patients showed rise in platelet count at 24 and 48 h, respectively. In the absence of bleeding, platelet transfusion was prevented in 64% of patients with an IPF level of 10% or more.
Subject(s)
Dengue/complications , Thrombocytopenia/etiology , Blood Platelets , Dengue/epidemiology , Humans , Platelet Count , Platelet Transfusion , Prospective Studies , Thrombocytopenia/epidemiology , Thrombocytopenia/therapySubject(s)
Hyperpigmentation/etiology , Vitamin B 12 Deficiency/complications , Vitamin B 12 Deficiency/drug therapy , Vitamin B 12/administration & dosage , Vitamins/administration & dosage , Aged , Humans , Hyperpigmentation/drug therapy , Injections, Intramuscular , Male , Treatment Outcome , Vitamins/therapeutic useABSTRACT
Three cases of Hypermobility Syndrome (HS) are discussed. The first case was a young female, aged 24, with musculoskeletal symptoms since 5 years. Second was an 18 year old male with similar symptoms since 3 years. The third was an elderly female who presented with knee joint osteoarthritis (OA) and apparent but reducible deformities of hands mimicking rheumatoid arthritis (RA). All three patients had hypermobility of joints in absence of demonstrable systemic rheumatic disease. The prevalence, clinical features and management of the entity is discussed. An increased awareness of this condition among physicians is warranted as some patients may be erroneously diagnosed as RA/SLE and may be put on DMARDs and steroids.
