Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Acta Neuropathol Commun ; 12(1): 52, 2024 Apr 04.
Article in English | MEDLINE | ID: mdl-38576010

ABSTRACT

The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and related tauopathies. Inoculation-based tau propagation models can recapitulate the stereotypical spread of tau and reproduce various types of tau inclusions linked to specific tauopathy, albeit with varying degrees of fidelity. With this systematic review, we underscore the significance of judicious selection and meticulous functional, biochemical, and biophysical characterization of various tau inocula. Furthermore, we highlight the necessity of choosing suitable animal models and inoculation sites, along with the critical need for validation of fibrillary pathology using confirmatory staining, to accurately recapitulate disease-specific inclusions. As a practical guide, we put forth a framework for establishing a benchmark of inoculation-based tau propagation models that holds promise for use in preclinical testing of disease-modifying drugs.


Subject(s)
Alzheimer Disease , Tauopathies , Animals , Alzheimer Disease/pathology , Neurofibrillary Tangles/pathology , Disease Models, Animal , Tauopathies/pathology , tau Proteins/metabolism , Brain/pathology
2.
DNA Repair (Amst) ; 139: 103678, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38669748

ABSTRACT

Alzheimer disease (AD) is the most prominent form of dementia and has received considerable attention due to its growing burden on economic, healthcare and basic societal infrastructures. The two major neuropathological hallmarks of AD, i.e., extracellular amyloid beta (Aß) peptide plaques and intracellular hyperphosphorylated Tau neurofibrillary tangles, have been the focus of much research, with an eye on understanding underlying disease mechanisms and identifying novel therapeutic avenues. One often overlooked aspect of AD is how Aß and Tau may, through indirect and direct mechanisms, affect genome integrity. Herein, we review evidence that Aß and Tau abnormalities induce excessive genomic stress and impair genome maintenance mechanisms, events that can promote DNA damage-induced neuronal cell loss and associated brain atrophy.


Subject(s)
Alzheimer Disease , Amyloid beta-Peptides , DNA Damage , DNA Repair , tau Proteins , Alzheimer Disease/metabolism , Alzheimer Disease/genetics , Humans , Amyloid beta-Peptides/metabolism , tau Proteins/metabolism , tau Proteins/genetics , Animals
SELECTION OF CITATIONS
SEARCH DETAIL