ABSTRACT
BACKGROUND: The Fib-4 index is a simple and inexpensive biomarker to delineate liver fibrosis in chronic hepatitis C. AIM: To assess the accuracy of the FIB-4 index in chronic hepatitis B. METHODS: We compared the FIB-4 index with 138 synchronous liver biopsies and with 372 synchronous FibroTest performed either in France or in an endemic area (Mayotte, an overseas collectivity of France). RESULTS: The FIB-4 index allowed the correct identification of patients with nil-to-moderate fibrosis with an area under the receiving operating characteristic curve of 0.81 (P < 0.001), increasing as a function of the length of the liver biopsy (up to 0.94 for liver biopsies >or=20 mm). A cut-off value Subject(s)
Alanine Transaminase
, Aspartate Aminotransferases
, Hepatitis B, Chronic/diagnosis
, Liver Cirrhosis/diagnosis
, Adult
, Biomarkers
, Comoros
, Female
, France
, Hepatitis B, Chronic/blood
, Hepatitis B, Chronic/pathology
, Humans
, Liver Cirrhosis/blood
, Liver Cirrhosis/pathology
, Liver Function Tests
, Male
, Middle Aged
, RNA, Viral/blood
, ROC Curve
ABSTRACT
We report the case of a young man who developed multiple liver cell adenomas 13 years after a mesentericocaval shunt. Radiological findings did not provide diagnosis. Histological findings of two biopsied nodules were compatible with liver cell adenoma. Our patient had no known risk factors for liver cell adenomas. We discuss the hypothesis that disturbed hepatic vascularisation could promote the development of liver cell adenomas.
