Exploring statistical and machine learning techniques to identify factors influencing indoor radon concentration.

Radon is a radioactive gas with a carcinogenic effect. The malign effect on human health is, however, mostly influenced by the level of exposure. Dangerous exposure occurs predominantly indoors where the level of indoor radon concentration (IRC) is, in its turn, influenced by several factors. The current study aims to investigate the combined effects of geology, pedology, and house characteristics on the IRC based on 3132 passive radon measurements conducted in Romania. Several techniques for evaluating the impact of predictors on the dependent variable were used, from univariate statistics to artificial neural network and random forest regressor (RFR). The RFR model outperformed the other investigated models in terms of R2 (0.14) and RMSE (0.83) for the radon concentration, as a dependent continuous variable. Using IRC discretized into two classes, based on the median (115 Bq/m3), an AUC-ROC value of 0.61 was obtained for logistic regression and 0.62 for the random forest classifier. The presence of cellar beneath the investigated room, the construction period, the height above the sea level or the floor type are the main predictors determined by the models used.

A new approach to radon temporal correction factor based on active environmental monitoring devices.

The present study aims to identify novel means of increasing the accuracy of the estimated annual indoor radon concentration based on the application of temporal correction factors to short-term radon measurements. The necessity of accurate and more reliable temporal correction factors is in high demand, in the present age of speed. In this sense, radon measurements were continuously carried out, using a newly developed smart device accompanied by CR-39 detectors, for one full year, in 71 residential buildings located in 5 Romanian cities. The coefficient of variation for the temporal correction factors calculated for combinations between the start month and the duration of the measurement presented a low value (less than 10%) for measurements longer than 7 months, while a variability close to 20% can be reached by measurements of up to 4 months. Results obtained by generalized estimating equations indicate that average temporal correction factors are positively associated with CO2 ratio, as well as the interaction between this parameter and the month in which the measurement took place. The impact of the indoor-outdoor temperature differences was statistically insignificant. The obtained results could represent a reference point in the elaboration of new strategies for calculating the temporal correction factors and, consequently, the reduction of the uncertainties related to the estimation of the annual indoor radon concentration.

Comprehensive survey on radon mitigation and indoor air quality in energy efficient buildings from Romania.

Over the last 10 years applied scientific research has been carried out in Romania to tacked the residential radon issues. The increased interest to reduce the carbon footprint of buildings has lead to the implementation and use of new architectural solutions aimed to save energy in houses and other buildings. As a consequence, the degree of retrofit in existing buildings and energy efficiency of new buildings promoted the need to not only mitigate indoor radon, but improve indoor air quality overall. The present study found that the while the best performance in radon reduction was confirmed to be based on sub-slab depressurization (61% - 95% reduction), centralized and decentralized mechanical supply and exhaust ventilation with heat recovery yielded a good efficiency in overall improvement of indoor air quality (CO2, VOC, RH, temperature). The outcome of our research, as well as future perspectives, take into account the recommended harmonization of energy efficiency programs with those of public health by finding and applying the best technologies in compliance with energy saving and indoor environmental quality.

The FIRST large-scale mapping of radon concentration in soil gas and water in Romania.

In the framework of the last Council Directive 2013/59 (Euratom, 2014) laying down basic safety standards for protection against the dangers arising from exposure to ionizing radiation, the problem of radon was assumed in Romania at national level by responsible authorities through the design and development of a National Radon Action Plan and an adequate legislation (HG nr. 526/2018). In order to identify radon risk areas, however, it is necessary to perform systematic radon measurements in different environmental media (soil gas, water, indoor air) and to map the results. This paper presents an atlas of up-to-date radon in soil and water levels for central and western part of Romania. The radon in soil map includes data from 2564 measurements carried out on-site, using Luk3C radon detector. The Luk-VR system was used to measure radon activity concentration from 2452 samples of drinking water. The average radon activity concentration was 29.3 kBq m-3 for soil gas, respectively 9.8 Bq l-1 for water dissolved air. Mapping of radon can be a useful tool to implement radon policies at both the national and local levels, defining priority areas for further study when land-use decisions must be made.

ASSESSMENT OF ANNUAL EFFECTIVE DOSE FROM EXPOSURE TO NATURAL RADIOACTIVITY SOURCES IN A CASE-CONTROL STUDY IN BIHOR COUNTY, ROMANIA.

The purpose of the article is to evaluate the annual effective dose for 80 women divided into two samples; one sample located in the former uranium Baita-Stei area, hereinafter referred to as case sample, respectively for a control sample, located in the same county, but exposed in most cases to indoor radon activity concentrations <300 Bq m-3. In this regard, the homemade 'RaThoGamma' kit was used, which contained two thermoluminescent dosimeters, a CR-39 track detector (RSKS) for indoor radon activity concentration, two CR-39 track detectors (Radtrak2®/ Radtrak2T®) for radon and thoron activity concentrations as well as Direct Radon Progeny Sensors/Direct Thoron Progeny Sensors for measuring time-averaged radon and thoron progenies concentrations. In addition, a total of 80 water samples were collected in order to evaluate the ingestion dose due to radon and radium activity concentrations in drinking water. The maximum total annual effective dose in the control sample was 14.1 mSv, while in the case sample the maximum annual effective dose was 60.5 mSv. This difference is mainly due to radon progenies inhalation. Other pathways did not show a statistically significant difference between the two samples, showing a minor contribution to the annual effective dose.

THE CHALLENGE IN USING THE RETROSPECTIVE ASSESSMENT OF RESIDENTIAL RADON CONCENTRATION.

In the present study, the contemporary indoor radon activity concentration and the surface-deposited 210Po activity were measured in 65 Romanian dwellings. The activity of trapped 210Po on the glass surface was measured using the (CR-LR) difference technique. The retrospective radon activity concentration estimated on the basis of age-adjusted 210Po activity was found to have a geometric mean of 318 Bq m-3, being higher than the geometric mean (250 Bq m-3) of the contemporary indoor radon measurements, measured with two types of track detectors (RSKS and Radtrak2®). By applying Lin's concordance correlation coefficient, a substantial strength of agreement (rC = 0.94) was obtained between RSKS and Radtrak2® results, respectively a poor agreement (rC = 0.71) between the retrospective and contemporary methods. The ratio between contemporary and retrospective radon concentrations has a geometric mean of 0.8 and range from 0.2 to 3.9.

COMPARATIVE STUDY OF RADON AND THORON MEASUREMENTS IN FOUR ROMANIAN SHOW CAVES.

Measurements have been carried out using four types of passive detectors in four of the most popular show caves in Romania. Three types of detectors (RSKS, RadTrak and CD) were used for radon measurements and two (Raduet and CD) for thoron measurement. Activity concentrations in air were measured in the same locations for two seasons, autumn and winter. Measured values for the different caves varied between below detection limit (5 Bq m-3) and 4024 Bq m-3 for radon and from below 10 to 583 Bq m-3 for thoron. The results indicate a very good correlation between RSKS and RadTrak detectors (r = 0.96). The most significant difference between radon concentrations measured with different types of detectors (RSKS and CD) was higher than 150%. The study suggests that the activity concentration of radon in caves, measured using track detectors, could not be influenced by the type of detector used if the microclimate factor is acknowledged.

Preliminary results regarding the first map of residential radon in some regions in Romania.

Radon represents the most important contribution of population exposure to natural ionising radiation. This article presents the first indoor radon map in some regions of Romania based on 883 surveyed buildings in the Stei-BaiTa radon-prone region and 864 in other regions of Romania. Indoor radon measurements were performed in the last 10 y by using CR-39 nuclear track detectors exposed for 3-12 months on ground floor levels of dwellings. Excluding the Stei-BaiTa radon-prone region, an average indoor radon concentration of 126 Bq m(-3) was calculated for Romanian houses. In the Stei-BaiTa radon-prone area, the average indoor concentration was 292 Bq m(-3). About 21 % of the investigated dwellings in the Stei-BaiTa radon-prone region exceed the threshold of 400 Bq m(-3), while 5 % of the dwellings in other areas of Romania exceed the same threshold. As expected, indoor radon concentration is not uniformly distributed throughout Romania. The map shows a high variability among surveyed regions, mainly due to the differences in geology. The radon emanation rate is substantially influenced by the soil characteristics, such as the soil permeability and soil gas radon concentration. Since higher permeability enables the increased migration of soil gas and radon from the soil into the building, elevated levels of indoor radon can be expected in more permeable soil environments.

Mesenchymal stem cell irradiation in culture engages differential effect of hyper-fractionated radiotherapy for head and neck cancers.

PURPOSE: The purpose of this study was to challenge current knowledge on the potential therapeutic advantages of stem cells in radiotherapy by developing an in vitro model of the healthy tissue surrounding or replacing the widely resected tumor. After radical surgery, the start of radiotherapy is often delayed due to wound healing process, with potential loss of the opportunity for treating microscopic disease instead of macroscopic early recurrence. Hyperfractionated radiotherapy, contrary to the standard one, can extend the limits of radical surgery and shorten the gap before the onset of postoperative radiotherapy, with potential improvement in local control. METHODS: By using both mesenchymal stem cells and pre-differentiated osteoblasts, cultured in proper pro-osteogenic media after cell irradiation, we investigated both the differences in the response to DNA damage between lineages undergoing differentiation in culture and the intensity of the mineralization process. RESULTS: Ionizing radiation stimulated stem cell proliferation and differentiation at 0.5 Gy and 1 Gy, thus confirming in vitro the clinical results of hyperfractionated irradiation randomized trials in head and neck cancers -HNCs-. CONCLUSION: To our knowledge, this study is the first to investigate the biophysics of low dose gamma irradiation on stem cell culture, focusing on the potential applications in radiation oncology. For advanced oral cavity and oropharyngeal cancers, as radical surgery often implies major bone resection, the use of mesenchymal stem cells as bone reconstruction vectors might shorten the onset of adjuvant hyperfractionated radiotherapy which enhances the mineralization process. As postoperative radiotherapy has recently being revisited for osteosarcoma, this scenario could impact also on bone reconstruction process in this pathology.