ABSTRACT
For robots to become integrated into our daily environment, they must be designed to gain sufficient trust of both users and bystanders. This is in particular important for social robots including those that assume the role of a mediator, working towards positively shaping relationships and interactions between individuals. One crucial factor influencing trust is the appropriate handling of personal information. Previous research on privacy has focused on data collection, secure storage, and abstract third-party disclosure risks. However, robot mediators may face situations where the disclosure of private information about one person to another specific person appears necessary. It is not clear if, how, and to what extent robots should share private information between people. This study presents an online investigation into appropriate robotic disclosure strategies. Using a vignette design, participants were presented with written descriptions of situations where a social robot reveals personal information about its owner to support pro-social human-human interaction. Participants were asked to choose the most appropriate robot behaviors, which differed in the level of information disclosure. We aimed to explore the effects of disclosure context, such as the relationship to the other person and the information content. The findings indicate that both the information content and relationship configurations significantly influence the perception of appropriate behavior but are not the sole determinants of disclosure-adequacy perception. The results also suggest that expected benefits of disclosure and individual general privacy attitudes serve as additional influential factors. These insights can inform the design of future mediating robots, enabling them to make more privacy-appropriate decisions which could foster trust and acceptance.
ABSTRACT
The identification of new biomarkers is essential in the implementation of personalized health care strategies that offer new therapeutic approaches with optimized and individualized treatment. In support of hypothesis generation and testing in the course of our biomarker research an online portal and respective function-tested reverse transcription quantitative real-time PCR assays (RT-qPCR) facilitated the selection of relevant biomarker genes. We have established workflows applicable for convenient high throughput gene expression analysis in biomarker research with cell lines (in vitro studies) and xenograft mouse models (in vivo studies) as well as formalin-fixed paraffin-embedded tissue (FFPET) sections from various human research and clinical tumor samples. Out of 92 putative biomarker candidate genes selected in silico, 35 were shown to exhibit differential expression in various tumor cell lines. These were further analysed by in vivo xenograft mouse models, which identified 13 candidate genes including potential response prediction biomarkers and a potential pharmacodynamic biomarker. Six of these candidate genes were selected for further evaluation in FFPET samples, where optimized RNA isolation, reverse transcription and qPCR assays provided reliable determination of relative expression levels as precondition for differential gene expression analysis of FFPET samples derived from projected clinical studies. Thus, we successfully applied function tested RT-qPCR assays in our biomarker research for hypothesis generation with in vitro and in vivo models as well as for hypothesis testing with human FFPET samples. Hence, appropriate function-tested RT-qPCR assays are available in biomarker research accompanying the different stages of drug development, starting from target identification up to early clinical development. The workflow presented here supports the identification and validation of new biomarkers and may lead to advances in efforts to achieve the goal of personalized health care.