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2.
Biomolecules ; 11(5)2021 05 08.
Article in English | MEDLINE | ID: mdl-34066859

ABSTRACT

Diabetic foot wound healing is a major clinical problem due to impaired angiogenesis and bacterial infection. Therefore, an effective regenerative dressing is desiderated with the function of promoting revascularization and anti-bacteria. Herein, a multifunctional injectable composite hydrogel was prepared by incorporation of the cerium-containing bioactive glass (Ce-BG) into Gelatin methacryloyl (GelMA) hydrogel. The Ce-BG was synthesized by combining sol-gel method with template method, which maintained spherical shape, chemical structure and phase constitution of bioactive glass (BG). The Ce-BG/GelMA hydrogels had good cytocompatibility, promoted endothelial cells migration and tube formation by releasing Si ion. In vitro antibacterial tests showed that 5 mol % CeO2-containing bioactive glass/GelMA (5/G) composite hydrogel exhibited excellent antibacterial properties. In vivo study demonstrated that the 5/G hydrogel could significantly improve wound healing in diabetic rats by accelerating the formation of granulation tissue, collagen deposition and angiogenesis. All in all, these results indicate that the 5/G hydrogel could enhance diabetic wound healing. Therefore, the development of multifunctional materials with antibacterial and angiogenic functions is of great significance to promote the repair of diabetic wound healing.


Subject(s)
Anti-Bacterial Agents/administration & dosage , Cerium/administration & dosage , Diabetes Mellitus, Experimental/complications , Wound Healing/drug effects , Animals , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Cell Line , Cell Movement/drug effects , Cerium/chemistry , Cerium/pharmacology , Collagen/metabolism , Diabetes Mellitus, Experimental/metabolism , Gelatin/chemistry , Human Umbilical Vein Endothelial Cells , Humans , Hydrogels , Metal Nanoparticles , Methacrylates/chemistry , Mice , Rats , Streptozocin/adverse effects
3.
Guang Pu Xue Yu Guang Pu Fen Xi ; 35(7): 1774-8, 2015 Jul.
Article in Chinese | MEDLINE | ID: mdl-26717723

ABSTRACT

Atmospheric aerosols have important impacts on human health, the environment and the climate system. Micro Pulse Lidar (MPL) is a new effective tool for detecting atmosphere aerosol horizontal distribution. And the extinction coefficient inversion and error analysis are important aspects of data processing. In order to detect the horizontal distribution of atmospheric aerosol near the ground, slope and Fernald algorithms were both used to invert horizontal MPL data and then the results were compared. The error analysis showed that the error of the slope algorithm and Fernald algorithm were mainly from theoretical model and some assumptions respectively. Though there still some problems exist in those two horizontal extinction coefficient inversions, they can present the spatial and temporal distribution of aerosol particles accurately, and the correlations with the forward-scattering visibility sensor are both high with the value of 95%. Furthermore relatively speaking, Fernald algorithm is more suitable for the inversion of horizontal extinction coefficient.


Subject(s)
Aerosols/analysis , Air Pollution/analysis , Algorithms , Atmosphere/analysis , Climate
4.
Guang Pu Xue Yu Guang Pu Fen Xi ; 32(12): 3304-8, 2012 Dec.
Article in Chinese | MEDLINE | ID: mdl-23427557

ABSTRACT

Aerosols interfere with differential absorption lidar ozone concentration measurement and can introduce significant errors. A new retrieval method was introduced, and ozone concentration and aerosol extinction coefficient were gained simultaneously based on the retrieval method. The variables were analyzed by experiment including aerosol lidar ratio, aerosol wavelength exponent, and aerosol-molecular ratio at the reference point. The results show that these parameters introduce error less than 8% below 1 km. The measurement error derives chiefly from signal noise and the parameters introduce error less than 3% above 1 km. Finally the vertical profile of tropospheric ozone concentration and aerosol extinction coefficient were derived by using this algorithm. The retrieval results of the algorithm and traditional dual-wavelength difference algorithm are compared and analyzed. Experimental results indicate that the algorithm is feasible, and the algorithm can reduce differential absorption lidar measurement error introduced by aerosol.

5.
Huan Jing Ke Xue ; 31(1): 17-21, 2010 Jan.
Article in Chinese | MEDLINE | ID: mdl-20329510

ABSTRACT

In order to research the effect of high humidity on the growth of aerosol particles, the APS, TEOM and BC instruments were used to monitor the aerosol in Beijing during August, 2007. The results show that, under steady-state weather condition, the correlation coefficient between the mass concentration of PM10 and BC aerosol is 0.82, but the correlation between the number concentration and the mass concentration of PM10 is not in accordance with that under non-steady-state weather condition. Tie number concentration and the ratio of fine particles less than 1 microm to the whole samples increase obviously. The change of aerosol particles size distribution suggests that the size of aerosol particles increases obviously by moisture absorption under the high humid condition.


Subject(s)
Aerosols/analysis , Air Pollutants/analysis , Humidity , Particulate Matter/analysis , China , Particle Size , Seasons
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