ABSTRACT
BACKGROUND AND AIM: We prospectively compared the clinical outcomes of radical and conservative surgical procedures for primary liver hydatid cysts, additionally radical surgical procedures with and without the two-month administration of albendazole after the operation were compared. METHODS: Overall, 90 patients undergoing open surgical treatment for liver hydatid cysts were divided into three surgical groups: first group, patients who underwent radical surgery (pericystectomy) followed by albendazole treatment for 2 months following the operation group; second group, patients who underwent radical surgery(pericystectomy) without receiving albendazole after surgery group; third group, patients, who underwent conservative surgery (partial cystectomy) with albendazole treatment after surgery. The clinical outcomes and rate of recurrence were analyzed in follow-up period. RESULTS: The mean surgery duration in the Radical groups was significantly longer in comparison to the Conservative surgery + Albendazole group. (212.0 and 202.5 min vs. 173.2 min; p < 0.05). Blood loss in the Radical groups was significantly higher in comparison to the Conservative surgery + Albendazole group (218.3 and 174.6 ml vs. 67.2 ml; p < 0.05). However, postoperative complication rate in the Radical group was significantly lower in comparison to Conservative surgery + Albendazole group (13.3% [n = 4] and 6.7% [n = 2] vs. 36% [n = 11]; p < 0.05). The postoperative hospital stay in both Radical groups was significantly lower in comparison to the Conservative surgery + Albendazole group (7.9 and 7.4 days vs. 11.3 days; p < 0.05). CONCLUSION: In comparison to conservative surgery, radical surgery is a preferable treatment modality for patients with active liver hydatid cysts. Postoperative albendazole treatment is preferable, regardless of the type of surgical procedure.
ABSTRACT
OBJECTIVES: Patients with chronic end-stage liver disease present a significant problem in the Republic of Kazakhstan. The liver transplant program was started in December 2011 and for May 2015, more than 80 liver transplant operations have been performed in 7 different hospitals of the country. MATERIALS AND METHODS: The main problem that hinders the wide implementation of liver transplant in our country is poor development of regularity of deceased-organ donation system. This is because of the specific mentality of the population and imperfect legislation. RESULTS: From 26 operated recipients, 19 lead a normal life (73.1%), receiving a minimal immunosuppressive therapy. In patients with cirrhosis of viral cause, there are no cases of viral hepatitis reinfection. CONCLUSIONS: Preliminary findings based on a small experience showed a good perceptiveness of developing of Liver Transplant program in Kazakhstan.
