[Reduced consciousness levels caused by hyperammonaemia]. / Bewustzijnsdaling door hyperammoniëmie.

Hyperammonaemia is an important cause of lethargy. In this article, we describe a lesser-known but potential fatal cause of hyperammonaemia. A 27-year-old woman presented with lethargy caused by hyperammonaemia. She was treated with the emergency regime that is used to treat hyperammonaemia in urea cycle defects. Although this effectively lowered the ammonia levels, the clinical situation of the patient initially deteriorated and she was transferred to the Intensive Care Unit and intubated. Urine culture identified Proteus mirabilis, a urea-splitting bacterium that caused the hyperammonaemia. Prompt and adequate treatment with antibiotics and adequate drainage of urine was started and she completely recovered. Although every patient can get hyperammonaemia caused by urinary tract infection with urea-splitting bacteria, patients with structural bladder abnormalities are at greater risk. Lethargy can be the only presenting symptom. When recognized early, it is quite treatable and has a good prognosis.

Physical activity and respiratory symptoms in children: the Generation R Study.

BACKGROUND: To assess the relationship between physical activity in second year of life and respiratory symptoms during the pre-school period. METHODS: This study was embedded in the Generation R Study, a large prospective birth-cohort study in Rotterdam, the Netherlands. Physical activity was measured in the second year of life by an Actigraph accelerometer in a subgroup of 347 children (182 boys, 165 girls; mean age 25.1 months) and data were expressed as counts per 15 sec in categories: light activity (302-614 counts/15 sec), moderate activity (615-1,230 counts/15 sec), and vigorous activity (≥1,231 counts/15 sec). Respiratory symptoms were assessed by the International Study of Asthma and Allergies in Childhood Questionnaire in the third and fourth year of life. RESULTS: Physical activity levels were not associated with wheezing symptoms in the third and fourth year of life (OR: 0.98; 95% CI: 0.92-1.05 and OR: 0.99; 95% CI: 0.92-1.07 for total activity, respectively), nor associated with shortness of breath symptoms (OR: 0.98; 95% CI: 0.92-1.05 and OR 1.03; 95% CI: 0.96-1.11 for total activity, respectively). CONCLUSION: These results suggest that physical activity may not play an important role in the development of respiratory symptoms in pre-school children.

Preschool physical activity and functional constipation: the Generation R study.

OBJECTIVES: Decreased physical activity levels in children may partly explain the rising prevalence of functional constipation in childhood. The aim of the present study, therefore, was to examine the association between physical activity and functional constipation during the preschool period. METHODS: This study was embedded in the Generation R study, a large prospective birth-cohort study in Rotterdam, The Netherlands. Physical activity was measured by an Actigraph accelerometer in 347 children (182 boys, 165 girls; mean age 25.1 months) and data were expressed as counts per minute. Data were categorized into light activity (302-614 counts/15 seconds), moderate activity (615-1230 counts/15 seconds), and vigorous activity (≥1231 counts/15 seconds). Functional constipation in the third and fourth year of life was defined according to the Rome II criteria. RESULTS: Children spending time in the highest tertile of light (adjusted odds ratio [OR] 0.34; 95% confidence interval [CI] 0.13-0.87), moderate (adjusted OR 0.37; 95% CI 0.14-0.97), and total activity (adjusted OR 0.37; 95% CI 0.15-0.92) at the age of 2 years had significantly less functional constipation in the fourth year of life. For functional constipation in the third year of life, the results were in similar direction but not statistically significant. Additionally, children with physical activity of more than the WHO recommendation of 60 min/day had significantly less functional constipation in the fourth year of life (adjusted OR 0.48; 95% CI 0.24-0.97). CONCLUSIONS: Physical activity is associated with a decreased risk of functional constipation in the preschool period, but this may be time dependent.