Effect of polypharmacy and Fall-Risk-Increasing Drugs (FRIDs) on falls among Brazilian older adults: The SABE cohort study.

Polypharmacy, considered as the use of multiple medications, has been one of the factors associated with a higher risk of falls among older adults. However, the association of this factor regardless of the use of Fall-Risk-Increasing Drugs (FRIDs) has not been extensively explored. OBJECTIVES: This study aimed to evaluate the longitudinal association of polypharmacy with falls and verify whether this association is independent of FRID use. METHODS: A longitudinal study was conducted with a representative sample of the urban population aged 60 years and over in the city of São Paulo, Brazil, from 2000 to 2006. The analysis of the association among polypharmacy, the use of FRIDs, and the occurrence of falls over the years was performed using Generalized Estimating Equation (GEE) models adjusted for covariates. RESULTS: The association between polypharmacy and falls was significantly attenuated after the adjustment for covariates and FRIDs. Users of two or more FRIDs had higher odds of falls (OR = 1.51; CI [1.16; 1.96]). CONCLUSION: FRID use was associated with the occurrence of falls among older adults. The number of medications must be kept to the minimum necessary, and FRIDs should be avoided in approaches to preventing falls among older adults.

Socioeconomic and sex inequalities in chronic pain: A population-based cross-sectional study.

OBJECTIVE: We investigated the impact of socioeconomic inequalities on chronic pain of older adults according to sex. MATERIALS AND METHODS: This population-based cross-sectional study used survey data from the 2015 cohort of the SABE Study (Saúde, Bem-estar e Envelhecimento), Brazil. Socioeconomic status was examined at individual level (educational attainment, financial independence, and race/skin color) and contextual level (Human Development Index). We analyzed the association between variables using the chi-square test and the Rao & Scott correction. Logistic regression models were adjusted for risk factors. RESULTS: The study comprised 1,207 older adults representing 1,365,514 residents 60≥ years of age in the city of São Paulo. Chronic pain was more frequent in females (27.2%) than in males (14.5%) (p<0.001). Females evidenced the worst self-perception of pain, especially those of the most vulnerable socioeconomic strata. Social inequalities impacted chronic pain in different ways between sexes. Among females, unfavorable living conditions (OR = 1.59; 95%CI 1.07; 2,37) and Blacks/Browns females were most likely to have chronic pain (OR = 1.32; 95%CI 1.01; 1.74). Among males, only the individual aspects were significant for the occurrence of chronic pain, such as low educational attainment (OR = 1.88; 95%CI 1.16; 3.04) and insufficient income (OR = 1.63; 95%CI 1.01; 2.62). DISCUSSION: The potential for inequality was greater for females than for males reflecting structural factors inherent in a highly unequal society. Conclusions: Equity-oriented health policies are critical to preventing pain in human aging.

Immunogenetics of HLA-B: SNP, allele, and haplotype diversity in populations from different continents and ancestry backgrounds.

HLA-B is among the most variable gene in the human genome. This gene encodes a key molecule for antigen presentation to CD8+ T lymphocytes and NK cell modulation. Despite the myriad of studies evaluating its coding region (with an emphasis on exons 2 and 3), few studies evaluated introns and regulatory sequences in real population samples. Thus, HLA-B variability is probably underestimated. We applied a bioinformatics pipeline tailored for HLA genes on 5347 samples from 80 different populations, which includes more than 1000 admixed Brazilians, to evaluate the HLA-B variability (SNPs, indels, MNPs, alleles, and haplotypes) in exons, introns, and regulatory regions. We observed 610 variable sites throughout HLA-B; the most frequent variants are shared worldwide. However, the haplotype distribution is geographically structured. We detected 920 full-length haplotypes (exons, introns, and untranslated regions) encoding 239 different protein sequences. HLA-B gene diversity is higher in admixed populations and Europeans while lower in African ancestry individuals. Each HLA-B allele group is associated with specific promoter sequences. This HLA-B variation resource may improve HLA imputation accuracy and disease-association studies and provide evolutionary insights regarding HLA-B genetic diversity in human populations.

Overweight in Older Adults: A Follow-Up of Fifteen Years of the SABE Survey.

Despite extensive research on overweight and obesity, there are few studies that present longitudinal statistical analyses among non-institutionalized older adults, particularly in low- and middle-income countries. This study aimed to assess the prevalence and factors associated with excess weight in older adults from the same cohort over a period of fifteen years. A total of 264 subjects aged (≥60 years) from the SABE survey (Health, Wellbeing and Aging) in the years 2000, 2006, 2010, and 2015 in the city of São Paulo, Brazil, were evaluated. Overweight was assessed by a BMI of ≥28 kg/m2. Multinomial logistic regression models adjusted for sociodemographic and health data were used to assess factors associated with excess weight. After normal weight, overweight was the most prevalent nutritional status in all evaluated periods: 34.02% in 2000 (95%CI: 28.29-40.26); 34.86% in 2006 (95%CI: 28.77-41.49%); 41.38% in 2010 (95%CI: 35.25-47.79); 33.75% in 2015 (95%CI: 28.02-40.01). Being male was negatively associated with being overweight in all years (OR: 0.34 in 2000; OR: 0.36 in 2006; OR: 0.27 in 2010; and OR: 0.43 in 2015). A greater number of chronic diseases and worse functionality were the main factors associated with overweight, regardless of gender, age, marital status, education, physical activity, and alcohol or tobacco consumption. Older adults with overweight and obesity, a greater number of chronic diseases, and difficulties in carrying out daily tasks required a greater commitment to healthcare. Health services must be prepared to accommodate this rapidly growing population in low- and middle-income countries.

[Factors associated with limitations in functional mobility in elderly in the city of São Paulo, Brazil: a comparative analysis of 15 years]. / Fatores associados à limitação da mobilidade funcional em idosos do Município de São Paulo, Brasil: análise comparativa ao longo de 15 anos.

The study aimed to analyze the prevalence of self-reported limitation of functional mobility and associated factors from 2000 to 2015 in elderly residing in the city of São Paulo, Brazil. The analyses used data from the four waves (2000, 2006, 2010, and 2015) in the Health, Well-Being, and Aging Study (SABE). Regression models were conducted to analyze the demographic, socioeconomic, behavioral, and health-related characteristics of individuals associated with limitations of mobility in each wave of the study, and multilevel analysis was performed for comparison between the four waves. The results showed an increase in the prevalence of self-reported limitations in mobility, most evident in the year 2006. There was also an association between chronic health conditions such as history of stroke (PR = 1.43; 95%CI: 1.29; 1.58, in 2000), presence of osteoarticular diseases (PR = 1.35; 95%CI: 1.23; 1.49, in 2015), and complaint of "backache" (PR = 1.33; 95%CI: 1.22; 1.45, in 2006), as well as with socioeconomic aspects such as insufficient income (PR = 1.17; 95%CI: 1.07; 1.28, in 2010). In a context of rapid population aging, these results provide relevant information for promoting public policies to prevent the decline in mobility in the elderly.

Este estudo teve como objetivo analisar a prevalência de limitação na mobilidade funcional autorreferida e os fatores associados no período entre os anos 2000 e 2015, em idosos residentes no Município de São Paulo, Brasil. Para as presentes análises foram utilizados os dados das quatro ondas (2000, 2006, 2010 e 2015) do Estudo Saúde, Bem Estar e Envelhecimento (SABE). Foram conduzidos modelos de regressão para analisar as características demográficas, socioeconômicas, comportamentais e relativas à saúde dos indivíduos associadas à limitação da mobilidade em cada onda do estudo, e análise multinível para a comparação entre as quatro ondas. Os resultados indicaram aumento nas prevalências de limitações na mobilidade autorreferida, mais evidente no ano de 2006. Foi observado, ainda, associação com condições crônicas de saúde, como a história de AVC (RP = 1,43; IC95%: 1,29; 1,58, em 2000), a presença de doenças osteoarticulares (RP = 1,35; IC95%: 1,23; 1,49, em 2015), e a queixa de "dor nas costas" (RP = 1,33; IC95%: 1,22; 1,45, em 2006), bem como com aspectos socioeconômicos, como a renda insuficiente (RP = 1,17; IC95%: 1,07; 1,28, em 2010). Em um contexto de envelhecimento populacional acelerado, esses resultados trazem informações relevantes para a promoção de políticas públicas voltadas à prevenção de declínio da mobilidade em pessoas idosas.

Este estudio tuvo como objetivo analizar la prevalencia de limitación en la movilidad funcional autoinformada y sus factores asociados durante el período entre los años 2000 y 2015, en ancianos residentes en el Municipio de São Paulo, Brasil. Para los análisis actuales se utilizaron los datos de cuatro oleadas (2000, 2006, 2010 y 2015) del Estudio Salud, Bienestar y Envejecimiento (SABE). Se aplicaron modelos de regresión para analizar las características demográficas, socioeconómicas, comportamentales y relativas a la salud de los individuos, asociadas a la limitación de la movilidad en cada oleada del estudio, y un análisis multinivel para la comparación entre las 4 oleadas. Los resultados indicaron un aumento en las prevalencias de limitaciones respecto a la movilidad autoinformada, pero fue evidente en el año 2006. Se observó, incluso, una asociación con las condiciones crónicas de salud, como un historial de ACV (RP = 1,43; IC95%: 1,29; 1,58, en 2000), la presencia de enfermedades osteoarticulares (RP = 1,35; IC95%: 1,23; 1,49, en 2015), y la queja de "dolor de espalda" (RP = 1,33; IC95%: 1,22; 1,45, en 2006), así como con aspectos socioeconómicos, como la renta insuficiente (RP = 1,17; IC95%: 1,07; 1,28, en 2010). En un contexto de envejecimiento poblacional acelerado, esos resultados presentan información relevante para la promoción de políticas públicas dirigidas a la prevención del declive de la movilidad en personas ancianas.

Difficulties in accessing health services among the elderly in the city of São Paulo-Brazil.

To identify difficulties in accessing health services by the elderly in the city of São Paulo/Brazil and the contributory factors that reflect inequalities. This is a cross-sectional study that used data from the Health, Well-being and Aging Study (SABE). The population is composed of elderly ≥ 60 years old, of both sexes, living in the urban area of São Paulo. For this analysis, we used data from the 2015 cohort of the SABE study, containing a sample of 1,221 individuals. The proportions of access difficulty and, through logistic regression, the associated factors were verified, based on Andersen's Behavioral Model, which considers factors of predisposition, enabling and need as individual determinants of access to health care. It was observed that 37.0% of the elderly reported difficulty accessing health services when they needed it. This difficulty was greatest among females (42.3%), aged 60 to 69 years (40.9%), black race/color (58.8%), illiterate (44.5%), single/separated/divorced (44.3%), with income slower than one salary minimum (46.8%), without health insurance (51.9%), with poor/very poor self-assessment of health (54.7%), with multimorbidity (40.1%), frail (47.2%) and among those who used polypharmacy (40.8%). After multivariate analysis, in the final model, there was a positive association between difficulty of access and predisposing factors (female gender, age group 60 to 69 years, black race/color, illiterate), enabling factors (possession of health insurance) and need factors (regular and poor/very poor self-assessment of health and pre-fragility and frailty condition). The presence of difficulty in access associated with predisposing, enabling and need factors reflect the existence of inequalities caused by barriers that point to weaknesses in the organization of services. The identification of these barriers that hinder access highlights important points that can have an impact on the equity and resolution of care.

Association between low level of physical activity and mobility limitation in older adults: evidence from the SABE study.

Several studies are limited by verifying the level of physical activity with questionnaires and not through objective measurement in older adults. This article aims to analyze the association between a low level of physical activity with accelerometry) and mobility limitation in older adults. A population-based cross-sectional study conducted with 543 older adults. Multiple regression analysis was performed using hierarchical analysis, grouping the variables into two blocks ordered according to the precedence with which they acted on the outcomes. Among the evaluated older adults, 13.7% presented mobility limitations and among these 60.39% were in the low level of physical activity group. Older adults with a low level of physical activity (OR = 3.49 [2.0 - 6.13]), aged 75 and over (OR = 1.97 [1.03 - 3.72]), living without a partner (OR = 2.01 [1.09 - 3.68]), having difficulty performing basic (OR = 2.49 [1.45 - 4.28]) and instrumental (OR = 2.28) [1.18 - 4.36]) activities of daily life, and multimorbidity (OR = 2.06 [1.04 - 4.08]) were independently associated with mobility limitation. A low level of physical activity increases the chance of mobility limitation in older adults, regardless of sociodemographic and clinical variables.

Association between low level of physical activity and mobility limitation in older adults: evidence from the SABE study / Associação entre baixo nível de atividade física e limitação de mobilidade em idoso: evidência do estudo SABE

Abstract Several studies are limited by verifying the level of physical activity with questionnaires and not through objective measurement in older adults. This article aims to analyze the association between a low level of physical activity with accelerometry) and mobility limitation in older adults. A population-based cross-sectional study conducted with 543 older adults. Multiple regression analysis was performed using hierarchical analysis, grouping the variables into two blocks ordered according to the precedence with which they acted on the outcomes. Among the evaluated older adults, 13.7% presented mobility limitations and among these 60.39% were in the low level of physical activity group. Older adults with a low level of physical activity (OR = 3.49 [2.0 - 6.13]), aged 75 and over (OR = 1.97 [1.03 - 3.72]), living without a partner (OR = 2.01 [1.09 - 3.68]), having difficulty performing basic (OR = 2.49 [1.45 - 4.28]) and instrumental (OR = 2.28) [1.18 - 4.36]) activities of daily life, and multimorbidity (OR = 2.06 [1.04 - 4.08]) were independently associated with mobility limitation. A low level of physical activity increases the chance of mobility limitation in older adults, regardless of sociodemographic and clinical variables.

Resumo Vários estudos são limitados por meio da verificação do nível de atividade física com questionários, mas não possuem medidas objetivas em adultos mais velhos. O objetivo deste artigo é analisar a associação entre um baixo nível de atividade física e limitação de mobilidade em idosos. Um estudo transversal de base populacional realizado com 543 idosos. A análise múltipla da regressão foi realizada usando a análise hierárquica, agrupando as variáveis em dois blocos ordenados de acordo com a precedência com que atuaram sobre os resultados. Entre os idosos avaliados, 13,7% apresentaram limitações de mobilidade e entre estes 60,39% estavam no baixo nível de atividade física. Idosos com um baixo nível de atividade física (OR = 3,49 [2,0 - 6,13]), com idade igual ou superior a 75 anos (OR = 1,97 [1,03 - 3,72]), vivendo sem parceiro (OR = 2,01 [1,09 - 3,68]), dificuldade de viver sem um parceiro (OR = 2,01 [1,09 - 3,68]), dificuldades com atividades básicas (OR = 2,49 [1,45 - 4,28]) e as atividades instrumentais (OR = 2.28) [1.18 - 4.36]) atividades da vida do dia a dia e multimobilidade (OR = 2,06 [1,04 - 4,08]) foram associadas independentemente à mobilidade. Um baixo nível de atividade física aumenta a possibilidade de limitação da mobilidade em adultos idosos, independentemente das variáveis sociodemográficas e clínicas.

Sexual activity and satisfaction in older adults from a Brazilian cohort study

Objectives: Although the majority of older adults experience sexual satisfaction regardless of their sexual activity, there are few studies that address sexuality in aging, especially in Latin America. The objective of this study was to assess the prevalence of sexual activity and satisfaction among older adults in two time-points, as well as their sociodemographic and health predictors.Method: We analyze data from 1,464 older adults aged 60 years or over from the Health, Well-Being, and Aging (SABE) cohort study conducted in Brazil. Multivariable regression models were used to determinate the factors associated with sexual activity and sexual satisfaction, stratified by gender. Results: Among older adults, the prevalence of sexual activity was 48%, while the vast majority reported feeling sexually satisfied (80%). Men had more sexual activity than women, while women presented greater sexual satisfaction than men. After the follow-up, older adults that were married were more likely to have sexual activity. In women, being older than 71 years was associated with lower sexual activity. In men, those with mobility problems and depression were less likely to have sexual activity. Regarding sexual satisfaction, having depression remained a leading factor for lower sexual satisfaction in men.Conclusion: Despite beliefs, a high percentage of older adults reported being sexually active and feeling sexually satisfied. Our results highlight the gender difference in the predictors of sexual activity and sexual satisfaction. Since sexuality is important for well-being throughout life, preventing factors that decrease sexual activity and sexual satisfaction in aging could help improve the quality of life of older adults.

Fatores associados à limitação da mobilidade funcional em idosos do Município de São Paulo, Brasil: análise comparativa ao longo de 15 anos / Factors associated with limitations in functional mobility in elderly in the city of São Paulo, Brazil: a comparative analysis of 15 years / Factores asociados a la limitación de la morbilidad funcional en ancianos del Municipio de São Paulo, Brasil: análisis comparativo a lo largo de 15 años

Este estudo teve como objetivo analisar a prevalência de limitação na mobilidade funcional autorreferida e os fatores associados no período entre os anos 2000 e 2015, em idosos residentes no Município de São Paulo, Brasil. Para as presentes análises foram utilizados os dados das quatro ondas (2000, 2006, 2010 e 2015) do Estudo Saúde, Bem Estar e Envelhecimento (SABE). Foram conduzidos modelos de regressão para analisar as características demográficas, socioeconômicas, comportamentais e relativas à saúde dos indivíduos associadas à limitação da mobilidade em cada onda do estudo, e análise multinível para a comparação entre as quatro ondas. Os resultados indicaram aumento nas prevalências de limitações na mobilidade autorreferida, mais evidente no ano de 2006. Foi observado, ainda, associação com condições crônicas de saúde, como a história de AVC (RP = 1,43; IC95%: 1,29; 1,58, em 2000), a presença de doenças osteoarticulares (RP = 1,35; IC95%: 1,23; 1,49, em 2015), e a queixa de "dor nas costas" (RP = 1,33; IC95%: 1,22; 1,45, em 2006), bem como com aspectos socioeconômicos, como a renda insuficiente (RP = 1,17; IC95%: 1,07; 1,28, em 2010). Em um contexto de envelhecimento populacional acelerado, esses resultados trazem informações relevantes para a promoção de políticas públicas voltadas à prevenção de declínio da mobilidade em pessoas idosas.

The study aimed to analyze the prevalence of self-reported limitation of functional mobility and associated factors from 2000 to 2015 in elderly residing in the city of São Paulo, Brazil. The analyses used data from the four waves (2000, 2006, 2010, and 2015) in the Health, Well-Being, and Aging Study (SABE). Regression models were conducted to analyze the demographic, socioeconomic, behavioral, and health-related characteristics of individuals associated with limitations of mobility in each wave of the study, and multilevel analysis was performed for comparison between the four waves. The results showed an increase in the prevalence of self-reported limitations in mobility, most evident in the year 2006. There was also an association between chronic health conditions such as history of stroke (PR = 1.43; 95%CI: 1.29; 1.58, in 2000), presence of osteoarticular diseases (PR = 1.35; 95%CI: 1.23; 1.49, in 2015), and complaint of "backache" (PR = 1.33; 95%CI: 1.22; 1.45, in 2006), as well as with socioeconomic aspects such as insufficient income (PR = 1.17; 95%CI: 1.07; 1.28, in 2010). In a context of rapid population aging, these results provide relevant information for promoting public policies to prevent the decline in mobility in the elderly.

Este estudio tuvo como objetivo analizar la prevalencia de limitación en la movilidad funcional autoinformada y sus factores asociados durante el período entre los años 2000 y 2015, en ancianos residentes en el Municipio de São Paulo, Brasil. Para los análisis actuales se utilizaron los datos de cuatro oleadas (2000, 2006, 2010 y 2015) del Estudio Salud, Bienestar y Envejecimiento (SABE). Se aplicaron modelos de regresión para analizar las características demográficas, socioeconómicas, comportamentales y relativas a la salud de los individuos, asociadas a la limitación de la movilidad en cada oleada del estudio, y un análisis multinivel para la comparación entre las 4 oleadas. Los resultados indicaron un aumento en las prevalencias de limitaciones respecto a la movilidad autoinformada, pero fue evidente en el año 2006. Se observó, incluso, una asociación con las condiciones crónicas de salud, como un historial de ACV (RP = 1,43; IC95%: 1,29; 1,58, en 2000), la presencia de enfermedades osteoarticulares (RP = 1,35; IC95%: 1,23; 1,49, en 2015), y la queja de "dolor de espalda" (RP = 1,33; IC95%: 1,22; 1,45, en 2006), así como con aspectos socioeconómicos, como la renta insuficiente (RP = 1,17; IC95%: 1,07; 1,28, en 2010). En un contexto de envejecimiento poblacional acelerado, esos resultados presentan información relevante para la promoción de políticas públicas dirigidas a la prevención del declive de la movilidad en personas ancianas.

Factors associated with body mass index changes among older adults: a ten-year follow-up.

To examine changes in body mass index (BMI) among older Brazilian adults and associated factors. Longitudinal, population-based study, conducted in São Paulo, Brazil. Adults aged 60 years or over (n = 1,796) from the first wave of data collection from the Health, Well-Being, and Aging Study (SABE Project) conducted from 2000 to 2010. Repeated mixed-effects linear regression was used to analyze longitudinal changes in BMI and to examine whether sociodemographic characteristics, health conditions, and social behaviors were associated with these changes. Mean BMI decreased after 70 years. Men had lower BMI than women (ß = -1.86, 95%CI: -2.35; -1.37). Older adults who consumed alcohol (ß = 0.30, 95%CI: 0.06; 0.54), had more than one chronic disease (ß = 0.19, 95%CI: 0.26; 0.72) and who did not perform physical activity (ß = 0.56, 95%CI: 0.38; 0.74) had higher BMI. Subjects who smoked (ß = -0.40, 95%CI: -0.76; -0.04) and who reported having eaten less food in recent months (ß = -0.48, 95%CI: -0.71; -0.24) had lower BMI. In older Brazilians, several sociodemographic characteristics, health conditions, and behaviors predict BMI. Increasing prevalence of chronic diseases and growing sedentary behaviors in Brazil may have detrimental effects on BMI at older ages.

Socioeconomic Factors and Health Status Disparities Associated with Difficulty in ADLs and IADLs among Long-Lived Populations in Brazil: A Cross-Sectional Study.

OBJECTIVE: To evaluate the association between socioeconomic factors, health status, and Functional Capacity (FC) in the oldest senior citizens in a metropolis and a poor rural region of Brazil. METHOD: Cross-sectional study of 417 seniors aged ≥80 years, data collected through Brazil's Health, Well-being and Aging survey. FC assessed by self-reporting of difficulties in Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs). Chi-square tests and multiple logistic regression analyses were performed using "R" statistical software. RESULTS: Socioeconomic and demographic inequalities in Brazil can influence FC in seniors aged 80 years and older. Comparatively, urban long-lived people had a higher prevalence of difficulties for ADLs and rural ones showed more difficulties for IADLs. Among urban oldest seniors, female gender and lower-income were correlated with difficulties for IADLs. Among rural oldest seniors, female gender, stroke, joint disease, and inadequate weight independently were correlated with difficulties for ADLs, while the number of chronic diseases was associated with difficulties for IADLs. CONCLUSION: Financial constraints may favor the development of functional limitations among older seniors in large urban centers. In poor rural areas, inadequate nutritional status and chronic diseases may increase their susceptibility to functional decline.

Edentulism-free life expectancy among older Brazilian adults: SABE study, 2006-2016.

AIM: To assess edentulism-free life expectancy (EFLE) and the related inequalities by sex and schooling among older Brazilian adults from 2006 to 2016. BACKGROUND: Tooth loss is related to shortened longevity and unhealthy life expectancy in old age. MATERIALS AND METHODS: The outcome of the study was EFLE, assessed by age, sex and schooling. EFLE was estimated using the Sullivan method, considering the years and proportion of remaining life and the prevalence of edentulism-assessed in the Health, Well-being, and Aging cohort study, as well as the official mortality data for adults aged 60 years or older living in São Paulo, Brazil. RESULTS: EFLE increased from 10.9 (95% CI: 10.4-11.5) to 13.8 (95% CI: 13.2-14.5) years, considering data from 2006 to 2016, among 60-year-old individuals. In relative terms, these individuals expected to live 50.7% (95% CI: 48.1-53.2) of their remaining life free of edentulism in 2006, while this expectation was 62.8% (95% CI: 60.0-65.6) in 2016. Within both years, women and the less educated had lower EFLE than men and the higher educated. CONCLUSION: EFLE increased from 2006 to 2016. However, inequalities concerning sex and education remained significant, thereby highlighting the need to continuously address inequalities in tooth loss throughout life to contribute to a healthy ageing.

Accuracy of different handgrip values to identify mobility limitation in older adults.

BACKGROUND/OBJECTIVE: Mobility limitation is commonly the first sign of impaired physical function and predisposes older adults to disability. Moreover, recent epidemiological studies have classified neuromuscular strength as the best explanator of mobility limitation. However, existing cutoffs have not been adequately analyzed regarding accuracy. Therefore, our aims were to define and compare the accuracy of different cutoff points of handgrip strength for the identification of mobility limitation. METHODS: Cross-sectional study with 5783 participants from the SABE (Saúde, Bem-Estar e Envelhecimento [Health, Wellbeing and Aging]) and ELSA (English Longitudinal Study of Ageing) cohorts aged 60 years or older. Handgrip strength was measured using a dynamometer. Walking speed <0.8 m/s was considered mobility limitation. Receiver operating characteristic curves and probabilities of presenting mobility limitation were calculated. RESULTS: Handgrip strength <32 kg for men and <21 kg for women demonstrated good diagnostic accuracy for mobility limitation, with 49.1% sensitivity and 79.8% specificity for men and 58.6% sensitivity and 72.9% specificity for women. The fully adjusted models had an area under the curve of 0.82 for men and 0.83 for women, with odds of presenting mobility limitation of 1.88 [95% CI: 1.50 - 2.37] for men and 1.89 [95% CI: 1.57 - 2.27] for women. CONCLUSIONS: The results of this study support the accuracy of handgrip strength as a clinical marker of mobility limitation. Furthermore, manual dynamometry is easily incorporated into clinical practice, has a good cost-benefit, besides being a simple, valid, reliable and effective method for use in both the scientific community and outpatient practice.

Methodological description of the mapping of Brazilian long-term care facilities for older adults / Descrição metodológica do mapeamento das instituições de longa permanência para idosos no Brasil

OBJECTIVE: To describe the methodological approach adopted to build a database of long-term care facilities (LCTFs) in Brazil. METHODS: This exploratory research was conducted for 12 months, between August 2020 and July 2021, based on primarily publicly accessible data. First, the Unified Social Assistance System (Sistema Único de Assistência Social [SUAS]) database from 2019 was adopted as the primary source of information. In addition, public agencies and managers were consulted and invited to share their databases, while researchers and private entities collaborated by making their spreadsheets available. Data were organized in spreadsheets for each Brazilian state. LTCFs not catering to older adults (aged 60 years and over) were excluded. Duplicate data were excluded when overlaps were identified. RESULTS: This brief communication describes the methodology adopted for mapping the current status of Brazilian LTCFs. Despite its caveats, this study represents an important advance in the identification, characterization, and monitoring of these services nationwide. A total of 5769 facilities were found in the 2019 SUAS census. After excluding facilities not caring for residents aged 60 years or over, this number decreased to 2381 LTCFs. The consolidation and filtering of information from multiple data sources led to the identification of 7029 LTCFs throughout the country. CONCLUSION: Building a solid database was paramount to devising a national policy on long-term care. By including multiple sources, the scope of this survey was wider than all previous efforts and constituted an unprecedented collaborative experience in the country, including the potential to become the first national dataset for the Brazilian LTC secto

OBJETIVO: Descrever a abordagem metodológica adotada para a construção de um banco de dados brasileiro de instituições de longa permanência (ILPIs) no país. METODOLOGIA: Esta pesquisa exploratória foi realizada durante 12 meses, entre agosto de 2020 ­ 2021, com base principalmente em dados acessíveis ao público. Em primeiro lugar, o banco de dados do Sistema Único de Assistência Social para 2019 foi adotado como principal fonte de informação. Além disso, órgãos públicos e gestores foram consultados e convidados a compartilhar seus bancos de dados. Da mesma forma, pesquisadores e entidades privadas colaboraram disponibilizando suas planilhas. Os dados foram colocados em planilhas para cada estado brasileiro. Excluíram-se as ILPIs que não atendiam a idosos (60 anos ou mais). Dados duplicados foram excluídos quando as sobreposições foram identificadas. RESULTADOS: Esta comunicação breve descreve a metodologia adotada para mapear a situação atual das ILPIs brasileiras. Apesar de suas ressalvas, este estudo representa um importante avanço na identificação, caracterização e monitoramento desses serviços em âmbito nacional. Um total de 5769 instalações foram encontradas no censo do SUAS de 2019. Após a exclusão dos estabelecimentos que não atendiam residentes idosos, esse total passou para 2381. A consolidação e filtragem das informações de múltiplas fontes de dados levaram à identificação de 7029 ILPIs para o país como um todo. CONCLUSÃO: A construção de um banco de dados sólido é fundamental para a formulação de uma Política Nacional de Cuidados de Longa Duração. Por incluir fontes múltiplas, o escopo desta pesquisa é muito maior do que todos os esforços anteriores e constitui uma experiência colaborativa sem precedentes no país, incluindo o potencial de se tornar o primeiro conjunto de dados nacional para o setor.

Epidemiological characteristics of influenza-like illness outbreaks in long-term care facilities of the state of São Paulo, Brazil / Características epidemiológicas dos surtos de síndrome gripal em instituições de longa permanência para idosos no estado de São Paulo, Brasil

Long-term care facilities for older adults present a high risk of outbreaks since they concentrate often more frail and vulnerable individuals. OBJECTIVE: To describe the epidemiological characteristics of influenza-like illness outbreaks and cases among older people in long-term care facilities in the state of São Paulo, Brazil. METODS: The analysis was performed through an exploratory and descriptive approach, with records from the outbreak module of the National System of Notifiable Diseases between January 2020 and June 2021. RESULTS: Outbreaks of influenza-like illness in this department represented 24.93% of all notifications. The highest concentration was seen in the state capital and metropolitan area. A total of 1 018 confirmed outbreaks were observed, involving 6 110 cases and 1 240 deaths among older people. Of these cases, 71.67% were confirmed for coronavirus disease 19 (COVID-19), 12.77% for the influenza virus, and 15.56% for other respiratory viruses. The percentages regarding death outcomes were similar, with a 20.29% lethality of influenza-like illness. Within the studied group, the older adults were the most affected. A statistical difference was observed between cases and deaths. CONCLUSIONS: Owing to the current scenario and the known vulnerabilities of these facilities, there is an urgent need for joint and articulated action by various administrative levels in order to minimize the devastating effects of influenza-like illness outbreaks (especially of COVID19) in older adults at long-term care homes. The strengthening of information systems and their interoperability are considered of utmost importance in order to improve the quality of information on outbreaks, which is essential during a pandemic.

Instituições de longa permanência para idosos são locais que apresentam um alto risco de surtos epidêmicos, visto que concentram indivíduos, frequentemente mais frágeis e vulneráveis. OBJETIVO: Descrever as características epidemiológicas de surtos de síndrome gripal entre idosos em instituições de longa permanência no estado de São Paulo. MÉTODOS: A análise foi realizada através de uma abordagem exploratória e descritiva, utilizando-se de registros do Sistema de Informações de Agravos de Notificação, módulo surto, entre janeiro de 2020 e junho de 2021. RESULTADOS: Surtos de síndrome gripal neste departamento representaram 24,93% do total de notificações. A maior concentração de surtos ocorreu na capital e região metropolitana. Foram observados 1018 surtos confirmados, envolvendo 6110 casos e 1240 óbitos em idosos. Entre estes casos, 71,67% foram confirmados para COVID-19, 12,77% para o vírus Influenza e 15,56%, para outros vírus respiratórios. Óbitos apresentaram porcentagens semelhantes, com a letalidade de síndrome gripal sendo de 20,29%. No grupo estudado, idosos mais longevos foram os mais acometidos. Houve diferença estatística entre casos e óbitos. CONCLUSÕES: Devido ao cenário atual e às conhecidas vulnerabilidades destas instituições, há a necessidade urgente de uma ação conjunta e articulada por parte de diversas esferas administrativas para minimizar os efeitos devastadores de surtos de síndrome gripal, especialmente os de COVID-19, em instituições de longa permanência. O fortalecimento de sistemas de informação e sua interoperabilidade são considerados de vital importância para melhorar a qualidade da informação sobre surtos institucionais, a qual é essencial durante uma pandemia.

Factors associated with body mass index changes among older adults: a ten-year follow-up / Fatores associados a alterações no índice de massa corporal entre idosos: um seguimento de dez anos / Factores asociados con índice de masa corporal entre adultos mayores: un seguimiento de 10 años

To examine changes in body mass index (BMI) among older Brazilian adults and associated factors. Longitudinal, population-based study, conducted in São Paulo, Brazil. Adults aged 60 years or over (n = 1,796) from the first wave of data collection from the Health, Well-Being, and Aging Study (SABE Project) conducted from 2000 to 2010. Repeated mixed-effects linear regression was used to analyze longitudinal changes in BMI and to examine whether sociodemographic characteristics, health conditions, and social behaviors were associated with these changes. Mean BMI decreased after 70 years. Men had lower BMI than women (β = -1.86, 95%CI: -2.35; -1.37). Older adults who consumed alcohol (β = 0.30, 95%CI: 0.06; 0.54), had more than one chronic disease (β = 0.19, 95%CI: 0.26; 0.72) and who did not perform physical activity (β = 0.56, 95%CI: 0.38; 0.74) had higher BMI. Subjects who smoked (β = -0.40, 95%CI: -0.76; -0.04) and who reported having eaten less food in recent months (β = -0.48, 95%CI: -0.71; -0.24) had lower BMI. In older Brazilians, several sociodemographic characteristics, health conditions, and behaviors predict BMI. Increasing prevalence of chronic diseases and growing sedentary behaviors in Brazil may have detrimental effects on BMI at older ages.

O objetivo foi examinar alterações no índice de massa corporal (IMC) e fatores associados em idosos brasileiros. Este foi um estudo longitudinal, populacional, realizado em São Paulo, Brasil. Os participantes eram adultos com 60 anos ou mais (n = 1.796) da primeira onda da coleta de dados do Projeto Saúde, Bem-Estar e Envelhecimento (Projeto SABE), realizada entre 2000 e 2010. Foi usada regressão linear de medidas repetidas de efeitos mistos para analisar as mudanças longitudinais no IMC e examinar a associação entre características sociodemográficas, condições de saúde e comportamentos sociais e essas mudanças. O IMC médio diminuiu depois dos 70 anos de idade. Os homens tinham IMC mais baixo que as mulheres (β = -1,86, IC95%: -2,35; -1,37). Os idosos que consumiam álcool (β = 0,30, IC95%: 0,06; 0,54), com mais de uma doença crônica (β = 0,19, IC95%: 0,26; 0,72) e que não praticavam atividade física (β = 0,56, IC95%: 0,38; 0,74) tinham IMC mais alto. Idosos fumantes (β = -0,40, IC95%: -0,76; -0,04) e que relatavam menor consumo alimentar nos últimos meses (β = -0,48, IC95%: -0,71; -0,24) tinham IMC mais baixo. Entre os idosos brasileiros, diversas características sociodemográficas, condições de saúde e comportamentos predizem o IMC. O aumento da prevalência de doenças crônicas e de comportamentos sedentários no Brasil pode ter efeitos prejudiciais sobre o IMC nas idades mais avançadas.

El objetivo fue examinar cambios en el índice de masa corporal (IMC) entre adultos mayores brasileños y sus factores asociados. Estudio longitudinal de base poblacional, llevado a cabo en São Paulo, Brasil. Los participantes eran adultos con 60 años o más (n = 1.796) de la primera ronda de recogida de datos procedentes de la Encuesta sobre Salud, Bienestar y Envejecimiento (Proyecto SABE), realizado entre 2000 y 2010. Se usó una regresión lineal mixta de efectos repetidos para analizar cambios longitudinales en el IMC, y examinar si las características sociodemográficas, condiciones de salud y comportamientos sociales estuvieron asociados con estos cambios. La media del índice de masa corporal decreció después de los 70 años. Los hombres tenían un índice de masa corporal más bajo que las mujeres (β = -1,86, IC95%: -2,35; -1,37). Los adultos mayores que consumieron alcohol (β = 0,30, 95%CI: 0,06; 0,54), tenían más de una enfermedad crónica (β = 0,19, IC95%: 0,26; 0,72) y quienes no realizaban ninguna actividad física (β = 0,56, IC95%: 0,38; 0,74) tenían un mayor índice de masa corporal. Los individuos que fumaban (β = -0.40, IC95%: -0,76; -0,04) y quienes informaron de haber comido menos en los últimos meses (β = -0,48, IC95%: -0,71; -0,24) tenían un índice de masa corporal más bajo. En los brasileños más viejos, diversas características sociodemográficas, condiciones de salud, y comportamientos predicen el índice de masa corporal. La prevalencia ascendente de enfermedades crónicas, así como los crecientes comportamientos sedentarios en Brasil pueden tener efectos perjudiciales en el índice de peso corporal en las edades más avanzadas.

Factors associated with transitions between frailty states among older persons in Brazil, 2006-2010 / Fatores associados às transições nos estados de fragilidade entre idosos no Brasil, 2006-2010

Abstract Background Frailty is considered one of the major conditions faced by ageing societies. Little has been reported about the transitions between the different frailty states in developing countries. Objective This study aimed to identify the factors associated with transitions between frailty states between 2006 and 2010 among older adults in Brazil. Method The present investigation is part of the SABE study (Health, Well-being and Ageing). Frailty state was classified according to the Fried's criteria (nonfrail, prefrail, and frail). The final study sample was composed of 1,399 individuals representing 1,019,243 older adults in the city of Sao Paulo, Brazil. Multiple logistic regression was used to identify factors associated with changes in frailty states. Results Women were more likely to present a decline in frailty states. In the prefrail-to-nonfrail model, level of education was the most strongly associated factor. Advanced age and difficulty in performing at least one basic activity of daily living reduced in 9 and 64% the risk of becoming nonfrail, respectively. Conclusion Addressing the factors associated with transition between frailty states among older adults is essential. Adequate interventions are important to reduce vulnerability and improve the health and well-being of older persons.

Resumo Introdução A fragilidade é considerada uma das principais condições enfrentadas pelas sociedades que envelhecem. Poucos estudos têm explorado as transições entre os diferentes estados de fragilidade nos países em desenvolvimento. Objetivo Identificar os fatores associados às transições de estado de fragilidade dos idosos no Brasil no período entre 2006 e 2010. Método A presente investigação é parte do estudo SABE (Saúde, Bem-Estar e Envelhecimento). O estado de fragilidade foi classificado de acordo com os critérios da Fried (não frágil, pré-frágil e frágil). A amostra final era composta por 1.399 indivíduos que representam 1.019.243 idosos na cidade de São Paulo. Modelos de regressão logística binária múltiplo foram estimados para identificar os fatores associados às mudanças no estado de fragilidade. Resultados As mulheres eram mais propensas a declinar para o estado de fragilidade. No modelo de pré-frágil para não frágil, o nível de escolaridade foi o fator mais fortemente relacionado. Aumento na idade e dificuldade em pelo menos uma atividade básica de vida diária reduziram em 9% e 64% o risco de se tornar não frágil, respectivamente. Conclusão Abordar os fatores associados com as transições de estados de fragilidade entre idosos é essencial. Adequadas intervenções são importantes para reduzir vulnerabilidade e melhorar a saúde e bem-estar dos idosos.