Epidemiological profile, temporal analysis, and future projections of suicide cases in rural cities in the extreme south of Brazil.

The present study aimed to verify the time series (2000-2017) of death rates by suicide and its associated factors in 4 municipalities in the extreme south of Brazil. Data were obtained through the analysis of medical reports and police report bulletins at the Instituto Médico Legal, in the city of Rio Grande. The suicide rate in the Rio Grande region varied from 4 to 11 suicides per 100,000 inhabitants and it is estimated that by 2030 this rate could reach 16.5 suicides per 100,000 inhabitants. The rural cities of Santa Vitória do Palmar and Chuí present even higher suicide averages when compared to Rio Grande, the most populous city of the four. The death rate from suicide increased gradually in the period analyzed, with the prevalence rising among the youngest and the elderly population. A more comprehensive understanding of the influences of environmental issues on suicidal decisions constitutes an important action that needs to be taken, both because of regional vulnerabilities and the target population identified. Evidence indicates that knowledge of factors affecting individuals residing in this Brazilian region where increased suicide rates are recorded needs to be recognized as a priority.

Musculoskeletal pain during and after SARS-CoV-2 infection and healthcare utilization: a cross-sectional study.

BACKGROUND: The COVID-19 pandemic necessitated the reorganization of health services to cater to the needs of individuals affected by the virus. OBJECTIVE: This study aimed to examine the association between musculoskeletal pain during and after SARS-CoV-2 infection and the utilization of health services among adults in southern Brazil.  METHODS: A cross-sectional study was conducted with individuals aged 18 years and older, who were diagnosed with COVID-19 between December 2020 and March 2021. Questionnaires were electronically collected using tablets through the REDCap platform via phone calls. The health service utilization outcomes assessed included Primary Health Care, general practitioners, private emergency care, and specialized services. The exposure variable was the presence of musculoskeletal pain during and after SARS-CoV-2 infection in different regions, such as cervical, upper limbs, thoracic, lumbar, and lower limbs. Poisson regression analysis was employed to assess the relationship between health service utilization during and after SARS-CoV-2 infection and musculoskeletal pain during and after the infection with SARS-CoV-2 among adults in southern Brazil. Data were analyzed using the Stata 16.1 statistical package.  RESULTS: A total of 2,919 individuals were interviewed. Overall, individuals with musculoskeletal pain were found to utilize health services approximately 15 percentage points higher when compared to those without musculoskeletal pain. In adjusted analysis, individuals who reported musculoskeletal pain during and after SARS-CoV-2 infection were up to twice as likely to use health services. Among them, the emergency care unit was the most frequently used service, particularly in those with pain in the lower limbs (RP=2.19, 95% CI 1.66-2.87) and thoracic region (RP=2.04, 95% CI 1.47-2.84). Notably, the highest magnitudes of association were observed with emergency care units, specialist doctors, and specialized services, especially neurologists, who were two to three times more likely to be sought, followed by pulmonologists.  CONCLUSION: Health service utilization was significantly associated with musculoskeletal pain during and after SARS-CoV-2 infection. All regions, except for the cervical region, showed a correlation with the use of Primary Health Care. The thoracic region featured an association with pulmonologists and emergency room utilization. Additionally, health services like emergency care units, specialist doctors, and specialized services, including cardiologists and neurologists, were commonly utilized across all regions in southern Brazil.

Is Binge Drinking Associated With Specific Types of Exercise and Free Time Sports? A Pooled Analysis With 718,147 Adults.

OBJECTIVE: To verify the association between exercise and free time sport types and binge drinking in a large sample of adults. METHODS: Data of 718,147 adults from the "Surveillance of Risk and Protection Factors for Chronic Diseases by Telephone Survey" were used. We described the demographic and behavioral variables, and negative binomial regression analyzed the association between exercise and free time sport types and binge drinking adjusted by demographics variables, body mass index status, and television time. RESULTS: Outdoor walking/running was the most common exercise reported (20.0%, 95% confidence interval [CI], 19.8%-20.2%), followed by team sports (8.1%; 95% CI, 8.0%-8.2%) and strengthening (8.0%; 95% CI, 7.9%-8.1%). The prevalence of binge drinking for each exercise and free time sport type ranged from 6.9% (water aerobics) to 31.9% (team sports). Participants engaging in strengthening (prevalence ratio = 1.12; 95% CI, 1.04-1.21, P = .002) and team sports (prevalence ratio = 1.11; 95% CI, 1.07-1.17, P < .001) were more likely to binge drink more frequently in the past 30 days than inactive participants. CONCLUSIONS: It appears that the participants' profile plays an important role in the underlying social context of this association. Participants with more frequent strengthening and less frequent team sports practice, who were primarily younger and single, were more likely to binge drink frequently.

Physical activity during early life and the risk of all-cause mortality in midlife: findings from a birth cohort study.

BACKGROUND: The objective of this study was to examine the association between physical activity during childhood and adolescence and the risk of all-cause mortality in midlife. We analyzed data from a birth cohort (The 1958 National Child Development Survey), including births in England, Wales and Scotland. METHODS: Physical activity was assessed using questionnaires at ages 7, 11 and 16. Death certificates defined all-cause mortality. Cumulative exposure, sensitive and critical periods, and physical activity trajectory from childhood to adolescence were tested using multivariate Cox proportional hazard models. The sweep the death was confirmed was defined as the time event. RESULTS: From age 23 to 55, 8.9% of participants (n = 9398) died. Physical activity in childhood and adolescence affected the risk of all-cause mortality in midlife. In men, physical activity at ages 11 [hazard ratio (HR): 0.77; 95% confidence interval (CI): 0.60-0.98] and 16 (HR: 0.60; 95% CI: 0.46-0.78) was associated with reduced risk of all-cause mortality. In women, physical activity at age 16 (HR: 0.68; 95% CI: 0.48-0.95) was associated with reduced risk of all-cause mortality. Physical activity in adolescence eliminated the risk of all-cause mortality associated with physical inactivity in adulthood in women. CONCLUSIONS: Physical activity during childhood and adolescence was associated with reduced risk of all-cause mortality with different effects by sex.

Impact of hepatitis C virus eradication with direct-acting antivirals on glycidic metabolism

ABSTRACT Objective: To compare the glucose metabolism of patients with chronic hepatitis C virus infection treated with direct-acting antivirals (DAAs) in pretreatment and sustained viral response (SVR) periods. Materials and methods: This was an intervention pre-post study of 273 patients with chronic hepatitis C virus infection treated with DAAs from March 2018 to December 2019. Glycidic metabolism was evaluated through homeostasis model assessment (HOMA) - insulin resistance (IR) and HOMA-β indices and assessments of insulinemia and HbA1c levels. These parameters were analyzed with a T test by paired comparison of the means of the variables and Wilcoxon's test paired for the median; in the variables with an abnormal distribution, the Z score was generated for the mean in both the pretreatment and SVR periods. Statistical significance was considered at p ≤ 0.05. Results: Among 273 participants, 125 (45.8%) had prediabetes, and 50 (18.3%) had diabetes. In SVR, there was a significant increase in platelets, albumin, alkaline phosphatase, cholesterol and triglycerides and a significant decrease in aspartate aminotransferase, alanine aminotransferase, gamma GT and bilirubin. The HOMA-IR and HOMA-β indices increased in SVR from 1.95 to 2.29 (p = 0.087) and 71.20 to 82.60 (p = 0.001), respectively. Insulinemia increased from 7.60 μU/mL to 8.90 μU/mL (p = 0.011). HbA1c decreased from 5.6 to 5.4 (p < 0.001). Among patients with prediabetes and those with diabetes, the reduction in HbA1c values was significant (p = 0.006 and p = 0.026, respectively). Conclusion: SVR significantly impacts and leads to improvement in glucose metabolism in patients with chronic liver disease induced by hepatitis C virus.

Factors associated with sleep quality in university students. / Fatores associados à qualidade do sono de estudantes universitários.

To investigate factors associated with poor sleep quality. A cross-sectional study was conducted in 2019 with random sampling. Information on sleep was obtained using the Mini Sleep Questionnaire (MSQ). Independent variables included sociodemographic, behavioural, academic and psychological health characteristics. Adjusted analyzes were performed using Poisson regression. A total of 996 undergraduate students participated in the study. The poor sleep quality affected 23.1% of the sample (95%CI 20.5-25.9), ranging from 13.4% for those with little concern about violence in the neighbourhood to 36.5% for those with less social support. In the adjusted analysis, female sex [PR] 1.81; (95%CI 1.33-2.45), concern about violence in the neighbourhood [PR] 2.21; (95%CI 1.48-3.28), discrimination at university [PR] 1.42; (95%CI 1.08-1.86) and food insecurity [PR] 1.45; (95%CI 1.11-1.89) were associated with the presence of poor sleep quality, as well as having less social support and income and suffering psychological distress. The results highlight socioeconomic and mental health factors that affect sleep quality and demonstrate the need for reflection and interventions capable of minimizing this problem.

Investigar fatores associados a pior qualidade do sono. Estudo transversal realizado em 2019, com amostragem aleatória sistemática. Informações sobre sono foram obtidas através do Mini Sleep Questionaire (MSQ). Variáveis independentes incluíram características sociodemográficas, comportamentais, acadêmicas e de saúde psicológica. Análises ajustadas foram feitas com regressão de Poisson. Participaram 996 estudantes de graduação. A pior qualidade de sono atingiu 23,1% da amostra (IC95% 20,5-25,9), oscilando de 13,4% para os com pouca preocupação com violência no bairro a 36,5% para aqueles com menor suporte social. Na análise ajustada, sexo feminino [RP] 1,81; (IC95% 1,33-2,45), preocupação com violência no bairro [RP] 2,21; (IC95% 1,48-3,28), discriminação na universidade [RP] 1,42; (IC95% 1,08-1,86) e insegurança alimentar [RP] 1,45; (IC95% 1,11-1,89) associaram-se a presença de pior qualidade do sono, assim como ter menor suporte social e renda e apresentar sofrimento psicológico. Os resultados destacam fatores socioeconômicos e de saúde mental que interferem na qualidade do sono e demonstram a necessidade de reflexão e proposição de intervenções capazes de minimizar este problema.

[The experience of forced sexual intercourse among undergraduate students: associated factors and possible consequences]. / Experiência de relação sexual forçada entre estudantes de graduação: fatores associados e possíveis consequências.

The scope of this article is to investigate the prevalence of the experience of forced sexual intercourse on life and its possible consequences on mental and sexual health among undergraduate students at a public university in Brazil. It is a quantitative cross-sectional study with 996 undergraduate students. Sampling was carried out systematically by single-stage clusters. Descriptive, bivariate and multivariate analyses were performed using the Poisson Regression model, and the etiological fractions of the consequences of forced sexual intercourse were calculated. The lifetime prevalence of forced sexual intercourse was 12.1%. Female sex, non-heterosexual sexual orientation, first sexual intercourse before the age of 14, child food insecurity and domestic violence were associated with a higher prevalence of the outcome. Individuals who experienced forced sexual intercourse were more likely to be diagnosed with sexually transmitted infections and to represent a potential suicide risk. The study revealed the problems of sexual violence in the university context.

O objetivo deste artigo é investigar a prevalência de relação sexual forçada na vida e suas possíveis consequências na saúde mental e sexual em acadêmicos de cursos de graduação de uma universidade pública no Brasil. Estudo transversal quantitativo com 996 estudantes de graduação. A amostragem realizada de forma sistemática por conglomerados. Foi usado o modelo de Regressão de Poisson, e foram calculadas as frações etiológicas das consequências de relação sexual forçada. A prevalência de relação sexual forçada ao longo da vida foi de 12,1%. Sexo feminino, orientação sexual não heterossexual, primeira relação sexual antes de 14 anos de idade, insegurança alimentar e violência no contexto doméstico na infância foram associados à maior prevalência do desfecho. Indivíduos que sofreram relação sexual forçada foram mais propensos a apresentar diagnóstico de infecções sexualmente transmissíveis e de ter risco de suicídio. O estudo evidenciou a problemática da violência sexual no contexto universitário.

Experiência de relação sexual forçada entre estudantes de graduação: fatores associados e possíveis consequências / The experience of forced sexual intercourse among undergraduate students: associated factors and possible consequences

Resumo O objetivo deste artigo é investigar a prevalência de relação sexual forçada na vida e suas possíveis consequências na saúde mental e sexual em acadêmicos de cursos de graduação de uma universidade pública no Brasil. Estudo transversal quantitativo com 996 estudantes de graduação. A amostragem realizada de forma sistemática por conglomerados. Foi usado o modelo de Regressão de Poisson, e foram calculadas as frações etiológicas das consequências de relação sexual forçada. A prevalência de relação sexual forçada ao longo da vida foi de 12,1%. Sexo feminino, orientação sexual não heterossexual, primeira relação sexual antes de 14 anos de idade, insegurança alimentar e violência no contexto doméstico na infância foram associados à maior prevalência do desfecho. Indivíduos que sofreram relação sexual forçada foram mais propensos a apresentar diagnóstico de infecções sexualmente transmissíveis e de ter risco de suicídio. O estudo evidenciou a problemática da violência sexual no contexto universitário.

Abstract The scope of this article is to investigate the prevalence of the experience of forced sexual intercourse on life and its possible consequences on mental and sexual health among undergraduate students at a public university in Brazil. It is a quantitative cross-sectional study with 996 undergraduate students. Sampling was carried out systematically by single-stage clusters. Descriptive, bivariate and multivariate analyses were performed using the Poisson Regression model, and the etiological fractions of the consequences of forced sexual intercourse were calculated. The lifetime prevalence of forced sexual intercourse was 12.1%. Female sex, non-heterosexual sexual orientation, first sexual intercourse before the age of 14, child food insecurity and domestic violence were associated with a higher prevalence of the outcome. Individuals who experienced forced sexual intercourse were more likely to be diagnosed with sexually transmitted infections and to represent a potential suicide risk. The study revealed the problems of sexual violence in the university context.

Fatores associados à qualidade do sono de estudantes universitários / Factors associated with sleep quality in university students

Resumo Investigar fatores associados a pior qualidade do sono. Estudo transversal realizado em 2019, com amostragem aleatória sistemática. Informações sobre sono foram obtidas através do Mini Sleep Questionaire (MSQ). Variáveis independentes incluíram características sociodemográficas, comportamentais, acadêmicas e de saúde psicológica. Análises ajustadas foram feitas com regressão de Poisson. Participaram 996 estudantes de graduação. A pior qualidade de sono atingiu 23,1% da amostra (IC95% 20,5-25,9), oscilando de 13,4% para os com pouca preocupação com violência no bairro a 36,5% para aqueles com menor suporte social. Na análise ajustada, sexo feminino [RP] 1,81; (IC95% 1,33-2,45), preocupação com violência no bairro [RP] 2,21; (IC95% 1,48-3,28), discriminação na universidade [RP] 1,42; (IC95% 1,08-1,86) e insegurança alimentar [RP] 1,45; (IC95% 1,11-1,89) associaram-se a presença de pior qualidade do sono, assim como ter menor suporte social e renda e apresentar sofrimento psicológico. Os resultados destacam fatores socioeconômicos e de saúde mental que interferem na qualidade do sono e demonstram a necessidade de reflexão e proposição de intervenções capazes de minimizar este problema.

Abstract To investigate factors associated with poor sleep quality. A cross-sectional study was conducted in 2019 with random sampling. Information on sleep was obtained using the Mini Sleep Questionnaire (MSQ). Independent variables included sociodemographic, behavioural, academic and psychological health characteristics. Adjusted analyzes were performed using Poisson regression. A total of 996 undergraduate students participated in the study. The poor sleep quality affected 23.1% of the sample (95%CI 20.5-25.9), ranging from 13.4% for those with little concern about violence in the neighbourhood to 36.5% for those with less social support. In the adjusted analysis, female sex [PR] 1.81; (95%CI 1.33-2.45), concern about violence in the neighbourhood [PR] 2.21; (95%CI 1.48-3.28), discrimination at university [PR] 1.42; (95%CI 1.08-1.86) and food insecurity [PR] 1.45; (95%CI 1.11-1.89) were associated with the presence of poor sleep quality, as well as having less social support and income and suffering psychological distress. The results highlight socioeconomic and mental health factors that affect sleep quality and demonstrate the need for reflection and interventions capable of minimizing this problem.

Remote work and back pain during the COVID-19 pandemic in adults and older population in South Brazil.

This article aims to investigate the association between remote work and Back Pain during the COVID-19 pandemic, and to analyze this relationship according to the body mass index. Population-based, cross-sectional study carried in two cities in southern Brazil, in individuals aged 18 years and over. Data were collected through household interviews from October to January 2020/21. Outcomes: back pain (cervical, thoracic, lumbar/acute, chronic) and pain intensity. Exposure variable: remote work. For the analyses, Poisson regression with robust adjustment for variance was used, stratified by BMI (eutrophic vs overweight/obese), and restricted to those who had worked in the past month. 1,016 had worked during the pandemic, average 42 years old (SD = 14), varying from 18 to 93 years. Remote work was performed by 7.7% of the individuals. Prevalence of back pain: 25.6% (95%CI: 19.5 to 31.7%). Overweight/obese remote workers felt pain acute cervical pain PR = 2.82 (95%CI: 1.15 to 6.92); chronic low back PR = 1.85 (95%CI: 1.04 to 3.29); acute thoracic PR = 1.81(95%CI: 3.76 to 8.68) compared to those who did not work. About one in four remote workers reported back pain during of the COVID-19 pandemic. BMI proved to be an important moderator between outcomes and exposure variable.

Remote work and back pain during the COVID-19 pandemic in adults and older population in South Brazil / Trabalho remoto e dores nas costas durante a pandemia da COVID-19 em adultos e idosos no Sul do Brasil

Abstract This article aims to investigate the association between remote work and Back Pain during the COVID-19 pandemic, and to analyze this relationship according to the body mass index. Population-based, cross-sectional study carried in two cities in southern Brazil, in individuals aged 18 years and over. Data were collected through household interviews from October to January 2020/21. Outcomes: back pain (cervical, thoracic, lumbar/acute, chronic) and pain intensity. Exposure variable: remote work. For the analyses, Poisson regression with robust adjustment for variance was used, stratified by BMI (eutrophic vs overweight/obese), and restricted to those who had worked in the past month. 1,016 had worked during the pandemic, average 42 years old (SD = 14), varying from 18 to 93 years. Remote work was performed by 7.7% of the individuals. Prevalence of back pain: 25.6% (95%CI: 19.5 to 31.7%). Overweight/obese remote workers felt pain acute cervical pain PR = 2.82 (95%CI: 1.15 to 6.92); chronic low back PR = 1.85 (95%CI: 1.04 to 3.29); acute thoracic PR = 1.81(95%CI: 3.76 to 8.68) compared to those who did not work. About one in four remote workers reported back pain during of the COVID-19 pandemic. BMI proved to be an important moderator between outcomes and exposure variable.

Resumo O objetivo deste artigo é investigar a associação entre trabalho remoto e dores nas costas durante a pandemia da COVID-19 e analisar essa relação segundo o índice de massa corporal. Estudo transversal de base populacional realizado em duas cidades no sul do Brasil em indivíduos acima de 18 anos. Dados foram coletados por meio de entrevistas domiciliares entre outubro-janeiro de 2020-2021. Desfechos: dor nas costas (cervical, torácica, lombar/aguda, crônica) e intensidade da dor. Variável de exposição: trabalho remoto. Para as análises, foram utilizadas regressão de Poisson com ajuste robusto para variância, estratificadas pelo IMC (eutrófico vs. sobrepeso/obeso) e restritas àqueles que trabalharam no último mês. Durante a pandemia, 1.016 trabalharam, média 42 anos (DP = 14), entre 18 a 93 anos. Trabalho remoto foi realizado por 7,7% dos indivíduos. Prevalência de dor nas costas: 25.6% (IC95%:19,5 a 31,7%). Trabalhadores remotos com sobrepeso/obesidade sentiram dor aguda cervical RP = 2,82 (IC95%:1,15 a 6,92); torácica aguda RP = 1,81 (IC95%:3,76 a 8,68); lombar crônica RP = 1,85 (IC95%:1,04 a 3,29), comparados àqueles que não trabalharam. Cerca de um em cada quatro trabalhadores remotos reportou dor nas costas durante a pandemia. O IMC mostrou-se ser um importante moderador entre defechos e variável de exposição.

Estresse percebido entre estudantes de graduação: fatores associados, a influência do modelo ENEM/SiSU e possíveis consequências sobre a saúde / Perceived stress among undergraduate students: associated factors, influence of the ENEM/SiSU model, and its possible consequences on health

RESUMO Objetivo: Medir os níveis de estresse percebido, os fatores associados, em especial o impacto da escolha e satisfação com o curso, bem como as possíveis consequências desse desfecho entre graduandos. Métodos: Estudo transversal conduzido em 2019 com 996 estudantes de graduação de uma universidade pública no Sul do Brasil. A amostragem foi realizada de forma sistemática por conglomerados em único estágio. O desfecho foi avaliado por meio da Escala de Estresse Percebido. As análises de fatores associados e possíveis consequências foram realizadas por meio de regressão linear múltipla e regressão de Poisson, respectivamente. Resultados: O escore médio de estresse percebido foi de 31,1 (DP = 9). Indivíduos do sexo feminino, de orientação sexual não heterossexual, mais pobres, com insegurança alimentar, com medo de violência no bairro, com percepção de difícil acesso a serviço psicológico e com menor suporte social foram os mais estressados. Participantes mais velhos e com algum nível de atividade física foram menos estressados. A insatisfação com o curso atual, e não o fato de ser o curso desejado no ingresso, foi associada ao estresse. Uso não médico de remédio prescrito, ansiedade generalizada, sintomas depressivos e pior qualidade de sono e de vida foram identificados como possíveis consequências do estresse. Conclusões: O modelo ENEM/SiSU parece não exercer efeito no estresse. Além disso, esse desfecho foi mais elevado entre indivíduos mais vulneráveis, tendo contribuído para diversos desfechos negativos em saúde mental. Recomenda-se o fortalecimento de serviços de assistência estudantil para que esses casos sejam identificados e manejados.

ABSTRACT Objective: To measure levels of perceived stress, associated factors, especially the impact of choice and satisfaction with the course, as well as the possible consequences of this outcome among undergraduates. Methods: Cross-sectional study conducted in 2019 with 996 undergraduate students from a public university in southern Brazil. Sampling was carried out systematically by single-stage clusters. The outcome was assessed using the Perceived Stress Scale. Analysis of associated factors and possible consequences were performed using multiple linear regression and Poisson regression, respectively. Results: Mean perceived stress score was 31.1 (SD = 9). Female individuals, with non-heterosexual orientation, poorer, with food insecurity, with fear of violence in the neighborhood, with perception of difficult access to psychological services and with less social support were the most stressed. Older participants with some level of physical activity were less stressed. Dissatisfaction with the current course, rather than the fact that it was the desired course prior admission, was associated with high levels of stress. Non-medical use of prescribed medication, generalized anxiety, depressive symptoms, and poorer quality of sleep and life were identified as possible consequences of stress. Conclusions: The ENEM/SiSU model seems to have no effect on stress. Furthermore, this outcome was higher among more vulnerable individuals, having contributed to several negative outcomes in mental health. It is recommended to strengthen student assistance services so that these cases can be identified and managed.

A Study on the Health and Wellness of Undergraduate Students (SABES-Grad): methodological aspects of a nationwide multicenter and multilevel study overlapping with the Covid-19 pandemic.

INTRODUCTION: The academic environment can negatively impact the mental health of undergraduate students, particularly in the context of the coronavirus disease 2019 (Covid-19) pandemic. This study aimed to describe the methodological and operational aspects of a study of the health and well-being of undergraduate students: the Study on the Health and Wellness of Undergraduate Students (SABES-Grad) project. METHOD: This was a nationwide cross-sectional study divided across two data collection strategies: a single-center, on-site data collection carried out in 2019 at the Universidade Federal do Rio Grande (FURG) and a multicenter, multilevel, online data collection carried out in 2020/2021 at FURG, the Universidade Federal Fluminense (UFF), the Universidade Federal do Mato Grosso (UFMT), the Universidade do Estado do Amazonas (UEA), and the Universidade Federal Rural de Pernambuco (UFRPE). The main outcomes of interest were depressive symptoms, generalized anxiety, and suicide risk. RESULTS: A total of 996 students participated in the 2019 data collection (63.8% female; median age of 22 years; response rate of 85.2%) and 5,720 students participated in the 2020/2021 collection (66.7% female; median age of 22 years; response rate of 84.3%). Significant variations in socioeconomic and demographic profiles were observed between the different universities. Approximately one-third of the sample had been tested for Covid-19 in 2020/2021, 7.8% of whom had tested positive. CONCLUSION: The SABES-Grad project was the result of collaborative work between several actors from public universities in Brazil. Several aspects of the preparation and execution of this research are discussed in terms of its originality and relevance. Barriers and limitations and strategies adopted to overcome them are also presented.

Internet addiction and depressive symptoms: a dose-response effect mediated by levels of physical activity.

INTRODUCTION: There are several negative impacts on the physical and mental health of people presenting internet addiction, including development of mood disorders, such as depression. OBJECTIVE: The aim of the study was to evaluate the association between internet addiction and depressive symptoms, as well as to test the mediating role of physical activity in this association. METHODS: A cross-sectional study was conducted with undergraduate students from three universities (one private and two public institutions) in southern Brazil. Depressive symptoms were measured with the Beck Depression Inventory (BDI-21), internet addiction with the Internet Addiction Test (IAT-20), and physical activity with the International Physical Activity Questionnaire (IPAQ - short version). Poisson regression and the Karlson-Holm-Breen mediation method were used for statistical analyses. RESULTS: We observed a dose-response relationship between internet addiction and depressive symptoms. Levels of physical activity mediated the association between moderate internet addiction and depressive symptoms, accounting for 10.7% of the effect observed. CONCLUSION: Internet addiction can be detrimental to individuals' health, contributing to development of depressive symptoms. Along with psychological and pharmacological therapies, prescription of physical activities is recommended.

Suicide risk among undergraduate students in Brazil in the periods before and during the COVID-19 pandemic: results of the SABES-Grad national survey.

BACKGROUND: Undergraduate students present high rates of psychological distress, including suicide risk. Due to the coronavirus disease 2019 (COVID-19) pandemic, this scenario may have been aggravated. Thus, the objective of the current study was to evaluate changes in the suicide risk rate from the period before to during the COVID-19 pandemic, as well as the factors associated with this outcome among Brazilian undergraduate students. METHODS: This was a nationwide survey carried out in Brazil with a cross-sectional design, including two data collection periods: a single-center in-person collection in 2019 and another multicenter online collection in 2020/2021. Data were collected using self-administered instruments. The outcome was a high risk of suicide, measured through the Mini International Neuropsychiatric Interview. Analyses were carried out on data from two periods, i.e. before and during the pandemic (bivariate analysis and interaction tests), and a model of associated factors (multivariate analysis using Poisson regression) was developed including all participating universities distributed in the five regions of Brazil. RESULTS: In total, 6716 Brazilian undergraduate students participated (996 in 2019 and 5720 in 2020/2021). The prevalence of a high suicide risk rose from 11.3% to 17.0%, especially among women and poorer individuals. The prevalence of a high risk of suicide among Brazilian undergraduates was 19.6% and was associated with several socioeconomic, academic, pandemic, and mental health factors. CONCLUSIONS: The prevalence of a high suicide risk increased from prepandemic to during the pandemic, appearing to be largely influenced by social determinants, in conjunction with the implications of the COVID-19 pandemic.

Impact of hepatitis C virus eradication with direct-acting antivirals on glycidic metabolism.

Objective: To compare the glucose metabolism of patients with chronic hepatitis C virus infection treated with direct-acting antivirals (DAAs) in pretreatment and sustained viral response (SVR) periods. Materials and methods: This was an intervention pre-post study of 273 patients with chronic hepatitis C virus infection treated with DAAs from March 2018 to December 2019. Glycidic metabolism was evaluated through homeostasis model assessment (HOMA) - insulin resistance (IR) and HOMA-ß indices and assessments of insulinemia and HbA1c levels. These parameters were analyzed with a T test by paired comparison of the means of the variables and Wilcoxon's test paired for the median; in the variables with an abnormal distribution, the Z score was generated for the mean in both the pretreatment and SVR periods. Statistical significance was considered at p ≤ 0.05. Results: Among 273 participants, 125 (45.8%) had prediabetes, and 50 (18.3%) had diabetes. In SVR, there was a significant increase in platelets, albumin, alkaline phosphatase, cholesterol and triglycerides and a significant decrease in aspartate aminotransferase, alanine aminotransferase, gamma GT and bilirubin. The HOMA-IR and HOMA-ß indices increased in SVR from 1.95 to 2.29 (p = 0.087) and 71.20 to 82.60 (p = 0.001), respectively. Insulinemia increased from 7.60 µU/mL to 8.90 µU/mL (p = 0.011). HbA1c decreased from 5.6 to 5.4 (p < 0.001). Among patients with prediabetes and those with diabetes, the reduction in HbA1c values was significant (p = 0.006 and p = 0.026, respectively). Conclusion: SVR significantly impacts and leads to improvement in glucose metabolism in patients with chronic liver disease induced by hepatitis C virus.

Internet addiction and depressive symptoms: a dose-response effect mediated by levels of physical activity

Abstract Introduction There are several negative impacts on the physical and mental health of people presenting internet addiction, including development of mood disorders, such as depression. Objective The aim of the study was to evaluate the association between internet addiction and depressive symptoms, as well as to test the mediating role of physical activity in this association. Methods A cross-sectional study was conducted with undergraduate students from three universities (one private and two public institutions) in southern Brazil. Depressive symptoms were measured with the Beck Depression Inventory (BDI-21), internet addiction with the Internet Addiction Test (IAT-20), and physical activity with the International Physical Activity Questionnaire (IPAQ - short version). Poisson regression and the Karlson-Holm-Breen mediation method were used for statistical analyses. Results We observed a dose-response relationship between internet addiction and depressive symptoms. Levels of physical activity mediated the association between moderate internet addiction and depressive symptoms, accounting for 10.7% of the effect observed. Conclusion Internet addiction can be detrimental to individuals' health, contributing to development of depressive symptoms. Along with psychological and pharmacological therapies, prescription of physical activities is recommended.

Determinantes sociais da qualidade de vida entre estudantes de graduação e sua associação com o risco de suicídio / Social determinants of quality of life among undergraduate students and their association with suicide risk

Objetivo: avaliar a qualidade de vida e a relação com o risco de suicídio. Métodos: estudo transversal com graduandos de uma universidade pública do Brasil. A qualidade de vida foi mensurada pelo WHOQOL-Bref. Um modelo hierarquizado foi testado através de regressão linear simples. A associação da qualidade de vida com risco de suicídio foi avaliada pela Regressão de Poisson. Resultados: participaram 996 estudantes com escore médio de qualidade de vida de 61,0±13,8. Sexo feminino, cor da pele não branca, orientação sexual não heterossexual, mais pobres, com insegurança alimentar, que utilizam transporte público, com medo de violência no bairro, histórico de discriminação e insatisfeitos com o curso de graduação tiveram pior qualidade de vida, que levou à probabilidade 11 vezes maior de risco de suicídio. Conclusão: o nível de qualidade de vida da amostra estudada foi baixo, estando associado a maior vulnerabilidade socioeconômica, o que contribui para o aumento no risco de suicídio. Sugere-se o fortalecimento dos serviços de assistência estudantil das universidades como forma de promover maior qualidade de vida por meio de ações de promoção de bem-estar social, o que poderá produzir efeitos na saúde mental dos estudantes

Objective: to evaluate the quality of life and the relationship with the risk of suicide. Methods: crosssectional study with undergraduates from a public university in Brazil. Quality of life was measured by the WHOQOL-Bref. A hierarchical model was tested using simple linear regression. The association of quality of life with suicide risk was assessed by Poisson regression. Results: 996 students participated with an average quality of life score of 61.0±13.8. Female gender, non-white, non-heterosexual sexual orientation, poorer, food insecure, using public transport, fear of violence in the neighborhood, history of discrimination and dissatisfied with the undergraduate course had a worse quality of life, which led to an 11-fold increased likelihood of suicide risk. Conclusion: the level of quality of life of the sample studied was low, being associated with greater socioeconomic vulnerability, which contributes to the increased risk of suicide. It is suggested to strengthen student assistance servi-ces at universities to promote improvements in quality of life through actions to promote social wellbeing, which may have effects on students' mental health

A Study on the Health and Wellness of Undergraduate Students (SABES-Grad): methodological aspects of a nationwide multicenter and multilevel study overlapping with the Covid-19 pandemic

Abstract Introduction The academic environment can negatively impact the mental health of undergraduate students, particularly in the context of the coronavirus disease 2019 (Covid-19) pandemic. This study aimed to describe the methodological and operational aspects of a study of the health and well-being of undergraduate students: the Study on the Health and Wellness of Undergraduate Students (SABES-Grad) project. Method This was a nationwide cross-sectional study divided across two data collection strategies: a single-center, on-site data collection carried out in 2019 at the Universidade Federal do Rio Grande (FURG) and a multicenter, multilevel, online data collection carried out in 2020/2021 at FURG, the Universidade Federal Fluminense (UFF), the Universidade Federal do Mato Grosso (UFMT), the Universidade do Estado do Amazonas (UEA), and the Universidade Federal Rural de Pernambuco (UFRPE). The main outcomes of interest were depressive symptoms, generalized anxiety, and suicide risk. Results A total of 996 students participated in the 2019 data collection (63.8% female; median age of 22 years; response rate of 85.2%) and 5,720 students participated in the 2020/2021 collection (66.7% female; median age of 22 years; response rate of 84.3%). Significant variations in socioeconomic and demographic profiles were observed between the different universities. Approximately one-third of the sample had been tested for Covid-19 in 2020/2021, 7.8% of whom had tested positive. Conclusion The SABES-Grad project was the result of collaborative work between several actors from public universities in Brazil. Several aspects of the preparation and execution of this research are discussed in terms of its originality and relevance. Barriers and limitations and strategies adopted to overcome them are also presented.