ABSTRACT
OBJECTIVES: To evaluate neuromuscular signs and symptoms in patients with newly diagnosed hypothyroidism and hyperthyroidism. METHODS: A prospective cohort study was performed in adult patients with newly diagnosed thyroid dysfunction. Patients were evaluated clinically with hand held dynamometry and with electrodiagnosis. The clinical features of weakness and sensory signs and the biochemical data were evaluated during treatment. RESULTS: In hypothyroid patients 79% had neuromuscular complaints, 38% had clinical weakness (manual muscle strength testing) in one or more muscle groups, 42% had signs of sensorimotor axonal neuropathy, and 29% had carpal tunnel syndrome. Serum creatine kinase did not correlate with weakness. After 1 year of treatment 13% of the patients still had weakness. In hyperthyroid patients 67% had neuromuscular symptoms, 62% had clinical weakness in at least one muscle group that correlated with FT4 concentrations, but not with serum CK. Nineteen per cent of the patients had sensory-motor axonal neuropathy and 0% had carpal tunnel syndrome. The neuromuscular signs developed rapidly, early in the course of the disorder and were severe, but resolved rapidly and completely during treatment (average time 3.6 months). CONCLUSIONS: Neuromuscular symptoms and signs were present in most patients. About 40% of the hypothyroid patients and 20% of the hyperthyroid patients had predominantly sensory signs of a sensorimotor axonal neuropathy early in the course of thyroid disease. Weakness in hyperthyroidism evolved rapidly at an early stage of the disorder and resolved completely during treatment, suggesting a functional muscle disorder. Hand held dynamometry is sensitive for the detection of weakness and for the clinical evaluation of treatment effects. Weakness in hypothyroidism is more difficult to treat, suggesting myopathy.
Subject(s)
Hyperthyroidism/diagnosis , Hypothyroidism/diagnosis , Neuromuscular Diseases/diagnosis , Adult , Aged , Aged, 80 and over , Carpal Tunnel Syndrome/diagnosis , Carpal Tunnel Syndrome/physiopathology , Cohort Studies , Diagnosis, Differential , Electromyography , Female , Humans , Hyperthyroidism/physiopathology , Hypothyroidism/physiopathology , Male , Middle Aged , Muscle Weakness/diagnosis , Muscle Weakness/physiopathology , Neural Conduction/physiology , Neurologic Examination , Neuromuscular Diseases/physiopathology , Neuromuscular Junction/physiopathology , Prospective Studies , Thyroid Function TestsSubject(s)
Leukodystrophy, Globoid Cell/diagnosis , Adult , Diagnostic Errors , Humans , Middle AgedABSTRACT
A 36-year-old man with a history of migraine without aura, presented with recurrent bouts of severe headache, perception of flashing lights in both visual fields, and transient bilateral neurological deficits. In view of his history, migraine with aura was considered. Ancillary investigations showed bilateral extracranial internal carotid artery dissection. This case illustrates that when attacks of severe headache with scotomata and transient bilateral neurological deficits occur in a patient with a history of migraine, the diagnosis of carotid artery dissection should be considered, especially when the pattern of headache is different or when some clinical characteristics have not been experienced previously.
Subject(s)
Carotid Artery Diseases/diagnosis , Migraine Disorders/diagnosis , Adult , Carotid Artery Diseases/physiopathology , Carotid Artery, Internal , Diagnosis, Differential , Humans , MaleABSTRACT
Anaesthesia with ether or a mixture of fentanyl and fluanisone diminished the clearance of infused spermidine from plasma in WAG/Rij rats considerably. The renal excretion of infused spermidine in unanaesthetized animals was only very small. The diminished plasma clearance of infused spermidine in anaesthetized animals therefore cannot be explained by loss of renal excretion.
