A SIMULATION MODEL OF THE OPEN PENETRATING SPINAL CORD TRAUMA WITH DURABLE PERSISTENCE OF BIOCOMPATIBLE FOREIGN BODY OF THE VERTEBRAL COLUMN CHANNELL. SYNDROME OF POSTTRAUMATIC SPASTICITY.

Dynamics of the posttraumatic spasticity syndrome, a key component of spinal trauma, was investigated on simulation model of the open penetrating spinal cord (SC) trauma on adult male rats of aWistarline after half transection of the SC cross'section with its durable compression by biocompatible foreign body. Squeezing of the injured SC by foreign body potentiates formation of spasticity syndrome, and do not influence or restricts a severe pain syndrome occurrence. Reduction of the SC squeezing due to the foreign body elongation and reduction of its volume was accompanied by trustwor' thy rising of functional activity and the spasticity reduction in paretic extremity. Changes in activity of efferent chain of the movement system while formation of spasticity syn' drome in simulated trauma have occurred in both parts of SC ' in the injured one and in intact one as well, its severity did not correlate with presence of foreign body in zone of trauma.

[[Durable persistence of a biocompatible foreign body in a vertebral channel in open penetrating trauma of a spinal cord: clinico-experimental and pathomorphological peculiarities].]

Simulation model of open penetrating wound of a spinal cord (SC) with its durable com- pression by biocompatible foreign body, was tasted. Experimental animals - mature male rats (inbred line, descendent from a Wistar breed); the trauma simulation model - a left- sided transsection of the SC half on the Txi level; experimental groups: the main (a SC trau- ma + homotopic implantation of microporous hydrogel fragment - foreign body [n=10]), groups of comparison (the SC trauma [n=16]; the SC trauma + homotopic implantation of chemically identical analogue of hydrogel - NeuroGelTM [n=20]). A SC compression by a foreign body worsens the regeneration process course essentially: during first 2 mo the function index of a hind ipsilateral extremity in experimental animals of the main group was the lowest in the experiment - (1.30 ? 0.94) points in accordance to BBB scale, during 3 - 4 mo - the function index had enhanced trustworthy - up to (2.35 ? 0.95) points in accor- dance to BBB scale, what is connected with lowering of a local pressure on a SC tissue due to change of the foreign body form and volume. In 24 weeks the function index of hind ipsi- lateral extremity had constituted (8.45 ? 0.92) points - while application of NeuroGeTM and (2.35 ? 0.95) points - of the foreign body; the tissue processes in the implants localization zone had differed essentially. The tasted simulation model reproduces satisfactory a mechanical component of the foreign body impact on a SC tissue. The SC compression reduction, even in a late follow-up period, had improved the conditions and results of recenerative process essentially.