[Investigation of relation between LPO, AOD and some immune parameters in patients with chronic kidney disease].

Time course of lipid peroxidation and the state of antioxidant system of patients with chronic kidney disease were studied. Increases of conjugated dienes, malonic dialdehyde, lipid peroxidation degree were found. Alterations in ceruloplasmin activity, observed in blood of patients depended on the stage of the disease. Content of lipid peroxidation products was also dissimilar during the first and the second stage of disease. Estimation of ceruloplasmin activity and content of conjugated dienes were the most suitable parameters for monitoring treatment of chronic renal disease.

Determination of the quadratic slope parameter in eta-->3pi(0) decay.

We have determined the quadratic slope parameter alpha for eta-->3pi(0) to be alpha = -0.031(4) from a 99% pure sample of 10(6)eta-->3pi(0) decays produced in the reaction pi(-)p-->n(eta) close to the eta threshold using the Crystal Ball detector at the AGS. The result is four times more precise than the present world data and disagrees with current chiral perturbation theory calculations by about four standard deviations.

[Microbiology of suppurative wound in laser radiation]. / Mikrobiologicheskaia kharakteristika gnoinoi rany pri lazernom obluchenii.

Comparative quantitative and qualitative appraisal of purulent lesions of the soft tissues in surgical patients treated with the infrared lasers "Uzor" (pulse) and "Skalyar (continuous) and by the traditional methods (antibiotics, antiseptics, ointments) was conducted under clinical conditions. Abscesses, mastitis, and phlegmons were studied before and after the operation and on the 3rd, 6th, and 12th postoperative day. It was found that Staphylococcus aureus in a monoculture was the etiological cause of purulent infection in 75.2% of cases. The bactericidal effect of pulse and continuous infrared irradiation led to a decrease in the number of infected patients and more rapid cleansing of the wound. In treatment with Skalyar the focus of affection was cleaned completely by the 6th day. Qualitative improvement of the cultural, biochemical, and lysogenic properties and antibiotic sensitivity of the staphylococcus isolated from patients in dynamics during irradiation did not occur.

[The effect of starvation of lipid peroxidation in synaptosomal and mitochondrial factions of various brain structures]. / Vliianie golodaniia na lipoperoksidatsiiu v sinaptosomal'noi i mitokhondrial'noi fraktsiiakh raznykh struktur mozga.

Content of lipid hydroperoxides (LHP) and malonic dialdehyde (MDA) was measured in homogenates of rat brain cortex (limbic, sensomotor and orbital cortex) and subcortex brain structures (hypothalamus, medulla oblongata, and midbrain) and in their synaptosomal and mitochondrial fractions within various periods of starvation 1, 2, 3, 5 and 7 days. Lipid peroxidation was shown to intensify distinctly in the brain regions studied especially in the sensomotor cortex only after relatively long-term starvation during 5-7 days. The rate of lipid peroxidation was considerably higher in mitochondrial fractions of these brain structures studied than in the synaptosomes; high contents of LHP and MDA was found in mitochondria. Activation of lipid peroxidation appears to be distinctly responsible for impairment of the structure and functional components of nervous cells occurring during long-term starvation.

[Laser radiation in the infrared range in the treatment of aseptic postoperative wounds]. / Lazernoe izluchenie infrakrasnogo diapazona v lechenii asepticheskikh posleoperatsionnykh ran.

An analysis of results of treatment of 85 patients subjected to planned operations for calculous cholecystitis and inguinal hernias with the application of high-energy CO2 and YAG laser, surgical scalpel was performed. For local treatment of the aseptic wounds radiation of semiconduction arsenide gallium laser "Uzor" was used. Results of the investigation suggest that laser infrared radiation promotes rapid liquidation of acute inflammatory symptoms, quicker healing and smooth course of the postoperative period. The method is recommended for wide introduction into clinical practice.

[Increasing the scar strength after preventive skin irradiation with low-intensity laser]. / Povyshenie prochnosti rubtsa pri preventivnom obluchenii kozhi nizkointensivnym lazerom.

In the experiment on 218 white rats, it was established that preliminary influencing upon the site of a future incision with the infrared laser radiation in constant regime within the range of from 1 to 150 mW (dosage of radiation per 1 field of 0.06-9.3 J/cm2) facilitated pronounced stimulation of the processes of collagen formation and significant increase in strength of a forming scar. In increasing the power of radiation, the reparative processes in a wound are slowed and disturbed; in power of 250 mW, a wound heals by second intention, in average, after (32.6 +/- 3.2) days.

[Electromyography in the evaluation of the functional state of the internal neuromuscular apparatus of the larynx in myasthenia]. / Elektromiografiia v otsenke funktsional'nogo sostoianiia vnutrennego nervno-myshechnogo apparata gortani pri miastenii.

Using needle transcutaneous electromyography of internal laryngeal muscles and kalymin tests, 40 patients with myasthenia of different forms were examined. It was found that patients with generalized and local pharyngeal-facial forms of the disease developed latent generalization of myasthenic injury. Characteristic changes can be used to determine the degree of disorders in the internal nervous-muscular apparatus of the larynx.

[Prolonged local enzyme therapy of suppurative wounds]. / Mestnaia prolongirovannaia énzimoterapiia gnoinykh ran.

The article analyses the results of treatment of 150 patients with purulent diseases of the soft tissues of various localization, in which after surgical treatment the purulent focus immobilized trypsin (50 patients), trypsin with lysozyme immobilized on gauze (50 patients), and antiseptics (50 patients) were used for topical treatment of the formed wounds. The results of the treatment showed that topical prolonged enzyme therapy of purulent wounds with the use of trypsin immobilized on gauze and that with lysozyme promotes cleansing of the wounds, reduces microbial dissemination, intensifies reparative processes, and reduces the terms of treatment.

[Use of laser-enzyme therapy in preparing purulent wounds for early plastic closure]. / Primenenie lazeroénzimoterapii pri podgotovke gnoinykh ran k rannemu plasticheskomu zakrytiiu.

The results of treatment of 370 patients with purulent soft tissue diseases have shown that laseroenzymotherapy of the suppurating wounds contributed to their rapid cleaning, maintenance of microbial colonization at a stable low level, activation of reparative processes. This permitted to prepare a wound surface for closure at the nearest days after the operation.

[Co2 laser treatment of epithelial passages and cysts of the coccyx]. / Lechenie épitelial'nykh khodov i kist kopchika s primeneniem Co2-lazera.

The article analyses treatment of 312 patients among which 156 were treated with the use of a CO2 laser and 156 by the traditional method. Study of the results showed that with the use of the CO2 laser the duration of in-patient treatment after radical operation was reduced by 5 days and out-patient rehabilitation by 13 days. the number of postoperative complications reduced considerably, single-stage radical operation could be carried out in the acute period of the disease, an operation for excision of a suppurating cyst could be completed by applying primary sutures with complete closure of the wound in 71.7% of cases, and that a recurrence of the disease could be prevented. Wide introduction of CO2 laser in surgical treatment of epithelial passages and cysts of the coccyx is recommended.

[Effect of polyene antibiotics on the activity of prostaglandin metabolism enzymes in various layers of the kidney in young rats]. / Vliianie polienovykh antibiotikov na aktivnost' fermentov metabolizma prostaglandinov v raznykh sloiakh pochek molodykh krys.

Effect of polyenic antibiotics amphotericin B, levorin, nystatin on activity of prostaglandin metabolizing enzymes was studied in cortex, medullar and papillary layers of young rat kidneys. Amphotericin B was shown to exhibit the maximal effect on the enzymatic activity. Distinct "impairing" action of the antibiotics, especially of amphotericin B, was found in medullar and papillary layers of kidney at the end of the experiment carried out within 8 days.

[Effect of antioxidants on the synthesis of prostaglandins, prostacyclin and thromboxane in different layers of the kidneys of old rats]. / Vliianie antioksidantov na sintez prostaglandinov, prostatsiklina i tromboksana v raznykh sloiakh pochek starykh krys.

The effects of L-tocopherol and synthetic antioxidants on synthesis of prostaglandins, thromboxane B2 and prostacyclin in different layers of the kidney against the background of chronic administration of polyene antibiotics (amphotericin B, levorin, nystatin) were studied in the experiments on aged rats. It was concluded that synthetic antioxidants regulate synthesis of these biologically active substances and also are able to protect the organ from the damaging effect of polyene antibiotics.

[Effect of polyene antibiotics on the enzyme activity of prostaglandin metabolism in different layers of the kidneys of old rats]. / Vliianie polienovykh antibiotikov na aktivnost' fermentov metabolizma prostaglandinov v raznykh sloiakh pochek starykh krys.

Experiments with noninbred albino rats weighing 500-600 g showed that the level of the effect of polyene antibiotics such as amphotericin B, levorin and nystatin on the activity of the main enzymes involved in prostaglandin metabolism was different. It was demonstrated that amphotericin B had the highest effect on the activity of 15-PG-dehydrogenase and PGE2-9-ketoreductase, while the effect of sodium nystatin was the least. Both the enzymes were markedly stimulated within the first hours after the antibiotic administration. Within the following hours and days a significant decrease in the activity of the enzymes was observed, especially in the medullary and papillary kidney layers. The results suggest that the polyene antibiotics had an impairing action on the functions of the enzymes of this group.

[Prostaglandin synthetase activity in the different layers of the kidneys of young rats exposed to polyene antibiotics]. / Aktivnost' prostaglandinsintetazy v raznykh sloiakh pochek molodykh krys pri deistvii polienovykh antibiotikov.

Prostaglandin (PG)-synthestase activity was studied in the cortical, medullary and papillary kidney layers in young rats subjected to prolonged administration of polyene antibiotics (amphotericin B, levorin and nystatin). This activity was markedly increased during the first few hours after the administration of amphotericin B. At later terms a pronounced decline in the enzyme activity was observed. The changes were most prominent in the medullary and papillary layers. The other two antibiotics were less potent. The experimental results have shown that amphotericin B had maximal effect on renal PG-synthetase activity, while the sodium salt of nystatin was least effective.