ABSTRACT
The interaction of an E/A=57.6-MeV ^{17}Ne beam with a Be target is used to populate levels in ^{16}Ne following neutron knockout reactions. The decay of ^{16}Ne states into the three-body ^{14}O+p+p continuum is observed in the High Resolution Array (HiRA). For the first time for a 2p emitter, correlations between the momenta of the three decay products are measured with sufficient resolution and statistics to allow for an unambiguous demonstration of their dependence on the long-range nature of the Coulomb interaction. Contrary to previous measurements, our measured limit Γ<80 keV for the intrinsic decay width of the ground state is not in contradiction to the small values (of the order of keV) predicted theoretically.
ABSTRACT
The interaction of an E/A=70-MeV (7)Be beam with a Be target was used to populate levels in (6)Be following neutron knockout reactions. The three-body decay of the ground and first excited states into the α+p+p exit channel were detected in the High Resolution Array. Precise three-body correlations extracted from the experimental data allowed us to obtain insight into the mechanism of the three-body democratic decay. The correlation data are in good agreement with a three-cluster-model calculation and thus validate this theoretical approach over a broad energy range.
ABSTRACT
The 0+ ground state of the 10He nucleus produced in the 3H(8He,p)10He reaction was found at about 2.1±0.2 MeV (Γâ¼2 MeV) above the three-body ^{8}He+n+n breakup threshold. Angular correlations observed for ^{10}He decay products show prominent interference patterns allowing us to draw conclusions about the structure of low-energy excited states. We interpret the observed correlations as a coherent superposition of a broad 1- state having a maximum at energy 4-6 MeV and a 2+ state above 6 MeV, setting both on top of the 0+ state "tail." This anomalous level ordering indicates that the breakdown of the N=8 shell known in 12Be thus extends also to the ^{10}He system.
ABSTRACT
The paper considers the significance of complex entrance of chloroform from portable water into the human body (enterally, inhalationally, and through the intact skin). It shows it necessary to toughen the maximum permissible concentration (MPC) of chloroform in the portable drinking, by taking into account of the multiplicity of routes of its action on the population. The authors present the results of their own investigations of the levels of chloroform in the air of bath and shower rooms before and after taking a shower and filling the bath with water, as well as in the airspace layer above the water of an indoor swimming pool, by using chromatographic mass-spectrometry.
Subject(s)
Chloroform/adverse effects , Health Status Indicators , Solvents/adverse effects , Water/standards , Carcinogens/toxicity , Humans , RussiaSubject(s)
Bufanolides/metabolism , Diabetes Mellitus/etiology , Enzyme Inhibitors/metabolism , Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors , Animals , Bufanolides/urine , Cardenolides/metabolism , Diabetes Mellitus/metabolism , Erythrocytes/enzymology , Humans , Male , Ouabain/metabolism , Protein Isoforms/metabolism , Rats , Saponins/metabolismABSTRACT
The proposed system for evaluating the quality and efficiency of medical care, including universal parameters with quantitative expression, allows the comparison, evaluation, and mathematical processing of these parameters. The method helps detect violations of medical technologies, irrational utilization of resources, directly compare the results and use them for preliminary testing of validity of the managing decisions.
Subject(s)
Efficiency, Organizational , Hospital Administration/methods , Medical Audit/methods , Efficiency, Organizational/economics , Efficiency, Organizational/statistics & numerical data , Hospital Administration/economics , Hospital Administration/statistics & numerical data , Medical Audit/economics , Medical Audit/statistics & numerical data , Russia , Socioeconomic FactorsABSTRACT
In F2 hybrids between self-sterile plants of the Volkhova cultivar and self-fertile lines with established self-fertility mutations (sf-mutations) at the major incompatibility loci S (1R), Z (2R), and T (5R), the effect of sf-mutations on the inheritance of secalin-encoding, isozyme, and morphological markers located on the same chromosomes was investigated. Linkage between loci Prx7 and S and locus Sec3 coding for high-molecular-weight secalins on chromosome 1R was shown for the first time The frequency of recombination between Prx7 and Sec3 and between S and Sec3 was 29.1 +/- 4.8% and 30.9 +/- 7.0%, respectively. Independent inheritance of locus Z and isozyme markers of chromosome 2R, Est3/5 and beta-Glu, from locus Sec2 encoding 75-kDa gamma-secalins was shown; in hybrids, the recombination frequency between Est3/5 and locus Z varied from 19.2 +/- 8.1 to 50%. Independent inheritance of morphological (Ddw and Hs) and isozyme markers (Est4, Est6/9, and Aco2) of chromosome 5R from locus T located on the same chromosome was demonstrated.
Subject(s)
Chromosome Mapping , Glycoproteins/genetics , Mutation , Plant Proteins/genetics , Secale/genetics , Genetic Markers , Glutens , Recombination, GeneticABSTRACT
Nubaine (N) was used in 92 patients operated on the lungs, heart and major vessels, abdominal organs. N at a dose of 0.3 mg/kg caused adequate analgesia in 62-85% of cases on days 1-3 after surgery; it is an effective analgesic among those used in patients with acute postoperative pain. The effect of N on circulation, respiration, gas exchange, metabolism, and hormonal status was studied. It has been shown that N is a safe agent which has no considerable effect on respiration, hemodynamics, blood gas composition, and metabolism. In patients at high risk analgesia with N caused no serious side effects.
Subject(s)
Nalbuphine/therapeutic use , Postoperative Care , Adult , Aged , Aged, 80 and over , Analysis of Variance , Drug Evaluation , Hemodynamics/drug effects , Humans , Nalbuphine/adverse effects , Nalbuphine/pharmacology , Pain Measurement , Pain, Postoperative/drug therapy , Pain, Postoperative/epidemiology , Pain, Postoperative/physiopathology , Pulmonary Gas Exchange/drug effects , Respiration/drug effects , Surgical Procedures, Operative , Time FactorsABSTRACT
The immunologic parameters were studied in 38 patients with hydatid disease of the liver and abdomen before and after a single hemoexfusion (HE) in a volume of 400 ml. Among the patients who were examined there were those with uncomplicated hydatid disease of the liver (group I, second clinical stage, 25 persons), patients with suppuration of hydatid cysts (group 11, 10 persons), and two patients with multiple hydatid cysts complicated by their suppuration and calcification with involvement of large areas of the liver. Comparative analysis of immunological parameters in patients before and in the first 24 hours after HE showed a difference between the groups of patients and the controls. The parameters were restored to their initial values in patients of both groups 3-5 days after HE. The results of the study allow the conclusion that in screening patients with hydatid disease of the liver and abdominal cavity for preoperative HE a strict individual approach is necessary with the patient's general condition, the clinical form of the disease, and complications on the part of the cysts being taken into account.
Subject(s)
Blood Transfusion, Autologous , Echinococcosis/immunology , Preoperative Care/methods , Abdomen , Antibody Formation , Combined Modality Therapy , Echinococcosis/complications , Echinococcosis/therapy , Echinococcosis, Hepatic/complications , Echinococcosis, Hepatic/immunology , Echinococcosis, Hepatic/therapy , Humans , Immunity, Cellular , Postoperative Complications/epidemiology , Postoperative Complications/prevention & control , Time FactorsABSTRACT
The effects of single 1-hour immobilization stress exposure and of long-term (40 days) adaptation to intermittent high altitude hypoxia (in hypobaric chamber at "altitude" 4000 m, 4 hr, a day) on serum myoglobin content were studied in Wistar rats. It has been shown that such stress exposure induced the 2.5 fold increase in the serum myoglobin content. The adaptation did not change the myoglobin content, but effectively limited mentioned above stress-induced increase in the serum myoglobin level. These data suggest that serum myoglobin content can be used as a criterion for stress damage and efficiency of factors protecting against stress damage.
Subject(s)
Myoglobin/metabolism , Stress, Physiological/blood , Acute Disease , Adaptation, Physiological , Altitude , Animals , Biomarkers/blood , Hypoxia/blood , Male , Rats , Rats, Wistar , Restraint, Physical , Stress, Physiological/prevention & controlABSTRACT
Prostacyclin-thromboxane system and platelet hemostasis have been studied in 56 patients upon aortocoronary bypass surgery with uncomplicated early postoperative period. It has been established that cardiopulmonary bypass surgery leads to a considerable increase in 6-keto-PGF1 alpha and TXB2 levels per platelet, as compared to preoperative values. By hour 18 postoperatively 6-keto-PGF1 alpha to platelet number ratio returns to baseline, while TXB2 to platelet number ratio remains higher than preoperative values, which determines a shift in 6-keto-PGF1 alpha to TXB2 ratio towards TXB2, thus ensuring, probably, enhanced platelet aggregation properties. Thrombocytopenia, a decrease in platelet aggregation properties and elevated blood plasma level of beta-thromboglobulin were observed upon aortocoronary bypass surgery. By hour 18 postoperatively the number of platelets increased significantly, their aggregation properties were enhanced, beta-thromboglobulin blood plasma level was reduced, however, the parameters under study did not reach normal values at that time. Increased levels of 6-keto-PGF1 alpha and TXB2 per platelet in the early postoperative period are considered an important component of compensatory-adaptive body reactions directed to normalization of the damaged body functions, namely hemostasis and microcirculation.
Subject(s)
6-Ketoprostaglandin F1 alpha/blood , Blood Platelets/physiology , Coronary Artery Bypass , Hemostasis , Myocardial Ischemia/surgery , Thromboxane B2/blood , Adult , Aged , Humans , Middle Aged , Myocardial Ischemia/bloodABSTRACT
It has been found that narcotic analgesics (morphine, fentanyl and dipidolor), inhalation anesthetics (phthorothan and frilen) and an intravenous anesthetic calypsol suppress lower esophageal contractility. Comparison of lower esophageal contractility with hemodynamic parameters and ACTH and cortisol blood plasma content have revealed a direct correlation. It is concluded that the method of dynamic control over lower esophageal contractility may be an objective test controlling the adequacy of anesthesia during various surgical interventions.
Subject(s)
Anesthesia/methods , Esophagus/drug effects , Muscle Contraction/drug effects , Muscle, Smooth/drug effects , Esophagus/physiology , Humans , Muscle, Smooth/physiologyABSTRACT
Prostacyclin-thromboxane system (PTS) and platelet-vascular hemostasis have been studied in the preoperative period in 35 ischemic patients. A marked PTS disbalance with predominance of plasma thromboxane has been found. It has been established that in patients with postinfarction cardiosclerosis plasma prostacyclin content was significantly higher than in patients without myocardial infarction. The study of platelet function has demonstrated normal platelet aggregation rate and an increased level of beta-thromboglobulin in the blood of ischemic patients. Acetylsalicylic acid (250 mg/daily) was used for the correction of the disturbances observed, it reduced platelet aggregation, but had no effect on PTS and platelet release.
Subject(s)
Blood Platelets/physiology , Coronary Disease/blood , Epoprostenol/blood , Hemostasis/physiology , Thromboxanes/blood , Adult , Coronary Artery Bypass , Coronary Disease/surgery , Humans , Middle Aged , Preoperative CareABSTRACT
The authors analyze the results of measuring the content of vasopressin, renin, angiotensin II and aldosterone coupled with the results of studying hemodynamics, acid-base state, and lactate in the arterial blood during operations on the heart in 32 patients with different acquired heart diseases. The main attention was concentrated on studies into the nature of humoral changes during extracorporeal circulation in three types of anesthesia. In group I, anesthesia was maintained by fentanyl given in a dose of 5-6 micrograms/kg/h, diazepam (0.1 mg/kg/h), and arduan (0.02 mg/kg/h). In the second observation group, at the beginning of perfusion the patients were administered trimetotan (artonad) (0.2 mg/kg), and in group III, the dose of fentanyl was raised during perfusion to 10-12 micrograms/kg/h. It is concluded that during extracorporeal circulation, it is desirable that the dose of fentanyl be increased to attain more adequate anesthesia in that period of heart surgery. The magnitude of humoral changes occurring in the body during extracorporeal circulation served as a criterion for anesthesia adequacy.
Subject(s)
Anesthesia, General , Extracorporeal Circulation , Heart Diseases/surgery , Hemodynamics/physiology , Renin-Angiotensin System/physiology , Vasopressins/physiology , Adult , Dose-Response Relationship, Drug , Female , Fentanyl/administration & dosage , Fentanyl/pharmacology , Heart Diseases/physiopathology , Hemodynamics/drug effects , Humans , Ketamine/administration & dosage , Ketamine/pharmacology , Male , Middle Aged , Renin-Angiotensin System/drug effects , Stimulation, ChemicalABSTRACT
The state of renin-angiotensin-aldosterone system has been studied in 43 patients after aortocoronary bypass surgery. Renin activity, angiotensin II and aldosterone content have been studied, using radioimmunoassay, in comparison with hemodynamic findings and water-electrolyte balance parameters. The study was performed in patients with uncomplicated postoperative period and in patients with acute circulation disturbances just after surgery and 3, 6, 18 and 48 hours after surgical intervention. It has been shown that in uncomplicated postoperative period there is a 6-8-fold increase in plasma renin content and a 1.5-2-fold increase in aldosterone concentration. Despite an increase in aldosterone activity clinical signs of hyperaldosteronism became evident by the 18-48th hour postoperatively. A persistent increase in renin-angiotensin-aldosterone system activity in patients with acute circulation disturbances is considered as a compensatory body reaction directed at stabilization of the circulating blood volume and heart performance.
Subject(s)
Coronary Artery Bypass , Renin-Angiotensin System/physiology , Adult , Humans , Middle Aged , Postoperative PeriodABSTRACT
A comparative evaluation of rheographic changes in regional pulmonary hemodynamics and renin-angiotensin and kinin-kallikrein activities was carried out on 9 volunteers exposed to antiorthostatic hypokinesia (-8 degrees) for 14 days. It was found that pulmonary circulation shifted in the apical direction due to increase in arterial tonicity and phasic variations of venous lumen. During the study blood renin increased significantly (P less than 0.05) whereas prekallikrein and kallikrein inhibitor varied insignificantly. It was concluded that the renin-angiotensin system played and important role in the changes of functional topography of pulmonary circulation in simulated microgravity conditions.