Protective Effect of Platelet-Rich Plasma on Cisplatin-Induced Nephrotoxicity in Adult Male Albino Rats: Histological and Immunohistochemical Study.

Cisplatin is a potent antineoplastic drug that is used for treatment of many solid tumors. It has a wide range of adverse effects. Nephrotoxicity is the most common one of them. Platelet-rich plasma (PRP) is an autologous human plasma that activates the tissue regeneration through cell proliferation and differentiation. Study the role of PRP in amelioration of cisplatin-induced nephrotoxicity on the kidney of adult male albino rats by biochemical, morphometric, histological, and immunohistochemical studies. Thirty-five adult male albino rats were used. Thirty rats were included as experimental group and five were used to obtain the PRP. The experimental group was classified into as follows: control group which received 1mL of sterile saline by intraperitoneal injection (IP), cisplatin-treated group which received cisplatin 7.5 mg/kg IP in a single dose and cisplatin and PRP-treated group rats received cisplatin 7.5 mg/kg single IP dose followed by 1ml of PRP IP after 24 h of cisplatin injection. There was a significant increase in urea and creatinine levels in cisplatin-treated group in comparison to the control and the PRP groups. The kidneys of cisplatin-treated group showed distorted renal structure, where specimens of PRP-treated group revealed restoration of the classical appearance of the renal tissue similar to the control group. PRP has protective effects on renal structure and functions and it helps to ameliorate the histological changes induced by cisplatin.

Reconstruction of Femur Length Using Epiphyseal and Diaphyseal Diameters in Contemporary Egyptian Sample, with Application to Ancient Egyptians.

Inferences in bioarchaeology and forensic contexts require mathematical stature estimation using long bone lengths. This study aimed to identify predictors of femur length (FL) from epiphyseal and diaphyseal width measurements that are not bound to assumptions of sex or laterality. To compute linear regression models, both standard and new measurements around the diaphyseal dominant nutrient foramina (NF) were collected on modern femora (n = 64) from the unidentified skeletal collection housed at Alexandria University. Four equations were then validated on an ancient Egyptian sample (n = 73) from the Goldman Osteometric Data Set to evaluate the effect of sex subdivision on the accuracy of FL and indirect stature estimations using Raxter's formulas. Most of models reflected significant positive association (r > 0.60) between width variables and FL. Oddly, the distance from the proximal end to the NF correlated weakly with FL (r = 0.34). The stepwise selected equations preferred measurements around NF to midshaft, with the anteroposterior diameter included in the proximal fragment model (r = 0.77), and circumference in diaphyseal fragment model (r = 0.62). Tested equations performed consistently on the ancient Egyptian sample. Measurements from the femoral proximal fragment are more reliable predictors than those from the distal fragment, with the exception of femur neck diameter. However, distal epicondylar breadth is a better predictor of FL in females than in males. Indirect stature estimation showed a reasonable degree of accuracy in both sexes. These models can be applied successfully in contemporary and ancient Egyptian fragmentary remains; however, due to larger size of femora from the Old Kingdom sample, they would be most applicable to individuals from later dynasties.