Repetitive mild traumatic brain injury alters central and peripheral clock gene expression in the adolescent rat.

Mild traumatic brain injury (mTBI) or concussion is a common injury worldwide leading to substantial medical costs and a high burden on society. In adolescents, falls and sports related trauma are often the causes of mTBI. Importantly, critical brain growth and development occurs during this sensitive period making the prospect of a brain injury a worrying phenomenon. Upwards of 70% of patients report circadian disruption following these injuries and this has been shown to impede recovery. Therefore, we sought to determine if core circadian clock gene expression was disrupted in rat model of repetitive mTBI (RmTBI). Male and female adolescent rats (n = 129) received sham or RmTBI. The animals were then euthanized at different times throughout the day and night. Tissue from the hypothalamus, cerebellum, hippocampus, liver, and small intestine were evaluated for the expression of per1, per2, cry1, clock, bmal1 and rev-erb-α. We found most clock genes varied across the day/night indicating circadian expression patterns. In the hypothalamus we found RmTBI altered the expression of cry1 and bmal1 in addition to sex differences in per2, cry1, clock, bmal1 and rev-erb- α. In the cerebellum, per1, per2, cry1, clock, bmal1 and rev-erb-α rhythms were all knocked out by RmTBI in addition to sex differences in cry1, clock and bmal1 expression. We also detected a significant decrease in overall expression of all clock genes in males in the middle of the night. In the hippocampus we found that RmTBI changed the rhythm of rev-erb-α expression in addition to sex differences in bmal1 expression. In the liver we detected strong rhythms in all genes examined, however only per2 expression was knocked out by RmTBI, in addition we also detected sex differences in per2 and cry1. We also detected an overall decrease in female clock gene expression in the early night. In the small intestine, RmTBI altered cry1 expression and there were sex differences in rev-erb-α. These results indicate that RmTBI alters core circadian clock gene expression in the central and peripheral nervous system in a time, tissue and sex dependent manner. This may be disrupting important phase relationships between the brain and peripheral nervous system and contributing to post-injury symptomology and also highlights the importance for time and sex dependent assessment of injury outcomes.

Changing the criteria applied to acceleration and deceleration efforts changes the types of player actions detected.

This study identified and profiled the types of player actions of Australian football players executed during high acceleration and/or deceleration efforts and identified how the duration exceeding the acceleration or deceleration threshold influenced the identified executed player actions. The commencing speed of the acceleration and deceleration efforts were also assessed. Acceleration and deceleration efforts of 22 Australian football players monitored with a 10-Hz GNSS device across two matches were analysed. Synchronised video footage of the matches was used to identify the player actions executed during acceleration and deceleration efforts. Linear mixed models were conducted to examine the relationship between commencing speed, player action, and duration exceeding the effort threshold. 'Linear movement' and 'jump' were the most frequently executed player actions for high accelerations and 'stop' and 'being tackled' for high decelerations. Significant differences were observed in commencing speed between player actions for the high deceleration efforts. Furthermore, it was found that a higher commencing speed was associated with an increased duration exceeding the deceleration threshold. These findings will help practitioners and researchers with selecting minimum-duration criteria for acceleration and deceleration efforts and provide an understanding of the types of player actions executed during these efforts.

Techniques to derive and clean acceleration and deceleration data of athlete tracking technologies in team sports: A scoping review.

The application of acceleration and deceleration data as a measure of an athlete's physical performance is common practice in team sports. Acceleration and deceleration are monitored with athlete tracking technologies during training and games to quantify training load, prevent injury and enhance performance. However, inconsistencies exist throughout the literature in the reported methodological procedures used to quantify acceleration and deceleration. The object of this review was to systematically map and provide a summary of the methodological procedures being used on acceleration and deceleration data obtained from athlete tracking technologies in team sports and describe the applications of the data. Systematic searches of multiple databases were undertaken. To be included, studies must have investigated full body acceleration and/or deceleration data of athlete tracking technologies. The search identified 276 eligible studies. Most studies (60%) did not provide information on how the data was derived and what sequence of steps were taken to clean the data. Acceleration and deceleration data were commonly applied to quantify and describe movement demands using effort metrics. This scoping review identified research gaps in the methodological procedures and deriving and cleaning techniques that warrant future research focussing on their effect on acceleration and deceleration data.

Interchangeability of player movement variables from different athlete tracking systems in professional soccer.

This study assessed the interchangeability between 10-Hz multi-GNSS GPS devices (Vector®) and two optical tracking systems (TRACAB® and Second Spectrum®). The agreement between data from the optical tracking systems when processed with manufacturer and GPS-filtered software was also assessed. Thirty players competing in the English Premier League were monitored using three different tracking systems across five matches. To determine the interchangeability between systems, player movement variables including, total distance, high-speed running distance (19.8-25.2 km·h-1), sprinting distance (>25.2 km·h-1), efforts >19.8 km·h-1 and maximal speed were compared. Equations were formed using linear regression and linear mixed-effects models to allow interchangeability of player movement variables between systems. Over half of the variance of most interchangeability equations were explained and associated with very strong positive correlations (r > 0.72). Small to huge differences were found between systems for most player movement variables. Data of optical tracking systems had decreased values in speed variables >19.8 km·h-1 when processed through GPS software. This study provides equations for practitioners to interchange player movement variables between TRACAB, Second Spectrum and Vector GPS systems with reduced error. This will enable practitioners to combine and share data captured with different tracking systems to analyse and improve their training.

Moving Toward a More Comprehensive Analysis of Acceleration Profiles in Elite Youth Football.

In football, having greater acceleration ability may decide the most important moments within matches. Up to now, commonly used acceleration variables have typically been investigated in isolation, with each variable suffering from unique limitations. Subsequently, any findings may provide a limited representation of what specific acceleration demands had actually occurred. Without gaining a comprehensive understanding of acceleration demands in football, it appears difficult to identify how to best monitor and maximize the long-term development of acceleration ability in footballers, all whilst doing so in a safe, sport-specific manner. Moving toward a more comprehensive analysis of acceleration profiles addresses this, as it can provide a more robust, informative understanding of the unique acceleration demands of competitive match-play. This perspective article aims to discuss the benefits of adopting a more comprehensive analysis of the acceleration demands during competitive matches for football players, by simultaneously analyzing high-intensity accelerations, repeated high acceleration ability (RHAA), and average acceleration. We discuss examples of the calculation and application of a more comprehensive acceleration profile at a team level throughout the course of an entire elite youth football season, as well as on an individual level. Monitoring acceleration profiles more comprehensively not only appears important from a training load/injury prevention perspective, but also, equips coaches and conditioning staff with the specific information necessary to develop and prescribe individualized, acceleration-emphasized training protocols that are replicable to the demands of match-play. Examples of such protocols are provided.