1.
Fam Cancer
; 21(3): 363-368, 2022 07.
Article
in English
| MEDLINE
| ID: mdl-34524588
ABSTRACT
PTEN is a tumour suppressor gene involved in regulating cell division. Pathogenic germline variants in PTEN predispose to benign and malignant growths of numerous organs, including of the breast. In the following report, we describe the first documented case of a fibroadenoma developing in ectopic breast tissue of the vulva in a patient with a germline pathogenic variant in PTEN. This highlights the risk of hyperplasia developing in any breast tissue, including rare ectopic sites, particularly in patients with underlying germline variants in cancer susceptibility genes.
Subject(s)
Breast Neoplasms , Fibroadenoma , Fibroma , Hamartoma Syndrome, Multiple , Breast Neoplasms/genetics , Breast Neoplasms/pathology , Female , Fibroadenoma/genetics , Germ-Line Mutation , Hamartoma Syndrome, Multiple/genetics , Humans , PTEN Phosphohydrolase/genetics , Vulva/pathology
2.
Am J Dermatopathol
; 42(8): 618-619, 2020 Aug.
Article
in English
| MEDLINE
| ID: mdl-32701702
Subject(s)
Bowen's Disease/pathology , Immunocompromised Host , Immunosuppressive Agents/adverse effects , Leishmaniasis, Cutaneous/pathology , Skin Neoplasms/pathology , Skin/pathology , Aged , Biopsy , Bowen's Disease/immunology , Humans , Leishmaniasis, Cutaneous/immunology , Leishmaniasis, Cutaneous/parasitology , Male , Skin/immunology , Skin/parasitology , Skin Neoplasms/immunology
3.
4.
Clin Dysmorphol
; 23(1): 29-31, 2014 Jan.
Article
in English
| MEDLINE
| ID: mdl-24300292