ABSTRACT
ABSTRACT: Hemangioblastoma (HB) is the most common primary intra-axial posterior fossa tumor in adults and is a benign vascular neoplasm. We report the case of a 73-year-old man suffering from biochemical recurrence of prostate cancer where intense overexpression of prostate-specific membrane antigen (PSMA) was observed in HB in a PSMA PET/CT. Overexpression of PSMA in tumor-associated vascular structures has been proposed as an explanation of PSMA ligand uptake in several nonprostatic tumors. Given the pathological nature of HB, this mechanism may explain the intense overexpression of PSMA observed in present case.
Subject(s)
Antigens, Surface/metabolism , Cerebellar Neoplasms/diagnostic imaging , Glutamate Carboxypeptidase II/metabolism , Hemangioblastoma/diagnostic imaging , Positron Emission Tomography Computed Tomography , Aged , Cerebellar Neoplasms/metabolism , Cerebellar Neoplasms/pathology , Gene Expression Regulation, Neoplastic , Hemangioblastoma/metabolism , Hemangioblastoma/pathology , Humans , MaleABSTRACT
Endogenous Clostridium septicum endophthalmitis is a rare and fulminant ocular infection, usually encountered in immunocompromised or diabetic patients. It is also highly associated with both gastrointestinal and hematologic malignancies. We describe herein the detection of an adenocarcinoma of the cecum on PET/CT with F-FDG in a patient with an active endogenous C. septicum endophthalmitis of the right eye. FDG PET/CT should be considered for all patients with endogenous endophthalmitis to exclude an occult malignancy, especially colorectal cancer.