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Equine Vet J Suppl ; (29): 77-80, 1999 Apr.
Article in English | MEDLINE | ID: mdl-10696300

ABSTRACT

A multicentre, blinded, randomised complete-block, field trial was conducted with 140 horses and foals age 4 weeks-28 years to determine if omeprazole paste is effective and safe in promoting healing of spontaneous gastric ulcers under a variety of field conditions and in different breeds and ages of horses. Horses in the study had gastric ulceration as determined by gastroscopy and were divided into replicates of 4 or 5 animals. One horse in each replicate was assigned randomly to receive an empty omeprazole syringe (sham-dosed control) and the remaining horses received omeprazole paste once daily for 28 days. Gastroscopy was repeated at the end of the study. Horses treated with omeprazole had significantly (P < 0.01) more improvement in ulcer scores at the end of the study compared with controls. Ulcers were improved in 32.4 and 99.0% of the control and omeprazole groups, respectively. Ulcers were completely healed in 8.9 and 86.7% of the control and omeprazole groups, respectively. Under typical field conditions, omeprazole was effective at enhancing healing of spontaneous gastric ulcers in horses of a variety of ages and breeds.


Subject(s)
Enzyme Inhibitors/therapeutic use , Horse Diseases/drug therapy , Omeprazole/therapeutic use , Stomach Ulcer/veterinary , Administration, Oral , Age Factors , Animals , Animals, Newborn , Breeding , Double-Blind Method , Enzyme Inhibitors/administration & dosage , Female , Gastroscopy/veterinary , Horses , Housing, Animal , Male , Ointments , Omeprazole/administration & dosage , Severity of Illness Index , Stomach Ulcer/drug therapy , Treatment Outcome , United States
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