Proximal ulnar fractures in adults: a review of 163 cases.

The aim of this study was to report the epidemiological characteristics and the experience of 5 departments of trauma, in France, in the management of fractures of the proximal ulna. 163 patients with fractures of the proximal ulna with a mean age of 49.9 years (range 16-97) were managed. The most common mode of injury was a motor vehicle collision (48%). 18% sustained associated injuries to the ipsilateral limb. Open fractures were present in 42 patients (25%). A total of 109 patients had a fracture of the olecranon, with the Mayo 2A and B types most frequently seen (66%). The patients were invited for clinical examination at a mean duration of 16 months, retrospectively. Validated patient-oriented assessment scores involving the Mayo Elbow Performance Index (MEPI) and the Broberg and Morrey score were evaluated. All patients had follow-up radiographs. The mean arc of elbow motion was 130° (70-150°). The mean MEPI was 91 (20-100) with good results in 23% and excellent results in 52% of the patients. The mean Broberg and Morrey score was 90 after isolated olecranon fracture, and decreased with the complexity of the lesion. 117 fractures (72%) healed with ulnohumeral congruity. 9 fracture non-unions occurred (6%). Although the fracture of the proximal ulna can be described in several classifications, none of them accommodate it satisfactorily, because of the complexity of the lesion. The coronoid process is the keystone for the stability of the elbow. It forms the anterior buttress with the radial head. Tension band wire fixation is by far the commonest technique of internal fixation used for the treatment of non-comminuted olecranon fractures. Dorsal plate fixation is a useful option by providing improved fixation of complex comminuted fractures and fracture-dislocations. The radiocapitellar joint has to be restored appropriately, preserving the radial head when possible and replacing it with a prosthesis otherwise. The lateral collateral ligament complex is commonly disrupted and usually can be reattached to its origin from the lateral epicondyle. In addition, a brief period of hinged external fixation should be considered.

45°-45°-30°Frog-leg radiograph for diagnosing cam-type anterior femoroacetabular impingement: Reproducibility and thresholds.

BACKGROUND: The many radiographic views suggested for evaluating anterior femoroacetabular impingement (FAI), due to a cam effect, are not specific for this condition and have not been proven of diagnostic value in studies, including control groups. Using a new and specific radiographic view, we evaluated the reproducibility of the main radiographic criteria for FAI, determined normal values for these criteria in a control group, and established diagnostic threshold values. HYPOTHESIS: This specific view offers good reproducibility and effectively detects abnormal values of criteria for FAI. MATERIALS AND METHODS: Inter-observer and intra-observer reproducibility of specific radiographic criteria (αangle and modified head-neck offset [HNO]) were computed from preoperative and postoperative radiographs of 96 hips (75 patients, 61 males and 14 females) using the specific 45°-45°-30° frog-leg view (F45 view). Values in the group with FAI were compared to those in a control group of asymptomatic volunteers (100 hips, 27 males and 23 females). RESULTS: Inter-observer and intra-observer reproducibility was very good, with intra-class correlation coefficients of 0.955and 0.987, respectively, for the α angle and of 0.895 and 0.984, respectively, for the HNO. Mean values of both parameters differed significantly between the FAI and control groups: 73.9° (53° to 96°) vs. 49.3° (35° to 69°) for the αangle, respectively; and 2.5mm (-4.6 to 9.4) vs. 7.6mm (1.7 to 11.8) for HNO, respectively. The normal values defined as the boundary of the 95% reference interval in the control group were<60.2° for the α angle, and>4.6mm for the HNO. DISCUSSION: The45°-45°-30° frog-leg view is useful for diagnosing FAI due to a cam effect. This view is easy to perform, and the thresholds determined in our study assist in its interpretation: α angle values>58° in females and>63° in males indicate cam-type femoral geometry. In both genders, HNO values<5mm support a diagnosis of anterior FAI. LEVEL OF EVIDENCE: Level III, case-control study.

The frequency of sequelae of slipped upper femoral epiphysis in cam-type femoroacetabular impingement.

Slipped upper femoral epiphysis (SUFE) is one of the known causes of cam-type femoroacetabular impingement (FAI). The aim of this study was to determine the proportion of FAI cases considered to be secondary to SUFE-like deformities. We performed a case-control study on 96 hips (75 patients: mean age 38 years (15.4 to 63.5)) that had been surgically treated for FAI between July 2005 and May 2011. Three independent observers measured the lateral view head-neck index (LVHNI) to detect any SUFE-like deformity on lateral hip radiographs taken in 45° flexion, 45° abduction and 30° external rotation. A control group of 108 healthy hips in 54 patients was included for comparison (mean age 36.5 years (24.3 to 53.9). The impingement group had a mean LVHNI of 7.6% (16.7% to -2%) versus 3.2% in the control group (10.8% to -3%) (p < 0.001). A total of 42 hips (43.7%) had an index value > 9% in the impingement group versus only six hips (5.5%) in the control group (p < 0.001). The impingement group had a mean α angle of 73.9° (96.2° to 53.4°) versus 48.2° (65° to 37°) in the control group (p < 0.001). Our results suggest that SUFE is one of the primary aetiological factors for cam-type FAI.

Frequency of radiographic signs of slipped capital femoral epiphysiolysis sequelae in hip arthroplasty candidates for coxarthrosis.

INTRODUCTION: The rate of osteoarthritis of the hip secondary to slipped capital femoral epiphysis (SCFE) is a subject of debate, and its frequency is underestimated in particular because of subclinical forms that may not be diagnosed during childhood. HYPOTHESIS: The frequency of radiographic anomalies subsequent to SCFE in adults requiring hip arthroplasty is higher than that reported in recent studies (6% to 15%). MATERIALS AND METHODS: A prospective single-center epidemiological radiography study was performed by one observer. Hip X-rays of patients who were being treated by arthroplasty for advanced hip osteoarthritis between January 2010 and May 2012 were analyzed. The etiology of osteoarthritis was classified in each patient according to the data obtained (primary, SCFE, dysplasia, protrusio acetabuli, other). The lateral view head-neck index (LVHNI) was used to quantify posterior translation of the femoral head, and identify SCFE sequelae. RESULTS: One hundred and eighty-six hips were included. Osteoarthritis was considered primary in 51 patients (27.4%), secondary to dysplasia in 42 (22.5%), protrusio acetabuli in 38 (20.5%) or another disease in nine (4.9%) while 46 hips (24.7%) presented a radiographic image suggesting SCFE past history. SCFE type deformities were the primary etiology of osteoarthritis in patients less than 60years old (30/84 or 35.7%). The mean age of patients in the SCFE group was 56.2years old (26-80) compared to 66 (54-91) for the primary osteoarthritis group (P<0.0001). The mean LVHNI was 13% (9-24%) in the SFCE group, the mean body mass index was 27.1kg/m(2) (±3.5; 18.2-35.4) in the SFCE group and the male to female ratio was 7.3/1. CONCLUSION: Our study identified a population with a morphological SCFE type anomaly of the coxofemoral joint (LVHNI>9%), which results in the development of earlier osteoarthritis than that found in the rest of the population. SCFE is more common than reported in the literature because it is the first etiology of osteoarthritis of the hip in subjects less than 60years old. LEVEL OF EVIDENCE: Level III. Diagnostic prospective study with a control group.

The lateral view head-neck index (LVHNI): a diagnostic tool for the sequelae of slipped capital femoral epiphysis.

INTRODUCTION: It is a well-known fact that slipped capital femoral epiphysis (SCFE) is one of the causes of premature hip osteoarthritis and anterior femoroacetabular impingement. But there are no reliable, published diagnostic methods to measure the residual deformity of slipped capital femoral epiphysis. We propose using the lateral view head-neck index (LVHNI) measurement on a specific lateral X-ray view of the hip for this purpose. HYPOTHESIS: The LVHNI can detect and quantify the posterior translation of the femoral head and this index can be measured reliably. MATERIALS AND METHODS: A prospective radiography study was performed by three observers. The hip X-rays of patients who were being treated by arthroplasty for hip osteoarthritis (total hip replacement or hip resurfacing) between January 2010 and December 2011 were analyzed. The LVHNI, which quantifies the posterior translation of the femoral head, was measured on a lateral view of the hip in 45° flexion/45° abduction/30° external rotation. The presence of a pistol grip deformity on A/P X-rays was also assessed. RESULTS: The analysis was performed on 131 hips in 120 patients having an average age of 61 years (range 37-91). The chosen LVHNI threshold of 9% resulted in a sensitivity of 89.1% (95% CI: 78.8%-95.5%) and a specificity of 82.4% (95% CI: 71.2%-89.7%) for detecting the presence of a pistol grip deformity. Twenty percent of the hips with no visible deformity on A/P X-rays had a pathological index value. The inter-observer reproducibility was good for the LHNI [intraclass correlation coefficient (ICC): 0.61; 95% CI: 0.51-0.71] and for detecting a pistol grip deformity (ICC: 0.74; 95% CI: 0.62-0.85). The intra-observer reproducibility was excellent for the LHNI (ICC: 0.78; 95% CI: 0.57-0.88) and the pistol grip deformity (ICC: 0.85; 95% CI: 0.74-0.92). CONCLUSION: The LVHNI is a reliable and reproducible tool to identify deformities secondary to SCFE on specific lateral femoral neck X-rays. If the index value is greater than 9%, SCFE sequelae may be present. In addition, this study showed that 20% of hips with normal A/P X-rays had a pathological index. LEVEL OF EVIDENCE: Level IV, prospective diagnostic study without control group.

Surgery for femoroacetabular impingement using a minimally invasive anterolateral approach: analysis of 118 cases at 2.2-year follow-up.

INTRODUCTION: Treatment of femoroacetabular impingement (FAI) has progressed over time from using long incisions and dislocation to using arthroscopic surgery. Minimally invasive treatment has rarely been evaluated and a minimally invasive, anterolateral approach has not been used up to now for this indication. A prospective, on-going study was performed to evaluate surgical treatment of FAI with a minimally invasive, anterolateral approach. HYPOTHESIS: Femoral neck, acetabulum and labrum abnormalities can be corrected without significant morbidity using a minimally invasive, anterolateral approach without dislocation. PATIENTS AND METHODS: Treatment of 120 FAI cases (108 patients, 16 women, 92 men, 12 bilateral cases during one surgical session), average age: 34 years (18.9-63.5 years), was done prospectively and in an uninterrupted series. Two cases were lost to follow-up; 106 patients (118 FAI cases) were evaluated with a follow-up of at least 1 year. Assessments consisted of the Non-Arthritic Hip Score (NAHS), WOMAC, measurement of internal rotation with 90° flexion and the Nötzli alpha angle on an A/P radiograph in 45° of flexion, 45° abduction and 30° external rotation. RESULTS: Blood loss averaged 1.2g/dl (range 0.5 to 2.7g/dl) and the average operative time was 44.9 minutes (range 30 to 65). With an average follow-up of 2.2 years (range 12 to 54 months), the NAHS changed by 32.5 points (P<0.0001), internal rotation by 19.0° (P<0.0001) and the alpha angle by -24.9° (P<0.0001). Eight surgical revisions were required (6.8%) (four haematomas, two capsular debridement, two additional procedures on the acetabulum) and these had a good outcome; there were no nerve-related or infection-related complications. Four failures (3.5%) were revised by arthroplasty (two patients experienced residual pain and two patients rapidly progressed to osteoarthritis). Eighteen cases progressed by only one Tönnis stage. Brooker stage II and III ossification were observed in 12 cases (10.2%) but these did not affect the functional score and range of motion improvement. DISCUSSION: This approach, which can be learned and performed quickly, does not require any specific materials and yields a reliable surgical procedure without major complications. This short-term study, where the central cartilaginous compartment was not explored and the labrum was not sutured, comprised a consecutive, non-selected series of patients (independent of age, weight, osteoarthritis stage) and had encouraging results. LEVEL OF EVIDENCE: Level III, prospective study, no control group.

Posterior dislocation of the sternoclavicular joint and epiphyseal disruption of the medial clavicle with posterior displacement in sports participants.

We retrospectively analysed the clinical results of 30 patients with injuries of the sternoclavicular joint at a minimum of 12 months' follow-up. A closed reduction was attempted in 14 cases. It was successful in only five of ten dislocations, and failed in all four epiphyseal disruptions. A total of 25 patients underwent surgical reduction, in 18 cases in conjunction with a stabilisation procedure. At a mean follow-up of 60 months, four patients were lost to follow-up. The functional results in the remainder were satisfactory, and 18 patients were able to resume their usual sports activity at the same level. There was no statistically significant difference between epiphyseal disruption and sternoclavicular dislocation (p > 0.05), but the functional scores (Simple Shoulder Test, Disability of Arm, Shoulder, Hand, and Constant scores) were better when an associated stabilisation procedure had been performed rather than reduction alone (p = 0.05, p = 0.04 and p = 0.07, respectively). We recommend meticulous pre-operative clinical assessment with CT scans. In sternoclavicular dislocation managed within the first 48 hours and with no sign of mediastinal complication, a closed reduction can be attempted, although this was unsuccessful in half of our cases. A control CT scan is mandatory. In all other cases, and particularly if epiphyseal disruption is suspected, we recommend open reduction with a stabilisation procedure by costaclavicular cerclage or tenodesis. The use of a Kirschner wire should be avoided.

Psychopathology in people with epilepsy and intellectual disability; an investigation of potential explanatory variables.

OBJECTIVES: There are few studies on epilepsy and psychopathology in people with intellectual disability (mental retardation) despite epilepsy prevalence rates that are thirty times higher than in the general population. The aims of this study, therefore, were to identify reliable, epilepsy-specific predictors of psychiatric and behavioural disorder in these patients, and to investigate reliable predictors of carer stress. METHODS: A database of 685 patients was compiled, from which 250 were randomly selected. Structured interviews were completed on 186 of these 250 patients (74%) (108 men, 78 women; mean age (SD) 35.5 (10.1)) comprising descriptive, clinical and functional components, and validated measures of psychopathology for which comparative data were available. Logistic and linear regression methods were used to identify predictors. RESULTS: One-third of patients with epilepsy and intellectual disability met criteria for possible psychiatric disorder, particularly affective/neurotic disorder; twice the comparison rates for intellectual disability alone. Behavioural problem levels, however, were lower than population norms. Regression models explaining modest amounts of variance (R(2)< or =24%) suggested certain seizure phenomena (greater seizure severity, more seizures in past month, lesser tendency to loss of consciousness during seizures) as particular risk factors for psychiatric disorder. General disability factors such as level of intellectual, sensory or motor disability and side effects of medication, however, contributed more to explaining behavioural problems. Around half of the family carers reported significant stress, and one-third exhibited clinically significant anxiety symptoms. Younger carers were more stressed, and side effects from patients' medication also contributed to carer stress. CONCLUSIONS: Although epilepsy in itself may be a risk factor for psychopathology in a minority of people with intellectual disability, some epilepsy-specific factors may predict psychiatric disorder. Behavioural problems need to be considered separately from psychiatric disorder because general factors, more closely associated with disability, are stronger predictors of their occurrence.

Development and validation of the Glasgow Epilepsy Outcome Scale (GEOS): a new instrument for measuring concerns about epilepsy in people with mental retardation.

PURPOSE: To develop a measure for use with adults with epilepsy and mental retardation, capable of assessing both clinical and care concerns and of quantifying treatment outcomes. METHODS: Extensive validational and other psychometric evaluation was undertaken, comprising initial scale development work with 48 carers and 46 health practitioners, followed by formal field testing on a sample of 186 patients, using 384 respondents (160 clinicians, 141 staff, 83 family). Recognised qualitative methods were applied to identify central themes, and psychometric procedures generated data on validity, reliability, and component structure. RESULTS: A total of 1,007 items of concern was generated, which was reduced systematically to a representative set of 90 items. The GEOS-90 comprises four subscales: concerns about "seizures," "treatment," "caring," and "social impact," each explaining approximately 70% of variance. Subscales and factor scales had strong internal consistency (alpha > or = 0.82). Stepwise linear regression was applied to derive a short-form version with similar structure. Thirty-five items were retained (GEOS-35; alpha > or = 0.89). Both scales discriminated moderately on clinical variables (number of seizure types, mono- vs. polytherapy, seizure frequency; all values of p < 0.05) and demonstrated concurrent validity with interview ratings from the ELDQOL (p < 0.05). CONCLUSIONS: The GEOS scales appear valid and reliable for use with clinical populations of people with mental retardation.

Biological implications of the interaction (via silanol groups) of silicon with metal ions.

Since the demonstration, in 1972, of the essentiality of silicon in higher animals, bio-inorganic chemists have speculated about the site and mechanism of action of silicon. Bone and connective tissue have been identified as tissues that are altered in the absence of silicon. Si-C bonds are foreign to biochemistry so organic bonding must be via Si-O-C, but the instability of the ester bond in aqueous solution at pH 7.4 has prompted us to investigate the interactions of silicic acid. Silicic acid could, by hydrogen bonding, alter the conformation of organic macromolecules, since hydrogen bond association can inhibit silanol condensation. However, silanols are also able to interact with metal ions that are basic at physiological pH, e.g. Fe3+ or Al3+ but not Ca2+, and such interactions are known in geochemistry. The observed effects of Si on hard and soft tissue could therefore result from interactions of Si(OH)4 with Fe3+, which is involved in connective tissue synthesis (via enzymes, e.g. prolyl hydroxylase) and damage (via iron-catalysed radical generation), or with Al3+ which exerts toxic effects at sites (bone and brain) at which Si has also been observed. Although we have demonstrated several Fe3+/Si interactions, we have not been able to show their relevance in a biochemical context. Al3+ interacts with Si(OH)4 in aqueous solution and preliminary experiments have suggested that silicic acid can counteract deleterious effects of aluminium, for example the activity of prolyl hydroxylase, an observation with implications not only in osteogenesis but also in Alzheimer's disease and aluminium toxicity in acidified waters.