ABSTRACT
Preterm birth (PTB) is the leading cause of death in children under five, yet comprehensive studies are hindered by its multiple complex etiologies. Epidemiological associations between PTB and maternal characteristics have been previously described. This work used multiomic profiling and multivariate modeling to investigate the biological signatures of these characteristics. Maternal covariates were collected during pregnancy from 13,841 pregnant women across five sites. Plasma samples from 231 participants were analyzed to generate proteomic, metabolomic, and lipidomic datasets. Machine learning models showed robust performance for the prediction of PTB (AUROC = 0.70), time-to-delivery (r = 0.65), maternal age (r = 0.59), gravidity (r = 0.56), and BMI (r = 0.81). Time-to-delivery biological correlates included fetal-associated proteins (e.g., ALPP, AFP, and PGF) and immune proteins (e.g., PD-L1, CCL28, and LIFR). Maternal age negatively correlated with collagen COL9A1, gravidity with endothelial NOS and inflammatory chemokine CXCL13, and BMI with leptin and structural protein FABP4. These results provide an integrated view of epidemiological factors associated with PTB and identify biological signatures of clinical covariates affecting this disease.
Subject(s)
Premature Birth , Infant, Newborn , Pregnancy , Child , Humans , Female , Premature Birth/epidemiology , Developing Countries , Multiomics , Proteomics , Chemokines, CCABSTRACT
La cefalea tipo cluster (cefalea en racimos) hace parte de un grupo de cefaleas primarias definidas por la SociedadInternacional de Cefaleas como cefaleas trigémino autonómicas. Es una condición clínica infrecuente que puedeser confundida con otras cefaleas primarias como: hemicránea paroxística, SUNCT y neuralgia del trigémino.Existen muchas enfermedades y lesiones intracraneales que pueden simular una cefalea tipo cluster, dentro deestas causas sintomáticas, los desórdenes neurooftalmologicos deben ser parte del diagnóstico diferencial detodos los pacientes con cefalea tipo cluster like. Hacemos el reporte de un paciente con cefalea tipo cluster likey síndrome de Charles Bonnet asociado a glaucoma intermitente de ángulo cerrado...
Cluster headache is part of a group of primary headache disorders defined by the International HeadacheSociety as trigeminal autonomic headaches. It is a rare clinical condition that can be confused with other primaryheadaches such as paroxysmal hemicrania, SUNCT and trigeminal neuralgia. There are many diseasesand intracranial lesions that may mimic cluster headache, within these symptomatic causes, neuro-ophthalmicdisorders should be part of the differential diagnosis of all patients with cluster like headache. We report thecase of a patient with cluster like headache and Charles Bonnet syndrome associated with intermittent angleclosureglaucoma...
