Subject(s)
Coinfection , Mucositis , Pneumonia, Mycoplasma , Humans , Mycoplasma pneumoniae , Mucositis/etiology , Mucositis/drug therapy , Coinfection/diagnosis , Coinfection/drug therapy , Pneumonia, Mycoplasma/complications , Pneumonia, Mycoplasma/diagnosis , Pneumonia, Mycoplasma/drug therapy , Anti-Bacterial Agents/therapeutic useABSTRACT
"Corymbiform" is a term found in medical literature as early as 1876 to describe a central larger lesion with smaller surrounding lesions, leading to the appearance of an irregular border. While the term in current medical literature most often describes a possible morphology of secondary syphilis, the authors have noted this pattern presenting in other cutaneous conditions. We present a commentary on the corymbiform pattern in dermatology including a series of photographs of cutaneous disorders presenting in a corymbiform morphology in pediatric patients. While the term corymbiform is not commonly used in the present-day dermatologic literature, increased recognition and use of this term may aid in the recognition of various dermatologic diagnoses presenting in a less common morphology and may also lend to increased fluidity of dermatologic descriptions in the literature.
Subject(s)
Dermatitis , Dermatology , Lupus Erythematosus, Cutaneous , Syphilis , Humans , Child , Syphilis/diagnosisABSTRACT
Annular erythema of infancy is a rare, benign disease characterized by enlarging annular patches and plaques that resolve spontaneously. Histopathology typically demonstrates a perivascular mixed lymphohistiocytic infiltrate with increased eosinophils. We present two cases of annular erythema of infancy, at ages 2-4 weeks, and review the literature on annular erythema of infancy. It is important to differentiate this distinct, benign disease from serious autoimmune or infectious processes, such as neonatal lupus erythematosus and syphilis, which may present with similar annular lesions in infancy.
Subject(s)
Eosinophilia , Lupus Erythematosus, Systemic , Skin Diseases, Genetic , Infant, Newborn , Humans , Infant , Erythema/diagnosis , Erythema/pathology , Skin Diseases, Genetic/pathology , Eosinophilia/pathology , Rare DiseasesABSTRACT
An 18-year-old Black female presented with a 2-year history of bilateral upper eyelid swelling and the recent onset of multiple subcutaneous nodules on the arms. She had previously undergone evaluation and treatment for presumed angioedema. Biopsies of the eyelid and an arm nodule demonstrated non-necrotizing granulomatous inflammation with special stains negative for acid-fast bacilli and fungi, and the patient was diagnosed with subcutaneous sarcoidosis. The isolated finding of bilateral eyelid swelling 2 years prior to the onset of additional cutaneous findings led to a significant delay in diagnosis, highlighting the importance of considering sarcoidosis in the differential diagnosis for bilateral eyelid swelling.
Subject(s)
Angioedema , Sarcoidosis , Humans , Female , Adolescent , Sarcoidosis/complications , Sarcoidosis/diagnosis , Sarcoidosis/pathology , Eyelids/pathology , Angioedema/diagnosis , Edema/diagnosis , Edema/etiology , Diagnosis, DifferentialSubject(s)
Hyperpigmentation , Female , Humans , Hyperpigmentation/diagnosis , Hyperpigmentation/etiologyABSTRACT
Focal dermal hypoplasia (FDH), or Goltz syndrome, is a rare genodermatosis affecting tissues of mesodermal and ectodermal origin. The characteristic skin changes have been reported to symptomatically flare in response to certain triggers as well as to progress over time in some cases. We present the case of a 5-year-old girl with cutaneous flaring and progression of FDH in the setting of septic shock. This case adds to the growing body of literature on both flaring and progression of the cutaneous manifestations of FDH.
Subject(s)
Focal Dermal Hypoplasia , Shock, Septic , Female , Humans , Child, Preschool , Focal Dermal Hypoplasia/complications , Acute Disease , SkinSubject(s)
Infant, Premature , Skin Abnormalities/pathology , Skin Diseases, Vesiculobullous/pathology , Skin Diseases/pathology , Biopsy, Needle , Diagnosis, Differential , Humans , Immunohistochemistry , Infant, Newborn , Male , Rare Diseases , Severity of Illness Index , Skin Abnormalities/etiology , Skin Diseases/congenital , Skin Diseases, Vesiculobullous/congenitalABSTRACT
Pemphigus foliaceus (PF) is an autoimmune bullous disorder that has occasionally been reported to present as a polycyclic or arcuate eruption in children. We present a case of childhood PF presenting as an annular and polycyclic eruption, which initially led to a diagnostic conundrum and a delay in diagnosis but which ultimately responded well to therapy with systemic steroids and rituximab infusions. We briefly review the literature on polycyclic presentations of PF in childhood as well as the use of rituximab for pediatric pemphigus.