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[CORRECTION OF INTRAABDOMINAL PRESSURE IN RATS IN AN ACUTE PANCREATITIS, USING INFUSION OF MYORELAXANT OF A DURABLE ACTION PIPECURONIUM BROMIDE].
Morgun, A S; Sukhodolya, A I; Kabanov, O V; Sukhodolya, S A; Falaleyeva, M; Beregova, T V.
Klin Khir ; (1): 67-9, 2017.
Article in Ukrainian | MEDLINE | ID: mdl-30272925

ABSTRACT

Impact of a durable action of myorelaxant pipecuronium bromide on intraabdominal pressure (IAP) in rats in experimentally simulated acute peritonitis was studied. In the rats in purulent pancreatitis, іnduced by L-аrginin, IAP was in 4,5 times high (p < 0.001), than in intact laboratory animals. Pipecuronium bromide have lowered IAP by 33.4%, witnessing efficacy of application of myorelaxants in treatment of intraabdominal hypertension in purulent pancreatitis.


Subject(s)
Intra-Abdominal Hypertension/drug therapy , Neuromuscular Nondepolarizing Agents/pharmacology , Peritonitis/physiopathology , Pipecuronium/pharmacology , Acute Disease , Animals , Animals, Outbred Strains , Arginine/administration & dosage , Injections, Intramuscular , Injections, Intraperitoneal , Intra-Abdominal Hypertension/chemically induced , Intra-Abdominal Hypertension/complications , Intra-Abdominal Hypertension/physiopathology , Peritonitis/chemically induced , Peritonitis/complications , Rats
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