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Re: Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesis.

Kinnersley, Ben; Buch, Stephan; Castellví-Bel, Sergi; Farrington, Susan Mary; Forsti, Asta; Hampe, Jochen; Hemminki, Kari; Hofstra, Robert M W; Northwood, Emma; Palles, Claire; Pinheiro, Manuela; Ruiz-Ponte, Clara; Schafmayer, Clemens; Teixeira, Manuel R; Westers, Helga; Wezel, Tom van; Bishop, D Timothy; Tomlinson, Ian; Dunlop, Malcolm G; Houlston, Richard S.

J Natl Cancer Inst ; 106(5)2014 Apr 26.

Article in English | MEDLINE | ID: mdl-24771875

Subject(s)

Adenoma/genetics , Carcinoma/genetics , Colorectal Neoplasms/genetics , DNA Damage , DNA Glycosylases/genetics , DNA Repair/genetics , Mutation , Female , Humans , Male

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

Dunlop, Malcolm G; Dobbins, Sara E; Farrington, Susan Mary; Jones, Angela M; Palles, Claire; Whiffin, Nicola; Tenesa, Albert; Spain, Sarah; Broderick, Peter; Ooi, Li-Yin; Domingo, Enric; Smillie, Claire; Henrion, Marc; Frampton, Matthew; Martin, Lynn; Grimes, Graeme; Gorman, Maggie; Semple, Colin; Ma, Yusanne P; Barclay, Ella; Prendergast, James; Cazier, Jean-Baptiste; Olver, Bianca; Penegar, Steven; Lubbe, Steven; Chander, Ian; Carvajal-Carmona, Luis G; Ballereau, Stephane; Lloyd, Amy; Vijayakrishnan, Jayaram; Zgaga, Lina; Rudan, Igor; Theodoratou, Evropi; Starr, John M; Deary, Ian; Kirac, Iva; Kovacevic, Dujo; Aaltonen, Lauri A; Renkonen-Sinisalo, Laura; Mecklin, Jukka-Pekka; Matsuda, Koichi; Nakamura, Yusuke; Okada, Yukinori; Gallinger, Steven; Duggan, David J; Conti, David; Newcomb, Polly; Hopper, John; Jenkins, Mark A; Schumacher, Fredrick.

Nat Genet ; 44(7): 770-6, 2012 May 27.

Article in English | MEDLINE | ID: mdl-22634755

ABSTRACT

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

Subject(s)

Colorectal Neoplasms/genetics , Cyclin-Dependent Kinase Inhibitor p21/genetics , DNA Polymerase III/genetics , Membrane Proteins/genetics , Case-Control Studies , Genetic Loci , Genetic Predisposition to Disease , Genetic Variation , Genome-Wide Association Study/methods , Humans

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