1.
Bioorg Med Chem Lett
; 20(2): 608-11, 2010 Jan 15.
Article
in English
| MEDLINE
| ID: mdl-20005710
ABSTRACT
The triaryl bis-sulfone 1 was modified by converting the aryl A-ring to a piperidine ring. The piperidine ring was further elaborated to a spirocyclopropyl piperidine moiety. The effect on CB2 binding potency, rat calcium channel affinity, and CYP 2C9 inhibition is described.