ABSTRACT
AIM: To present the results of work of National Medical Research Center of Treatment and Rehabilitation, reassigned for COVID-19 patients treatment during pandemic. Run-up methodology, procedures and working process organization are detailed. MATERIALS AND METHODS: 354 COVID-19 patients were treated from 13.04.2020 to 10.06.2020 [age 59 (470) years, 56% women, body mass index 28.5 (24.932.2) kg/m2]. Patients were admitted at 8 (611) day of sickness. In-hospital stay was 16 (1420) days. RESULTS: NEWS scale at the day of admittance was 2 (14); 2 (13) in patients discharged alive and 6 (47) in died patients, p=0.0001. So prognostic accuracy of NEWS scale was confirmed as very well (area under ROC-curve = 0.819). 69 patients (19.5%) were treated at intensive care department for 7 (413) days. 13 patients died, 11 of them had COVID-19 as direct or indirect cause of death. Total in-hospital mortality was 3.67%, in-hospital mortality of COVID-19 patients 3.1%. 17 healthcare workers (HCW), contacted with COVID-19 patients were infected (2.67%). 4 HCW, who had no direct contact with patients were also infected and 7 HCW were infected before the first patient was admitted. No one of them died. CONCLUSION: Complex tasks of healthcare organization during COVID-19 pandemic can be solved quickly with acceptable quality, characterized by low levels of patients; mortality and HCW infection.
Subject(s)
COVID-19 , Pandemics , Female , Hospitals , Humans , Male , Middle Aged , Moscow/epidemiology , SARS-CoV-2ABSTRACT
We studied the effects of dihydroquercetin (3.3.4.5.7-pentahydroxyflavanone, a new Russian patented preparation) on functional activity of polymorphonuclear neutrophils from patients with non-insulin-dependent diabetes mellitus. Flavonoids (quercetin and its derivative dihydroquercetin) dose-dependently suppressed generation of anion radicals and hypochlorous acid and production of malonic dialdehyde during oxidation of neutrophil membranes. Dihydroquercetin decreased activities of protein kinase C and myeloperoxidase in activated polymorphonuclear neutrophils and could bind transition metals (Fe2+). These properties determine the ability of dihydroquercetin to decrease in vitro functional activity of polymorphonuclear neutrophils from patients with non-insulin-dependent diabetes mellitus.
Subject(s)
Antioxidants/pharmacology , Diabetes Mellitus, Type 2/drug therapy , Diabetes Mellitus, Type 2/physiopathology , Neutrophils/drug effects , Quercetin/analogs & derivatives , Quercetin/pharmacology , Adult , Aged , Case-Control Studies , Humans , Hypochlorous Acid/metabolism , In Vitro Techniques , Lipid Peroxidation/drug effects , Male , Middle Aged , Neutrophils/physiology , Superoxides/metabolismABSTRACT
Experimental silicosis was induced by quartz-containing dust administered intratracheally to Wistar male rats. Proteoclastic enzymes terrilytine was found to arrest pulmonary fibrosis, which was proved by inhibited development of silicotic granulomas and their lowered fibrosis. Terrilytine was most effective when inhaled in a dose of 0.08 PU per rat. Injected intraperitoneally, terrilytine in the dose elevated from 0.1-0.2 to 0.3 PU inhibited fibrosis developing in the presence of marked serous desquamative alveolitis. Incorporation of the enzyme in the cholesterol-lecithin liposomes prevents this side effect in the lungs. Liposomes injected intraperitoneally do not influence the development of pulmonary fibrosis in silicosis.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Amylases/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Peptide Hydrolases/therapeutic use , Silicosis/drug therapy , Adjuvants, Immunologic/administration & dosage , Amylases/administration & dosage , Animals , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Disease Models, Animal , Drug Combinations , Drug Evaluation, Preclinical , Lung/drug effects , Lung/pathology , Male , Peptide Hydrolases/administration & dosage , Pulmonary Fibrosis/drug therapy , Pulmonary Fibrosis/etiology , Pulmonary Fibrosis/pathology , Rats , Rats, Wistar , Silicosis/etiology , Silicosis/pathologyABSTRACT
A group of patients with occupational disease and female sewing-machine operators were medically examined with a broad set of biochemical techniques aimed at the detection of metabolic disorders in the locomotor system tissues. Noninflammatory dystrophic changes were found. The muscular component was dominating in comparison with the osseous one in the genesis of the degenerative dystrophic processes, which manifested in the clinical course. Laboratory manifestations were revealed related to the lowered energy supply and oxygenation of the skeleton muscles in patients with neuromuscular and osteo-muscular++ syndromes. The metabolic disorders were diagnosed at the early stages of myalgia.