Measurement of the ν_{e}-Nucleus Charged-Current Double-Differential Cross Section at ⟨E_{ν}⟩=2.4 GeV Using NOvA.

The inclusive electron neutrino charged-current cross section is measured in the NOvA near detector using 8.02×10^{20} protons-on-target in the NuMI beam. The sample of GeV electron neutrino interactions is the largest analyzed to date and is limited by ≃17% systematic rather than the ≃7.4% statistical uncertainties. The double-differential cross section in final-state electron energy and angle is presented for the first time, together with the single-differential dependence on Q^{2} (squared four-momentum transfer) and energy, in the range 1 GeV≤E_{ν}<6 GeV. Detailed comparisons are made to the predictions of the GENIE, GiBUU, NEUT, and NuWro neutrino event generators. The data do not strongly favor a model over the others consistently across all three cross sections measured, though some models have especially good or poor agreement in the single differential cross section vs Q^{2}.

Search for Active-Sterile Antineutrino Mixing Using Neutral-Current Interactions with the NOvA Experiment.

This Letter reports results from the first long-baseline search for sterile antineutrinos mixing in an accelerator-based antineutrino-dominated beam. The rate of neutral-current interactions in the two NOvA detectors, at distances of 1 and 810 km from the beam source, is analyzed using an exposure of 12.51×10^{20} protons-on-target from the NuMI beam at Fermilab running in antineutrino mode. A total of 121 of neutral-current candidates are observed at the far detector, compared to a prediction of 122±11(stat.)±15(syst.) assuming mixing only between three active flavors. No evidence for ν[over ¯]_{µ}→ν[over ¯]_{s} oscillation is observed. Interpreting this result within a 3+1 model, constraints are placed on the mixing angles θ_{24}<25° and θ_{34}<32° at the 90% C.L. for 0.05 eV^{2}≤Δm_{41}^{2}≤0.5 eV^{2}, the range of mass splittings that produces no significant oscillations at the near detector. These are the first 3+1 confidence limits set using long-baseline accelerator antineutrinos.

Tuberculosis peritoneal con presentación clínica como cáncer ovárico avanzado: revisión de la literatura / Peritoneal tuberculosis with clinical presentation as advanced ovarian cancer

Se presenta el caso de paciente con ascitis, masa pelviana y CA 125 elevado, sugerentes de cáncer ovárico avanzado. Se realizó laparoscopía que demostró lesiones compatibles con tuberculosis peritoneal. La biopsia laparoscópica de las lesiones demostró granulomas, por lo que no se realizó más cirugía y se inició tratamiento antituberculoso específico con buena respuesta clínica. Se revisa en la literatura tuberculosis peritoneal y su dificultad con el diagnóstico diferencial con cáncer de ovario avanzado.

It is presented the case of a patient with ascites, pelvic mass and elevated CA 125, all suggested of advanced ovarian cancer. It was made a laparoscopy that evidenced lesions of peritoneal tuberculosis. The laparoscopic biopsy of the lesions demostrated granulomas, for that there was no more surgery made and antituberculosis specific treatment was started, with good clinical response. It is revisited in the literature peritoneal tuberculosis and its difficult differential diagnoses with advanced ovarian cancer.

Dermatitis actínica crónica / Chronic actinic dermatitis

Se presenta un paciente con una dermatitis actínica crónica (DAC) que consulta a nuestro Servicio con un cuadro tipo eritrodérmico, que se agrava a la exposición solar. Sus estudios histopatológicos mostraron distintos patrones: infiltrados inflamatorios inespecíficos, espongiosis, etc, pero no se hallaron células atípicas. El cuadro mejora con la administración de beta-carotenos y corticoides locales (AU)

Dermatitis actínica crónica / Chronic actinic dermatitis

Se presenta un paciente con una dermatitis actínica crónica (DAC) que consulta a nuestro Servicio con un cuadro tipo eritrodérmico, que se agrava a la exposición solar. Sus estudios histopatológicos mostraron distintos patrones: infiltrados inflamatorios inespecíficos, espongiosis, etc, pero no se hallaron células atípicas. El cuadro mejora con la administración de beta-carotenos y corticoides locales

Costello syndrome: phenotype, natural history, differential diagnosis, and possible cause.

We describe 8 patients affected with Costello syndrome including an affected sib pair and review the literature on 29 previously reported cases. We emphasize an association with advanced parental age, which is consistent with autosomal dominant inheritance with germline mosaicism. The pathogenesis appears to involve metabolic dysfunction, with growth disturbance, storage disorder appearance, acanthosis nigricans, hypertrophic cardiomyopathy, and occasional abnormalities of glucose metabolism. Although the cause is currently unknown, Costello syndrome is interesting because of a potential genetic-metabolic etiology.

Lupus eritomatoso sistémico: análisis de las manifestaciones clínicas al diagnóstico de sesenta casos pediátricos / Eritomatoso systemic lupus: analysis of clinical manifestations in the diagnosis of sixty pediatric cases

El lupus eritematoso sistémico (LES) es una enfermedad por autinmunidad que representa un desafio para el pediatra debido a la variedad de sus formas de presentación. Se revisaron 60 historias clínicas de pacientes con LES atendidos en el hospital de pediaría Juan P. Garrahan en el lapso entre agosto de 1987 y agosto de 1993, con el objetivo de analizar las manifestaciones clínicas en el momento del diagnóstico basándonos en los criterios de clasificación del Colegio Americano de Reumatología (A.C.R.). Los datos que se evaluaron fueron: diagnósticos previos relacionados, la enfermedad, tiempo transcurridos hasta el diagnóstico, sexo, edad al diagnóstico, manifestaciones clínicas al diagnóstico, serología y laboratorio general. La edad media de presentación fue de 12 años, con predominio del sexo femenino. Los diagnósticos previos más frecuentes fueron artritis reumatoidea juvenil (ARJ), fiebre reumática (FR) y purpura trombocitopénica autoinmune (PTA). La mayor parte de los pacientes tuvieron diagnóstico confirmado entre los 3 y 12 meses de aparición de los sintomas. La evolución más rápida se asoció a formas más graves. Se encontró menor afectación dermatológica que la referida por el A. C. R. ( 1982). El 43 por ciento de los pacientes mostraron compromiso renal, y el mismo porcenaje tuvo afectación articular. El 16 por ciento de la población mostró patología pulmonar y el 25 por ciento trastornos cardíacos, sobre todo pricarditis. Se concluye que por la heterogeneidad de formas clínicas de presentación y el compromiso de múltiples sistemas de la economia, se impone la atencion multidisciplinaria de estos niños, manteniendo un alto grado de sospecha clínica y reiterando periódicamene el laboratorio inmunológico.

Infantile-onset multisystem inflammatory disease: a differential diagnosis of systemic juvenile rheumatoid arthritis.

We describe four unrelated children with neonatal maculopapular rash, fever, arthritis, hepatosplenomegaly, lymphadenopathy, eye involvement, and neurologic symptoms. Radiographs of the joints were surprisingly similar, showing an abnormal epiphyseal and metaphyseal appearance. These clinical and radiologic findings allowed us to include these children in a very peculiar syndrome described as infantile-onset multisystemic inflammatory disease. A chondrosarcoma developed in one of our patients.

Utility of the Pediatric Symptom Checklist as a psychosocial screen to meet the federal Early and Periodic Screening, Diagnosis, and Treatment (EPSDT) standards: a pilot study.

OBJECTIVE: To examine the usefulness of the Pediatric Symptom Checklist (PSC) as the psychosocial screening measure to meet federal Medicaid/Early and Periodic Screening, Diagnosis, and Treatment (EPSDT) standards in a low-income Hispanic community. DESIGN AND SETTING: Three hundred seventy-nine children (aged 6 to 16 years) were screened with the PSC in a 10-month period during well child visits to three clinics in Ventura and San Mateo counties in California. The PSC was available in English and Spanish and was administered both in written (paper-and-pencil) and oral formats. Follow-up services were provided for children identified as needing evaluation. RESULTS: The Cronbach alpha was high (r = 0.91) for the PSC in the whole sample and virtually identical for English, Spanish, oral, and written formats. All the PSC items were significantly associated with total score on the PSC in English, Spanish, oral, and written formats. Overall, the PSC identified 10.6% of the sample as at risk for psychosocial problems. Thirty-six children (9.5% of sample) were referred for mental health follow-up. Public health data from Ventura County showed a statistically significant increase in referrals for psychologic problems during the study period in two locations using the PSC: from 0.5% to 2.9% of the school-aged children seen. CONCLUSION: The PSC provides a feasible, well-accepted method for screening for psychosocial problems during EPSDT examinations of school-aged children. Psychosocial screening using a validated instrument such as the PSC, as well as increased efforts to refer positive screening results, track outcomes, and assess cost benefits should be essential requirements in capitated Medicaid approaches to caring for poor children.

Colecistitis aguda. Analisis clinicoquirurgico de 300 casos (1965-1981). / Acute cholecystitis. Clinicosurgical analysis of 300 cases (1965-1981)

Se presenta un estudio sobre 300 casos de colecistitis aguda. El 59% era del sexo femenino; el 73% tenia entre 50 y 79 anos de edad. En su gran mayoria fueron complicaciones de litiasis biliar. Del total de casos se trataron quirurgicamente 251 enfermos (83,7%). Hubo un 35,8% de complicaciones postoperatorias y una mortalidad global del 12,3% (37 pacientes). Opina el autor que la edad es muy importante ya que por debajo de los 50 anos no fallecio ningun enfermo de la serie

Colecistitis aguda. Analisis clinicoquirurgico de 300 casos (1965-1981). / Acute cholecystitis. Clinicosurgical analysis of 300 cases (1965-1981)

Se presenta un estudio sobre 300 casos de colecistitis aguda. El 59% era del sexo femenino; el 73% tenia entre 50 y 79 anos de edad. En su gran mayoria fueron complicaciones de litiasis biliar. Del total de casos se trataron quirurgicamente 251 enfermos (83,7%). Hubo un 35,8% de complicaciones postoperatorias y una mortalidad global del 12,3% (37 pacientes). Opina el autor que la edad es muy importante ya que por debajo de los 50 anos no fallecio ningun enfermo de la serie

Familial variable immunodeficiency: autosomal dominant pattern of inheritance with variable expression of the defect(s).

In 1963, Rosen and Bougas reported the case of a woman with recurrent infection, marked elevation of 19S, and virtual absence of 7S gamma globulin. Recently, members of her family were found to have similar abnormalities: Ten of the 37 family members tested had elevated levels of serum IgM accompanied by a combined deficiency of IgG and IgA in three, and by a deficiency of either IgG or IgA in two. In five, an increase in IgM was the sole abnormality. Two children had deficiencies of IgG and IgA with normal serum levels of IgM. Ten of the 12 affected individuals had no IgD detectable by radial immunodiffusion and six had a low percentage of IgG-bearing B lymphocytes. A lack of correlation between the immunochemical abnormalities and either the presence or severity of clinical illness was observed. The presence of immunodeficiency in three generations and in both sexes of this family suggests an autosomal dominant mode of inheritance with variable penetrance of the defect.